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- Опубликовано: 13 окт 2024
- GHB (gamma-hydroxybutyrate) is a central nervous system (CNS) depressant that was originally used as an anesthetic agent. It has since been abused for its euphoric and sedative effects, leading to its classification as a Schedule III controlled substance in the United States. GHB is available in both liquid and powder form and is commonly used recreationally in party scenes and as a date-rape drug.
GBL (gamma-butyrolactone) and 1,4-butanediol (BD) are analogs of GHB and are used as precursors for its production. Both GBL and BD are colorless and odorless liquids that are sold as cleaning agents and solvents. However, these substances can be converted into GHB in the body and cause similar effects.
In a clinical setting, GHB has been used as a treatment for narcolepsy and cataplexy, as well as for the treatment of alcohol and opioid withdrawal. It has also been used as an adjunct to anesthesia and in the treatment of depression and anxiety.
The pharmacology of GHB involves its ability to bind to GHB receptors in the brain and increase the release of GABA (gamma-aminobutyric acid), a neurotransmitter that causes sedation and relaxation. GHB has a fast onset of action and a short duration of effect, lasting anywhere from 1 to 4 hours.
The pharmacokinetics of GHB involve its rapid absorption from the gastrointestinal tract and its rapid elimination from the body. The half-life of GHB is short, and its clearance from the body is primarily dependent on its metabolism in the liver.
The side effects of GHB use include drowsiness, confusion, dizziness, nausea, and vomiting. Overdose of GHB can lead to unconsciousness, respiratory depression, and even death. Withdrawal from GHB use can cause anxiety, insomnia, tremors, and seizures.
In conclusion, GHB and its analogs, GBL, and BD are CNS depressants that have a high potential for abuse and addiction. While GHB has some limited clinical uses, its abuse potential and the risk of overdose and withdrawal make it a dangerous drug. It is important to educate individuals on the dangers of GHB and to monitor its use in a clinical setting to prevent abuse and negative outcomes.
Discussions and comments in our videos are for informational purposes only and should not replace the advice of a qualified medical professional. Please consult with your doctor before making any changes to your medical treatment or lifestyle.
GHB, 1-4B and GBL have no activity on the GABA-A receptor. They target the GHB receptor and GABA-B receptor. Do some research into it
Thank you for this video 🥰but I need the IR SPECTRA of this molecule(GHB) if you can please .
Why? 😂
I encourage people to look into above average Baclofen dosing and then taper to help diminish an withdrawal.
What does baclofen feel like? Can you just take Xanax instead?
Informative👌
GBL is a mucus membrane irritant. What happens to your stomach if you take it 5x/day for years? Does it harm the stomach lining?
Repeated exposure to gamma-butyrolactone (GBL), especially at high frequencies and doses, can lead to serious health consequences. If taken five times a day for years, the stomach lining would likely suffer significant damage, potentially leading to ulcers, gastritis, and increased risk of gastrointestinal bleeding. Additionally, long-term use of GBL can cause liver and kidney damage, neurological issues, addiction, and respiratory depression. It’s crucial to seek medical assistance immediately if you suspect GBL abuse or if you’re experiencing any adverse effects.
@@medheads Thank you, My doctors don’t know what GBL is. There are no medical professional who can help.
Let’s say someone has been taking 5x/daily for 10 years, with no measurable effects including perfect blood markers. All I have is worry about possible side effects due to “membrane irritant”.
I have not seen a single paper or report about GBL physical harm. Can you please help me with data? Where can I get actual scientific & medically backed answers?
Is there an online telemedicine expert I can talk to?
While GBL isn't as extensively studied as some other substances, there are still resources and avenues for obtaining accurate, medically backed information.
Firstly, it's essential to acknowledge that long-term use of GBL, especially at the frequency and duration you mentioned, can pose significant health risks, even if you haven't experienced noticeable effects or changes in your blood markers. GBL is metabolized into gamma-hydroxybutyric acid (GHB) in the body, which can have central nervous system depressant effects and potential for addiction and withdrawal symptoms.
While there might be a scarcity of mainstream medical literature specifically on GBL, academic research databases like PubMed or Google Scholar can still yield valuable insights. Look for studies on GHB, as the two substances are closely related pharmacologically, and many findings about GHB may be applicable to GBL.
@@medheads Well said yes I do that kind of research. I can attest to many of the side effects of overuse. Thank you for your response.