DeepMind solves protein folding | AlphaFold 2
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- Опубликовано: 19 июн 2024
- A quick video on the basics of DeepMind's AlphaFold 2 breakthrough. Please support this channel by checking out our sponsors:
- Vincero: vincerowatches.com/lex to get up to 25% off + free shipping
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References and good blogs, articles, videos:
[1] AlphaFold 2: deepmind.com/blog/article/alp...
[2] AlphaFold 1: deepmind.com/blog/article/Alp...
[3] AlphaFold 1 paper: www.nature.com/articles/s4158...
[4] CASP14 Results: www.predictioncenter.org/casp...
[20] AlphaFold 2 video from Yannic Kilcher: • DeepMind's AlphaFold 2...
[21] Science: www.sciencemag.org/news/2020/...
[22] Nature: www.nature.com/articles/d4158...
[23] Fortune: fortune.com/2020/11/30/deepmi...
OUTLINE:
0:00 - What happened?
1:03 - How big is this accomplishment?
4:39 - Proteins and amino acids
5:17 - Protein folding
8:26 - How AlphaFold 1 works
9:45 - How AlphaFold 2 works
12:09 - Why is this breakthrough important?
13:19 - Long-term future impact 
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A quick video on the basics of DeepMind's AlphaFold 2 breakthrough. Here are the timestamps:
0:00 - What happened?
1:03 - How big is this accomplishment?
4:39 - Proteins and amino acids
5:17 - Protein folding
8:26 - How AlphaFold 1 works
9:45 - How AlphaFold 2 works
12:09 - Why is this breakthrough important?
13:19 - Long-term future impact
Please support this channel by checking out our sponsors:
- Vincero: vincerowatches.com/lex to get up to 25% off + free shipping
- Four Sigmatic: foursigmatic.com/lex and use code LexPod to get up to 60% off
16:00 Quick shout out to sponsors
I was hoping you’d comment on this
You're freaking beautiful, Lex
I am deeply skeptical about the generalizability of this. I hope I am wrong.
@@eliriekeberg7127 Obviously we haven't seen the paper yet, but the nature of competition makes it so that it's very likely this is generalizable.
To the question of, do we like these short videos? Absolutely, and you said that you really enjoy making them. Double positive. Keep up the amazing work Lex
*raises hand*🙋🏼✌🏻😁✅🟢🦾💯😋🌟😎🔥
i second this motion & share these thoughts
It'd be nice to see his face too tho
Thanks Lex, love your stuff.
"Hopefully I'm not being too poetic" 😂 that's why we love you Lex
You inspire me in many ways lex. You alone have spawned a massive interest in deep learning and AI in me and I can’t thank you enough. I just wanted to chime in just in case you see this comment and let you know you continue to massively positively influence my life. I really appreciate the time and love you put in to the things you release to the internet and I do my best to reciprocate that in my own ways every day.
I've started to despise his overly romantic side. This is distracting me and turning me off. I've started watching less of his content of late.
Others like it, so it's likely a win
@@DheerajBhaskar I mean he's very young, he's never been married, has no kids, is basically an adult child who's brilliant
@ozafter1 So becoming a "real" adult has nothing to do with extreme understanding of themselves and the world around them, but better yet having kids and developing a jaded world view? Maybe I'm being unfair to your argument but life with or without kids or a wife is not any less of a life.
Lex talks about heavily impactful things, life is weird, and no one likes a bore. He asks questions and entertains concepts that most people's egos would be far too afraid of even bringing up, no matter how trivial the sentiment itself might actually be.
We see this a lot with Rogan too. This is why people enjoy their content to the extent they do. Rogan has kids and a wife by the way.
@@nateo7045 i didn't say that. i don't think he has an extremely deep understanding of himself (except in terms of learning and discipline), other people, or society at large. he's comically naive on human relationships and business. but whatever, i love the guy and this podcast is nothing short of amazing to me.
Big respect for you man, been following you since you only had 50k followers. You are such a great mixture of intelligence, wisdom, respect, dry humor, thoughtfulness, open-mindedness, and integrity. Hardly ever do you see a person climb to the highest heights of academia, science, athletics/martial arts, and personal development (and maintain their sense of humility I might add)....Cheers Lex, from a fellow engineer and martial arts enthusiast, I'm proud of you and I can't wait to see what 2021 has in store for you man
Only reason I’m here to emanate Lex
...what this guy said!
And above all, look at his eyes any time he talks about love. He is one of the best humans alive today. I really wish we could make him a president of the world.
Would love more of these mini-lecture episodes. Great work Lex
Yeah...now all he has to do is crank out a steady stream of these one-in-a-lifetime scientific advances and he'll get right on it!
@metoo :)
The moment I heard of this breakthrough, I was excited for the sure to come video of you explaining it. And you haven't disappointed me one bit! This was such a well structured and explained video and I love your personality that goes with the explaining (the occasional poetic or philosophical thoughts). Thank you so much for this video!
Yes, please make more vids like this. Appreciate the concise, informative report.
This is such a huge accomplishment! Great video as always.
Keep doing these Lex, they are so well done and explain a ton of good info in a reasonable amount of time! I love how the short term and long term implications are broken down nicely. I love the slide deck design too.
Ever since I heard the announcement I was hoping to see you do a video about it. Thank you Lex!
Great video! quick and important content! very inspirational as always.
these short videos are great! I read the alphafold blog earlier, and now watching your video!
@Lex Fridman Keep trying to scam people, fake Lex.
*dead serious monotone educational voice*
"I'm just here to have some fun"
I've heard stronger emotional inflection at a Stephen Hawking lecture.
Im just here for the data lol
reminds me of Charlie Rose from the 80s,,and i love it,,its my ASMR
It's LEX .. he is not that monotone .. just microtonal..
@@sudoall i know lol but i am here to have some fun
Thanks Lex, I really enjoy this style of video. Please keep them coming!
Please make more of these! I bet a lot of your viewers, like me, are undergrads in compsci. Seeing where our degrees could take us and how the skillset we're learning can be applied in a byte-sized video, that can be watched while on the toilet in the morning is great.
Halfway through the video... so far I have not understood one word of what is going on. Kind of happy about that and VERY glad that there are people like you around that can keep an eye on this stuff.
Love these mini-lectures. Your slides are next-level
I love those short videos that touch on recent advancements in AI - more please. Would love more technical details.
Thanks for this break down Lex, super interesting
Please keep making quick videos like this talking about topics you find fascinating
@Lex Fridman stfu fake Lex
Lex this is one of the best videos I've seen on your channel! As a current BME student this was immensely helpful to my understanding - thank you!
@Lex Fridman Keep trying to scam people, fake Lex.
Hmm yes, I’ll use this as copy-paste.
Please make more of these videos! this format is easy to digest esp
Your videos are very very informative and teach concepts that matter(to me at least). Grateful for your time and effort. Keep dishing out more!!
This is super helpful Lex, please keep these videos up! Thanks!
Next podcast idea: Interview with one of the team members of the AlphaFold project.
That would be great if he could convince someone from Deepmind to come on
@@aryangod2003 I didn't know that. Thanks!
@@tn15_ Ya it's too bad he could only get people like:
Andrew Ng,
Elon Musk,
Stephen Wolfram,
James Gosling,
Francois Chollet,
Richard Karp,
Jack Dorsey,
David Silver (who btw is a lead researcher at deepmind),
Grant Sanderson,
Daphne Koller,
Donald Knuth,
Noam Chomsky,
Richard Dawkins,
Garry Kasporav,
Bjarne Stroustrup,
Daniel Kahneman,
Leonard Suskind,
Jeff Atwood,
Yoshua Bengio,
Gilbert Strang,
Michael l. Jordan,
Richard Feynman,
Alan Turing,
Albert Einstein,
and other "low tier" guests to come on.
But in all seriousness, the quality of this podcast is really superb; the fact that he interviewed everyone on that list besides for the last three is really amazing.
@@neslef3 I meant no slight to the quality of the podcast with my comment -- only that I was interested in hearing more from DeepMind and I figured Lex had the pull to get the interview. I only stumbled upon this channel 4 months ago, so I still have a lot of catching up to do! Also, I agree with you. The content on here is phenomenal and unlike much else on YT.
@@tn15_ Definitely didn't think you were saying anything bad about Lex, if anything thought maybe you just didn't know about him. I mostly just wanted to take the moment to list some of the incredible people he had on the podcast as he never ceases to amaze me with his guests!
great summary of the new breakthrough. I think more of these shorter videos would do well, I enjoy them
Thanks for the summary. Very cool, quick and concise.
Love these kinds of videos Lex, keep them coming please!
That is really inspiring, the progress we see in all subjects of science is far beyond my expectations. Thanks Lex for giving this insight
Great video as usual!
Love the quick videos, please make more!
These short videos are fun for us too. Thank you Lex for teaching us in a way we can easily understand.
Damn, what a time to be alive!
Also, huge thanks to you Lex, for all the work you do and such videos especially. I was just thinking about learning more about AlphaFold and protein folding in general when I read the news.
Great video Lex! Keep them coming.
Thank you for this video. Really nice work. Definitely would love to see more of such kind of short educational videos.
@Lex Fridman Keep trying to scam people, fake Lex.
Personally I'm very excited about this. Our boys at Deep Mind have done it again, this is a huge accomplishment.
Great video Lex, this format is fun and really digestible.
this is a great summary. thank you
This quick videos are great, please keep making them.
Thank you for highlighting this breakthrough Lex! I would not have realized that something so incredible had been discovered and how much potential a discovery like this holds unless an expert like you had called attention to it, thank you!
I just spotted this video. Lex! Yes, by all means, please keep on creating these educational lecture segments. You have a terrific way of breaking these complex lessons down to be understandable and fun to analyze.
Please keep doing this type of videos! Very informative and fun!!!
A Lex Fridman video on AlphaFold2 was not what I expected but definitely what I needed. Thank you for everything you do!
Amazing accomplishment 👏.
Unbelievable, Bless you all working on this 🙏
WOW! Thanks for bringing this to my attention.
These videos are great! Helpful and compact. Keep 'em coming! :)
This kind of videos are amazing. Keep it up Lex!
Beyond the monotone voice you can hear his enthusiasm. Just hearing how excited he is to talk about this makes me excited to hear about it. Love beyond bounds for Lex!
Wow that's exactly the AlphaFold coverage I needed!!
Thank you so much Lex, you are a beast!
Man what a time to be alive.
Thank you for everything you do Lex!
glad you got this up so fast!
@Lex Fridman Keep trying to scam people, fake Lex.
Thank you for this quick summary
Great summary. I do hope you make more like this
Thanks Lex. Groundbreaking development explained in groundbreaking video. You're honest, passionate and we trust you. Thanks a lot.
This video is a great overview. I hope to see your coverage when the paper comes out. Thank you.
This was a good roundup. Great new video with Demis too... keep em coming
Thx for all the knowledge your spreading! Great video
Really impressive work by Lex in just a few days. I get a lot out of this and hope to see more regarding this breakthrough. Particularly I realized that I need to learn more about transformers. I'm not sure what it means but seems similar to the idea that has been on my mind for a while regarding the determination of relevant features...
You would make the world's best professor. Super easy to understanding for dense material. A little dry humour to make sure you're paying attention.
Really appreciate you sharing what you learn. Thank you very much!
Great vid lex. Short and to the point.
Fantastic listening to you as always. Really nice news format. Thanks for you videos.
Lex, I truly appreciate your work brother.
Thank you. Wonderful and timely. Your podcast has provided great content, especially during the necessary social distancing of this year.
@Lex Fridman Keep trying to scam people, fake Lex.
Thank you so much Lex. You have explained this extremely well thank you
Lex, don't dare to ever stop making videos like this!
These short videos are definitely useful Lex
I love the quick video format lex! Perfect to squeeze in before work 😃
@Lex Fridman Keep trying to scam people, fake Lex.
“Inspiring beyond words” that’s right!
Very useful. Please make more!
Make more, these quick videos are Awesome.
Thank you for this very nice presentation, Lex!
Ted Chiang wrote a short story called "The evolution of human science" in which he tackled the idea of a future were AIs are so advanced scientists are rendered useless in the traditional sense. Won't give any spoilers, it's a very short one if you wanna search for it and read it. This AlphaFold achievement is huge!
Excellent summary insight. Thanks for a guide thru this most complex field.
Great work. Thank you for doing this Episode.
Thank you so much for this video! I'm late to this fascinating and moving party that is your channel. It's growing on me very rapidly, though!
Thanks for the video Lex! I couldn't be more excited about this breakthrough. The profound implications for the future (years, not decades) of health really hit me in a deep way and make the AI revolution feel like it's well and truly underway.
Cool! Thank you for making this video. Make more videos like this please! It’s like reading an abstract of a paper. I appreciate the visualizations. If I can request, I want to see more animations.
Lex do more of these videos my man! Great work!
Keep doing the videos Lex.. you are helping me to learn something new every single day..❤️❤️
@Lex Fridman Keep trying to scam people, fake Lex.
Thanks for the breakdown, Lex. I've been excited to read about what is coming out of the AlphaFold news but your breakdown, as usual, is the most entertaining and informative.
White Ness Not really sure what you're trying to say. Seems like there was a good breakthrough and I was excited to learn about it. What do you want me to doubt? Doubt that the problem is solved? I don't have the expertise for that. Let's hear what those experts have to say. Doubt that the solution will fix anything? Again, don't have the expertise for that, but it looks promising. If you have doubt, then get to work and let us know your perspective.
Thank you Sir! It is quite an inspiring topic. Love your clear explanation!
That was a great explanation of protein folding and alphafold2. Please make another video explaining alphafold2 once the paper releases
Great video!! Please keep doing these type of video's. As an AI student at a university in the Netherlands it's great to keep up to date with reality in this way, thank you.
Fascinating video. Thank you.
Yes, very helpful Lex, thank you!!!
Love this sort of content, Lex, please do more
@Lex Fridman Keep trying to scam people, fake Lex.
Now it makes sense. Thanks Lex.
I was waiting soooooo much on them to do it.
Great video ... clear ... great topic ... and the correct message: "try to learn something new every day ..."
This I is what I was waiting for ❤️ thanks Lex , you are amazing. Waiting for your next video with self driving car model test and you playing a guitar.
How do you manage all these things at same time is amazing. Keep rocking and keep hustling.🔥🔥🔥🔥
Enjoyable, great, and exciting videos, some of the best things the internet brought to us.
Keep doing this kind of videos. They are amazing!
@Lex Fridman Keep trying to scam people, fake Lex.
you are the best thing to happen to youtube in years! Love the podcast!
Very inspiring! Definitely going to spend some time today reading up on protein folding. Thanks for the lesson.
@Lex Fridman You've been hacked lol
Great video Lex! More please!
this was great lex!
Great Job! I particularly liked when you nerded-out at the end with the mind blowing awe-ness of encoded systems of proteins. Just like mathematics, computer language, and esoteric studies, Biology contains encoded information in plain sight. That 4 simple molecules in our DNA control all the diversity in Life as we see it and may be seemingly linked through gradual evolution, or even the daily process in an organism from their DNA through to every protien-fxn they need in a day/life/life cycle is computationally mind-blowing and YES ALPHA-FOLD WILL OPEN THE DOOR TO A NEW FUTURE. Whew, See i just nerded-out too.
Great explanation, thank you.
Dude, you’re smart. I just found your videos and love them. Ty