My transcript notes of the video: 00:01 In this lecture we are going to cover the pharmacology of drugs acting on gastrointestinal system so let's get right into it the gastrointestinal tract is a part of 00:12 the human digestive system which includes the mouth esophagus stomach and intestines plus the accessory organs of digestion such as the salivary glands pancreas liver and gallbladder now the nervous system and endocrine 00:26 system work together to control gastric secretions and motility associated with the movement of food throughout the gastrointestinal tract digestion starts with a side thought or smell of food when the brain anticipates 00:39 an incoming meal the vagus nerve sends a message to the stomach to stimulate gastric secretion the mucosal lining of the stomach contains numerous gastric glands these glands open to the surface of the mucosa 00:52 through tiny holes called gastric pits there are a few different types of cells that make up the gastric glands surface and neck mucous cells which produce jelly-like substance called mucus that protects the lining of the 01:05 stomach parietal cells which produce hydrochloric acid that creates a low ph environment in the stomach chief cells which produce pepsinogen and gastric lipase enzymes that are 01:17 responsible for digestion of dietary proteins and fat enterochromafin-like cells which produce histamine that helps to induce the production of acid and g cells which produce peptide 01:30 hormone gastrin that is responsible for regulation of gastric activity now the vagus nerve is the single neural link between the brain's higher functions and gastric secretion in response to food intake vagus nerve 01:45 becomes excited and begins to release acetylcholine acetylcholine exerts its effects in the stomach directly through activation of muscarinic m3 receptors on parierle cells as well as indirectly through 01:57 activation of m1 receptors on enterochromafin-like cells to initiate histamine release and m3 receptors on g-cells to initiate gastrin release subsequently parieral cells are stimulated by histamine via h2 receptors 02:13 and by gastrin which acts on ecl cells cholecystokinin b receptors to enhance the histamine release in addition to directly stimulating parietal cells which also express cholecystokinin b receptors 02:28 now the activation of h2 receptor by histamine causes intracellular cnp levels to increase while the activation of m3 receptor by zero coin and cholecystokinin b receptor by gastrin causes intracellular calcium levels to 02:41 increase these independent pathways then converge to activate protein kinase cascade that in turn triggers translocation of hydrogen potassium 80 base also known as the proton pump from cytoplasm to the 02:53 apical surface the proton pump is the terminal staging gastric acid secretion being directly responsible for the active transport of hydrogen ions out of the cell in exchange for potassium ions 03:06 chloride ions are also secreted from parietal cells into the lumen by simple diffusion in the stomach lumen hydrogen chloride and water combine to form hydrochloric acid which creates a highly acidic 03:18 environment for digestion now understanding the physiology of gastric acid secretion and the pathophysiology of acid-related diseases such as gastroesophageal reflux and peptic ulcer has led to the development 03:31 of various ways to decrease acid exposure one of the pharmacological approaches aimed at neutralizing secreted acid is to prevent stimulation of the parietal cell 03:42 this can be achieved with the use of drugs called h2 receptor antagonists which work by competitively inhibiting histamine binding at h2 receptors on the parietal cells resulting in reduction of 03:53 histamine-mediated acid secretion drugs that belong to this class include cymetidine fomotidine nizadidine and ranitidine now another pharmacological approach is to directly disrupt the functioning of 04:08 the proton pump responsible for acid secretion this can be achieved with the use of drugs called proton pump inhibitors which work by binding to the hydrogen potassium atpase and suppressing the 04:19 secretion of hydrogen ions into the gastric lumen drugs that belong to this class include dexalonsoprazole esomeprazole lansoprazole omeprazole pantoprazole and rebeprazole 04:34 all right so while h2 receptor antagonists and proton pump inhibitors can provide a sustained suppression of gastric acid secretion patients needing immediate relief from their symptoms may benefit from a faster acting agent 04:47 belonging to a drug class known as non-systemic antacids members of this class include aluminum hydroxide magnesium hydroxide and calcium carbonate unlike the other acid-reducing agents 05:00 non-systemic antacids do not decrease acid secretion but instead act primarily by directly neutralizing hydrochloric acid this happens as a result of simple chemical reaction that combines a metal 05:12 ion from an antacid compound with a gastric acid binding group to form a salt and water this in turn raises the ph of the stomach contents and provides rapid relief from hyper acidity To get the full transcript and PDF notes with screenshot - Try Askify notes chrome extension tool
Thank you so much for this video. With help from your past videos I have successfully retained the concepts and passed my last pharmacology and clinical pharmacy class two weeks ago. I will keep watching of course as it is always nice to review what was learned. Thanks again and as always, very informative content.
I just completed 3 semesters which all had pharmacology as a subject And i cant stress it enough as to how thankful i am for this team that makes these videos This is probably the first time i scored well and actually felt like i learnt something about the subject, in fact i learnt a lot I hope i can support this channel by becoming a patreon in the future
Thank u so much 🥰 ❤️ Plz don't stop making videos on yt I really can't imagine studying pharma without your videos...they are really very helpful ...may God bless u 😌
Finally 😁 I have been waiting for these videos ☺️ You are totally the best A request for other videos such as antimalarial drugs as well as cough not forgetting management of pain These videos have been of a great help
Thanks for your hard work and strenuous efforts you have made to collect the conceptual information and deliver to us. I used to look for your video lecture , At the last I got it now. Many many thanks to u...
This content on pharmacology is called as chef’s kiss ! I should be paying you the fees that I squandered on my med school teachers . Thankgod for creating you and thank you for creating this content ,,,,,you are GODSENT. 🙌🏻🙌🏻🙌🏻🙌🏻🙌🏻🙌🏻🙌🏻💫💫💫💫💫🌱🌱🌱🌱✨✨✨✨✨
First of all, I would like to thank you for the perfect explanation and simple delivery of information. I would also like you to touch on some topics such as antianginal, ADHD, antiprotozoal, antihelmintic, anemia,gout, DMARDs, urologic disorders.
Love ur videos .Short,accurate and interesting to watch,hope u drop many more like antihelminths, drugs in gout etc Thanks from 🇰🇪 loving pham all because to this videos
Antibacterial medications called 'nitroimidazoles' primarily used to treat infections caused by protozoans & bacteria should have been added to the video. Edit: Thanks a lot for uploading videos.
Thanks so much doctor, I have final pharmacology exams in 4 days and I was so confused because there are some chapters I don't understand but your videos helped alot ❤️ All my love form Sudan 🇸🇩
Can you do a video on how antidepressants affect the gut and how the side effects like brain zaps work? I feel so unfocused and so much pain and pressure in my head from trying to taper off.
Amazing video, really helped me to understand concepts and memorize the drug groups for my pharmacology exam. Also I love the whip sound in the antiemetics part. 😂
@Zahra Imaan Dear if am not wrong Tentin has Dexamphetamine 5mg , in which case *Speed Pharmacology* have already discussed about the stimulants like In-direct acting Amphetamine and Cocaine in Adrenergic Receptors & agonists drugs link of video ruclips.net/video/KtmV-yMDYPI/видео.html kindly check the video and thank him
![BLACK BAG - Official Trailer [HD] - Only in Theaters March 14](http://i.ytimg.com/vi/Du0Xp8WX_7I/mqdefault.jpg)
I Learned A lot from this video. Thnku sir. Who is watching this in 2024?
Me
me
Me
I am
Mae
My transcript notes of the video:
00:01
In this lecture we are going to cover the pharmacology of drugs acting on gastrointestinal system so let's get right into it the gastrointestinal tract is a part of
00:12
the human digestive system which includes the mouth esophagus stomach and intestines plus the accessory organs of digestion such as the salivary glands pancreas liver and gallbladder now the nervous system and endocrine
00:26
system work together to control gastric secretions and motility associated with the movement of food throughout the gastrointestinal tract digestion starts with a side thought or smell of food when the brain anticipates
00:39
an incoming meal the vagus nerve sends a message to the stomach to stimulate gastric secretion the mucosal lining of the stomach contains numerous gastric glands these glands open to the surface of the mucosa
00:52
through tiny holes called gastric pits there are a few different types of cells that make up the gastric glands surface and neck mucous cells which produce jelly-like substance called mucus that protects the lining of the
01:05
stomach parietal cells which produce hydrochloric acid that creates a low ph environment in the stomach chief cells which produce pepsinogen and gastric lipase enzymes that are
01:17
responsible for digestion of dietary proteins and fat enterochromafin-like cells which produce histamine that helps to induce the production of acid and g cells which produce peptide
01:30
hormone gastrin that is responsible for regulation of gastric activity now the vagus nerve is the single neural link between the brain's higher functions and gastric secretion in response to food intake vagus nerve
01:45
becomes excited and begins to release acetylcholine acetylcholine exerts its effects in the stomach directly through activation of muscarinic m3 receptors on parierle cells as well as indirectly through
01:57
activation of m1 receptors on enterochromafin-like cells to initiate histamine release and m3 receptors on g-cells to initiate gastrin release subsequently parieral cells are stimulated by histamine via h2 receptors
02:13
and by gastrin which acts on ecl cells cholecystokinin b receptors to enhance the histamine release in addition to directly stimulating parietal cells which also express cholecystokinin b receptors
02:28
now the activation of h2 receptor by histamine causes intracellular cnp levels to increase while the activation of m3 receptor by zero coin and cholecystokinin b receptor by gastrin causes intracellular calcium levels to
02:41
increase these independent pathways then converge to activate protein kinase cascade that in turn triggers translocation of hydrogen potassium 80 base also known as the proton pump from cytoplasm to the
02:53
apical surface the proton pump is the terminal staging gastric acid secretion being directly responsible for the active transport of hydrogen ions out of the cell in exchange for potassium ions
03:06
chloride ions are also secreted from parietal cells into the lumen by simple diffusion in the stomach lumen hydrogen chloride and water combine to form hydrochloric acid which creates a highly acidic
03:18
environment for digestion now understanding the physiology of gastric acid secretion and the pathophysiology of acid-related diseases such as gastroesophageal reflux and peptic ulcer has led to the development
03:31
of various ways to decrease acid exposure one of the pharmacological approaches aimed at neutralizing secreted acid is to prevent stimulation of the parietal cell
03:42
this can be achieved with the use of drugs called h2 receptor antagonists which work by competitively inhibiting histamine binding at h2 receptors on the parietal cells resulting in reduction of
03:53
histamine-mediated acid secretion drugs that belong to this class include cymetidine fomotidine nizadidine and ranitidine now another pharmacological approach is to directly disrupt the functioning of
04:08
the proton pump responsible for acid secretion this can be achieved with the use of drugs called proton pump inhibitors which work by binding to the hydrogen potassium atpase and suppressing the
04:19
secretion of hydrogen ions into the gastric lumen drugs that belong to this class include dexalonsoprazole esomeprazole lansoprazole omeprazole pantoprazole and rebeprazole
04:34
all right so while h2 receptor antagonists and proton pump inhibitors can provide a sustained suppression of gastric acid secretion patients needing immediate relief from their symptoms may benefit from a faster acting agent
04:47
belonging to a drug class known as non-systemic antacids members of this class include aluminum hydroxide magnesium hydroxide and calcium carbonate unlike the other acid-reducing agents
05:00
non-systemic antacids do not decrease acid secretion but instead act primarily by directly neutralizing hydrochloric acid this happens as a result of simple chemical reaction that combines a metal
05:12
ion from an antacid compound with a gastric acid binding group to form a salt and water this in turn raises the ph of the stomach contents and provides rapid relief from hyper acidity
To get the full transcript and PDF notes with screenshot - Try Askify notes chrome extension tool
Sir please cover the general side effects of particular pharmacological class and the drug of choice for the disease.
Thank you so much for this video. With help from your past videos I have successfully retained the concepts and passed my last pharmacology and clinical pharmacy class two weeks ago. I will keep watching of course as it is always nice to review what was learned. Thanks again and as always, very informative content.
The best pharmacology channel ever ❤️
I just completed 3 semesters which all had pharmacology as a subject
And i cant stress it enough as to how thankful i am for this team that makes these videos
This is probably the first time i scored well and actually felt like i learnt something about the subject, in fact i learnt a lot
I hope i can support this channel by becoming a patreon in the future
Just fall in love with your explanation
I am preparing for my test for M.phill and your videos helping me a lot to revise the whole concept.
You are the goat of pharmacology
Your videos famous in the medical universities of the Uzbekistan.
Best pharmacology channel, you are amazing
Thanks
Thank u so much 🥰 ❤️
Plz don't stop making videos on yt I really can't imagine studying pharma without your videos...they are really very helpful ...may God bless u 😌
Perfect,you're the best man you make pharmacology easy for me🙏👏
I have been waiting for this for so long 😩, thank you so much
yeah, seriously me too!
Yay, finally some GI tract pharmacology, thank you
I've been waiting for this video thumbs up👍
Thanks alot from Egypt 🇪🇬
100 % worth watching and beautiful animation
I love your videos & how crisp they are
Finally 😁 I have been waiting for these videos ☺️
You are totally the best
A request for other videos such as antimalarial drugs as well as cough not forgetting management of pain
These videos have been of a great help
I also need
Sir will u please provide us the drug of choice of every disease
thank you for coming back
Good to see you back ❤
That’s so amazing! Thank you sm for the amazing explanation
Thanks for your hard work and strenuous efforts you have made to collect the conceptual information and deliver to us.
I used to look for your video lecture ,
At the last I got it now.
Many many thanks to u...
Great video literally you summarize 4 lecture in my college into this 14 minutes , thank you so much 🔥❤️ …
Best video on this topic! Thank you so much.
I love this channel so much ❤
Very well expained, Thank you so much
This content on pharmacology is called as chef’s kiss ! I should be paying you the fees that I squandered on my med school teachers . Thankgod for creating you and thank you for creating this content ,,,,,you are GODSENT. 🙌🏻🙌🏻🙌🏻🙌🏻🙌🏻🙌🏻🙌🏻💫💫💫💫💫🌱🌱🌱🌱✨✨✨✨✨
First of all, I would like to thank you for the perfect explanation and simple delivery of information. I would also like you to touch on some topics such as antianginal, ADHD, antiprotozoal, antihelmintic, anemia,gout, DMARDs, urologic disorders.
Love ur videos .Short,accurate and interesting to watch,hope u drop many more like antihelminths, drugs in gout etc
Thanks from 🇰🇪 loving pham all because to this videos
Awesome video. So easy to understand. Thank you so much.
Thnks for coming back
Informative and quick refresher. Thanks! :)
Wow ..what an interesting explainnation of the whole git in just 14 minutes 🎉❤❤❤
You came back... 🥺🥺🥺💫❤️
Love from Indian medical colleges ❤🎉
superb sir, great less timel valuable. thaank you very much
Antibacterial medications called 'nitroimidazoles' primarily used to treat infections caused by protozoans & bacteria should have been added to the video.
Edit: Thanks a lot for uploading videos.
Just amazing as always.
Thanks, for very usefull information
Excellent! 👍
Thanks for lecture ..its helps a lot...❤
feels so good to listen your voice
you are the best!
Thank you very much,today i had pharmacology exam and i did it great thanks to your videos .you make it very esay🌹
Thanks so much doctor, I have final pharmacology exams in 4 days and I was so confused because there are some chapters I don't understand but your videos helped alot ❤️
All my love form Sudan 🇸🇩
Learning from Uganda....❤
Can you do a video on how antidepressants affect the gut and how the side effects like brain zaps work?
I feel so unfocused and so much pain and pressure in my head from trying to taper off.
You guys are the best
Your videos are really really helpful ❤
Bunch of thanks to youu…
(From Bangladesh)
Thank you soooooooooo much
That was really helpful❤❤❤
Thanks for your lecture. It helps me lot❤
Amazing video, really helped me to understand concepts and memorize the drug groups for my pharmacology exam.
Also I love the whip sound in the antiemetics part. 😂
Wow wow wow ❤❤❤ amazing yar whenever I am doubt I prefer your 😊channel only
Sir please upoload other system also specially endocrine , chemotherapy, anginal drugs 🥀
Thanks 👍
This video is really very helpful
Life saving -🎩✨️
So informative and well made video
Thank you for these videos. They are so helpful!
Getting good views right please make time and do some more and cover all the topics it is really helping us a lot
you're doing great
wish you the best brother 🙏 ❤ 💙 🙌 💪 ♥
Excellent cover for GI symptom management keep on sir
Thank you so much for these vedios❤
Very informative sharing
just Amazing wow
You're doing incredible work, please continue your hard work ❤️💕
In love with your videos....and clear concepts 🤩
Thank you 😊
Thanks! Can you please do a video with antispasmodic, antiflatulents and gastric pro kinetics
Thank you so much!!! I always love your vids and recommending them to my pharmacy classmates ❤️❤️
Sir please explain Anti-malarial drugs
Very well made, thank you 👍
Thanks for the help
You are awesome!!
Do some of these gastrointestinal drugs cause serious side effects
Brief and complete
It was as usual one perfect lecture, and once again made my concepts crystal clear...Thank you sooo much Sir!
Glad I could help :)
Thank you Sir 😊
Can you pls make a video for Endocrine Pharmacology involving Corticosteroids??
Well explained. I appreciate
Greaaat i love it ❤❤❤
love your job bro
Great work man💚👍🏻
I always enjoy your videos and revise my information hear
Thank you for the post
Very Useful
Thanks brother 🙏. Please explain how atropine prevent drug abuse of diphenoxylate in brain 🧠.
Thank you so much 🙏
I salute you for this great effort and I wish there is a summary or pdf in Video description
pdf summary will come in the near future
Please can you do a video on Autocoids
You not mention nk1 ,opiods blocker and cannaboid .also serotonin realses from platelets when cytotoxocs drug arre present there
Please make a video on Rhumetoid Arthritis 🥺
8:45 I wished you also mentioned Domperidon.
Please app used in this video
Thank you very much
Wow thankyou for your content, straight forward and fun. I would really like to see tentin drugs for ADHD/ADD 😊
@Zahra Imaan
Dear if am not wrong Tentin has Dexamphetamine 5mg , in which case *Speed Pharmacology* have already discussed about the stimulants like In-direct acting Amphetamine and Cocaine in Adrenergic Receptors & agonists drugs link of video ruclips.net/video/KtmV-yMDYPI/видео.html
kindly check the video and thank him
Please sir 🥺 make a video on GPCR in your simple language,,, your are gem 💎 sir
THANK YOU
💖 tnx dr sir