Beta Oxidation of Fatty acids Made Simple- Part 2
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- Опубликовано: 21 май 2017
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In biochemistry and metabolism, beta-oxidation is the catabolic process by which fatty acid molecules are broken down[1] in the cytosol in prokaryotes and in the mitochondria in eukaryotes to generate acetyl-CoA, which enters the citric acid cycle, and NADH and FADH2, which are co-enzymes used in the electron transport chain. It is named as such because the beta carbon of the fatty acid undergoes oxidation to a carbonyl group. Beta-oxidation is primarily facilitated by the mitochondrial trifunctional protein, an enzyme complex associated with the inner mitochondrial membrane, although some fatty acids are oxidized in peroxisomes.
Fatty acid catabolism consists of:
Activation and membrane transport of free fatty acids by binding to coenzyme A.
Oxidation of the beta carbon to a carbonyl group.
Cleavage of two-carbon segments resulting in acetyl-CoA.
Oxidation of acetyl-CoA to carbon dioxide in the citric acid cycle.
Electron transfer from electron carriers to the electron transport chain in oxidative phosphorylation.
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In the example of 16 carbon fatty acid ie palmitoyl fatty acid is having 18 carbons
@@manojmaddela6339 16 carbon Alkyl chain not 16 carbon fatty acid
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Hello! I did a bit of math and simplified the calculation for the number of ATP generated by a fatty acid to 7n-6, where n=the number of carbons in the fatty acid chain. It’s worth noting that this formula is only valid for even numbered fatty acid chains. Hope this helps!
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Great video, and it's really helpful. But the alkyl chain in palmitoylCoA must be CH3(CH2)14, because it has terminal methyl group, 14 carbon chains (CH2)14 and functional group (COOH).
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great video! correction in 3:00 - the R group should be of 14 carbons, since we've already counted the a,b carbons.
No
The 16 indicated total 16 carbons and not the no of carbons in R
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