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Dosing and safety of Methylene Blue
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- Опубликовано: 8 апр 2024
- There is a lot of confusion about the dosing of methylene blue for brain health and optimal cellular function.  This video discusses dosing of oral methylene blue as well risks and side effects. 
#methyleneblue #supplements #mitochondrialhealth
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I had a genetics testing panel which showed a mutation for Mitochondrial I Complex process. I began taking MB about 1 year ago, 30mg daily. Lifelong dark circles under my eyes cleared up, my skin health improved vastly and I no longer feel fatigued by early afternoon or evenings. I also tapered off of an SNRI and feel MB is a very natural antidepressant (at least for me). I will continue taking it as I also have APOE Alzheimer’s risks.
Thank you for your comment. I’m glad to hear that this works so well for you. A lot of my patients have reported great benefits.
Was the 30 mg your starting dose or did you gradually go up there?
@@JonasKuehneMD I began with 5mg and felt a noticeable improvement in energy but not much in terms of mood. I titrated to 30mg quickly, I do remember it being within my first order, so less than 1 month. I have responded very well, can’t think of any negative side effects.
Hi . Where did you buy it please ? Pharmacy or Amazon ? Liquid or capsules ? Thank you .
@@mgkchwould love to know as well. Ty for sharing your experience.
@@ToWhateverEnd Were you still on your SNRI when you started MD? Did you use MD to taper off your meds. Also, what SNRI were you taking if you dont mind me asking? Thank you, hope its okay asking all these questions.
If stuck on a deserted island and could only have one health enhancing compound, I would choose Methylene Blue. Micro dosing, 2 days on and 1-2 days off with intermittent longer breaks off, has been most effective. Improved focus, energy, mood, and restful sleep- with no side effects. Overall well being noticeably impacted.
Thank you for sharing this!
I have small pwder vial..how do u measure dosage ? Dropper measures 1ml up to 3
I've been taking about 20-30mg daily for month or bit more (in split doses, restored by ascorbic acid), which is 0.25mg/kg to 0.38mg/kg in my case and after that did a 4 day water fast and I actually noticed that urine was colored green until the very end of 4th day. So seemingly it did accumulate over time and I'll need to tune down the dosage. I've actually seen something similar in literature when they proposed that color may be indicative of patient oxidative status (the darker urine gets, the more oxidative stress there is), but I also think that taking pauses can help figure out individual dose. Thanks for the vid, was one reason I considered reducing the intake
That’s great information. Yes, ideal doses will vary individually. I always take one day off completely per week. I also noticed that while I take it in the morning usually around 9 AM, green or blue urine sometimes continues until the evening or longer. It is difficult to say how well one can predict the half-life based on that, but if methylene blue is still accumulating in urine, and able to change color then there should still be a significant amount left.
Awesome!!! Yup I was confused for this reason.
Excellent info and very comprehensive, thanks and I subscribed 🙂
Thank you! Much appreciated!
This is exactly the video & information I was looking for.....thanks doc.
Glad it was helpful!
Awesome information Doctor. Very much appreciated. Thank you so much for clarifying so much confusion on this topic.
Thank you for your comment. Very much appreciated.
Very informative. Thank you for the clarification on dosing.
Glad it was helpful!
Very good information. Clear, concise and to the point. Helps a lot. Thanks.
Glad it was helpful!
Thank you for great info.
Glad it was helpful!
Thank you 👍
Best explanation on how to dose methylene blue I was able to find on RUclips, as well as other clarifications which were not elaborated in other very informative and lengthy videos -- thank you, Doc!
Subscribed!
Thank you for your amazing feedback! Highly appreciated.
Yes I bought a bottle a long time ago but barely took any (1-2 drops every few days) since I had no idea how much to take and now I have leaky gut so need to check into this topic again
@@avarysse5782 The best info on how to heal a leaky gut I have found in the books and videos of cardiologist dr. Steven Gundry. Every 3 months he does blood tests on markers in his patients, to check if all the strategies he advises indeed have the desired results.
Thanks for the link. I had no idea where to buy pharmaceutical grade at a reasonable price.
Happy to help
Quantum on Amazon
Thanks, the sleep disturbances I've had have been crazy nightmares, so now make sure I take last dose way earlier in the day
Did it work?
@@JonasKuehneMD aye, takin 7mg with breakfast and 3mg with lunch, rather than the 3mg, 3mg, 3mg every meal that I started with, sleeps fine now and I do feel I'm a wee bit sharper for it, but this is just the 2nd week of using it
Thank you 🙏🏼
Good information Dr Jonas. I started taking MB, 35mg daily, yesterday for sarcoma cancer. Thank you for your posts!
Do you also take black cumin oil?
Essiac Tea 🙏🏻
@@m.b.593 do you have personal experience with essiac tea?
How is that going? I have sarcoma also and would like some feedback please
MB binds to 80% something of cancers - but what do you do with it? Which agent kills the bound cells?
I use CISS cure, so first deplete blood of antioxidants by taking F+ protocol to J.H., then after 3 hrs, I take a (sub-) drop of NaCIO2 I slowly rise.
This will hop sour tissue into the face, meaning NaCIO2 gets slit up and frees a CIO2 in sour milieu; and so far I found ALL cancer tissue is sour, because of ... GREED. It lost oxygen breathing and only does lactic acid circle.
But of course, many remedies and meditations, prayers, pure joy and lots of other brain states activating the amygdala more are purifying and doing the job of HEALING you.
So detox brain thus "decalcify" Amygdala from F, Hg, Pb, Al, and glyphosate and spike. Whatsoever toxins hacking down on breath of Life.
Thanks, great summary.
Some of the literature discusses drops, others mg.
The leaflet that came with mine stated 1% solution, each drop contains 0.5mg, and instructions to build up to 7 drops (3.5mg). The dosing chart in Mark Sloan's book is helpful.
I wanted to improve mental clarity (im 66) so i now take 14 drops or 7mg, which is enough for me.
Interesting info re: half life and taking a break.
PS, no microbiome issues at all, in fact i would say gut tolerance of grains has improved. I make my own yoghurt with foundation species like L. Reuteri
Thank you for your details comment. I also find that about 7 to 10 mg daily is sufficient. The issue with disruption of the gut micro biome seems to occur at higher doses above 30 mg daily for most people. Mental clarity and focus are also the reasons why I use it.
I found my dripper from my MitoBlue actually has 0.07ml, not the usual 0.05ml. No one does laser abrasive fine tuning on drop size of dropper tips fitting to viscousity of your fluid. But one can check with a scale or ml syringe. :)
Please use eg. 1 % g/ml as concentration, and calc with units.
(% is an abbreviation that leaves out the proper dimensions:
1% in reality is only a number, 0.01 - that‘s it.
What companies and private persons should do is write dimensions to numbers. So we do not buy apples and get pears.)
So we have a weight of an active ingredient like 1g and solve it in 100ml by „adding water till 100ml is reached“, in pharmacy latin „ad 100ml“.
This corresponds to concentration as mass per volume.
c=m/V so here
c = 1g / 100ml = 1% g/ml
Then you can actually calculate and check if all turns out nicely.
You take 8 drops of 0.07ml and want to know the dose in mg:
m=c*V = 1% g/ml * 0.07ml/drop * 8drops = 0.0056g = 5.6mg
(Yes, we use drops as a unit and it nicely cancels out, so all is fine!)
Done.
Measure drop size…:
So it may be informative to count e.g. 20drops and measure them out with a small syringe of proper size (I always buy some 1 / 2 / 5 / 10 ml , sometimes I get hold on a 20ml, to have easy fluid measurement available.
Found one 1ml that extends its piston into the outflow tip, so it has no „dead volume“, cool. B.Braun Inject-F 1ml. Very fine scale 0.01ml also).
@@andshofs5769 thank you for taking the time to reply.
Yes, I did in fact use a tiny 2ml syringe, removed the plunger and counted my drops into the empty chamber. It just helped me to reframe the volume I was using from drops into ml. 😊
@@maryhall3722 After using the dripper a while, I came to a larger dose and now count whole load of a dripper I repeatably fill. One can also use pump systems that have very repeatable volumes per puff. For sprays, one would have to drill the nozzle wider so no hard jet or droplets form.
I like to dig into combining it with detoxing stuff, had too many Hg fillings in teeths and too much ongoing reaction on certain safe-and-effective smurf parties... - as it improves the effectiveness of chelator like substances, VIt-C, NAC, Na-gluconate, EDTA (liposomal) etc., perhaps even to charcoal one swallows and that is a nice deposit also for stuff diffusing from blood into lumen of intestines.
Perhaps it works even to boost the citric oils also helping there.
from what vendor do you purchase your L. Reuteri and others?
ty
I started taking methylene Blue about five days ago, mainly for energy and for arthritis pain. I feel as of today it’s been helping and after dinner it seems like the pain was back and my energy had dipped so I’m glad you mentioned the half-life. I’ve been taking eighth drops in the morning. I think I may take another another eight in the afternoon now and see how I feel. Thanks for the video.
Thank you for your feedback. I noticed taking it too close to bedtime Impaired my sleep. I often take it in the morning around 9 AM, and then a second dose around 1 PM.
@@JonasKuehneMD thank you I think I’ll do a similar strategy. We’ll see how that works. Thanks again for the video and your information.!
Also, there is "nothhing boring about B0ron".
Or read the B0rax C0nspiracy, by WaIter L@st.
I just try not to mix it in glass or stomach, so at least some 1/2 hr apart.
If digging deeper, you will find many working remedies, and may smear campains against them.
I just discovered my biggest potential for self-healing is my infinite soul if one got his amygdala decalcified and dedicate to healing.
All the best!
Can you explain milligrams in terms of drops? I have been doing five drops a day sometimes twice a day and
I feel good but
I would like to know if five drops is too much too little.
@@Lovemarvez People vary in tolerability in multiple orders of magnitude. So do not count the milligrams, but do your proper dose finding and do dosing repeatably.
The calc is easy: 5dr * 0.05ml/dr * 1% g/ml = 0,0025 g = 2,5mg.
I assume a drop for you is standard drop 0,05ml (you only know if measuring it, mine on "Amaz EU is 0.075ml;) and you use a 1% solution, 1% is some eclipse of "1% g/ml" - and with the units it implicitly makes sense ;)
If you want to compare your redox state from what you see in your urine, you can first measure "blue absorption" in native urine, which is the "oxidized form" of MB, then add some ml CDS, and this makes all MB blue, so oxidized, so measure again absorption ratio to determine full content of MB.
I use some "Color Meter" by Contechity in iOS to measure colors with white balance on white paper I put next to probe.
Well works to some extend.
For the ones having heard of "Arduino":::
To do this more repeatably, any light interruptor circuit best with some modulation technique to eliminate daylight is welcome.
Most not wanting to modulate the led do it it dark cardboxes and by ramping up a LED till the reception levels match. Very linear.
But you can also do it to cross correlation I found nicely explained for cypress PSOC in AN2042 of cypress, see web.archive.org/web/20180702175100/www.cypress.com/documentation/application-notes/an2042-psoc-1-multifunctional-optical-sensor
You can of course download the zip with example code from archive. But since cypress was acquired by Infineon, do not expect the example code to run in their latest PSOC creator, but download some old one of the time of the code example.
Or transfer the code to a platform of choice, like some Arduino or raspi with some 24 bit A/D and D/A chip doing the job nicely and away from the noise of the micro controller. The neurotic will do optical signal transmission to the analog board that gets some analogue regulated power supply in some properly shielded case by some LED lighting fibre or TosLink fibre. So for the data transmission. But also for the measuring light signals. No EMF can creep to the AD if you shield it properly and use multi-layer PCB. And many capacitors and adjacent PCB layers 50µm ajar to have a ground plane capacitance.
By the same setup, and searching for DIY UV-VIS spectrometer, you can do full UV-VIS spectroscopy with reference points by cheap laser diodes with known wavelenghts, you can also use for fluorescence, so two-channel spectroscopy (one frequency illuminating and evoking fluorescence), and also determine some other useful concentrations, like CIO2 having 1250/cm as epsilon at 359 nm you will only find traps in internet Alibaba etc, so just get some standard money bill checking led 365nm and be done. And a multicolor LED for "unexpected" things like MB you can detect in red while green is the common reference channel, so measurement of both residual CDS and MB is possible, so you can check if they really kill themselves in conditions that are there in body. Please answer in substack or TG if this is interesting to you, and first here.I try o look after the bell some times a week ;)
New sub!
🙏
Thanks for the info doc much appreciated . How long does it take for it to kick in and you will feel the mental effects ? Do you stack it with other compounds to support mitochondria health and function ?
I noticed the effect within half an hour. I use coenzyme Q10, as well as nicotinamide riboside as well.
@@JonasKuehneMD Hey doc thanks for answering yeah i take nr/nmn , coq10 normal plus in ubiquinol form , Pqq, glycine/nac (and redlighttherapy) and now i am considering taking MB or do hyperbaric oxygen therapy. Again i appreciate you answering me and have a nice day my friend . 💪🙏✌
Thanks so much for the info. Can we take it with orange juice or another type of fruit juice to make the taste less bad? TIA.
Yes, that should not change the potency of methylene blue. You can also try to buy it in tablet form from Best 365 labs. There is a link in the video if you’re interested.
Thank you so much, what dosage for a cancer case?
I could not find specific dosing in the literature. I am not sure if intravenous or oral dosing would be used here. There are a lot of articles stating its anticancer effect especially when used together with red light at 630 nm.
Am I making a mistake??? Excellent information doctor. I have been taking MB in the 10mg/daily range daily. I consume it by mixing it in water with about 1 gram of pure Vitamin C powder. I allow it to sit for a few hours which turns it clear and allows me to drink it without the nasty staining in my mouth.
The information about working out and raising BP did give me pause for thought. I have been using it prior to working out , thinking it would oxygenate my blood and facilitate my workout. I also usually take a far infrared sauna after my workout. It sounds like I may be making a mistake ! I understand you are not giving medical advice or making a medical recommendation. Do you have a general opinion? Thanks again for your great content.
Thank you for your great comment. Methylene blue can slightly increase blood pressure and heart rate. Some people are more sensitive to this than others. For that reason, I do not take it before or right after a workout. Mixing it with vitamin C is a good idea as it turns it into leukomethylene blue, which converts back to methylene blue in the body.
I believe everyone is different in terms of how they may react to methyl blue for exercising; it seems that’s what the doctor is implying. I am interested myself, so I plan to start small dosing for workouts as starters.
Vitamin C will neutralise any potentkal stain if you can apply early enough, apparently.
Thank you for the tip. I will try it out.
Thanks for the dosing information. I'd been taking a moderate dose for a year, then upped it to 90mg's per day (split into 2 doses) to see if I'd notice any difference.
Not really. Only think I did notice was the half-life of color in my urine was blue to blue green all day and night. So looks like I'm saturated and need to drop back down.
I agree, I had tried increased doses and did not find improvement in cognitive function or energy levels. The risk of doses above 30 mg daily is disruption of the gut Microbiome, as MB can act as an antibiotic.
Is it a good idea to use Methylene Blue in suppository form? My concern is that after mouth cancer my mouth is so dry that I cannot get the stains off of my tongue/mouth. If taken orally is it best to dilute with water and drink or place the drops on the tongue? Even when I take it in pill form it stains my teeth and tongue for days.When I had cancer I used suppository forms of THC for better absorption and less stomach issues. I feel that suppository from of this might be best for less worry of staining but not sure if the MB could be placed in freezer. I usually keep my suppositories in freezer.
I am not aware of a suppository preparation of MB. If you take the tablet just as you are about to swallow your food it should not make any contact with your gums or tongue.
Hello thank you for your video. I have been taking MB for 2 days. 5mg via the dropper once in the morning and once in the evening. I took mines this morning and after two hours I started to feel like I had a fever and felt like I had too much coffee. is this something that happens? thank you :)
I have sort of felt that way after I took methylene blue before a workout. It can increase blood pressure and heart rate. This may vary from person to person and might need titration or cessation of use.
Awesome research. Using liquid how many drops???
Thank you. You have to check the bottle but liquids usually will say 0.5 mg per drop. If that is the case, and you want to take 5 mg, that would be 10 drops. I currently take 15 mg daily in tablet form. This is a lot easier.
@@JonasKuehneMD
Greetings Dr. Jonas Kuehne,
Thanks so much! One of the best videos about this I've seen. Good amount if knowledge. Known about Methylene Blue for a while. Mega research done on it . Don't feel the pharmaceutical heads want it to catch on. It's too inexpensive and dangerous to their income. It's a game changer! So grateful to have found it, saving lives ! Adding to that oxygenation of blood heals everything. Disease can't survive in an oxygenated environment. Dr.Mark Sircus is a world reknowned expert on this. Unfortunately his videos are still on YT but he appears not to be. Don't think he knows about Methylene Blue . Feel you and him could be friends, he still has his website. You both share a great intellct and open minds which facilitates genius in areas you're dedicated to.
Namaste 💥🕉💥
@@JonasKuehneMDMuch gratitude. Love your presentation.
Awesome research!
Also what is the best time to consume this? I am weight training in the morning? Thank u for your video 😊
He said after a morning workout is a great time.
Sorry, just saw your message. I would recommend to use it two hours before or one hour after a workout at least . taking it too short before a work out can increase blood pressure and heart rate which my case was very uncomfortable and potentially might have some danger as well. I do not take it later than about 2 PM as it is a bit activating and I found taking it at night kept me from sleeping. This varies from person to person though.
Usually have green urine, but not today. Why?
Do you know if anyone has tried to introduce this into their diet to help fight or manage limes disease?
I read that it has been used for Lyme disease, however I have not seen any studies or had personal experience with patients using it in this way. I will look into finding more research about this.
You can put MB drops in to empty capsules (which are cheap to buy), which will start to melt, so just consume within
Great tip!
I do that. The largest available capsules, size 000, take about 1.2-1.3 ml, corresponding to a 12-13 mg dose of MB with 1% solution. The ones I have used last 2-3 minutes from filling, you notice when they start to soften... I have been wondering if shelf stable capsules could be made if you mix the MB powder with oil instead of water. Oil will not dissolve the gelatine capsules... I am not sure how MB powder would mix with oil, I have not tried that yet. I think I would choose MCT-oil if I was to try that.
Thanks for that - is there any reason Caffeine could be a bad stack?
The company that makes the product on the thumbnail makes a version that uses L theanine and caffeine together with methylene blue for focus and memory. I think it is OK to combine them.
I experimented with 15mg of MB for about a week. I didn't notice any effect. However when I stopped my urine was still blueish for many(5) days. indicating it stays with you for a while.
That’s interesting that it lasted that long. I am not sure if we can accurately estimate half-life by its concentration in urine. It’s possible that that dose was already too high for you. It is a hormetic drug after all.
@@JonasKuehneMD I have a lot remaining. I’ll try 71/2 mg per day. I’m 130lb, 6ft and underweight.
How do we take it? Water? Tea? Coffee etc
You can take the tablets with food or just with water. The liquid drops are best mixed with water, but be careful because even diluted they will stain everything they touch.
Wondering when using the dropper how much drops would be recommended to take ( say for ADHD etc symptomps(?
Not official medical advice, but most people do well between 5 mg and 15 mg per day, with two days off per week. Most solutions at one percent will say on the label 0.5 mg per drop. If that is the case, that would mean anywhere between 10 and 30 drops.
Would anyone happen to know how many drops are safe to take of a 0.1% MB solution and how much other liquid should be added?
I can't seem to figure it out. Seeking Cerebral Healing. Thanking you in Advance.
This is not medical advice, but many people use anywhere from 5 mg to 15 mg MB daily. Most solutions are one percent. One drop then is 0.5 mg. This would mean anywhere from 10 to 30 drops per day. Much easier than that there is a tablet form available, which you see on the thumbnail. If interested, there is a link in the description.
Thank you Dr. Jonas.
Yet, in my haste I created a “0.1%” mixture as opposed to the “1%” with the powder I purchased.
The vendor provided a dropper with measurements in “milliliters”, i.e. #1,2,3+
Oh-Oh-Ok! Wait a minute!
As I am presently composing this comment, after ingesting just one drop of MB, it seems that my tangles are smoothing out and I’m able to receive the info clearer.
Wow!
So-oo… i.e.
1ml ➡️ 1,000 mg = 1 drop
25ml ➡️25,000mg = 25 drops
I’m trusting that no one will comment here with a “ Duh” because I’m sure on the day that the Math teacher taught measurements…
I was absent. 😆
Thank you again Dr. Jonas for your expedient response.
💧 Blue Magic 🪄 💧
thats to bad I suffer already from high BP.
Hello, can you tell me for how many months or years can I take methylene blue daily?
There are no long-term studies on this unfortunately. As with any supplement, it is probably good to take breaks here and there for a week or longer. Also, in my opinion, the daily dose should not exceed a maximum of 30 mg. I currently take between 10 and 15 mg daily.
Where to buy from a trusted source ? Which products ??
In tablet form I like “best365labs”. For drops I like “BpH”. Those are on Amazon.
Hey Doc, I'm somewhat still confused about dosing. I bought the same 1% USP Grade MB solution you show in your video. Here is what I did today:
25 drops of MB into about 1/2 cup (~100ml) of distilled water. If it's 0.5 mg/drop ... then I'm taking a dose of 12.5 mg ... is this correct? Oh, I also stirred in about 1500 mg of Vitamin C crystals to make the solution almost clear, but still a very pale blue.
Yes, it should be 0.5 mg per drop so 25 drops is 12.5 mg. You can use regular water and absolutely the vitamin C will briefly change the methylene blue to leucomethylene blue
@JonasKuehneMD - so am I taking a "good" daily dosage for brain health/anti-aging? Or too little to be of any effect? (I will re-watch your video in case I missed it). Thank you for your answers & videos!
Hey Doc, your latest video answered my questions. Thanks! 👍
If I race or have an intense workout, why is there not indication of methylene blue in my urine for about a day...even though my normal dosing schedule is uninterrupted. It's a great recovery indicator I just don't understand why really hard (above LT2 or 4mmol blood lactate) efforts seem to 'absorb' methylene blue for ~24 hours or so.
That’s an interesting observation. I don’t know the mechanism, but will look into this.
I usually take 1 drop from the dropper and have done fine. I accidentally took 3 drops from the dropper today. I hope I do OK with that amount.
I would check the dosing on the bottle. Usually one drop is 0.5 mg. So an extremely low dose.
For reference, I am taking 10 to 15 mg daily. On the bottle that I have been using that would be between 20 and 30 drops.
I put it in a capsule so no taste but green urine. I’m very careful of the microbiome. I’m 100 pounds and I only take 10 drops of 1% 5 times a week.
I also stopped the HTP I was taking.
I am not sure if you are in the us but best365labs has it in pill form:
www.best365labs.com/?ref=Jonas
@@JonasKuehneMD Thank you. 🙏🏼
I’m not disputing what you’re saying, but you’re the only one saying that you shouldn’t be taking 30mgs of MB per day!
When 30 mg is said to be the minimum dose, just to achieve the maximum benefits from methylene blue
We just started my.dad on it yesterday. He is dealing with Parkinson's. Have you seen any success with it for that?
Nicotine patches...DR ARDIS. SEARCH HIM OUT
How about taking methelen blue with lugos Iodine, Boron and a metheleted B complex?
These supplements should not influence the potency of methylene blue.
@@JonasKuehneMD Thanks! What is your opinion on Boron and Iodine? Have you or ae you doing a video on them?
Hello, I purchased usp grade methylene blue (99.99%). I am wondering if you have any information on dosages for a 42 year old male weighing 180 lb All of the information I have found is only specific to the 1% version.
Could you kindly point me to the right direction?
I cannot give medical advice on this platform, but for my patient’s, doses between five and 15 mg daily work extremely well. Many people will take one or two days off per week. Given a one percent solution, with 0.5 mg per drop (this should be stated on the label), that would mean between 10 and 30 drops per day, 5 days per week.
I am 50kg and am taking 15 drops of 1% USP grade MB. I am 78 yrs old and taking MB for improved brain function - memory, focus etc as well as back pain and Neuropathy. What wold be a suggested ideal dosage for me?
Great question. It varies, but most companies are doing research with around 15 mg daily. For most liquid preparation that would be 30 drops. This may be too much for some people though. Keep in mind that methylene blue can increase blood pressure and heartrate slightly. I think your current dose of 15 drops or 7.5 mg maybe sufficient. If your physician knows about methylene blue then this would be a good person to ask more specifically about your individual situation.
Dear Dr Kuehne, hopefully you will see this question which wasn't answered in your video. Re dosing does it make a difference for what one is dosing? In my case M.E. which is also known as CFS. You are the first person to point out that the recommended dose of .5- 4 mg per kg is for intravenous!
Thank you for comment. Yes, there can be variations in dosing for different applications. It is interesting that thereis not a very set dosing schedule. In my opinion, oral dosing can be anywhere between 5 mg to 30 mg daily. I would suggest to start low and slowly titrate up. The doses can be broken up to twice daily, however, I do not recommend to take it too late in the day as for some people this might impair sleep.
Do some research, he’s not a good dr trying to help, he’s a poison pusher!
These scammers use people vulnerabilities and illnesses.,
Do people experience blurriness of vision? I have a friend who experienced this and i am wondering if this a general side effect or not
Blurred vision is a possible side effect. It is dose dependent, and should be discussed with your primary care physician.
Where can we get. The test in the usa
Amazon... put in pharmaceutical grade. I found caps with vit. C.
Please clarify the dose. Are you talking mg of the 1% solution or mg adjusted to reflect the total amount of MB ?
I always refer to the total dose in milligram. If you use a one percent solution, and you have to check the label here, it usually means 0.5 mg per drop.
I just started 300 milligrams of bupropion - is low dose of methylene blue a problem to add
This is not medical advice. Bupropion or Wellbutrin is a norepinephrine and dopamine re-uptake inhibitor. It should not interfere much with serotonin. Also, as mentioned in the video, the low-dose that people usually take, myself included, of methylene blue around 5 to 15 mg daily is very unlikely to trigger serotonin syndrome even in someone on a higher dose of an SSRI. Of course ask your physician prior to starting.
Where do you get this stuff
www.best365labs.com/?ref=Jonas
Jonas 15 for 15% off
I've heard methylene blue acts as an MOA inhibitor. Is there a list of things to avoid? Can it be used with creatine, Wellbutrin?
Yes, methylene blue is a monoamine oxidized inhibitor. Theoretically this could lead to serotonin syndrome in someone already taking a medication that increases serotonin levels, such as an SSRI. In my opinion, this is very much dose dependent, and the low-dose needed for a dementia prevention protocol on the order of 10 to 15 mg daily should be very unlikely to trigger this. This is of course, not medical advice.
Also, Wellbutrin is a dopamine and norepinephrine reuptake inhibitor, and therefore unlikely to interact with methylene blue. Still, no medical advice.
If I want to use it as respiratory disease prevention, what would be a suitable dose and frequency?
This is not medical advice, but for my patients, I generally recommend between 10 and 15 mg daily.
@@JonasKuehneMD Thanks!
I know that MB has been used successfully for respiratory conditions in India to treat covid. I am interested in using it in a nebulizer, but cannot find any guidelines for using it that way.
I am not aware that it can be used this way. You should check with your pharmacist or physician about this.
It's used to treat long covid symptoms, not covid itself. Not sure how effective it is in either case
Are there advantages to taking methylene blue intravenously? Thank you
perhaps no gut-microbiome destruction at doses above 30 mg.
When I get up I drink a glass of water with lemon and ACV then I do my red light therapy I want to take my blue 30 minutes before the red light Do you know if the lemon water will effect the blue
It should not affect it. Ascorbic acid, so vitamin C can briefly turn methylene blue to leucomethylene blue. It is a redox molecule. This does not affect its efficacy.
@@JonasKuehneMD
thank you
Could anyone please confirm if MB can reduce muscle protein synthesis due to it reducing nitrous oxide?
I have no literature on this. But keep in mind that methylene blue improves mitochondrial health and function. This is certainly benefits muscle tissue building.
@@JonasKuehneMD yes in theory. I’m sure l read a paper that said a study had shown that MB had no effect and didn’t appear to inhibit muscle synthesis ( l can’t find that literature now) 😩…. However it didn’t explain the mechanism in which this was possible? Due to the presents of nitrous oxide during muscle protein synthesis is such a major contributing factor this a question that plages me! l am determined to find the answer! I’m obsessed with science and l have literally lost sleep trying to figure it out lol 😂💯 x
I love MB!!! It has made such a difference to my life! X 😊
Just curious.. how long does it take to start seeing results?
I notice the effect within about half an hour. There should not be tolerance or withdrawal on this so it’s OK to stop and take breaks in between.
@@JonasKuehneMD WOW. From the man himself. Thank you. :D I started this week with what turns out to be quite a small dose... 8 drops 1%. I thought I felt slight improvement in mood. Also thought I perceived less inflammatory aches and pains. I've upped it to 20 drops today and mood seems even better. I'm looking forward to even better results after longer term use.
Is this taken with water or just direct intake orally
Both is OK. The liquid is a very potent stain, so when I use that, I diluted it with water and drank it through a straw. Still will get you a very blue tongue. The tablets are much better in my opinion.
For concetration and brain fog how many drops you recommend ? I weight 104 kg
This is not medical advice as there are contradictions to methylene blue that should be discussed with your primary care provider. Most Solutions will have a concentration of 0.5 mg per drop. You need to confirm this with the label on the bottle. Methylene blue seems to work for concentration and brain fog anywhere between 5 and 15 mg for most people. At a concentration of 0.5 mg per drop, that would be between 10 and 30 drops. I prefer to use the tablets as the dosing is a lot easier and less messy. There is a link in the description of the video.
Does the neuro plus helps you with concetration ?
I feel fatigued when I take methylated Blue
I’ve been taking 15 drops for 2 months and waiting for the good results
It is an unusual experience. I’m wondering why you are reacting with fatigue. Are you taking any other supplements at the same time?
@@JonasKuehneMD sometimes it will give you a candida yeast die off in people that’s why their fatigue it goes away in time
Get tested for G6PD! If you have this genetic mutation, red blood cells will be broken down too fast. Most anti-malarials will cause the same along with legumes, especially Fava beans. G6PD is also called Favism for that reason. It's similar to sickle-cell disease but more prevalent in the Jewish population.
Would methylene blue do anything good for long covid? I know that the good bugs need to be replanted afterwards...
Long Covid is one of the indications why people used it over the last few years. I have a couple of patients that responded extremely well to it, and it has greatly decreased or even eliminated their brain fog. This is of course, not medical advice. For my patients I generally use around 15 mg daily.
Such a handsome man.
❤️🙏…blushing over here 😳😂
Hello? Not difficult to remove at all. Just mix an acid with water and apply to stain. Will get rid of the blue color. I have used dilute HCl, ascorbic acid, etc.
Thanks for the tip. I will try this out.
Would acetic acid (vinegar) work to neutralize the blue color?
You can use vitamin C, which will work quite well to turn it into Leucomethylene blue.
Is it ok to take if you are on anti depressants, I told my doctor I am going to take it, and she said she does not even know about methylene blue!
It’s best to show your doctor studies that have been done to familiarize herself with methylene blue. For example:
pubmed.ncbi.nlm.nih.gov/31144270/
@@JonasKuehneMD Thank you so much for that, as I would like to get off the drugs for depression. I will pass this onto her😀
I take two drops every 8 hours. Assuming the half life of MB is 6 hours, that gives the same end-of-day concentration of MB in the blood as 20 drops taken at the beginning of the day. Amazing, isn't it?
Does it impair your sleep if you take it later in the day?
@@JonasKuehneMD No, I can't say that it does. I get tired in the evening as usual. My thinking is that MB is not a stimulant like coffee or amphetamine. Also, two drops doesn't "spike" the blood concentration of MB.
If you take it sublingua does it affect your stomach bacteria.???
As far as I’m aware, there is no sublingual version of methylene blue. Any oral consumption can impact your bacteria in your digestive tract. It is a mild antibiotic after all. In my opinion, doses up to 30 mg per day should not disrupt your Microbiome.
I would think it could affect your mouth micro biome
I have a methylene blue that says 20 drops = 1ml which means 1 drop = 50 mg , what do you suggest me to do?
I don’t think that conversion is correct. It describes a volume, not a dose. Most bottles will say for a one percent solution one drop equals 0.5 mg. What does it say on your bottle?
Can someone help Me ? I weigh 90 kg, I use "MB 1%", how many drops do I need in a glass of water ? My only reference, is the colour, I only drink a glass with mild blue never intensive blue... Your take on that ? Tx/Merci
the brand is Vitalia Pharma" Albatru de Metilen"...
This is not medical advice. Most liquid MB is 0.5 mg per drop. To get roughly 15 mg, you would use 30 drops in water once a day.
@@JonasKuehneMD Merci but I would never take that much... I started with 1 drop yesterday. 2 or 3 today... My urine is already green, it means it has an effet on my body... I do have amitochondria disease and I need to be careful
where can you buy it in Germany?
On Amazon.de. Make sure that it is pharmaceutical grade.
Robert Franz.
So if I have a 1gm per 100ml solution that’s a 1% solution. I’m 54 kg. How much should I take?
I cannot give medical advice on this platform as I do not know any of your history. There are also a few contradictions to taking methylene blue. Personally, I take 15 mg daily at 80 kg bodyweight. Many people are OK between five and 10 mg daily. With liquid MB that would be between 10 and 20 drops, but this may vary from product to product.
Can it help an ekderly man with COPD?
I don’t think that methylene blue can specifically address the symptoms of COPD. It helps with energy production in all cells, so there might be mild, symptomatic improvement, however, it will not change the existing pathology.
Hello. I wonder if there is any benefit to combining this with vit C, and would it change with higher doses of vit C?
Yes, you can combine it with vitamin C. If you mix it in the liquid form, the methylene blue will actually turn into leukomethylene blue, which is not blue but clear. It will turn back to methylene blue after consumption and it does not change the potency or efficacy.
I took 18 mg first dose. Have Parkinsons. Is that ok?
Not medical advice, but I think that is a good dose. Most studies have been done with 15 mg daily. Always discuss any medication or supplement with your physician.
What is your expertise,Sir.
I am a primary care physician
@@JonasKuehneMD 🙏🏼🙏🏼🙏🏼
So it’s not dosed based on overall body weight?
There is a dose based on bodyweight which I mentioned in the beginning when used intravenously. I would still say that heavier people can use a slightly larger dose, of course, but in general, I would keep the dose under 30 mg daily for anyone to prevent disrupting the gutmicro biome.
@@JonasKuehneMD thanks. I’m 350lbs. I’ll start on the lower end and increase it. I’m trying this because I have auto immune disease. Hypothyroidism, arthritis, prediabetic and feeling weak all the time. I’ve been told that this might be with my mitochondria needs to get back in shape. I’ve done everything else. Cut out all the inflammatory oils and processed foods, for over a year now, but I don’t seem to be improving.
Sir I take 10 drops a day. It is 10mg per 20 drops so I guess I m taking 5mg a day.
I weigh 115 pounds. Do you feel this is about right for a healthy women?
I cannot give official advice on this platform, but I take somewhere between 7 to 10 mg daily at 180lbs weight.
@@JonasKuehneMD thank you for your time 🙂
How meny mg in a drop
Most liquids are 0.5 mg per drop. It should say so on the label though.
Is a milligram one drop?
In most cases one drop is 0.5 mg. This might vary from product to product though.
IF MB FROM SYNTHETIC CHEMICALS, WHERE HEAVY METAL COME FROM ?
I think it is from the manufacturing process.
PRICE USP MB 1000X INDUSTRIAL MB
A+B+C=MB, SO..A / B CONTAIN HM ..?!
Took 8 mg i had sérotonine syndrome i thing i have too much serotonin in my body
That is interesting at that low-dose. Are you taking SSRIs at the moment?
@@JonasKuehneMD nothing
10mg = 1ml
If it’s a 1% solution that is
@@dominickdelongpre4535 Volume has nothing to do with concentrations.
What are you calling vit c?
Ascorbic acid
think i deleted my neurons with some fishtank dye
www.best365labs.com/?ref=Jonas
This is a lot better than fish tank cleaner!
I watched a podcast with a former Dr. for the S.F. 49ers as its used for brain health. He said just go buy the Kordons(aquarium) product as its just as clean as usp.
I figure it must be clean as a tiny fragile fish would be highly sensitive to any metals present.
Not sure I’d risk that as the real deal. The USP grade is pretty cheap anyway.
I would not use anything but USP products as commercial methylene blue will contain a very high amount of heavy metals.
Hi can you tell me if this will interact with cbd oil . Also pysclobin or magic mushrooms and if it does how long between taking them
i want to try it but heard you can die lol idk
It is a hermetic drug, and overdoses, of course can be problematic. In my opinion, as long as you do not meet any of the contraindications to using it in the first place, low doses between 5 to 15 mg daily sugary, beneficial, and highly unlikely to result in an adverse reaction. Some of the contraindications are of course pregnancy and breast-feeding where even low-dose should be avoided. This is of course, not medical advice, and per RUclips guidelines. You should discuss any medication or supplement with your physician first.
@@JonasKuehneMD if I can get away with a low dose I’d like to try it. What are some good sources?
U talk too fast...learn how to pause n not be monotone😮😮😮😮😮
Slow down the playback speed:)
Worthless information. People are taking DROPS, you offer nothing in this area.
Please watch the entire video before commenting.
Don’t be a more-on!!
He clearly said what the mg content per drop is.
He knows nothing. German docs think HALF A MG of Melatonin is enough. All he states is wrong. No other Doctor states such a low dosage. You are one of his clowns. German too??? German society is terrible filled with clowns!!
Vitamin C gets rids of any staining ..
👍