DOCTOR reacts to CELLS AT WORK! // Episode 9 // "Thymocytes"
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- Опубликовано: 28 сен 2024
- Complete with clickbait thumbnail! I breakdown scenes from Thymocytes (episode 9) of Cells at Work (Hataraku Saibou) from a real doctor's perspective. I'll be reacting to scenes and attempting to share a little bit more about the science behind the anime!
In this episode we cover the T cell development, the thymus, positive and negative selection, and even have time for a baby photo too.
This is a particularly heavy immunology episode, I've tried to simplify it as best I can, I'll include clarifications in the description here as they crop up... which they will because of the complexity of the subject!
This is part of a series reviewing Cells at Work, you can find the whole playlist here:
• Doctor reacts to Cells...
You can watch Cells at Work! here:
crunchyroll.com...
If you enjoyed this please check out my other reviews of Medical TV dramas; House MD, Scrubs, The Good Doctor, Grey’s Anatomy, The Resident and ER! And also I did a series on Marvel movies too, more on that soon.
Instagram: / drhopesicknotes
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Clips used under fair use (education and review):
THANK YOU FOR NOT COPY STRIKING THIS VIDEO SO I CAN CONTINUE TO USE THESE GREAT SHOWS FOR EDUCATION AND REVIEW.
ALL Cells At Work! Clips owned by Kodansha / Kodansha USA and distributor Sony Music Entertainment (Japan) Inc.
Thank you to all the artists that make their music available for these videos:
Song 'Escapists' by The AutoDisko
Song 'First Day' by Huma-Huma
Song ‘Finding Me’ by Eveningland
#doctorreacts #doctorwatches #cellsatwork
Ah yes, the three types of T cells: jock, nerd, and boss lady.
You'll see the boss lady having pity with Cancer Cell, triggering cancer part 2
Not really, she's only defending him because she's in charge of defending body cells and since cancer cell is a cell. She's forced to defend him unless of course, he's not a cell.
@@DonoZeek SIKE, HE'S A CEL.
What about the NK Cell?
🤣🤣🤣
“Let’s get a bit nerdy here” we’re watch a doctor on you tube explaining an anime about how cells work...can we get nerdier?
Only if there are nerdy medical puns...
Oh wait... there are. Nevermind
Unnerving epiphany.
Michael Ramsey. Wait till I arrive at the scene.
I was thingking the same thing
I can only remember chemistry jokes but I know I wouldn't get a reaction.
i love that ed gets so into his immunology that he ends up spoiling the episode subject 5 minutes in by accident XD
That's why I watch the episode before I watch the youtube video.
myanimeaddict you probably meant ‘rogue’, not ‘rouge’ which means ‘red’.
@Olivier Dubreuil-Gagnon i think that they meant rogue not rouge
You may be a Junior Doctor in the UK but you're the Senior Doctor in my heart.
Now that's just cute or in this case KAWAII.
What a sentiment, lmao.
Are we calling him Hope-senpai now? 😅
@@julianakarasawa315 Hope-sensei
Woah! Hes in your heart? What type of cell is he
cells at work has been confirmed for a second season hope you do more reaction videos when it comes out.
Since Dr Hope Loves Cells at Work and loves how it's a lesson gold mine and an Immunology refresher. The chance of him reacting to season 2 is high.
Yeah, seen that news. It's great.
They are also putting out a dubbed version that is coming out in August!
I hope we get Cells at work black adapted in the future too.
At this rate, he has to change the name of the channel to "Cells at work with Dr Hope"
9:40 “Let’s get a little nerdy for a minute...”
Doc, we’re watching you react to an anime series about the inner workings of the human body, we really cannot possibly get any nerdier
A comment above would beg to differ
Fuckin lol bryan
Start writing some notes on grafts:
Note 1: Nail an autograft joke
Note 2: immediately regret said joke
That was funny
"Can I have your autograft?" I'm just here for the awful dad jokes :-D
I found that quite hilarious
@@chizomni It was!
Doctor jokes?
I kind of want to learn immunology and all other medical terms just to make jokes like these.
chizomni that's the irony... terrible dad jokes are the hilarious ones, as dad jokes are always cringey
Nobody:
Dendritic Cell: Here's the story of this cell's entire life.
You have a very cultured profile picture
@@ibudorongsapi6770
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Mysterious Kitten
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Mysterious Kitten seriously, because of Hetalia, I fall in love with Italy and their culture.
@@EarlyOwOwl I came here to escape Hetalia for a while. Apparently it isn't that easy X9
2 Cells at Work Videos back-to-back within 2 weeks?!
Doc, you spoil us~
Thanks for all your hard work!
I don't get the spoiler...
@@AlexSander-jr9et There's no spoilers of the narrative type here.
@@AlexSander-jr9et Spoiling as in PAMPERING!
1:17 Thank you for the Dad Joke
I like how you have Master Chief as your profile pic and the time stamp the joke is on is at 1:17 lol
@@Kai-vo5zq 😉
I almost had the impulse to click the dislike button after that joke 😂
Thank you for the ❤️, Doctor Hope
Doctor Hope doesn't realize it but he is slowly creating the Cells At Work home tabletop game.
I am learning so much from you, thank you. Now if only there was an anime about calculus...
1, 2, 3, 4 we are Integers at Work!
Hope Dr. Stone is adapted into an anime.
@@CryingZombie666 it is going to be there is already a trailer out.
@Magna Nice.
There's the Manga Guide to Calculus
“Welcome to hell, you useless runts!”
“Oh the flashback to medical school”
“...i’m kidding”
Hahahahaha. As a medical student, I feel you
That autograft joke lol. Even before you finished telling the joke, your face looked so done 😂
I love it when you get into the grit of how the processes CAW tries to simplify work. I think the T-cell selection process you laid out was pretty easy to follow, and offered an insight that I frankly didn't get when I watched CAW the first time through. In the show it seemed a bit more 'random' which cells were gonna pass and fail.
Your highschool Biology teacher explaining
Ah , sh*t here we go again.
Dr. Hope explaining.
Oh , sh*t where's my notes....even though i already graduated.
While it also shows what a difference a good teacher makes this is one of the anoyances of my life. I had such a large span of my life dedicated to learning and I resisted so much and now (that I have a full time job an 'adult timetable') and need to squeeze learning into my day I CRAVE new information and whenever I feel I didn't learn anything new in a day I feel really dissatified.
Oh Brain and your ways of working xD
i'm a vet nurse who regularly needs to know and understand veterinary medicine, but especially ongoing patient care and management. And holy shit, THANK YOU. I have learnt so much from you and your educational break down of complex systems esp throughout this series. I have pretty dibilitating ADHD and struggle with learning ANYTHING even if its life or death - but you, sir, are incredible. You are indeed filling the shoes of those who taught and inspired you and i hope to do the same. Thank you so much for these video's and your patience in teaching us all things about our own bodies (and those of our pet's too)
I loved Cells At Work already, but this series makes me appreciate the creativity and the science of the show even more.
Nice to see that the cat approves of your artwork.
Cat:"6/10, not a CATastrophe"
@@CryingZombie666 I could say something about that clawful cat pun but i play monster hunter where there is no shortage if cat puns!
@Hikaru WDM Meow God, such a purrfect display of cat pun, Nyaa!
@@CryingZombie666 lmao why thank you! I've literally had years of practice with my cats in mh (seriously the puns are bad in mh).
@Hikaru WDM You have cats? Which breeds?
I'm not big on "reaction" videos and it could write up a thorough treatise on why that is _(but I shan't),_ HOWEVER, I was pleased that I made an exception, for this particular video. It's like an extended education, on an already educational animated show, as well confirmation and explanations to what we're seeing; I quite like that! I know "react" is a popular term on RUclips, but I feel "Confirm" or any other fitting synonym would be more fitting.
I have not watched _'Cells at Work'_ myself, even though it looks pretty entertaining, on top of being informative, as is intended.
I DID however watch _'Once Upon a Time... Life', (1987~88)_ which was MY generations _'Cells at Work',_ I suppose. Clumsier animation, but still left me with vital information about my body, that I remember to this day. I hope _'Cells at Work'_ will do the same, a whoppin' 30+ years later! *Quick edit:* I just went back to see the first episode of the series, and you DO mention _'Once Upon a Time... Life'._ SPLENDID! 😄
I can't wait until Dr Hope gets to the Heat Stroke episode, because I'm sure he's going get a kick out of the ending.
No spoiler, please!
I can't wait until he gets to the finale
@@CryingZombie666 I'm not going to spoil anything.
@Genin99 You did by revealing the episode's title.
I hadn’t even realized that was next. I really liked that ending, but I feel like it kind of lessened the finale.
"Flashbacks to med school. Ha! I'm kidding."
Your face says you're not.
The process of how Helper T and Killer T cells are made is one of if not the COOLEST thing I've ever learned.
6:29
"Welcome to Hell, you useless runts!"
Dr. Hope : Ahh, the flashbacks...to medical (school)......
Me : Yes, that's me everyday.
Additional notes:
1. We found out this episode that Helper T Cell was actually a pretty good combatant, kind of like a prodigy. Meanwhile, Killer T C was actually kind of a runt, working hard to just be competitive. The dynamic remind many of Naruto and Sasuke, with Regulatory T Cell I guess representing Sakura.
2. Helper T was actually not that nice towards Killer T, but they were forced to be in the same room. Because of that Helper T finally saw that Killer T is more than meets the eye, and that he is working hard to be the best T Cell.
3. It all showed up when Helper T saw Killer T secretly training that "technique", which because of that, Helper T helped Killer T overcome his fears by reminding him of that "technique" which helped him "graduate" (albeit accidentaly).
4. At the end the two had the animé cliché of punching each other, showing themselves as sort of best friends now, even though they still kinda hate each other's guts hehe.
I always get baffled by how much care and details they manage to get into this series even down to representing the proteins and receptors. Truly marvilous^^
Doc looks just as handsome in 360p as he does in 1080p.
I would give the good Doctor a cuddle if he wanted it. :3 uwu
He teacc
He reacc
But most import
He absolute snacc
I bet he still looks handsome even in NES sprites!
I diagnose all of you with extreme dehydration because y’all are T.H.I.R.S.T.Y. 😂
They should have a Special Edition set with you as commentary explaining the medical terms and situations. I would totally buy it.
i loved this episode ^^ , showing the photos of the in-anime cells on the drawings helped, i must say
Me 3 Minutes Ago:
*Watching another video*
"After this video I'm going to sleep"
*Video finishes*
*Sees notifications*
"Never mind, gonna watch this one first."
new sick note CAW reaction video: exists
sleep: am i a joke to you?
Whenever you say "I'm kidding", I send my condolences 😅
Ahhh, Major Histocompatibility Complex 1 and 2.... this brings back so many good memories from my immunology courses :D
After 20 minutes now understand the T cell differentiations better than I did after 12 weeks of immunology ^^;
That Autograf joke calls for a continuation. Dr. Hope reacting to medical dad jokes?!
Great video as always!!
That would be an awesome video!
That baby picture was so adorable! Also, will definitely be coming back to this video when I have to memorize immune cell development.
Idk, man, but I cracked up when you said the joke,"What did the ressected skin cells say to the other skin cells? "Can I have your Autograft?"." lmao
I sat through an entire wix ad, enjoy your revenue, you champion.
I'm enjoying how much you can see their adult personalities in them. Helper T is always trying to get the most out of Killer T, and during the final exam he provokes an appropriate immune response from Killer T. Meanwhile Regulatory T is forever telling Killer T and Helper T to calm it down and focus on the job. Their professional qualities are their innate qualities which the thymocyte has simply nurtured.
"Let's get a little bit nerdy" as if this entire video isn't a nerd fest
TIL Dr. Hope isn't actually a doctor. His print of "MHC" was far too legible to be written by an actual doctor.
Lol my mom is a Doctor I can relate to this.
It took me 14 years to eventually read the shopping list she makes.
A minute?! I came here to become nerdy for 18 minutes and 10 seconds, man!
Thanks for sticking with Cells at work! You gave a great explanation of stuff most would have missed.
Oh my goodness judging by that photo of "young you", you were always meant to be a doctor! 😁
Have you had a look at HBO's Chernobyl yet? It's a very accurate portrayal of radiation-related illnesses on top of the amazing history and other details. I'm very curious about a medical professional's thoughts on the infamous nuclear disaster and its aftermath.
+1 to this!
Ikr same
It's not really accurate for the medical part. It's dramatized and made more extreme.
🎵🎵 autograft repair, autograft replace 🎵🎵
Me: There's no way Doctor Hope can get more adorable !
Doc: *shows a baby pic of his*
Me: ....Oh. My. God.
That was my reaction too
T cells can all be summed up by vibe checks. They give cells vibe checks and in turn they get vibe checks when they’re young.
I am taking AQA a Level Biology and I literally just had a question on CD4 helper T cells for my paper 1 today 😂
Ok, I was struggling to understand this bit in my physiology class when it came to blood products. You summed it up so perfectly, thank you!
Fantastic reaction and explanation!!
I knew a bit about the selection of T-cells in the thymus, but your explanation expanded my knowledge, thank you!
This is the best show about immunology ever made.
For physiology, I think Once upon a time... Life is ahead, any plans of reacting to it in the future? I think you'll enjoy expanding on it as much as you do on Cells at Work.
Best!
When Dentritic Cell laugh I instantly knew that the voice actor was Nobuhiko Okamoto
I hope we get a little bit more information about how Regulatory T Cells are formed, as the episode mainly focused on the Killer and Helper T Cells.
It's mostly the same process, different proteins tested but the concept is the same. Tregs are selected in the negative selection; in the long and short is Tregs are what become of t-cells that don't respond strong enough to trigger the death signal but too strong to become mature naive Effector T's. It's called a Goldilocks process, not too strong, not too weak but just right. That being said, Regulatory T was present in the same bootcamp as Helper T and the Killer T captain- she's with them in most of the training scenes and that's kind of all there is to it, there's not much materially different to show regarding how she differentiated. They all started as the same progenitor cell and specified during this period in the Thymus.
"Cat paw prints on paper" omg that is too cute!
Also, wow so happy you uploaded this. Fave medical react series!
You didn't cover how the regulatory T cells are picked. :(
The let's-get-a-bit-nerdy part of the video was so well-explained. When I was taking immunology fundamental, I was having a hard time trying get things straight, what's MHC, CD4, CD8, why do I care, what MHC binds to which. I ended up just memorizing it like a robot. Your 'moving' diagram is so helpful! The positive/negative selection was well explained too T^T ...Thisvideo would have been such great a supplemental material to studying for my immunology class 5-6 years ago :D
Doctor: I know your body very well...
Patient: H-how...?
Doctor: *SHOWS CELLS AT WORK EPISODES*
NANI?!
Bro you like added tons of value to the anime, now I understand the plot more deeply, also I don't have any medical background and I understood everything you just explained so kudos too you.
7:23 “separate the useful from the useless” ...in the English Dubbed version they use “separate the T-Cells from the Wannabe cells” 🤣
Didn't think the macrophages they showed also played a part. That is indeed nice detail on their part and there was a lot of explanation in this video in particular. The parts about positive and negative selection was very clear.
The thymic macrophages are the antigen presenters actually producing the class 1 and 2 MHC used to put the developing T's through the selection processes, plus you know, eating all the ones that die from failing either test.
Don't stop making *Cells at Work* reaction videos! Waiting for the next one
I like how you go deep on explanation the production and selection mechanics. Thank you.
Particularly wonderful to see how evolutionary principles not only works on the macro level, but on the micro level inside your own body.
i learned a lot omg!! thank you for the insight into positive and negative selection~~
Can’t believe you explained the concept of MHC well. I’ve been studying this since premed and during med school and this is the best explanation I’ve heard. Idk if it’s because I already know it but wow. 👏🏼👏🏼
This is my favorite class
Nothing like homeschooling yourself with Dr. Hope.
i love when you do these Dr. Hope, please do them more often
Show is called "Cells at Work", and is a sort of entutainment show about.. cells.
"I didn't think we'd cover quite so many cells."
There’s going to be a season 2 of Cells at Work! I can’t wait for you to react to it when it does get released!
Crush: what does your heart say about me?
Me who's had a 🐖 hetrograft: _oink oink_
Man I just found your reactions to Cells at Work yesterday and binged them all! Thank you for making me enjoy a show that I loved even more than I already did! The depth that you go in to detail breaking things down has made this such an enjoyable experience!
Lymphoid progenitor cell: This isn't even my final form!
You're giving me a much deeper appreciation for both this series and the immune system. I did grad neurobiology work so I know how deep the rabbit holes can go but never really learned immune systems. Thank you, senpai!
Been studying immunology for my new job and this has been so helpful -- thank you for helping me catch up!
3:41 Megakaryocytes actually appear in the manga, and... well, they're basically represented as an adult version of the platelets that apparently act as very stern drill sergeants (who react to seeing their charges proving themselves as up to their assigned duties by crying in joy and showering the kids with praise).
I only started watching when you made the first episode reaction to Cells at Work and I've watched every video, not just cells at work since. You are doing a great thing teaching people in bite-sized and easily consumable ways. I find myself learning, actually learning new things whilst enjoying doing so.
This anime along with Dr Hope's explanations would have been so helpful back in highschool when I had advanced biology. All i wanted at the time was to watch anime and youtube, but that didn't help me pass my lessons on the cardiovascular system. 7 years later and here I am hahaha
You spoke of the helper T cells and the cytotoxic T cells, but what about the regulatory T cells, how would they fit into the positive & negative selection?
Do they follow down the path of the Helper and if so, how does it become a regulatory T cell?
Regulatory T cells are a subset of CD4 helper T Cells
It's mostly the same process, different protein used to test but the concept is the same. Tregs are selected in the negative selection; in the long and short is Tregs are what become of t-cells that don't respond strong enough to trigger the death signal but too strong to become mature naive Effector T's. It's called a Goldilocks process, not too strong, not too weak but just right. That being said, Regulatory T was present in the same bootcamp as Helper T and the Killer T captain- she's with them in most of the training scenes and that's kind of all there is to it, there's not much materially different to show regarding how she differentiated when limiting the scope as it is.
I haven't done any biology since my GCE 'O' levels, mainly taking math as a degree now, and here I am entranced by Dr Hope's biology lessons xD
You learn something new everyday
There's one part I wished you'd covered, though it's not necessarily covered in the T-cell training arc of the episode, but that's - how are the Regulatory T-Cells produced? I thought you were going to say that the T-cells with both the 4 and the 8 appendages become the T-Reg cells, but since those are actually killed, how are the T-Reg cells created after all? A comment would suffice, but a short video would be even better! Thanks; this series (yours and Hataraku Saibou) have just been such a blast, I love it! And I love your appreciation and positivity toward the material as well! Truly why I subscribed.
Education system
Teachers today: i want all the chapters regarding to cells in this text book by tomarrow
Teachers in future: i want u watch all episodes of this anime by tomarrow reading written contiuations will also be good for u
Already happening in a few schools, some teachers have started using the show as watch-homework due to its overall accuracy. Less as a serious learning tool but as an easy way to set simple paradigms in students' minds to quickly understand the basic nature and function of cells to lay the groundwork to build the more complex knowledge on. Neutrophil as frontline soldiers was already the normal mental image taught, but things like platelets as kindergartners laying concrete is unique and pretty memorable for the basics of clotting.
@@gtf234 thats great
We just need more anime like this one and i know japan can do that
I remember doing research on positive and negative selection because of this episode and I was slightly confused because of all the proteins and extra details I wasn’t given so this really cleared things up 👍🏻
I've been watching Cells at Work, and then supplementing each episode with your videos. It has enhanced the experience, in my opinion.
i'm currently in med school (i got in 2 months ago) and it makes me so happy how i understand your commentary and the series much more easily now than i used and it's very very helpful for reviews 💖💞💗💕💖
Read books for 2 hours...... Nothing understood
Watched Sick Notes..... For 20 min.... Feel like a genius
I'm actually in medical school right now and immunology lecture came up , so I'm using this to prime myself LOL thank you Dr. Hope. This is super helpful for basic immunology and histology!!!
Just after watching this video I read about the official discovery of the x lymphocytes. A hybrid of T cells and B cells.
I like how they introduce the regulartory T cell just as the Killer T is throwing a native T through the window and knocking down the Helper T.
No! That was the best part! I was hoping to see them freak out trying to get their pictures back 😂
I really wish I had your videos when I was studying for immunology. I'm understanding this is a whole new way!
I absolutely love this, the clips are fun, but your explanation of what the clips are speaking about and double use of standard oral explanation and visual cues with the cute paper cut outs is very smart and fun to watch.
This is great work!
Cells: *Exist*
Dr. Hope: WEEEE
I just wanted to say you're one of the most wholesome sweetest youtube channels with a very wholesome community
These videos make me appreciate the show even more.
Hah , wish there were more medical anime , so I can see dr. hope explain them ...
Both Cells at Work and your reviews are always good for me to learn immunology, I got interested in immunology because of them
I was expecting a "this is not even their final form" reference. Either way, great video as always! :D
React to the surgery scenes from the anime "Monster"
My man back at it again with the informational anime
Your "Nerding out" session gets this Medical Biologist's seal of approval! Well done!