Metabolism of Drug (Part 02) | Phases of Drug Metabolism | Metabolism of Drug | ADME क्या होता है

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Thank you

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[@solutionpharmacy]

Thank you so much for your kind feedback and support. PDF are available on our solution pharmacy app

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1 thing to say that charged particles are ion not redical

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[@suniyonjanofficial9058]

Hi, I just starting watching from Absorption and its great video. Thank you so much. I understood very properly about Absorption and Distribution right after your videos but still quite confused about Metabolism. As the drugs get absorbed in stomach and small intestine and are distributed to the organs through blood vessels, what gets metabolized in liver? Drugs are already in blood. It says that drugs reach liver through hepatic portal veins but if the drugs are already in the boodstream, what reaches the liver from small intestine? Also, is bioavailability counted after distribution or just after metabolism? I need help with this please.

[@solutionpharmacy]

Thank you. Drug reachs to blood after Absorption but currently it is in inactive state but when it reaches to liver via heptaic vein it gets metabolized into active agent and now it is ready to give action for which it was taken. Without metabolism it will not give action. BA is calculated from plasma not by blood because plasma conc is actulual conc of drug. (But if drug is not in blood how it will be in plasm so it defined as blood conc) please watch the metabolism series it will help you.

[@suniyonjanofficial9058]

Thank you. So the inactive drugs stay in blood to those organs? And what happen to those drugs? Do they come back to liver for activation from those organs or liver gets drugs?
I got confused because after distribution, if the drugs reach brain, heart and kidney from blood vessels, which drugs reach liver for metabolism?
This might sound repetitive and stupid but I am confused. Thank you.

[@76ramanrai19]

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[@odiapharmacist5556]

@@suniyonjanofficial9058 drugs primarily reach the liver for their metabolism or Biotransformation... How ever it also reach to the brain, kidney as well as intestine where they get also metabolised in small amount.... That sites are also be used in metabolism of drugs.... But mainly it is seen that most of the drugs metabolised in the liver....in liver there are enzymes like cytochrome P450 and mono oxydase which are mostly responsible for carrying out all types of Biotransformations reactions...Where they get inactivated for the ease of elimination... So we can say that liver is the main site for metabolism

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Like Xanthine Oxidase catalyze which reaction?

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If u explain medicinal chemistry with the help of chemical structures of drug that will be more useful to us
Thanks

[@solutionpharmacy]

Thank you. But i am not expert of chemistry

[@dangerousgaming5959]

No worries....thanks for replying

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Shukriya