PLATELET DISORDERS made easy! Lifecycle and Classification

Platelets are a major component of our blood, however it can be very confusing to group the various platelet disorders.
Join us for a concise look at the platelet's life cycle - their synthesis and life cycle, as we classify the various diseases of the platelets.
Thanks for checking out the video

[@debigdogk9563]

Crispy clear. You are the best. Thank you ❤❤❤❤❤❤

[@pdcbamabama1890]

very clear . very simple n easy to comprehend

[@denadavis8353]

thank you for this -- a patient.

[@adeelamalik9631]

excellent

[@TheFujiwuji]

This video addresses low production of platelets very well (platelets not working, or not enough), but what about an abnormally HIGH level of platelets ("thrombocytosis"). What could be causing the problem in that case?

[@bunmed3817]

Great question. So again if we link it to the physiology of platelets it's a bit easier to understand. Since platelets function is to prevent bleeding, any chronic blood loss especially things such as gastric blood loss due to bowel cancer may raise them. There is also the issue with production of platelets. If an abnormality exists which causes an increase in platelet production (CML, ESSENTIAL THROMBOCYTHAEMIA, POLYCYTHAEMIA VERA) then the platelets may also be high

[@DesDownunder1]

How do antticoagulants like apixaban affect the platelets?

[@bunmed3817]

As far as I understand, Apixaban doesn't have a massive impact on platelet function. It is a direct Factor Xa inhibitor and as a result stops the formation of the firbin sheath, rather than affecting platelet function.
It therefore mainly exerts it's mechanism in secondary haemostasis, rather than primary. Hope that helps!

[@yasminho195]

Can I know the sources?

[@bunmed3817]

Hi thanks for checking out the video
I used EMEDICINE as the main source