Methylene Blue - updated
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- Опубликовано: 4 авг 2024
- I highly recommend CZTL Methylene Blue: cztl.bz/?ref=Lwr85
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This video review of Methylene Blue as a nootropic is an update to the video I recorded several years ago on Methylene Blue.
In this video you'll discover the nootropic benefits of Methylene Blue. Including why we use Methylene Blue as a nootropic, recommended dosage, side effects and clinical research.
Methylene Blue, a synthetic compound, is used as a nootropic to enhance memory, mood, and longevity.
It improves mitochondrial function and respiration in the brain, positively impacting memory and mood.
Methylene Blue shows promise in treating neurological disorders such as mild cognitive impairment, Alzheimer’s, and Parkinson’s disease.
And Methylene Blue acts as an antioxidant, increases brain cell lifespan, and positively affects neurotransmitters.
Some who use Methylene Blue report that when reading or studying, once you’re done, you should feel like you fully understand the subject material. And you’ll be able to use what you learned in the future.
Many neurohackers report the biggest nootropic effect they experience with Methylene Blue is “after the fact learning”. You take in the information. And it’s like your brain sorts through the material. Then stores it in a form you can easily access later.
This in-depth Methylene Blue review covers:
00:00 Methylene Blue intro
01:34 Methylene Blue as a nootropic
03:03 How does Methylene Blue work in the brain?
06:21 Methylene Blue benefits
11:53 How does Methylene Blue feel?
12:21 Methylene Blue clinical studies & research
13:41 Methylene Blue may may reduce Alzheimer's progression
15:12 Methylene Blue improves memory & reduces fear
16:35 Methylene Blue helps Bipolar Disorder
17:36 Methylene Blue recommended dosage
19:00 Methylene Blue potential drug interactions & side effects
20:15 Reduce the risk of Serotonin Syndrome
20:55 Where to buy Methylene Blue
22:26 Secrets of the Optimized Brain - free download
22:41 Head First - 2nd Edition
For more on Methylene Blue including a full transcript of this video and links to clinical studies, get it on my website here: nootropicsexpert.com/methylen...
I highly recommend CZTL Methylene Blue: cztl.bz/?ref=Lwr85
For a full list of all the most popular nootropics used today, go to: nootropicsexpert.com/nootropi...
The 2nd Edition of my book "Head First - The Complete Guide to Healing & Optimizing Your Brain with Nootropic Supplements" is 962-pages. And the best guide on the planet for fixing and optimizing your brain.
Head First 2nd Edition is available in hardcover, paperback or digital from all the major online booksellers including Amazon, Barnes & Noble, Balboa Press, Walmart, Apple books, and others. Get your copy here: geni.us/K1Bv
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The co-supplement that goes well with Methalene Blue with mood control is magnesium...
My personal experience is that MB also helps with candida overgrowth
Thanks for info.
Just got some after research and some chronic issues I have been dealing with that seems mysterious?!)
All labs come clean
I have watched quite a few methylene blue videos. This one is the most informative and easy to understand. Thank you!
Thank you Tom.
I've just been learning about this and here we have best source of them all.
The best blue video yet
Thanks!
Thank you sir for your videos they have been a tremendous help to all of us.
Thanks Zakaria.
Wow. Thank you!
Excellent - I started taking methylene blue shortly after I watched your first program on it. I appreciate all of the corroborating data - the bottom line is that it works. Dosage info was particularly helpful, I think I'll check into the powdered form, as well. Thanks!
Thank you Lee.
Great info.
Great video
I’ve been taking it for just over a week and have been blown away with just how many benefits I’m experiencing! Thank you so much for your thorough report! I always learn so much from your videos. 🙏🏼
Thanks Lisa.
@@NootropicsExpertwhat brand?
What's your experience?
HOW OFTEN YOU TAKE IT. I WAS PLANNING 2 DROPS FROM TINCTURE ONCE A WEEK
You can use MB twice per day.
Thumbs up and subscribed !
Thanks!
Welcome!
Im on amitriptyline for sleep and am great at 3 drops or 1 1/2 mg. So antidepressants may mean you take a lower dose like me. It has been like a miracle to me. Start at one drop and find your sweet spot. At 4 drops my blood pressure raises.
thanks for this vid
Welcome!
I Love MB - been taking it for 2 years (50mg 2xday in my own capsules which is below the dosage for my 175 lbs)) and the one supplement I can really tell that helps me with clarity and definitely my energy level. I just turned 70 and going strong. The only thing is my doctor is trying to determine why my hemoglobin and Red blood cells are below normal. I then read under MB one side affect was reduction of red blood cells on Nootropics website and in David's new book and actually he says so in the video. I wonder HOW it affects red blood cells?.
I'm not saying MB is the cause. I actually feel great and with low blood cells and low hemogobin you are supposed to feel fatigued but I don't at all.
Probably due to fact first off all the medical charts and their levels of anything are relative and not always call for panic.
Its how you feel that guides the healthy.
You body is functioning optimally thus needs less red blood cells and thus your iron count will follow as its in them.
Thank you . Keep swinging .
Great vid as always. I got some of the CZTL. Any affects on Libido?
Not that I know of.
on interactions, would also consider tramadol. although its considered a pain medication it acts as an ssri and also promotes additional serotonin. personally it worked great for long covid which appears like ME to be at least partly a mitochondrial problem. Sunlight and near infra red also amazing for mitochondrial dysfunction
I would not combine MB with Tramadol.
Methylene Blue helps me dump mercury.
So I am only using it infrequently.
Hopefully as I reduce my mercury load I can start taking it more regularly.
I am thinking of pairing it with my infrared sauna blanket.
How can you tell?
How do you know it’s doing this ? And that your mercury toxic ?
I use the troches designed by md's at Troscriptions.
I need to try this. My memory needs help big time.
did you remember to try it?
I take 10 drops per one glass of water, after this video I’m more convinced to consume regularly.
This is so detailed I’ll have to listen again and again
Thank you
Did I hear you correctly say that you shouldn’t take it if you’re taking L- Citruline?
Gary, I did not mention L-Citrulline in this video.
Dosage 18:10
Is this increase in blood pressure something to worry about? Not that many people have low blood pressure- most people have high.
Helps greatly with menopause night sweats i was having them 6 to 7 nights per week since ive been taking mb i havent had night sweats at all in over a month and my cycle seems to be coming back
That is great information. Thank you for sharing. You just helped a lot of women who visit this channel.
When do you recommend taking methylene blue first thing in the am hrs right when you wake, or before bed? Because it also helps for sleep but it does power up the mitochondrial so it's going to stimulate a lot of energy so I would think first thing in the morning, correct? There's quite a few bioackers that recommend only taking it a few times per week, but what do you recommend? Every day in the morning or one to two times per day or just a few times per week in the morning? Please let me know. Thank you. I love your channel. I've been following you for years cuz you have incredible info and insight on nootropics!! Thank you, greatly appreciated
Methylene Blue is water-soluble and has a half-life of about 5 hours. So you can dose twice a day. Usually morning and noon. But we have no data showing how long it can safely be used.
I suggest if using it long-term that you get your labs done a couple times per year. And keep an eye on your kidney and liver health.
Thank you for the update.
Does it need to be cycled, too?.
I've been doing so with KSM Ashwagandha.
Most nootropic supplement do not need to be cycled as long as you are staying within recommended dosages. I cannot think of a good reason to cycle Ashwagandha unless that is was works for you.
But MB has a half life of about 5 hours. So there will be nothing left in your system within about 10 hours. The days you cycle off of using Methylene Blue are the days you do not get its benefits.
Excellent update. @nootropicsexpert . Is it safe to stack low doses of modafinil such as 50-100mg with a 8-20mg dose of methylene blue? There appear to be no clear information on interactions between the two. Would you appreciate your view on this.
www.drugs.com/drug-interactions/bupropion-with-modafinil-440-0-1647-0.html
Hi David. Thank you fir all. the great advice and content 😊
Is it mcgs per kilo of body weight or mgs per kilo of body weight?
mg per body weight.
I take escitalopram for anxiety, would blue be a beneficial addition to my health.
@@NootropicsExpertThanks David!
Steven, go to pulse.ly/ilxwqgox61 and look up escitalopram and then look at the contraindication list. See if Methylene Blue is on that list.
@@NootropicsExpert Hi David! Would taking it alongside NAC be a problem?
Why cant we get the pill form without a prescription? It would solve the staining issues.
I'm down to .25mg of Clonasapam from 1mg. Can this be used to finally and totally get off of Clonasapam???
Not advised for those with /amalgam fillings ?
I just took 30 mg of the stuff then I read on reddit that someone only takes 4 mg and has good results. I can't tell any difference yet. I think I'll start with less next time! Do you take it everyday?
@nootropicsexpert
Thank you! I have a question about serotonin syndrome, as I understood I shouldn't take this with L-tryptophan or any other similar substance.
What about a microdosing protocol with mescaline? If you take L-tryptophan (or methylene blue) daily, and you stop taking them when you use your mescaline microdose, I shouldn't have any risk developing Serotonin Syndrome, right?
Because in a microdosing protocol you usually take the substance 2 times per week, I guess stopping taking other similar substances like this or L-tryptophan the same day as mescaline should prevent the risks, right?
Antonio, look up the half life of mescaline and see how long it stays in your system.
There's a sports medicine doctor , Lieaurance, ND , who has a report on methylene Blue and he says the warning to not take MB with Parkinson's meds has been debunked. It does not hurt to take it with the PD drugs.
How many mg in one drop?
Hi all.
Great video.
Ive a question
Does MB impact glutathione and catalase production adversely?
Thanks for any help
Not that I know of.
I am desperate to try MB. I suffer from a closed head brain injury and Lyme disease. My fear and confusion on the safety of taking it is that I also have hereditary hemochromatosis and can find no information on harm or benefit. Please help!
You need to ask your doctor about this because if you cannot find anything that means there is no data available. Chances are good that it is not a problem. But still worth checking with a medical professional who are familiar with Methylene Blue.
Can MB be taken safely during prolonged fasting ?
I wonder if this would be helpful in weening off caffeine... or addictive substances in general, given the positive effects on dopamine and serotonin, etc.
Caffeine is not doing my nervous system any favors, as someone on the autism spectrum. And I tend to experience withdrawals unfortunately. Any thoughts on this?
There is zero evidence, clinical or anecdotal, that Methylene Blue would help reduce withdrawal symptoms from anything.
So the recommended dose is .5 to 4 milligrams per kilogram of body weight. CTZL says for 1 percent solution to mix 1 gram of powder to 100 ml of water. CZTL says that .5ml of the 1% solution equals 5 mg. So for a 190 lb body or 86 kg woulod be .5*86=43mg. don't remember where I got the instructions for 9 drops of the one percent solution but that would only be 5mg according to CTZL. So how many drops should I be taking?
If 9 drops = 5 mg then 45 mg per day would be around 80 drops. But most find plenty of benefit from less than half that dose.
You say that you shouldn’t take if you have any renal impairment. It has made a positive difference to my ckd. My eGFR has improved. Perhaps you mean those with very advanced ckd ?
Richard, that's what the data says. But your mileage may vary as it clearly has.
Does MB interfere with the effects of SNRIs? Thank you.
Depending on the SNRI that combo will likely cause Serotonin Syndrome.
Is this safe to take if someone is on chemo? My dad has glioblastoma stage 4 and I want to try fenbendazole and methylene blue, my dads memory has started to decline in the last 3 weeks, the tumour is growing effecting his memory
Shane, you need to make sure Methylene Blue is not contraindicated with any drug your Dad is using. Use drugs.com, look up the drug, then click on contraindications and scroll down the entire list to Methylene Blue if it is listed.
In your opinion, did lithium orotate and methylene blue help someone with schizophrenia
Eder, yes for Lithium Orotate as a mood stabilizer. And studies have shown positive results for Methylene Blue as well: pulse.ly/ak2fuk2p1z
Sounds like a very valid nootropic. Does it really turn your urine blue? If so, how long does this last when a person terminates useage. Love your videos and information, well done, very educational.
Drew, it does turn your urine blue and that'll go away once MB is cleared from your body.
MB turn your urine green. Yellow plus blue = green.
Yep it sure does.
How does one avoid staining the teeth and mouth blue?
You don't. Methylene Blue was developed in the 1800's as a textile dye.
In your opinion is it okay to have black coffee,no sugar, shortly after taking MB? Thanks
It's safe as long as it works for you.
Great video Professor!Can I use that for treatment resistant depression and at which dosage?I am 175 lbs and out of antidepressants .
It depends. MB works for some and not others. Dosage depends on the strength of the solution you are using. Best to check with the manufacturer or wherever you got your Methylene Blue from for dosage suggestions.
@@NootropicsExpert Thank u very much for u'r respond Professor. U suggest something else ?
I cannot suggest anything else without know what is causing your treatment resistant depression. Best to schedule a consultation with me and I will help walk you through this discovery process.
@@PP-hn2rq did you find something for your depression? And does it help you?
Best thing that worked for me was the combo of Aniracetam and Sulbutiamine. But that was me. May not work for you.
Dose suggestions for Parkinson’s disease please? I’m 75kg so how many drops and should I take with vitamin C to enhance beneficial effects
Depends on what works for you. The standard adult dosage is 45 mg per day. But some use more and some use less.
Can dogs have mb? Everything on line says they can’t but then I don’t understand why not if it’s tested on animals !? Thank you
MB has been tested in animals but not sure about dogs. You'll need to ask your vet this question.
There are much kinds of animals, a Human is a kind of too
Where are people sourcing this though?
20:50 in the video
Any discount code?
Thanks
Naima, the best I can do with this company is the link I provided above in the notes section.
Does anyone know why this supplement makes me sleepy? Every time I take it I literally conk out within an hr or two
Thank you for this video! I would like to ask if MB could be taken together with Ashwagandha or Lion's Mane? Thank you!
Yes you can!
Has any affect on tinnitus ?
thats all great for the brain but does this improve literally every cell in the body?
It is an electron donor to wherever there are mitochondria. Which exist in nearly every cell in your body.
Can methylene blue treat someone with a TBI and improve their motor functions
I have not seen any evidence the MB can help with TBI. See my video Traumatic Brain Injury for other ideas: pulse.ly/ok6h6ow5m1
are there any OTC supplements that should not be used with MB?
Do NOT use 5-HTP, St. John's wort or CoQ10 with MB.
Can you safely use this the same day as you microdose banisteriopsis caapi and Bobinsana?
Absolutely not.
Where do you buy in the UK ....please help
Try the link I provided up in the notes because CZTL is based in Europe.
What dosage of methylene blue will fully inhibit maoi?
Jacob, it starts to become a problem at around 2 mg/kg of Methylene Blue.
Hi David. Does mixing vit c powder with methylene blue to make it clear when drinking it neutralise any of it's beneficial properties? Thank you
Not that I know of because the two compounds have very different mechanisms of action.
Thank you for the video --would you think MB is safe to take along with nitric oxide supplements (L Arginine 2000mg, L Citrulline 1000mg, L Carnitine 1000mg)
Curtis, good question but they are not contraindicated.
You really should read Mark Sloan's book bout methylene Blue. He says that it lowers nitric oxide in our bodies, and that is why it is good for us. NO is produced in response to stress and and is not a condition we ought to be in , and that nitric oxide is actually bad for us. I can't go into it here, its too long , but by the time I was done reading why and wherefores of it I was convinced. Skip the citrulline and the arginine and take the methylene blue. They work against one another.
Can MB be taken with Noopept? Also should you cycle MB?
They are not contraindicated and neither one needs to be cycled.
Can i take it with valium or mirtazapine?
Definitely NO because you'll very likely cause Serotonin Syndrome which is often deadly.
I made from powder form 1mg in a vial with 100mg water how i can dose it safely thanks
Check with the manufacturer. If it was CZTL they have a FAQ page with that info on their website.
How long you can take MB? Please any answer
For as long as it works for you.
I have yet to use methylene Blue , but as it is synthesized, why is it contaminated before being used and have to be pharmaceutically refined.
Barry, there is a great explanation in this article on why Methylene Blue is contaminated because of how it is produced: pulse.ly/bjnk57izos
what daily dose do you recommend
Best I can answer that is up to 45 mg per day. But most find benefits from half that dose.
I’m wondering about MB for someone that’s has low bp and literally can’t take a hot bath bc blood pressure bottoms when getting out. It’s happened at other times also but ER found no issues after extensive tests
Adding on to above, even getting blood work can bottom him into complete unconsciousness
Mary, if low blood pressure is an issue then this is likely the wrong supplement.
I’ve been taking it for two weeks and haven’t noticed anything at all. Does that mean I need to take more?
Clara, you either need to increase your dose or this is the wrong supplement for you.
what if someone has MTHFR and MTHFD polymorphisms?
Unknown. There are no clinical studies on it. Maybe someone else dealing with methylation issues can tell of their experience.
I'm looking for a source inside the EU... anyone?
CZTL ships to Europe as far as I know.
@@NootropicsExpertI can confirm. I ordered from the Netherlands.
Can i use Methylene Blue while supplementing psilocybin ?
Likely not a good idea. This is how psilocybin works: pulse.ly/amuxkcch20. I don't think any tests of have done with this combo but it looks like a good chance of Serotonin Syndrome.
@@NootropicsExpert Hi David - do you know what the trigger was that made someone decide to test a cotton dye (MB) for medicinal purposes ???
- this whole MB topic sounds ridiculously interesting !!!
yes MB is a MAO inhibitor
@@NootropicsExpert So maybe there's a general contraindication list for those of us taking other medications? Thanks for this video. I wonder did you mean that combo can cause "Serotonin Syndrome", or was that a joke ;-)?
I haven't a clue but remember no one back then understood how viruses worked or what caused them. They used to try really crazy things to cure disease as long as man has been on this earth.
Does this really turn the brain blue ?
We wouldn't know unless we autopsied your brain. And I don't think that is a good idea. Do you? 😊
What about people with Autism?? I didn’t hear anything on this topic. If it works with Alzheimer’s which is an austistic spectrum, I am wondering how this would work in autism.
I did no rind any research showing Methylene Blue worked for autism.
What is MB? What's in it, where is it from?
Watch the video.
Meth Blue, the best drug for a mitochondriac junkie.
I am taking it right now but don’t notice anything… been taking for a few weeks now. I take 3 drops and it still make the urine blue
You dose is likely too low. Depending on the strength of the solution you are using chances are the recommended dosage is more like 60 drops.
@@NootropicsExpert I am 100 lbs. the bottle has 50 ML.. I paid $30 on Amazon…. It is very expensive
Amazon is not likely a great place to find Pharmaceutical Grade Methylene Blue. But you are correct that nootropics can be "expensive".
So it seems like methylene blue is too good to be true. And I came across a video in a different language that said methylene blue breaks down glutathione in the cells. Is this true? Is this the downside to MB? This seems like a very huge downside….
Exactly the opposite is true.
Ok , now how many drops is 45mg’s
It depends on the strength of the solution. Some will take 90 drops to reach 45 mg. Some more or less depending on the strength. The manufacturer should include this on their FAQ page.
I've been using using it for 2 years I still don't know how much vodka I should use.
Start with a low Dose and go up till you feel better 😉
What happens when i take non pharma grade, is it dangerous?
Ali, non-pharma grade Methylene Blue is at least 10% or more heavy metals which are extremely toxic to your body and brain.
Don't eat cloves with methylene blue, not that most people would do that but I had been eating cloves before. Then I got mb and by the time I worked up to 12 drops in a days (or .6 of a serving, I became very tired and spiraled into depression which I am recovering from.
Cloves are antiparasitic. Maybe you had die off symptoms. I get pretty down when I detox heavy metals, parasites and mold.
That's likely not because you took it with clove - just because you are experiencing that doesn't mean correlation = causation. It's like a herxheimer reaction, because your body is dealing with unloading too much at once. Take your dose back down and start again very slowly.
I took MB for about 3 weeks and stopped.no idea why i am so depressed and lethargic Could it have been caused by MB?
If that is the only thing that changed and you were not depressed before then it must have been Methylene Blue that caused it.
@@NootropicsExpert I thought it was that cloves contain an moa inhibitor. Thank you for the information.
=> NootropicsExpert
Serotonin Syndrome is primarily a problem when using Methylene Blue with certain prescription drugs. The only nootropic supplements I can think of that "may" cause problems are St. John's wort and 5-HTP. A distant 2nd may be L-Tryptophan.
Should I not be taking 5HTP and St Johns wort and methylene blue at the same time? 😅
Absolutely not.
First
Thanks for updating the videos