HIRN Webinar: RNA Processing in Metabolic Tissues

Wednesday, July 12, 2023
Presentation by:
Lori Sussel, PhD, University of Colorado
Rohit Kulkarni, MD, PhD, Joslin Diabetes Center
Topics discussed:
Introduction: RNA processing is an important layer of regulation in the islet
RNA Splicing (endocrine cell-specific RNA-Splicing, alternate splicing in diabetic islets, splicing defects contribute to beta cell dysfunction
RNA Modifications (types of mRNA modifications in metabolic tissues, significance of m6A mRNA methylation in type 1 and type 2 diabetes, role of m6A and pseudouridine in mRNA and carRNA regulation)

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