MYOPIA ATROPINE: ATOM 2 Myopia control with Atropine
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- Опубликовано: 30 июн 2024
- MYOPIA ATROPINE: ATOM 2 Myopia control with Atropine
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This is a summary of the ATOM 2 myopia study: Atropine for the treatment of childhood myopia and myopia control. This study is one of the important studies that established what dose of Atropine is an effective treatment for myopia control in order to slow the progression of myopia in children.
Link to Journal articles
ATOM1: pubmed.ncbi.nlm.nih.gov/16996...
ATOM2: Phase 1: pubmed.ncbi.nlm.nih.gov/21963...
ATOM2: Phase 2: pubmed.ncbi.nlm.nih.gov/24315...
ATOM2; Phase 3: www.aao.org/assets/28fe020e-5...
CLINICAL PEARLS:
00:00 Intro
02:45 1. 0.01% Atropine has little effect on pupils and accomodation.
03:34 2. Lower dosages (0.5%, 0.1%, 0.01%) atropine are almost as effective at 1% in reducing myopia progression
04:45 3. 0.01% atropine is effective in myopia control
05:29 4. 0.01% atropine has less myopic rebound than higher doses
06:24 5. 0.01% atropine is the most effective in myopia progression in the long term
This study is a called Atropine for the Treatment of Childhood Myopia: Safety and Efficacy of 0.5%, 0.1%, and 0.01% Doses (Atropine for the Treatment of Myopia 2) and sometimes it is referred to as the ATOM 2 Study. It was published in the journal Ophthalmology in 2012.
ATOM 1 study showed that 1 % atropine works to reduce myopia progression there are 2 problems (lets call them symptoms) with 1% atropine: 1. It dilates your pupil so you may be sensitivite to lights and you may need to wear tinted lenses. And 2. It freezes your accommodation or ability to focus to will need to wear a bifocal lens.
So the ATOM 2 study looks at whether lower dosages of atropine are as effective as 1% atropine AND if the kids get less symptoms of atropine
So this is a double masked randomized study that looked at 400 kids between the ages 6-12. So this study has 2 phases to it. Phase one the kids used lower dosages atropine in each both eyes of either 0.5%, 0.1% or 0.01% atropine. One drop in each eye every evening for 2 years. I’ll tell you about phase 2 in a bit.
This is different from ATOM 1 because ATOM 1 they used 1% but only in one eye for 2 years.
The results for the lower dosages of atropine also showed a that they reduced the progression of myopia….and almost as much as the 1% atropine.
There was a myopic rebound after atropine was stopped, and it was greater in eyes that had received the higher concentrations of 0.5% and 0.1%atropine. The 0.01% atropine effect, however was more modulated and sustained.
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Very well explained.
Glad it was helpful!
@@GoodOptometryMorning hr44rh
Thank you for your efforts . Respect from me😊
Great article review! should do more videos like this one :) hugs from Mexico
Thanks. Sunday is the LAMP study
How does a patient titrate off of the %.1 Atropine without rebound myopia? Is it an exact science or just trial and error on the patient’s legal guardian’s part?
You should check with your prescribing eye doctor. There are not actual extablished protocols for discontinuing but your eye doctor will have some suggestions based on your particular case.
@@GoodOptometryMorning thanks !
Thanks so much for the great breakdown of ATOM2 findings. Thinking of starting my boys ages 15 and 12 (both already -5.75) on atropine drops per Optometrist recommendation. Wish we could combine it with OrthoK, but they can’t tolerate even soft contact lenses. Thanks again, great review.
is this not effective for adults?
can adults get cured
In the intro, he uses the word "SYMPTOMS", to refer to the negative effects of the drug, when he should be saying *SIDE EFFECTS.*
I don't like doctors who play little political games with me.
How is axial length measured? Is it done by dilating the pupils or can it be done without a dilated exam?
it can be done without dilation
Hello sir I am from india Sir I am suffering with myopia I doesn't clear vision from my eye plz suggest me best eye drop for rid of myopia
10000000000
iam 20 yrs adult having myopia , I used 1% atropine
is it dangerous?
I am feeling bright light