Metabolism of Drug (Part 01) | Introduction to Drug Metabolism | Metabolism | ADME | Pharmacokinetic
HTML-код
- Опубликовано: 24 авг 2024
- Download "Solution Pharmacy" Mobile App to Get All Uploaded Notes, Model Question Papers, Answer Papers, Online Test and other GPAT Materials - play.google.co...
Drug metabolism is the term used to describe the biotransformation of pharmaceutical substances in the body so that they can be eliminated more easily. The majority of metabolic processes that involve drugs occur in the liver, as the enzymes that facilitate the reactions are concentrated there.
The purpose of metabolism in the body is usually to change the chemical structure of the substance, to increase the ease with which it can be excreted from the body.
Drugs are metabolized through various reactions including:
(1) Oxidation
(2) Reduction
(3) Hydrolysis
(4) Hydration
(5) Conjugation
(6) Condensation
(7) Isomerization
There are often two phases of drug metabolism.
(1) Phase I: Non-synthetic reactions such as cleavage (e.g. oxidation, reduction, hydrolysis), formation or modification of a function group.
(2) Phase II: Synthetic reactions such as conjugation with an endogenous substance (e.g. sulfate, glycine, glucuronic acid).
The most common and important enzyme group involved in the Phase I metabolism of drugs is the cytochrome P450 (CYP450) superfamily of enzymes. This group of enzymes acts as a catalyst for the oxidation of many drugs. It can, in turn, also be induced or inhibited by many drugs and other substances. As a result, the metabolism of some drugs is affected by the presence of other substances. This is what is known as a drug interaction.
Some of the important enzymes in this family include:
CYP1A2
CYP2C9
CYP2C19
CYP2D6
CYP2E1
CYP3A4
Description Credit- www.news-medic...
Get in touch with the solution by just clicking following links-
Facebook Page- / pharmavideo
Facebook Group- / solutionpharamcy
Instagram- / solutionpharmacy
Mail Us for Free Pharmacology Materials- solutionpharmacy@gmail.com
LinkedIn- / pushpendrakpatel
Finaly i got it,, this channel is exactly what i was looking for
Thank you so much.
Same here
@@solutionpharmacy a
@@solutionpharmacy the best
@@solutionpharmacy to
Sir , I have just entered in 2nd year & luckily I found your channel & you are making pharmacology much more easier in this lockdown era!!! Thank you so much sir 😊...now already subscribed!
Thank you so much for your valuable feedback
Yes ..nidhi u r saying right very easy language and way of teaching is too good
Hello Sir, I'm practicing as a clinical pharmacist in Canada. I was just reviewing some pharmacology topics and found your youtube channel, you are doing a great job. i wish i had a good expert teacher like you when i was in my college. I will definitely recommend your videos to the Indian aspiring Canadian pharmacists. Great Job. Will connect with you in future.
Thank you so much sir
Your feedback and support is very vital for us. Thank you
Hello..It was really a nice and interesting lecture given by you.I am working in Pharma company in R&D sector for more than 7 years, was just surfing pharma classes out of interest and came across your videos. It is fantastic and hope it is going to help many students. Great work..Keep it up....
Thank you so much for your valuable reply and feedback sir. It is most imp for me to have feedback from experts like you.
Sir, er kono scope aache bhalo? Jodi bhalo kore kamate hoye?
Sir mai koi bhi medicine le raha hu to mujhe side effects ho ja raha hai. Q ho raha hai sir pls help me
Sir you are the bestest teacher of pharmacology 👍 and I will see all your pharmacology classes video here thankyou so much sir for your efforts
Thank you so much for your valuable feedback. Your satisfaction is my real award. This motivate me to give best. TC
Wht a fluency !! Super...Aap jaise teacher muze pahle kyu nahi mile
Thank you
Good to learn from you sir, but In this video I heard PCM is Antibiotic, I hope you said Antipyretic.
Hats off to you for everything.
I said antipyretic but due to simularity its sounds like antibiotic. I have already clarify this in comment box many times.
Sir thankyou so much for clearing my concepts i am.paying huge amount of money to college equal to mbbs for pharm d which is 6 year course in my college pharmacolgy teacher just reading slides only i am now more interested in pharmacolgy subject because of you thanks a lot sir you are doing a great job your method of teaching is very easy to understand and interesting also
Happy to know this. Thank you so much for your support and feedback
Very informative and very easy to understand all those tough things...thnx sir for such kind of effort for all of us ❤️
thanks a lot sir 😊😊....kash hamarale clg teachers bhi aapjaise hote 😓....but anyways ur video are very useful and helpful for we students ....you are great 😃....keep it up 😊
Thanks alot
Sir bohot bdiyaa sir 🙏🙏🙏🙏..
...sir aise hi video bnate rgeyiga hmara pharmacology subject acchha ho jayega ☺
Seriouly sir very nice video in the time of lockdown study jo ruk gai thi wpas start ho gai h bahot ache se smjte h aap concepts clear ho jate h
Ansh Ujjeniya Thank you so much. All the best and TC
THANKS SIR FOR MAKE MY CONCEPT OF METABOLISM
REALLY YOU ARE A GREAT TEACHER OF PHARMA
Way of learning is fabulous
Thank you so much
Tq sir
Satendra patel my pleasure sir
wow love you sir that was really interested i am going to see your all lectures
Thank you
Can we study it for MBbs also?
i am an mbbs student.. and this is going to be the part of my daily life to see your lectures, sir!
❤❤❤❤ for you...
Thank you so much for your love
Thanks sir for teaching all students for clear the concept of pharmacology,. 🥰🙏🙏👌👌
Welcome
Thank you sir, Aapka samjhane ka tareeka amezing hai..... Hum jaise backbencher bhi aasani se samajh jaate hai
Thank you so much for your feedback. Pata hai aapko ki jo back becher hote hai wo sabse aage jaate hai
Good video sir thanks 👍
My pleasure.
Great video sir
Tribikram Barai thank you
Sir aap bohat accha padhate hoo
Concept clear karne ke liye very very thank you sir .
Minz vlogs My pleasure. Thanks for such a nice compliment. Plz share with your friends.
Allah aapko mahfooz rkhe
Aur aap hm logo ko esehi gyaan dete rhe
Thank you sir❤
Shukriya
Easlyunderstable💯💯💯🎊🎉👍
Thank you
Asalamualikum..
Sir ur way of teaching is very good... I have read this topic 3 times on book but l cnt understand as much, but after listen ur lecture l understand very well, and also help me alot wt l read from the book....
thanx a lot sir..
Very happy to know that. Thank you for your feedback
Sir Aapke lecture me bahut achcha smjh ata h but voice speed level thhoda sa kam kijye please
MOHD SOHIL sorry for the issue. Ye purane videos the aur tab mai thoda fast tha ab slow ho gaya hai
Excellent video 👌🇮🇳
Thank you
Sir aap ka videos youtub pe sabase achha he
Thank you so much.
Sir mere liye app mere real guru hai tqq so much
@@solutionpharmacy a lot of thanks
Drx garima sahu Thank you so much dear
Im from MSc baground but want to learn pharmacology... 😊 hope This video will help me
I hope so too
Thank u sir, approx all concepts are cover in your videos.
Thanks alot
sir thank you so much for making pharmacy very easy🙏...very much grateful...
Very helpful sir.hope for more videos on next chapter....
Pabitra biswas thank you. I have uploaded many videos.
Good work
Thank you
Good to learn from you sir.respect from Pakistan🇵🇰🇵🇰🇵🇰
Thank you so much
Most helpful vedios
Thank you
Great sir
Thank you
Our power is explain in understand language
Thank you
Maa Shaa Allah very good videos
Thank you so much
Thank you sir🙏
Sir mn to aapka Fan ho gya, bhot mja aagya padhne m
Tauqueer Ahmad Thank you so much for your valuable feedback and support.
Thank you sir
It is very helpful
Most welcome
I will miss my pharmacolgy online class and listen to your videos which are more useful
Thank you so much for your support and feedback
Cristal clear metabolism thanks sir ji 👍👍👍👍🤗🤗🤗❤️❤️🌹🌹🌹🌹🌹
Thank you
Wow so easy lectures method
ali muhammad Thank you
Nice lecturer sir tx u so much
Thank you so much
Thanks
Nice lecture sir
sayyed Rashid Sultanpuri Thank you
Thank you sir 🔥🔥💯 good 👍 work
Thank you so much it was very helpful I really can't understand whole pharmacology and medicinal chemistry but after watching your videos I can say that I understand All these concept easily
Great. I am glad that my lecture is helping you. Wish you all the best
Best Ever
Thank you.
Nice video 👍
Thank you
Nice video sir🙏🙏🙏🙏
Thank you
🙌🙌 thankyou sir
My pleasure
Thank you sir. Your video is very informative And very easy to understand. Once again thank you sir.
Thank you sir
Thank u so much sir. Entero hepatic circulation ki video upload ki hai u tube pe
You are doing a great job sir it's very helpful
Thank youb
Sir your all video helfful and concept clear
Koi group ho to pls add sir
sajjan singh Thank you so much. Facebook me hamara group hai solution pharmacy ke naam se. Aap join kr sakte hai.
Great sir. Love and respect from Pakistan
Raja Huzaifa thank you
@@solutionpharmacy Sir, You deserve much respect 👍👍👍👍
Sir what is the need of taking drug if it alter in its form from active to inactive ....
Kindly elobrate it us for better understanding...
I m not questioning .
Always regards
Thank you for your love. See when we take drugs then it goes for metabolism and as per the chemical nature of drug it produce action either directly or by converting in its metabolites. Few drugs get inactivated but by oral route and not by parenteral. Thats why we study about such drugs.
thank you sir from Pakistan
Nice
local5ab Thank you n
Solution pharmacy one big request from my side ... Please upload all notes and everything in your application ... I want use there ... Must reply me .
Great
Thank you
धन्यवाद सर जी
Welcome
spectacular.
you made my day by this video . thanks a lot sir.
Thank you so much for your valuable feedback
Thank you sir God bless you 🙌
Thank you so much
Mai kashmir sai plz aaram sai pada dai bohot acha pasatai hai aap
Thank you
Thank u so much sir for such a good information ......
My pleasure. Thank you
Sir you are explaining very well,a big big tnq so much..!
thank you sir
Moat welcome
Very well explained in easy way ..... thanks
Thank you
Sir you are amazing😊😍
Thanku so much
Most welcome
Thanku sooo soooo much SR
My pleasure
Thanku so much sir❤️
My pleasure
You are great sir ,i love you😀
Thank you so much
superb excellent
Thank you
Mashallah👌👍
Shukriya
Thank you sir. It was really helpful.
Most welcome
U r best teacher really 😍😍🍸🍹🍷🍺
Thanks alot
What a awesome channel😍 excatly what i want
Thank you so much
U are awesome sir, God bless you 😇
Thank you so much
Thank you sir for best teaching 🙏
Very nice sir
Thank u sir
PUNEET BHARDWAJ my pleasure
Sir please kindly move aside whenever you are summarizing a point because what happens is we cant see the full sentence or points if you stand just in front of the board. Thankyou sir for providing clear concepts.
Really sorry for the issue. But we have already finished all videos and all are uploaded so can't change them.
Nice sir
Thank you
Your videos are very easy to learning and understanding
Sir, your video is very helpful for students
Thank you so much
Thanks 😊 sir
My pleasure
Thanks sir
My pleasure
Good one sir...
Thank you
Nice job Sir ji
Thnak you
Shukriya sr
Welcome
Thanku so much sir..😊
Thank you so much sir 😌😌
Sir thanku somuch🙏
My pleasure
Thank you Sir...
Thanks Sir 🙏🙏🙏, I Salute You
Most welcome
Osm ellobirated
Thank you
Absolutely genius 🙏🙏🙌
Sir video upload kr dijiye enterohepatic circulation ki plss😊
Abhi to nahi kar paunga. But aage kosis krunga
Nice videos ❤️❤️❤️
Thank you