18.2 Friedel Crafts Alkylation and Acylation | Organic Chemistry

Chad gives a thorough presentation covering Friedel-Crafts Alkylation and Friedel-Crafts Acylation. He begins with the mechanism of the Friedel-Crafts Alkylation and reveals the three shortcomings of the reaction:
1) The reaction is prone to occur multiple times (polyalkylation),
2) It is subject to rearrangements,
3) It doesn't work with strongly deactivated benzenes
Chad then presents the mechanism for the Friedel-Crafts Acylation and goes on to show how it is not subject to the first two shortcomings experienced by Friedel-Crafts Alkylations. Finally, Chad concludes the lesson with the Gattermann-Koch reaction, functionally a special case of the Friedel-Crafts Acylation.
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00:00 Lesson Introduction
00:39 Friedel-Crafts Alkylation
07:57 Friedel-Crafts Acylation
13:49 Gattermann-Koch Reaction
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[@user-ku6ue7cd7t]

A very beautiful and interesting explanation. I am a student at the College of Pharmacy, University of Baghdad. I have been following you for a while, and I was very impressed by your wonderful explanation.

[@ChadsPrep]

Glad to hear and Thank You.

[@user-ku6ue7cd7t]

@@ChadsPrep ♥️♥️♥️

[@RossCheyne-vv9sp]

Thank you all the way from South Africa. I am doing chemical engineering and you're the best!

[@ChadsPrep]

You're welcome and Thanks from USA!

[@AlfredMwale-06]

THANK YOU ALL THE WAY FROM ZAMBIA.

[@ChadsPrep]

You're welcome from USA!

[@krzysiuosiak7887]

This is extremely useful! Thank you for such a great explanation!

[@ChadsPrep]

You're welcome!

[@Zeyadhany]

thanks alot from Egypt 🇪🇬 ❤

[@ChadsPrep]

Very welcome from USA.

[@rong6968]

Awesome video. Thanks alot

[@ChadsPrep]

Glad you liked it, Minh - thanks for commenting!

[@footballxxxeditsgang176]

Great Video!!

[@ChadsPrep]

Thank you!

[@abbylowe1637]

Awesome video, Chad! Will you get a product for the top 4 EAS reactions even if NO2 is present? My understanding is that the only time NO2 will interfere is if it is Cl-R, or R-O-Cl (the bottom 2 reactions) Thanks!

[@ChadsPrep]

Hey Abby - do you mean will nitrobenzene still react? It does but will direct the addition of the new substituent to the meta position due to ring deactivation - did you check out this video ruclips.net/video/K05bDJMVgUI/видео.html on reactions of substituted benzene?

[@anveshashukla5356]

Thank you so much sir .......🎉🙏🏻
And where are you from

[@gamewarden2813]

Ty!

[@ChadsPrep]

Welcome!

[@abdoulazizdabo9064]

Thank you 🙏🏾

[@ChadsPrep]

Very welcome.

[@ConfusedGorge-uf9pp]

Thank you so much... From Pakistan 🇵🇰

[@ChadsPrep]

You're welcome from USA.

[@joeburreaux7953]

Instead of Chorine, could you use Bromine (with FeBr3) to carry out Friedel Craft Alkylation?

[@ChadsPrep]

You totally could Joe!

[@joeburreaux7953]

@@ChadsPrep Thanks for the quick reply, Chad!

[@ChadsPrep]

You're welcome Joe! And I will get back to you soon regarding your Biochem post :)

[@laura5878]

I like the way you say Koch

[@ChadsPrep]

Happy Studying!

[@andersonchen7501]

If I have a akyl chloride, can it react with FeBr3?

[@redkritter1225]

Yes since it’s a halogen

[@rileyonthatbeat3047]

I'm not quite grasping this concept at all 😩

[@ChadsPrep]

What are you struggling with?