Endometriosis is a disease of immune dysfunction
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- Опубликовано: 7 июн 2024
- Endometriosis is an inflammatory disease that’s affected by hormones but is not caused by hormones. Instead, endometriosis is, at least in part, a disease of immune dysfunction.
In this episode, Lara discusses some of the new endometriosis research including:
- the link with genes that increase the risk of autoimmune disease
- the role of a bacterial toxin called lipopolysaccharide or LPS, and
- new targets for natural immune-modulating treatment.
Links to:
- Blog post: Immune treatment for endometriosis www.larabriden.com/endometrio...
- Blog post: Why I prescribe iodine for breast pain, ovarian cysts, and PMDD www.larabriden.com/iodine-for...
Thank you. As a Endometriosis sufferer this makes perfect sense to me. I was diagnosed with Endometriosis at the age of 24 in 1984. Over the next ten years my endometriosis got so bad that I needed a hysterectomy, plus removal of my ovaries, fallopian tubes and appendix. I also had endometriosis on my bowel. The adhesions and lesions were so severe, that they stuck to my bowel causing a twisted bowel. On two occasions I had emergency, life saving bowel surgery to divide the adhesions. During this time I was on medication, firstly a progesterone treatment and then Danazol for the last 6 years. I didn’t have a period from the age of 24. Even on Danazol my Endometriosis worsened. My Gynaecologist was dumbfounded and couldn’t understand how I could end up with such an horrendous case of endometriosis whilst being on Danazol. The latest research answers that question. It’s taken most of my life to find a plausible answer. Thank you.👏👏👏👏
That is because progesterone treatment only shrinks endo in your womb surface and not on your intestines
Here in S.E. Asia this topic isn’t talked about enough. My wife has stage 4 endo and will go for surgery this month. I wish there were more experts like you promoting these science based discussions because here a lot of the FOR PROFIT medical industry just salivates at the profits by talking up last century’s surgery only approaches... for a condition that effects nearly 10% of all women at some degree, this is insanity. Here’s cheering for change
You are a very good spouse for doing research on your wife's condition. That is incredibly supportive of you and I wish my partners would have or would do the same you two are lucky to have each other
Thanks Lara, I read your book 4 years ago, started your protocol and cut gluten, most dairy (Not organic NZ butter) and took Zinc etc. The pain decreased almost 100%! I then had surgery 6 months later which I had told Dr's I suspected I hade Endo and of course they all denied untill surgery. Since then, I have trialed fasting whcih helps restart immune system and resets good bacteria and starves the bad bacteria. But noting beats what a Dry Fast did. I did 2x 48 Dry fasts in 1 month and WOW! it bought inflammation down and was very healing and noticeable to even a new burn I had on arm. Can't say I would recommend dry fasts to everyone as you would need to build up and try a 2-3 day water fast before hand. But all these many natural things will help. Hope this helps someone, God Bless💖
I have done one 4 day dry fast and two 3 day dry fasts. Several water fasts too. It didn’t help at all unfortunately. Diet however makes a big difference, less symptoms.
Thank you! I also take Arnica with Castor oil to rub on tummy... it seems to reduce pain.
Thanks ladies for good advice,am in pain now period nonstop with blood clots I will try.
@@SaritWorldkindly help what is arnica?
@@dorotejadnbsame here I was almost without any food for 18 hours fast ,sometimes only water but that dint helped ,as an Indian we often keep fast due to religious nature
Incredibly interesting. I often wonder if I have endometriosis.
Thank you very much for this podcast and video, Lara. Wonderful information for someone who is tossing and turning with endo pain right now. Thank you!
I'm Only just a 4th year of medical student, i just here to know more about endometriosis & found this amazing explanation... Thank you for upload this..
Thank you for continuing to research and discuss this common, but constantly overlooked disease.
The suggestions from your books and blog have literally helped transform my life. Thank you for your dedication to helping women. ❤️❤️❤️
Definitely a genetic link in my case. On my father's side I have an aunty with fibromyalgia who has 2 children with autoimmune diseases. Another aunt had her thyroid out and the other has 1 child with ibs, 1 with aspergers and another had her thyroid out. My grandmother was known to be in bed for days at a time so can only assume she also had endo.
I’m in so much pain. When I stop breathing, the pain stops.
Thank you so much, Dr. Briden. This is full of great info that I’ve never come across before. Thank you 🙏🏼🙏🏼
Wow thanks so much for sharing. Even after having hysterectomy, I had to have another surgery for endometriosis. I am also diagnosed with psoriasitic arthritis. I was also told that I am border line lupus. I have often thought that they were all somehow connected
Insightful, solid & actually relates to practical reality overall. Closer to the truth than most- this feels.
I've been going down a rabbit hole, watching these videos. It sounds like to me, that the diet needs to be examined throughout the cycle of a womans period. Perhaps certain days, or weeks when estrogen is at a certain level, women shouldn't eat certain plants/grains that have high LPS and maybe up the gut bacteria too? I am just trying to think of how to "roll with the punches" to lessen the pain. I know someone who has this pretty regularly.
This disease is so painful i remember a time i used to think that the strong natcotics that were prescribed and i thought those were sugar pills for this pain is untouchable.
Ketoprofen is the only thing that helps me
Very interesting! Thank you! Curious to know more about it!
Fantastic video huge thanks ive had Endometriosis and adenomyosis for many years and your video has just given me the encouragement i needed to sort my gut out 🎉❤ xxxx
Great video. The bacterial contamination theory isn’t all that crazy when you consider that reactive arthritis is a well known and common event after chlamydia infection (not to mention the myriad immunologic complications that crop up with secondary syphilis).
I also think a lot of women on the hereditary hemochromatosis spectrum present w endo but the genetic testing is never done.
Personally I think endo is a metabolic disease process. Particularly when you consider the role of aldosterone in de novo lipogenesis.
THANK YOU for this BRILLIANT analysis colleague 👏🏻👏🏻👏🏻👏🏻 Agree inmune related‼️
Brilliant video and information. Thank you.
Thanks so much for the breakdown, this is really helpful.
That was brilliantly helpful thank you 💛
Great information!
Good information bless u
This was very interesting and so well explained. I wish I had gotten that manual after my diagnosis. LOL. Thankfully, I had surgery the beginning of this year and am doing sooooooo much better. It's still a good thing to know. After all, there are women with similar struggles around me for sure!
Thank you for such a helpful and educational episode. For someone who has gone through excision surgery, do you think a restricted diet of gluten and dairy free is still needed or helpful? What lifestyle changes would you recommend post surgery?
Hello, hello, hello. Please respond to my comment. 😢😢 could you please do a video on Adenomyosis. The pain is horrible and the same as endometriosis, but Adenomyosis they recommend straight hysterectomy. This was an excellent video. I wish I had £50 million to give to do more research on this. I have never seen pain so horrible and traumatic. Prayers for all my endometriosis and Adenomyosis sisters.
God is with you sister, you are not alone❤️ may god heal you in Jesus name amen🙏🏻
I was diagnosed with Adenomyosis this year. It explained all my symptoms getting a diagnosis. Unlike endometriosis, I had never in my life heard of Adenomyosis until I was diagnosed. And everyone in my daily life who’ve I told about my diagnosis have never heard of it either. Sadly, there is just not enough information on this condition. I hope Dr. Briden will do a video on it!
Wow , wow, wow insightful 😮
This is amazing! None of this was explained to me by my doctor.
Thank you so much. You help so much. God bless you❤
Love your work Dr Lara Briden. The information you have provided here is so thorough so in-depth & most importantly life changing for women with this disease ❤ The info on your website is also next level too! Could you possibly do a similar video but on Adenomyosis?🙏?
Bless you 🙏
Thank you for the information, I have had endometriosis for 25 years. It looks like I’m getting closer to a solution.
THANK YOU
Thank you!! ❤❤
Thank you for this I have auto fibromialgia also Sjogens and inflammatory arthritis and thyroid .I just had a biopsy do the a thick pelvic linning with pain all day and night..
Thank you, Dr Mindy Pelz brought me here❤
Thank you!!
I have endometriosis and have been on progesterone for two years. The medication helps with the pain sometimes, though symptoms seem to come and go as they please. One thing that doesn't subside however is the fact that I get a terrible flu after every single period, especially during the winter. What can I do?
Does this information apply to those with Adenomyosis as well?
I never had gut issues until I started having endometriosis symptoms at age 36. Didnt even know I had it before then. Now that I had excision surgery, and have put a lot of effort into restoring my microbiome, my gut feels great. I eat gluten too :)
No one should be eating gluten. Wears holes in the intestines.
How are you restoring your microbiome. ?? What things you trying?
@@nadiraikram6198 prebiotics and probiotics every day! Lots of prebiotic foods like oats and blueberries and bananas, plus probiotic foods like kefir, kombucha, sauerkraut, aged cheeses. Also look up the IBD-AID diet.
Thank you Dr. For the vital info, I'm having some symptoms that I think might have to do with any of the endometriosis, the symptoms are: leg cramp during menstruation, menstruation cramp, ovulation cramp, constipation and blood while passing bowel also I've been trying to get pregnant but could not, pls help thanks.
Is there a link between endo and insulin resistance? Pcos?
Thank you so much for this information. I'm only eat lean meats and green vegetables and I've been trying to stay on that for a while and to be honest my endometriosis pain has improved but I still need surgery because prior to this diet it was already blocking and affecting my bowels.
Listen or read doctor McGregor's book - how not to die.
Go vegan, organic and maybe gluten free, eat lots of broccoli, check out black seed cumin oil
Hi I'm 35 just diagnosed with it
Will a gluten free diet help
I can’t thank you enough! I am battling with a complicated case of endometriosis. I also have interstitial cystitis which I believe is caused my a treatment resistant strain of E. coli (which also triggers LPS). I think all of these things are thoroughly intertwined. Planning on doing a microgen test also. This has been so helpful for those struggling with endometriosis, as the lack of doctors understanding or willing to help forces us to take the research into our own hands. If you’re looking for future ideas, I would really love if you could make a video on interstitial cystitis. It’s a common condition for those who also have endometriosis
Yes. I have pain from IC over 20 years after my hysterectomy.
Please stop eating oxalates. I have mild Ic and oxalates can trigger pain.
Same here! Anything helped you ? @@nettwench
Hello. I have a question. I am watching this and you mention environmental toxins. About 10 years ago we had a 6 month long natural has leak, which left me personally with severe fibromyalgia, I no longer had a menstrual cycle or even menopause. It just killed that entire system.
I do have a now 23 year old daughter that has already had surgery to try to help with her horrible endometriosis. Do you think there could be a link? I am desperately trying to help her
Doctor can carnivore diet help in endometriosis?
Gratidão 🙏
I’m having trouble finding the notes on iodine. Do you mind putting the information here in the comments?
I discuss safe-dosing of iodine in my books and in this blog post: www.larabriden.com/iodine-for-breast-pain-ovarian-cysts-and-pms/
I was doing some reading and it seems you are right. Its an immune system disease.
This means that the most likely cure COULD happen very quickly.
This can be achieved by asking thr appropriate companies to design a recombinant anitbody that could treat the disease.
These antibodies could be used to target specific markers or molecules in endometriosis
The pathogenesis of endometriosis, such as cytokines, growth factors, receptors, and enzymes.
Still enigmatic but a dim light is blinking far away😀
Hello from Canada! Thank you for the great work you do for the women around the world. I wanted to ask you, is there any difference in the treatment/management of Endo pain during perimenopause while taking bioidentical HRT? The estrogen part of the HRT is triggering intense Endo pain and I would like to get suggestions on the best approach in this scenario besides taking magnesium, zinc, vitamin d and being gluten free and dairy free, which are already part of my natural protocol.
thanks for the feedback and yes, estrogen therapy can worsen endo, unfortunately. In general, the approach would be to always pair it with oral micronized progesterone (see my latest video) and use the lowest possible dose of estrogen. Having progesterone in place can help. Also, androgens like low- dose testosterone and/or low-dose DHEA can help endo. But of course, talk to your doctor and maybe look at the anti-estrogen supplements I discuss in hormone repair manual (calcium-d-glucarate and high-dose iodine, but be careful with iodine).
@@LaraBriden Thank you so much for taking the time to reply to my message, Dr. Briden! Your suggestions are very welcome and I feel much better knowing that what you suggest is exactly what my Doctor prescribed. I am currently on Estradot 25, Prometrium 200 and half a pump of Androgel three times a week as my Testosterone level is very low at 0.4. Since I take Synthroid for my thyroid, I would prefer to stay away from the iodine. This is only the beginning of my fourth month on HRT and my doctor had to adjust my dosage of both, estrogen and progesterone to see if my Endo pain gets better. I had started with Estradot 50 and Prometrium 200 from day 1-14. Now I have the Estradot 25 and the Prometrium is continuously. The testosterone was also increased from 1/2 twice a week to 1/2 a pump three times a week and changed from applying on inner thighs to on the arms due to absorption issues. Thank you again for providing such great support and information!!!
Hi what kind of DR is treating you right now?
Endometriosis is usually associated pain, heavy bleeding etc. These can be effectively managed through Planet Ayurveda's Female Health Support and Pradarantak Choorna. These medicines will treat heavy bleeding and help in balancing hormones.
When you say antibiotics help women with endo... can we stay on antimicrobials like the ones you mentioned full time or should breaks be had?
For stronger antimicrobials like berberine, I generally prescribe a few courses spread over a few months. For gentler supplements, like probiotics and iodine, I prescribe longer-term.
Can i take curd ??
I have endo cyst of 8 cm on right ovary?? Can it be cured naturally or thru med n surgery my gynae told me for surgery plz rply
You cannot get personal health advice online. It's not safe and doctors can loose their license for such malpractice! It's highly inappropriate. You NEED to see one or even more doctors and get their direct opinions on your specific case after all the check-ups and imaging is done!
How are you doing now pls reply 🙏🙏
Does menopause stop endometrial growth?
Yes.
Thank you for this video. I have endometriosis and Crohn's disease. My endo was actually found in an MRI entrography. I also have respiratory problems for which I take Azithromycin. Do you think it would help with the bacteria side of my endo?
They have you on a daily antibiotic?? What?
Wow that's amazing. I'm supposed to get one of those mris soon
How did you find out you had Crohn’s? I had a colonoscopy but was told its normal….
@@muirgirlnot daily. Sat, Mon and Wed. My respiratory illness was quite severe. I had to also be on antifungous meds for 6 months
@@insertmyidentityhereI was having pain in my abdomen for a year, plus symptoms like fatigue, loss of appetite and loss of weight. I ended up getting fevers and diarrhea for about two months. Then upon doing blood test, they saw high CRP and ESR factors in my test showing inflammation. They did Colonoscopy. They found all part of my large bowel inflamed and they diagnosed Ulcerative Pan Colitis first. They also took biopsy from my ileum (last part of small intestine). And pathology if those biopsies confirmed Crohn's disease
Endometriosis is not retrograde menses. Women that have had a hysterectomy still get endometriosis.
100% agree that retrograde menstruation is not the main cause of endometriosis, especially once the disease has become established. It may, however, play a role in the initial origin of the endometrial-like tissue for some (but not all) women with endo. Most papers talk now about different origins for different types of lesions, ie. Superficial vs deep infiltrating.
And as I explain in the podcast, the MAIN cause of the disease is immune dysfunction.
@@LaraBriden fascinating! thanks for sharing this! do you have research/ citations that speak to the main cause of Endo being an immune dysfunction?
@@lemielange There are at least 1300 papers currently on endo and immune dysfunction, plus the 2021 textbook I cite in the video.
I think it's because the endometrial cells are deposited in the body by the retrograde. Once they are back-flowed via the fallopian tubes, they stay after the hysterectomy. Especially if they aren't seen by the performing doctor. ( If they are too small to be seen.) Then they can continue to grow as you mention, especially if a woman takes HRT. Even so, the endometrial cells make their own estrogen. So, for some people, the cure seems elusive. Perhaps atophagy by means of fasting can help. I haven't tried this yet. This is my case.
@@LaraBriden w
❤
Isn't retrograde menstruation as a cause of endo invalidated?
you need to do some better research on current thinking in endometriosis
Fusobacteria?
I’ve head about this as possible cause… the science is catching up to this possibility.
Thanks for the presentation but little science in your recommendations. We dont even know the causes and thre you have multiple recommendations, not really ethical