- Видео 27
- Просмотров 48 847
Human Islet Research Network
США
Добавлен 3 мар 2021
The Human Islet Research Network (HIRN) is a NIH NIDDK funded research network to support and organize translational diabetes research. To mission of the network is to better understand how beta cells are lost in
Type 1 Diabetes, and find innovative strategies to protect or replace functional beta-cell mass in diabetic patients.
Type 1 Diabetes, and find innovative strategies to protect or replace functional beta-cell mass in diabetic patients.
HIRN Webinar: Circulating Extracellular Vesicles in Type One Diabetes (T1D)
Thursday, October 24, 2024
Presentations by:
- Raghu Mirmira, MD, PhD, University of Chicago
- Ernesto Nakayasu, PhD, Pacific Northwest National Laboratory
- Emily Sims, MD, Indiana University School of Medicine
Topics discussed:
- A highly sensitive proteomics platform enables extracellular vesicle (EV) analysis from minimal plasma volumes.
- Proteomics analysis of auto-antibody positive plasma identifies potential biomarkers.
- Beta cell EVs carrying PD-L1 reduce CD8 T cell activation.
- Plasma EV PD-L1 cargo correlates with residual C-peptide in AAb+ individuals and in individuals with new-onset T1D
Presentations by:
- Raghu Mirmira, MD, PhD, University of Chicago
- Ernesto Nakayasu, PhD, Pacific Northwest National Laboratory
- Emily Sims, MD, Indiana University School of Medicine
Topics discussed:
- A highly sensitive proteomics platform enables extracellular vesicle (EV) analysis from minimal plasma volumes.
- Proteomics analysis of auto-antibody positive plasma identifies potential biomarkers.
- Beta cell EVs carrying PD-L1 reduce CD8 T cell activation.
- Plasma EV PD-L1 cargo correlates with residual C-peptide in AAb+ individuals and in individuals with new-onset T1D
Просмотров: 42
Видео
HIRN Webinar: Emerging Role for Tissue-specific Extracellular Vesicles in Disease Diagnosis
Просмотров 1195 месяцев назад
Tuesday, April 23, 2024 Presentations by: Saumya Das, MD, PhD, Massachusetts General Hospital Guoping Li, PhD, Massachusetts General Hospital Lingfei Sun, Massachusetts General Hospital Topics discussed: * EVs and their molecular cargo’s as biomarkers in cardiometabolic diseases Improving EV diagnostics by identifying tissue-specific EV markers. * How to use a bottom-up proteomic approach to id...
HIRN Webinar: Extensive Cell Turnover During Postnatal Pancreas Growth
Просмотров 938 месяцев назад
Thursday, January 11, 2024 Presentation by: Yuval Dor, Hebrew University of Jerusalem Topics Discussed: - Why is there a futile cycle of cell division and death during the growth of the exocrine pancreas? - Is this a general phenomenon in organ growth or a peculiarity of the pancreas? - What is the significance of early postnatal beta cell death?
HIRN Webinar: Microfluidic Models for T1D on a Chip
Просмотров 2168 месяцев назад
Tuesday, February 13, 2024 Presentations by: - Ashutosh Agarwal, PhD, University of Miami - Dan Huh, PhD, University of Pennsylvania - Chris Hughes, PhD, University of California, Irvine Topics Discussed: - Introduction to Microfluidic Devices - How to engineer blood vessels and vascularized tissue constructs for islet-immune interactions - How to combine islets with vascularized micro-organs w...
HIRN Webinar: Synthetic Biology and Type 1 Diabetes: New Approaches to Protect and Construct Islets
Просмотров 20610 месяцев назад
Tuesday, December 5, 2023 (1:00 pm Eastern / 10:00 am Pacific) Presentation by: Wendell Lim, PhD, Univ. California, San Francisco Topics Discussed: - Immune destruction of islets in T1D requires therapeutic strategies to protect and/or replace islets - Expanding set of synthetic biology tools for precision engineering of cell interactions/functions that could be applied to T1D - Engineering syn...
HIRN Webinar: A Roadmap to Restoring Tolerance in Type 1 Diabetes: CAR Tregs & Beyond
Просмотров 2 тыс.Год назад
Thursday, August 24, 2023 (1:00 pm Eastern / 10:00 am Pacific) Presentations by: Leonardo Ferreira, PhD, Medical University of South Carolina Qizhi Tang, PhD, University of California, San Francisco Topics Discussed: - What role do Tregs play in type 1 diabetes? - A brief history of Tregs in the clinic - Where is the Treg field heading?
HIRN Webinar: RNA Processing in Metabolic Tissues
Просмотров 10 тыс.Год назад
Wednesday, July 12, 2023 Presentation by: - Lori Sussel, PhD, University of Colorado - Rohit Kulkarni, MD, PhD, Joslin Diabetes Center Topics discussed: - Introduction: RNA processing is an important layer of regulation in the islet - RNA Splicing (endocrine cell-specific RNA-Splicing, alternate splicing in diabetic islets, splicing defects contribute to beta cell dysfunction - RNA Modification...
HIRN Webinar: Update on Type 1 Diabetes (T1D) Screening & Disease Modifying Therapies
Просмотров 1,4 тыс.Год назад
Tuesday, June 20, 2023 Presentations by: - Emily K Sims, MD, MS, Indiana University School of Medicine - Richard Oram, MD, PhD, University of Exeter Medical School Topics Discussed: - Approaches and broader applications to T1D risk screening - Approaches to disease modification & recent promising areas of advancement - Next steps and challenges for successful larger-scale application of screeni...
HIRN Webinar: Bifunctional Small Molecules: From PROTACs to Molecular Glues
Просмотров 3,3 тыс.Год назад
Tuesday, May 2, 2023 Presentation by: - Bridget Wagner, PhD, Broad Institute - Amit Choudhary, PhD, Broad Institute Topics discussed: - Descriptions of the different types of bifunctional molecules in drug discovery and development - PROTACs and their use in targeted protein degradation - Examples of bifunctional molecules that target cellular functions (e.g. phosphorylation)
HIRN Webinar: Stem Cell-based Platforms to Model Human Autoimmune Diabetes"
Просмотров 500Год назад
Tuesday, March 28, 2023 Presentations by: - Audrey Parent, PhD, University of California, San Francisco - Karla Leavens, MD, PhD, Children’s Hospital of Philadelphia Topics discussed: - Advantages of stem cell-based platforms to model human T1D - Current state of differentiation of T1D relevant cell types - Examples of disease modeling applications using stem cell derivatives - Development of m...
Webinar: Pancreatlas™: Mapping the Human Pancreas in Health and Disease
Просмотров 408Год назад
Thursday, November 10, 2022 Presentations by: - Marcela Brissova, PhD, Vanderbilt University - Jean-Philippe Cartailler, PhD, Vanderbilt University - Diane Saunders, PhD, Vanderbilt University Topics discussed: - Introduction to Pancreatlas platform - Overview of Global Search Function and Harmonized Metadata - Integration of Images across HPAP, HANDEL-P, nPOD, and IIDP Pancreatlas Website: pan...
Webinar: Reprogramming Human Regulatory T Cells to Quell Autoimmunity and Transplant Rejection
Просмотров 11 тыс.2 года назад
Tuesday, September 6, 2022 Presentations by: Leonardo Ferreira, PhD, Medical University of South Carolina Everett Meyer, MD, PhD, Stanford University Topics discussed: - What is a regulatory T cell (Treg)? When were they first discovered? What is a chimeric antigen receptor (CAR)? - How heterogenous is the Treg compartment? Do different Treg subsets perform different functions? How do tissue-re...
Webinar: A Library of Diabetes Resources: Opportunities and Applications for your Lab
Просмотров 2952 года назад
Thursday, July 21, 2022 Presentations by: Joyce Niland, PhD, City of Hope John Kaddis, PhD, City of Hope Sarah Tersey, PhD, University of Chicago Eddie James, PhD, Benaroya Research Institute Topics discussed: - Introduction to the Human Islet Research Network (HIRN) - Overview of the HIRN Resource Browser - Tools and Datasets Useful for Studying T1D (Mouse to Human Models) - Highlighting Resou...
Webinar: Introduction and Overview of the HIRN HPAP Pancreas Database (“PancDB”)
Просмотров 3362 года назад
Thursday, July 7, 2022 Presentations by: Golnaz Vahedi, University of Pennsylvania Colin McGovern, University of Pennsylvania Michael Stauffer, University of Pennsylvania Topics discussed: - Introduction to the Human Pancreas Analysis Program (HPAP) - Overview of the Pancreas Database (“PancDB”) - Demonstration of the v.20 PancDB Enhancements
Webinar: Why the Immune System Kills Beta but not Alpha Cells
Просмотров 8892 года назад
May 18, 2022 Presented by: Decio Eizirik from the ULB Center of Diabetes Research Topics discussed: - Alpha-cells are dysfunctional but not killed in type 1 diabetes - Are there different mechanisms for alpha-cell dysfunction in types 1 and 2 diabetes? - Learning from single cell RNAseq of alpha- and beta-cells exposed to pro-inflammatory cytokines - How do beta- and alpha-cells respond to vira...
Webinar: T Cell Antigen Discovery: Experimental & Computational Approaches
Просмотров 2 тыс.2 года назад
Webinar: T Cell Antigen Discovery: Experimental & Computational Approaches
Webinar: mRNA Modifications in Islet Biology
Просмотров 4252 года назад
Webinar: mRNA Modifications in Islet Biology
Webinar: FAIR Data and You: Are you ready for 2023?
Просмотров 3442 года назад
Webinar: FAIR Data and You: Are you ready for 2023?
Webinar: Elucidating the Endocrine Exocrine Communication Axis in the Pancreas
Просмотров 3543 года назад
Webinar: Elucidating the Endocrine Exocrine Communication Axis in the Pancreas
Human Islet Research Network (HIRN) Overview from the 2021 Annual Investigator Meeting
Просмотров 4343 года назад
Human Islet Research Network (HIRN) Overview from the 2021 Annual Investigator Meeting
Webinar: Intro to the Human Pancreas Analysis Program (HPAP): Real World Successful Data Analyses
Просмотров 1,6 тыс.3 года назад
Webinar: Intro to the Human Pancreas Analysis Program (HPAP): Real World Successful Data Analyses
Tutorial: Finding Resources for Bioinformatics Reuse on the HIRN Resource Browser
Просмотров 3653 года назад
Tutorial: Finding Resources for Bioinformatics Reuse on the HIRN Resource Browser
Webinar: Bridging the Gap - Pancreas Tissue Slices from Organ & Tissue Donors
Просмотров 2043 года назад
Webinar: Bridging the Gap - Pancreas Tissue Slices from Organ & Tissue Donors
Webinar: Exploring Humanized Mouse Models for Diabetes Research and Beyond
Просмотров 5 тыс.3 года назад
Webinar: Exploring Humanized Mouse Models for Diabetes Research and Beyond
Webinar: From Donation to Automation The Ins and Outs of High Throughput Islet Cell Culture
Просмотров 4533 года назад
Webinar: From Donation to Automation The Ins and Outs of High Throughput Islet Cell Culture
Webinar: Development and Use of Adeno Associated (AAV) Vectors
Просмотров 7 тыс.3 года назад
Webinar: Development and Use of Adeno Associated (AAV) Vectors
Webinar: Designing Tools and Materials to Create a Benchtop Window into the Islet-immune Interface
Просмотров 1663 года назад
Webinar: Designing Tools and Materials to Create a Benchtop Window into the Islet-immune Interface
Amazing presentations, congratulations!
😊😊
A very nice share. impressive😊😊😊
7:30 diagnosis, trials 9:05 AAV BIOLOGICAL 16:00 human/mouse 17:00 liver 20:30 limits ,genome size
What happened after 44:00?
So that means we are gonna reach to a functiona cure for type 1 diabetes in the next 5 to 10 years?🙏is it true?
THIS IS REALLY IMPORTANT FOR LONGEVITY
Great Speech from the Great Leaders in AAV research.. 👏👏👏👏