mTOR's Role In Metabolism | Dr Ted Naiman Ep 3

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  • Опубликовано: 1 янв 2025
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Комментарии • 58

  • @ModernHealthspan
    @ModernHealthspan  2 года назад +1

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  • @KenOtwell
    @KenOtwell 2 года назад +10

    Brilliant! Now that's the way to put things in context - which can only be done by someone who actually understands the entire context and isn't just pushing their latest product. Thanks so much for this.

    • @ModernHealthspan
      @ModernHealthspan  2 года назад +1

      Hi Ken, thanks for sharing. It does make sense, the thing that moves the needle most is body composition and metabolic health. So have the diet and lifestyle that enables you to get that right.

  • @mangott
    @mangott Год назад

    Dr. Ted Naiman nailed it here. This video needs a lot more views.

  • @jssmc73
    @jssmc73 2 года назад +3

    Best breakdown on this subject matter I've seen. Thanks for this!

  • @peterz53
    @peterz53 2 года назад +4

    Low insulin is so important. I recall that Prof Keith Baar also said that extra protein (and leucine supplements) around exercise time in the context of a healthy diet will only result in a transient mTOR increase.

    • @ModernHealthspan
      @ModernHealthspan  2 года назад +1

      Hi Peter, thanks for sharing. It does make sense, having continuous low insulin would have a bigger impact than transient protein spikes.

  • @SofiaCTardy
    @SofiaCTardy 2 года назад

    Wow. How many valuable information!!! Thank you, doctor Naiman!

  • @jimbob4456
    @jimbob4456 2 года назад +1

    Wow, very interesting explanation.

  • @ronm6585
    @ronm6585 2 года назад

    Thanks Richard.

  • @josejr.8328
    @josejr.8328 2 года назад +2

    Wow.. Dr. Naiman explains so well...

  • @js401
    @js401 2 года назад +1

    Nice conversation about our human metabolism 👍

  • @tonipieleanu
    @tonipieleanu 2 года назад +3

    How about if we compare mTOR stimulation from protein in the context of energy equated diets, in normal (non overfat or obese) people? I completely get the point that this is not an issue with high calorie diets, but how about maintenance diets? We should not compare only to the worst case scenario.

  • @robertwhite2449
    @robertwhite2449 2 года назад

    Thanks for putting the MTOR fears into context doc!
    So for those athletes/ bodybuilders that are eating 6-8 small protein meals a day it could be a genuine concern?

  • @pjaworek6793
    @pjaworek6793 2 года назад +2

    I'm somewhat relieved to hear protein intake isn't the biggest driver of mtor people. Is it bad to limit protein throughout the day? The presenter spends 23 hours without signaling mtor,
    correct?

    • @pjaworek6793
      @pjaworek6793 2 года назад

      *in people

    • @lizmallen3461
      @lizmallen3461 2 года назад

      Me too!!!! It’s all been so confusing but not anymore!!!

    • @robertwhite2449
      @robertwhite2449 2 года назад

      Dr Naiman has said previously he eats about 2-3 times a day over about a 6-8 hour window, and then fasts the rest of the day. I think he occasionally does some 24 hour fasts as well

  • @BigPictureYT
    @BigPictureYT Год назад

    Excellent. I always suspected that Valter Longo and David Sinclair were focused on the wrong problem. Ted looks a lot healthier than either of them, LOL.

  • @TheEnhancedMan
    @TheEnhancedMan 2 года назад +1

    Super interesting. I think I eat a similar amount of protein & fast 12 hours daily. Sure I'd slightly live slightly longer, walking around at 70kg rather than 80kg+ but low blood sugar & body fat is more important.

    • @ModernHealthspan
      @ModernHealthspan  2 года назад +3

      Hi Thanks for sharing. Lean body mass is associated with longevity.

  • @SteveHazel
    @SteveHazel 2 года назад

    i like how succinct he is.

  • @ThomasHUsher
    @ThomasHUsher 2 года назад

    Terrific!

  • @newdata
    @newdata 2 года назад

    the good doctor never thought of throwing both the carbo and protean keys away to mtor for maximum health to the power of 2?

    • @ModernHealthspan
      @ModernHealthspan  2 года назад

      Hi Brandon, thanks for your comment. Restricting mTOR was the subject of this section. Dr Naiman suggests the philosophy of the PE Diet for over all health. He did say in previous episodes that he had tried keto but now preferred the PE diet.

  • @sciencesimplified3890
    @sciencesimplified3890 7 месяцев назад

    If low mTOR is the goal, then clearly low-protein diet OPTIMIZES for low mTOR…. He uses this vague “area under the curve” argument, but proteins effect on mTOR is complex and some amino acids may cause a ‘qualitative’ increase in certain downstream mTOR pathways… a lean healthy high-fiber low-protein diet will have normal fasting insulin, so less protein would reduce those mTOR spikes, and for all we know it’s the amino acid mTOR spikes that reach some biochemical threshold that causes exponential increases in downstream mTOR consequences…. It’s hard to speculate with certainty, but I’m sorry but all the epidemiology SCREAMS OUT that low protein extends longevity, it alllllll points in the same direction… so how is it moronic to think high protein may not be OPTIMAL for long term health?

  • @SaiBabaDivineSongs
    @SaiBabaDivineSongs 2 года назад

    Excellent! thank you!

  • @olyav5819
    @olyav5819 2 года назад +3

    Very interesting, didn’t know that overweight people trig mTor all the time. Good to know that I can have a bit more protein:)

    • @ModernHealthspan
      @ModernHealthspan  2 года назад +1

      Hi Olya, thanks. I do think that what he says makes sense.

  • @greggbambu411
    @greggbambu411 2 года назад +2

    Wow
    So don't worry about too much protien. Get thin, and healthy, then eat as much protien as you like.

  • @ortcloud99
    @ortcloud99 2 года назад

    I follow the food pyramid because the gov would never lie to us.

  • @rayyu8538
    @rayyu8538 2 года назад

    It makes sense!

  • @GodfreyMann
    @GodfreyMann 2 года назад +2

    Dr Naiman’s over simplification of mTOR upregulation by consuming too much energy is INACCURATE and misleading.
    mTOR can be upregulated by:
    (1) a number of amino acids from protein breakdown;
    (2) the upregulation of insulin and IGF-1 via the AKT/TSC2/Rheb pathway, but that’s only happening via a high-carb diet not a high fat diet, because fat has an almost negligible affect on insulin levels.
    In other words, a diet such as the ketogenic diet can be highly calorific, yet have little effect on mTOR, because it has a low insulin:glucagon ratio which this makes complete sense because as we know the ketogenic diet is a catabolic fasting mimicking diet!
    This is why a high-carb low-fat diet isn’t optimal because it creates a high insulin:glucagon state.
    That said, Dr Naiman’s basic strategy is however sound: consuming a diet that isn’t upregulating mTOR continuously is far better for improved healthspan, and a ketogenic diet is one way of achieving this.

    • @ModernHealthspan
      @ModernHealthspan  2 года назад +2

      Hi Anthony, thanks for sharing. I think that you could follow Dr Naiman's strategy and have a ketogenic diet and I also prefer a low carb diet.

    • @sleepinglaffey3886
      @sleepinglaffey3886 Год назад

      @ModernHealthspan Not necessarily true. It is possible to stay relatively low on protein if you don't mind being very slow at putting on lean mass and are operating on ketones (Ideally saturated fats). especially if you've already done a 72 hour fast to force your body to be less wasteful. Lustig's work also notes that you can overrun the citrate cycle (and protein can turn into TG or wind up as ectopic visceral fat that way). I'm not against it however. just that as a meat based keto sprinter. there is no point to this high protein nonsense (unless in fact you've a Croatian athlete juicing on PEDs and steroids or someone who has a ego issue...).

  • @yuvalkapellner2551
    @yuvalkapellner2551 2 года назад

    Inaccurate. His claim is true only when comparing it to obese people. Those who live the most dont look like body builders and there is a good reason for it. Recent research shows fasting glucose level is higher when consuming high level of bcaa. And bcaa canot be completely eliminated , you will find some level of concentration in any protein so when you consume high level of protein such as 160g as mentioned you can count on it that if you drop to 90 you will be healthier in comparison to yourself before the change. considering also that you regulate your calorie intake for the right balance accordingly to mtach that change. When i say healthier it means with potential for higher life expectancy

    • @ModernHealthspan
      @ModernHealthspan  2 года назад

      Hi Yuval, thanks for sharing. At high level I see a couple of things, one is that if protein makes you feel full, it is an easier diet to stick with. The other is that lean muscle mass is associated with longevity. It is probably on a U shaped curve where body builders would see a decline, but countering sarcopenia is a real need. If consuming more protein makes it easier for me to stay lean and maintain muscle then I would go for that.

  • @M.Oui.
    @M.Oui. 2 года назад

    Its unfortunate Dr Naiman recommends the clot shot to his real patients. I recommend every doctor repent, cease and desist from criminality sooner rather than later.

  • @paulcohen6727
    @paulcohen6727 2 года назад

    No thanks, I'll stick to my low protein, high complex carb diet that is low in fat and zero in cholesterol. It's kept me at a constant 160 pounds for more than 30 years and I'm almost never sick.

    • @ModernHealthspan
      @ModernHealthspan  2 года назад

      Hi Paul, thanks for sharing. It certainly sounds like it is working for you.

  • @jontpt
    @jontpt 2 года назад

    Omg, citations f'ing needed for all these claims and assertions! C'mon people, just a little critical thinking and skepticism, I beg you!

    • @jimbob4456
      @jimbob4456 2 года назад

      You’re the kind of person who would find a way to argue even if there were citations for all these assertions. Nothing would satisfy you.

    • @jontpt
      @jontpt 2 года назад

      @@jimbob4456 no, I'm the type of person who likes to see citations when people make assertions and claims. That's the way science works. But then again you probably believe in magic sky fairies, so..

    • @GodfreyMann
      @GodfreyMann 2 года назад +2

      Most of what Dr Naiman is saying is non-controversial undergraduate level life-science. He does however over simplify which leads to a major inaccuracy which I go through in detail in my comment on this video.

    • @ModernHealthspan
      @ModernHealthspan  2 года назад

      Hi Jon, thanks for your comment. Data and having the scientific backing is important. Dr Naiman is an MD not a researcher. He has done background study on his topic but also he has a lot of experience in seeing what works for normal people. If there is a diet that I can stick with which gives me good body composition I think it would be better than a theoretical diet that I find very difficult.

  • @luckyhanger1326
    @luckyhanger1326 2 года назад

    No longevity scientist recommends eating excess protein like that.