What really happens when you mix medications? | Russ Altman
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- Опубликовано: 24 дек 2024
- If you take two different medications for two different reasons, here's a sobering thought: your doctor may not fully understand what happens when they're combined, because drug interactions are incredibly hard to study. In this fascinating and accessible talk, Russ Altman shows how doctors are studying unexpected drug interactions using a surprising resource: search engine queries.
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Pharmacy student here! Loved this talk! My mini research topics have been around this.
As a Public Services Librarian and Institutional Data Oracle, I found this FASCINATING.
As someone who lost a friend due to drug interactions (from a MD who prescribed the drugs together, and my friend had an adverse reaction), I think this kind of research is long overdue.
This is exactly how Big Data should be used. Great talk. Very appreciated.
+Talon3000 Its a difficult problem, on one hand the potential gains from exploiting big data for good simply cant be understated. On the other hand big datas potential for abuse is absolutely terrifying. Figuring out how to safely get as much positive out of big data with as little potential for abuse as possible isnt easy
+StrykerTen Simple enough, any use of the data to generate profit is inherently not to be trusted. The reason this use of the data seems relatively inoffensive is that the study being done was done for medical research, and medical research is almost always a public good.
StrykerTen
Government inherently shouldn't be trusted with the data either. They should have to prove necessity before violating privacy. An actual resisting court should grant warrants and it should be on a case by case request basis. Mass surveillance, by anyone, and especially without express informed consent, is a violation and the purpose of government is never to violate its citizens. You don't need to tell me how bad of an idea mass government surveillance is, history has already made that point.
But I maintain companies shouldn't be trusted with data. Who cares if you get ads that aren't targeted at you? All ads are a violation because all ads are lies and because advertisement is not solicited. If you want to know what game to buy, you look at what games are available and make a decision. The ad should never enter into it. It doesn't tell you which game is better to see an ad for it, it only tells you which company makes a better ad. The solution to a man (company) who comes into your home, pauses whatever you are watching/playing, and shouts at you to buy his product (ads) is to lock the door, not ask him to please shout at you about a product you might like. You might say the companies need to do it to make money but that just isn't true. Good products, in a world without advertisement but with ubiquitous communication, will naturally gain market share. And as the cigarette companies' experience shows, when neither you nor your competitor can advertise you make more money because you still sell your product but you don't have to spend the profits on advertising.
Ah, loved this talk! I have always wondered about this topic for many different reasons, and from a personal story! Medications in general can have many different and potential risks to them. One medication alone can have anywhere from 1-20+ different types of side effects with it. The more medications you add into the mix, the more complicated things can get.
Altman made a comment that if a patient is on a type of medication, then becomes depressed, a doctor may put that patient on an anti-depressant drug. Sounds great, and could get the job done. Right? Not necessarily. Do those two drugs clash? How will they react with one another? Which makes me think of my mother.
Depression runs in my family. My mom has had depression for as long as I can remember, and a couple of my aunts and uncles have also suffered from depression as well. There was one point in my life where I can remember that my mother was taking 6 different pills a day. All prescribed to her by the same doctor. She didn't think anything of it, rather than that is what her doctor prescribed, so that is what she was taking. However, one pill alone was 875 mg, which is a lot. My mother is a small woman. Just above 5 feet tall, and around 105 pounds, nothing big by any means. Until she was always tired, taking multiple naps throught the day (which was unlike her), and occasionally getting sick a couple times a week. I noticed, but didn't say anything. Until my dad had enough of it, and took her to the doctors. After 7 months of taking 6 pills a day, the doctor cut it back to just two. I had my mother back. She was fine, full of energy and life. So, here is my question, why 6? Six took my mother away, two I gained my mother back. Why do doctors always think more is better? Clearly, they did not know what mixing all of these would do to her tiny body, yet, I thought it was excessive to begin with.
More research and funding needs to go into this topic because it is something almost everyone goes through. I alone take two different pills each day. My brother takes two, and so does my mom. However, there are more people out in society that probably take a handful more than just two a day, that could be potentionaly putting harm to their body by doing so.
Overall, I agree with what Altman is saying when it comes to this topic on mixing medications. More studying needs to go into it, and more eyes need to be focused on this topic.
That was an excellent talk!
People should understand that ted does not care about the youtube comment section.
a comforting thought
I've seen TED reply to some comments before though.
+JellybellyWaffles Different people, the channel janitor is not the person organizing a TED conference
People have not understood for thousands of years that Gods do not care about people's prayers, offerings, requests, promises, etc. It is really more about the illusion of relevancy. Commenting is more about the momentary need of expressing your thoughts, than any expectation of future consequences of it. Just like doing drugs.
+CzechRiot very good connection but not all uploaders ignore their audience's comments. In fact most uploaders do because a dissatisfied audience leads to fewer views and a bad reputation
This is so important.
Finally some quality talks, I want education not useless garbage.
Man i kinda wanted to listen to another SJW talk about trans bathrooms or something instead of this science stuff
+Phillip Constantine I just subed I hope I never witness this
+One Great Bill
Oh, but you will.
Katatawnic welp guess ill walk myself out
+bassisku FUCKING THANK YOU!
Great talk here. I want to see more of this. Less PC nonsense. More educated practical talks.
Thank God, TED's back. Why don't the put the other emotional stuff on a separate channel? Keep this one for the science.
I am on 10 meds and have always believed that some combination of them impact me differently.
"Let's call him Nick because that's his name" lol
this is amazing.. doctor's are looking at this just now.. but doctor's in Nepal are already looking into it and prescribe the medicines.. :) but keep up the good work..
this is interesting do u mind sharing where you got this info from? I'm very interested in the research Nepalese doctors are carrying out in this subject matter :)
Xena T hey.. I dont know much about this kind of research but I knew a doctor who used to prescribe only while consulting with the patient about all their problems and with other related doctors about it to know its reactions and all..
The doctors from 'Sumeru Hospital, Dhapakhel' are great and provide the best services.. :)
Wow amazing subject! Fascinated by this especially knowing so many people taking multiple medications.
Great TED Talk. More like this in the future. Very enlightening and useful.
not just mixing medications with other medications, also mixing medications with exposure to hazardous workplace fumes, food/drink ingredients, skin care products, whatever bodybuilders are ingesting, etc. This stuff was obvious to me when I was a teenager and I've avoided pharmaceuticals like the plague ever since in case I actually need to take a medication someday. I haven't even taken tylenol in a decade and I'm feeling pretty great about that
the solution to headaches is to eat healthy and don't be dehydrated btw; i probably average one tiny headache every 3 years, even with my stressful life -> it's just that you're never going to see a commercial telling you to drink some water instead of an advil commercial. Telling people to drink water and get exercise and eat fruits and vegetables isn't a business and can't support marketing efforts like big pharma or 'healthy' fast food
As a medical doctor, I am part of an ever shrinking group of professionals who truly understand the medicine that they're prescribing. I do not give or prescribe any medication to my patients without fully understanding its effects, how it works with other medications, post-market observations, etc. Too many doctors in my profession are just dishing out medicine left and right without fully understanding it.
+Paul Brosnan And then they get mad when question anything they prescribe. I've lost count of how many times I've been prescribed antibiotics when I didn't have an infection. One of the times he did this, the pharmacist immediately called him to make sure he wanted me taking that specific antibiotic with blood thinners when it could cause bleeding. I just didn't take it because knew I didn't even need it.
Primalxbeast Generally, doctors tend to know what they're doing. However, as was mentioned in the talk above, they know how drugs work by themselves, but, we tend not to know how they work with others. I have taken the liberty of educating myself on how drugs work, as have most of the doctors in my practice (I work in a private hospital so we tend to be at the top of our game, public hospitals however simply don't have the qualified and educated staff that they need).
+Paul Brosnan Great to hear that, however, I don't think you can ever truly understand complex biochemical interactions. You can only move closer to the truth. It's asymptotic.
Paul Brosnan Well, it doesn't take much knowledge of drug interactions to figure out that a medication that can cause bleeding should be avoided if someone is on warfarin unless it's absolutely necessary, although warfarin is a pain in general when it comes to drug interactions.
This man is extremely intelligent. I thoroughly enjoyed it, and his bits of humor were not superfluous or wasted on me. These are brilliant men doing incredible things.
Why aren't you?
This is a great video. I was looking for how they interacted: where in the body, why, train of events etc., but I found something almost as interesting
Great info, wish the fda would also do studies more than few weeks with regard to side effects. Medications alone can affect your body in different ways in the long term!
Am I the only one who caught that Internet Explorer pretty much saves your whole browsing history for 18 months for "research purposes"? I'm actually not surprised.
+PickOfDestiny89 Google reads your mail for data to better advertise to you. So I'm sure they don't hold your searches sacred either. Firefox/Mozilla are the only ones trying to protect user privacy.
Good TED talk. I dig it, we need more research on this!
A very enlighten testimony. I hope his ideas will go a long way because more and more people are using the internet trying to help them selves about health issues ... because after all , individual physicians can also make mistakes and/or be mistinformed.
Why do people still use internet explorer?
+C4nadian maybe the use edge
we need more of this
great talk.
i wish there was a way to crowd source this without major privacy problems....imagine the combinations people could find if everyone curious could check.
quality talk at last
Woow this makes me think how much we do things randomly without thinking of such a thing 🤔
that was a good, confident and informative talk.
Yes. Yes yes yes. An often underestimated topic.
This was really great. You could tell that he was a teacher at some point. The talk was well put together and interesting. :3
Fantastic talk!
Amazing talk.
beautifully presented and a good topic
Back in 2017, the United Kingdom government announced an initiative to take on 250 pharmacists.
They were going to be tasked with initially going into Nursing and Care Homes to check medication interactions. I thought that was a perfect idea. To reduce harmful medication interactions to improve quality of life. Also reduce the NHS burden for over 65's as all meds are free for them.
Nothing has been reported anywhere since that announcement.
Huge drug companies do not care about interactions between medications, only that you live long enough to take their meds for years.
Then it was announced that any over the counter meds for skin problems, gluten allergy, many other allergies, urine infections, thrush, cystitis and a few others would no longer be prescribed. Each person is supposed to self diagnose without any testing.
How dangerous do we think that is?
Especially for the immunocompromised or allergy sufferers.
Common sense is always bypassed by those with profits in mind.
Good talk! And an interesting question explained in a good way for someone like me that has no idea of medicine and such. I would also like to ask a question: Where is Nick? Feels like Mr. Altman is presenting what he didn't found himself.
Interesting presentation
Very interesting work with great potential but this highlights that we really have no idea about drug interactions. Yet millions of people are on multiple drugs thinking that their doctor or pharmacist knows that it's safe and that it's somehow been studied. Know well that they don't and it hasn't.
This is a really cool talk, but I'm only writing this to say; I laughed so hard when he said "Well, we have the Bing searches..."
+TimeladyRose ...and even harder at "Well, If you use.. Internet Explorer..."
Very excellent Ted Talk. I don't know much about medicine but this was super easy to follow with a good message too.
I feel inspired now😎
This stuff is awesome. I wonder how many answers are just sitting there in the data with no need to conduct a new experiment.
That's a great thought
Microsoft phones home with everyone's search terms even where people explicitly avoid their search engine, and somehow Google are supposed to be the bad guys in this story.
+Major Gnuisance
pretty sure G would gladly sell the data, just not give it up for free / research
+Major Gnuisance I think you're on the wrong video bro...
+hadhad69 I think not. 8:45
+Major Gnuisance If google didn't give that data, and the researcher didn't have friends in Microsoft research, thousands of people could be getting diabetes for reasons they don't know as the effects hasn't been discovered yet.
+Major Gnuisance I didn't see any bad guys. Google's just doing what it does. You can't expect them to give over data to every random that asks, no matter the cause. He had a personal contact at Microsoft. In time, I'm sure Google will better see who they can share with.
He is right, media nowadays can be used to check for things like drug interactions. But he has a problem: He just got lucky with those 2 drugs. There are millions of drugs and many of them don't interact. He can't just try out all the interaction combinations, that takes hundreds of years, and not only that, new drugs come out everyday. So unless he has a method of knowing which drugs are more likely to interact with eachother (those who aren't already proven to interact, he is wrong by saying there are no studies of drugs interactions previous to his'), he will be blindly guessing for interactions his whole life.
In addition to your PDR, I suggest buying:"The Handbook of Drug Interaction" by Ashraf Mozayani, Lionel Raymon. Or you can just read Katzung's Basic & Clinical Pharmacology, which I consider the bible. Your the Dr, you should know. There's a lot I know & a lot I don't. When in doubt, look it up. Don't blame the FDA!
very interesting, how many fields of work could employ this type of work method
Don't we call this 'synergistic' or 'antagonistic' effect in science? Or, is there another proper term for this effect?
Good talk!
Great talk ;)
Commonsense remains uncommon.
Any drug can cause any short-term adverse effect and also unrecognized late adverse effects.
The most common response of medical doctors is to dismiss clients' reports of adverse symptoms. Human biochemistry is too complex and individual for protocols & pattern recognition approaches.
+Fazia A True but for the time being with start with these "individual for protocols & pattern recognition approaches" and build on, do further research and improve and improve on the approaches. With brilliant people like the presenter and others hard at work on research, we might be able get more insight to human biochemistry.
+Kwabena Kesseh Common belief, though "Insight" is already gratis to all: self-responsibility through lifestyle.
See Published statement by Richard Horton, Editor in Chief, Lancet 385, Apr 11 2015.
"It's easier to fool people than to convince them that they are being fooled." - Mark Twain
wellicht denkt u dat het leven is wat uw lichaam betreft maar het is de vocht die het leven geeft
When people fill out pages of forms at the Dr.'s and hit the question, "Do you take any medications?" Who analyzes that? Wow.
Damn it! I'm on Paroxetine 😓😫😩 how much longer do I have to live????
Francky48
Are ya still alive 🤗
wow, i'm on paroxetine and had no idea about this. this was interesting
So big brother watching your searches on a macro level has application for the public good?
+Andrew Stevens
n0, its still 0nly f0r c0rperate g00d.// n0w they can track wh0 is likely t0 sue them
had to watch this during my organic chem lab lolol
My best friend's dad died when she was like 8 because he had pneumonia and then he accidentally mixed medications that had a chemical reaction and killed him.
Yes many people died when take medecine without serch .if 1 medecine takeikng give gavep 3 hour after 3 to 4 hour then take other medecine
Got anxiety, better go and give him a Xanax
Focus, give him Adderall, sleep, give him Ambien
-Macklemore & Ryan lewis
And if we could not just gather data from pears about these reactions, but predict what the side effects would be? It would be marvelous.
"Let food be thy medicine" - Hippocrates
+The Blue Farmer Works great, until you actually need medicine lol
+The Blue Farmer This is why I eat exclusively multivitamins and benzodiazepines.
Jack C
Advice to live by there. Not live for long, sure, but hey, quality over quantity
Who's talking ?
What is his CV?
Hey does anyone know if there's any websites out there that i can put my medical info, so that it can be used by students and projects just like this? In the past, i've been scared that my info is either going to be locked down and proprietary, or will be shared with marketers and other assholes i don't want to help.
i'm diabetic (etc), and for a variety of years i have been tracking my medications, alcohol intake, exercise, weight, sleep patterns, mood, etc. But i have no-where useful to put this data.
I heard about websites like this in a past TED talk iirc, but that was a while ago. Maybe by now the landscape is more mature and the choice is more obvious. Anyone heard of anything?
+roidroid
Sry i haven't heard of anything but i just wanna say that it's cool that you wanna share the info.
Maybe you know a reliable Doctor or a good university to ask
al het vocht zit om u heen maar ook in u het kan horen en zien
So no one caught that Microsoft logs your searches on google and other sites for 18 months?
No surprise there.
Plenty of interaction checkers VERY FAR before you even thought to talk to Nick or write your little speech. I'm good w/ pharm. Better than the average guy/gal in my class. But no way do I remember "everything"!
How about using chemistry to learn more about the chemical interactions of drugs that you're interested in? That along with informatics should be useful. Not simple though, not simple
even... better.
Maybe the question should be, why would you need so many drugs?
see - Adverse Childhood Experiences study by Kaiser Permanente
When they said they monitor our internet for our benefit i would think medical benefit would be a part of that.
Why not use natural remedies?
"Adverse events or side effects." Adverse effects and side effects are not the same.
I feel bad for TED. An amazing track record of quality free content for years, but as soon as a couple of questionable talks get posted the internet turns into a whiney entitled brat acting like TED owes them something.
Wow, found out what has caused my Diabetes!
weet u dat de vocht in uw lichaam ook in een ander lichaam gedaan kan worden en dat daarmee leven wellicht in een ander lichaam terecht kan komen
interesting
Yes , more like this :D
haha. 'Internet explorer'. That is so funn---
funny.*
sorry, I got kicked off AOL, someone called my house
Paroxetine and Pravastatin don't interact..
what happened when you mix jet fuel and steel beams? xD lol
Nothing. Everybody knows jet fuel can't melt... Well, you know
+Ron ペルラス
you invade Iraq
Higher tin to brain ratio.
Ahahaha
+Spastmatiker
Hahaha! Nailed it!
Can i take mandy while on antidepressants, need an answer boys x
Who is going to type in 9 different drugs and a side effect into a search query? I can't see most people typing in more than 1 drug and a side effect or series of side effects at a time. If you as doctors really have no idea what happens when 9 drugs interact with one another, maybe its time to rethink the approach of using "the hammer" as a first line treatment, let alone the one and only treatment for every situation and be more open to adding other tools to your toolbox.
The situation always seems to play out like this. Get sick, go see a western medical doctor, doctor tosses drug at you for problem. Some time passes, get sick again, go see the doctor(same or another one) to treat that new problem, doctor tosses drug at you to treat that problem. Eventually you get sick, go see the doctor, they ask what meds you are on and for some reason are shocked when you are on like 5 different meds *face palm*..
My frined take her friend to out she took off all medecine .she eat frouts juice water .all fay out wiith friends laugh she sty with people live happy .she come at night and tired sleep very welll and she getup in morning very frish
they told us that drugs were bad.....
Microsoft keeps your search logs for 18 months!? Glad I use Chrome.
....meta-alchemy: the combination of medications to find further medicinal effects
If only there was a country that had a unified health care system with pooled data being automatically collected for its entire population.... Oh, like the UK's NHS! The greatest patient impact database on the planet.
Smart guy. ;)
More of this, less SJW... thanks!
Technology, Entertainment, Design.
It's great when a TED talk is about one of those, right?
+Major Gnuisance
The only thing "SJW" is good for is entertainment... perhaps TED has had it right, after all. lol
If you want to see how bad it is to mix drugs, watch my only video. It is 20 seconds long.
I’m trynna make my Abusive dad get really sick ( not tryna kill him) but sick b/c when he’s sick he’s not abusive he yells,beats us with punches and kicks like we’re grown men and I’m tired of it and this guy takes pain medication anyone know any common medication mix or common house items with honey (he drinks honey) to get him sick fast and painfully sick
Who is this straight white male and why isn't he self-flagellating himself out of spite for his skin color?
+J Ribs PATIENTS LIVES MATTER
Devoti It's a joke, calm down. TED has gone down in quality and has been less scientific over the years. Why does my comment bother you? Was it offensive? I'm confused as to what you think is wrong here.
+J Ribs how dare you have a sarcastic sense of humor about things your opinion is different from mine that makes it hate speech and I'm offended blah blah blah people are way too sensitive I miss the good old days when you could actually have a sense of humor
+Zack Robinson I remember back in the day when you could make a comment on RUclips where everyone in the comment chain didn't receive the same comment meant for someone else damn you Google
+J Ribs because your comment sounded racist.
SCIENCE! :D
+DrewKF
No. Not science.
+TheAnnoyingGunner Oh. It felt like SCIENCE. Apologies...
Классно что есть субтитры
Legal or illegal it is a drug planet!
Poison the patient with 11 drugs a day, because he had a sprained back. Those are Medical Procedures for the sucker.
And here we hold up our Health Care Professionals up as Demigods!
Did I just ear that Microsoft shared their internet traffic data with a private party without the users knowledge???... Shame on you. That's why people choose Chrome.
I guess the NSA spying is good for something.
Example: history.google.com/history/
Looks like somebody digivolved Jeff Goldblum.
Tow
Medecine should give gap after. 4 hour can take other medecine .im i right ???
data mining is a beautiful thing
I'm gonna get my hopes up again and praise ted for having interesting talks instead of the bullshit it's been publishing lately. Hopefully the next talk won't be yet another stupid sjw. Good work for now ted.