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- Опубликовано: 29 авг 2024
- While the extraordinarily expensive Repatha dramatically lowers LDL or “Bad Cholesterol” to levels of 30 mg, it fails to reduce the likelihood of death from all causes or even death from cardiovascular disease. Furthermore it barely budges the incidence of stroke or heart attack. Studies suggest a cost well in excess of $2,000,000 to prevent one heart related fatality. Originally thought of as a miracle drug, its lackluster results may lead to a reassessment of the importance of LDL in causing heart disease. As one eminent cardiologist says the drug may just be “performing cosmetic surgery on a laboratory value.”
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I've been on Repatha for just over 6 months. I've always had high cholesterol so when Repatha came along we figured why not give it a try .. my current statin was causing me the normal statin problems. Started Repatha June of 2019. My stats were: ldl 115, chol 202, tri 230, hdl 41. Think I was on Crestor at the time I made the switch. November 2019: ldl 71, chol 336, tri 667, hdl 38. December 2019: ldl 98, chol 427, tri 714, hdl 36.
As to the side affects it would be easier to tell you what I'm not experiencing. I have an appointment with the eye Dr. because my vision has changed to the point where I need new glasses. Always needed glasses to read .. not any more! In Nov. 2019 I ended up in ER with a blood clot and the next day back in ER with what appeared to be a kidney stone but wasn't .. nausea, chest pains, leg pains, etc.
I called Amgen directly and told them of the problems .. the minute I mentioned 'blood clot' I was transferred to their 'Safety Team' and the nurse there took all the info on my blood clot and told me to stop the drug immediatly.
The VA pharmacist went over all these results and is making them available to the FDA and is making the problems know to other VA facilities.
This drugs side effects came on very slowly .. its insidious in it's effects.
Thanks for the information. My cardiologist wants to put me on this.
Thanks for sharing this it’s important . Best wishes hope you find something without the side effects . I’m searching too.
Holy cow not worth it especially when they’re saying now people over 65 need all the ldl they can get
I add my thanks, with those of others. My Cardiologist is pushing me to take Pralulent or Leqvio, and I am pushing against. He is not happy, and now I am more determined to keep saying no.
This is a miracle drug. This was only a two-year trial. It is shocking they could reach a statistically valid endpoint in that short of a trial. He failed to mention that they were starting with a group with a very low LDL-C level.
Thanks Kenny, very precise and fair. i doubt the average doctor even knows the difference between relative risk and actual risk. They sure don't sound like it. Great job in spreading the news, medically and financially.
What is the difference? I did not quite understand the explanation 😬
Thank you!!!! I've been on Repatha for just over a year. It was able to bring my cholesterol down from 330 to 230. But lately I've been feeling like some of the NEW medical issues might be side effects. Severe gastrointestinal problems, liver, CKD . They blame it on my hypertension but I don't think so. PRETTY sure I'm stopping the repatha.🤗
I have also had severe gastro issues - the Doctor has said I can have a 'drug holiday' - to see if it clears up...
I have read just too many bad reviews..
It’s lowered my cholesterol beautifully but the side effects are scary
What are your side effects?
I’ve been on it for almost a year with none, but have not tested cholesterol levels as of yet.
Medicare Part D pays most of the cost, pre-auth required from doc.
Thank you Dr. Ken. Yeah, it’s expensive, and I’m not sure what actual benefit I’m getting from it.
@@Browneye57 muscle weakness and muscle pain , nerve pain , similar to statin pain , but statin pain was worse . I’m taking oxycodin because the pain is unbearable but Repatha happens to be the only thing on this earth that lowers my cholesterol . I had a mini Repatha break under the supervision of the cardiologist , my cholesterol went to unacceptable levels . Good news the cardiologist told me there are new drugs coming soon. In a perfect world wished there were drugs with no side effects.
The only problem is that Ldl not necesarily bad cholesterol. This is an old notion and a self serving notion for the pharmaceutical companies. Quite frankly LDL is not that predictive. Some people have very high LDL'S like myself and no heart disease. Some people have low LDL and have heart disease. Its about the particle size...subcomponents that makes up the LDL. Triglyceride/ LDL ratio is highly predictive for heart disease, 2 or lower is great, The higher the ratio your chance of blockage increases, My number is below a 2 it is about a 1. How did I do it? Fish oi lowers tryglycerides and raises Hdl. I added just a little alcohol to ny diet....increases hdl. Incidently the tryglceride/hdl ratio coressponds particle size. Also I use 1500mg of timed release niacin. Rapatha is wonderful for the pharmaceutical company....it probably unnecessary for most peope!!!!!!!!!!!!!!!!!!!!
nice!
this makes sense, my Dr. is pushing Repatha because my LDLs are 306 but i'm not overweight nor do I eat bad. How is are you numbers looking today?
@@MagicNomadic Hello my LDL is probably over 200 now "naked". I use niacin which lowered my LDL to about 135.
I use 1500 mg to 2000 mg/ day. I started out with time release and I switched over to regular niacin as I got older (Densified to the flush) Regular niacin does not impact liver enzymes.
@@MagicNomadic my numbers are good, but i need to use 1500 to 2 grams of niacin and an Omega 3. about 200 mg to lowe triglycerides. My Ldl was over 200 and niacin takes it down to about 135
I took it for a wile, besides the flushing which was not an issue it did raise my blood sugars about 5%. @@jimmiers8218
Terrific presentation. Thank you. As wife and researcher, I plan to listen again and take notes on this report to present first to my husband, and then take to my husband's cardiologist and PC physicians - who both want him to be taking Repatha as he has refused the statins. (15 years on them and he's done with the side effects with only a worsening of his atherosclerosis)
. I wonder if they'll be able to change my husband's mind?
Repatha has flat out kicked my butt. I have the "flu like symptoms" it lists as a side effect right now. They were preceded by stomach cramps and muscle aches. Wish I had never taken it. I'm wondering about long-term issues from this stuff, particularly any immunogenicity effects, and I just don't believe anything that comes from big pharma right now. I was prescribed this medication for high cholesterol as I cannot tolerate statins. And yes, I've tried several of them. If this works for you, great, but I will never use it again.
Yes me too I can’t tolerate statins because of bad GI . My doc gave me this to try I haven’t tried it yet . Scared to side effects. I thought this would be good but I don’t want more side effects. So frustrating.
Hi KBC, if you have a solution that is currently working for you for the cholesterol, please let me know. Maybe we can keep in contact with each other. I just don't know anymore. The statins are a big NO for me. And my doctor as well wanted me to receive the Repatha injections. NO. No way.... so now I'm just trying to figure out what to do.
Try Zetia.@@julieiqbal7884
Me too.
This video was made 6 years ago. Does Dr Ken have any new insight into Repatha ? its particularly interesting that he states there are not any side effects, (6 years ago), and of course we all know the side effects today. So would be interested in Dr Kens take on Repata in 2023
They probably censored him
Great Presentation! Thank you Dr!!
U was on repatha for more than 14 years til I started to smoke crack that helped me a lot better with my cholesterol levels .
Please all research Professor Sultan world head of vascular elected 2018. Article for I.M.Journal B.M.J. High cholesterol is not a heart risk, it is inflammation caused by diet, lifestyle etc that causes this problem. A blood test to discern the lipids of your L.D.L. for part B, this is the fine particle which is produced by inflammation and will adhere to arterial walls as plaque. The Japanese have the highest cholesterol readings in the world but the lowest incidence of 'Heart Disease.'
Low heart incidences due to eating lot of a food called Natto, it’s fermented soy beans, and used in their daily diets.. same as vit. K2/MK7 too keep calcium/ plaque out of heart artery walls.. here on YT explained by cardiologist:
✅m.ruclips.net/user/results?sp=mAEA&search_query=k2
I have been on Repatha for about three months and it works! My LDL is way down and my HDL has gone UP! My doctor is dancing in his office. But, when I begin to grow a second head, I'm won't continue. I am allergic to ALL Statins so I had no choice. If I can continue getting the financial aide, and the side affects are low - I'm good. Oh, and BTW, my fingernails are growing long and strong! Hooray.
How did you get the INs approval? MY DENIED
Are you still taking the Repartha and did you get any side effects
I'd love to talk to you since you have been on drug for 4 years. I cannot take statins and began Repatha at doctors insistence. How can we get in touch?
Thanks so much for the outstanding statistics and background info on this drug! The side effects I am experiencing are real but I had been plugging along taking it in hopes of reducing the chances of a heart attack or stroke. In the beginning I was hopeful but a bit skeptical as I am most sensitive to just about anything on the market. But I decided to at least "try". Now I know to always trust my instincts!
1Sharona Was
Here are the FACTS that pertain to me. Extremely high cholesterol due to genetics. 29 stents to date over a 20 year time period and 25 angioplasty procedures. 5 artery bypass and 3 scarred closed in less than 3 years (all were leg veins). Have been on statin drugs of all kinds for decades with nothing but side effects including severe muscle pain. Was put on Repatha in 2018. After 24 hours of the initial dose, I felt "not right" but was not really sure what it was. Within 48 hours of the initial dose I had "cold or flu" like symptoms including headache, runny nose, sore throat, and diarrhea. This continues up to my next dose as my doctor tells me that these side effects will pass. Within 24 hours of my second dose, I have severe diarrhea, lose my voice, extreme headaches, throwing up, severe hot and cold flashes, dizzy spells, unable to eat due to throwing up any foods or liquids, runny nose is now major sinus problems. Within 72 hours of taking second dose, I now have extreme and almost unbearable itching. I am scratching so much that my bed sheets are covered in blood from scratching in my sleep (very little sleep at this point) Called my doctor for some kind of relief and was told, "just take Benadryl and it will get better" Well after almost two weeks of constant throwing up, diarrhea, unbearable itching, headaches, sinus problems, sore throat and loss of voice, and no sleep, I found myself BEGGING FOR GOD TO TAKE ME so I could have some relief. Refused to listen to my doctor anymore and STOPPED TAKING THIS POISON !! It took MONTHS for the side effects to fully go away, but the diarrhea and throwing up ceased about a week before the next injection was due. The itching went away about a week after the next injection was due and I was covered in scabs from all the scratching. It took the longest time for the "cold and flu" like symptoms to go away, but they eventually did. The kicker was that after the second injection and BEFORE the next injection was due, my cholesterol was tested. I had to call the doctor numerous times to get the results only to find there was NO significant change. The doctor told me that it was because I was not on Repatha long enough. I told her that if I stayed on it any longer I WOULD HAVE BEEN DEAD! This is FACT not fiction. Every person handles medicines differently and for my doctor of over 10 years to tell me that I would not have any side effects from this drug was wrong on so many levels. TO THIS DAY, she has refused to put in my medical records all of the side effects that this drug caused to me. I have to wonder what kind of a kickback these doctors are getting for pushing this extremely expensive drug. All I can say is that this drug was POISON to my body. I have an extremely hard time believing I am the only person on this planet having this much trouble with this medication. In ALL of the years of fighting this disease, this was only the 2nd time that I had asked God to "just take me". The first time was after suffering for over 45 minutes with unbearable chest pains while suffering from a heart attack and waiting for the ambulance to show up. Ya the ambulance company got a "golden heart" award for "saving my life" on that day. My wife could have drove me to the hospital in less than 30 minutes and gave me the same treatment I received from the ambulance company and I don't think it would have cost me $7500.00 for my wife to take me. That was the first AND LAST time we call for an ambulance period and yes there have been several more heart attacks since this event. Off track I know, but the point is REPATHA IS BAD NEWS FOR A LOT OF PEOPLE, BEWARE OF THIS DRUG !!!!!
@@brywilder7582 I am sorry that it did not work for you -- and more sorry that your doctor is not at all supportive of you. That is very sad. I had my blood checked after three injections and boy, it was amazing how well it worked for me. I have had no side affects, excepts a little itching but it's so slight - but my fingernails are going like crazy - I'm happy for that. I applaud you for your decision to stop this drug. YOU KNOW YOUR BODY BETTER THAN A DOCTOR! God Bless! You know that there are programs that pay for ambulance services. I live in Michigan and we have LIFE ems. For $30.00 a year, it pays for any and all ambulance calls. You should look into it.
@@brywilder7582 Wow this is incredible and I believe you and appreciate your writing all of this. Two docs want my husband to take this, because 15 years on statins causing myriad problems, and INCREASING his atherscerosis (we will soon find out that yes indeed, statins CAUSE hardening of the arteries as they deregulate several important metallic processes as they disrupt the melavenite pathway of the liver including coq 10 and Vitamin synthesis, deregulation of selenium, and disable Vitamin K 2. Check out The Fat Emperor, Episode 21for an interview with Patrick Theut. You will never be the same, the truth is like velvet that stays permanently in the cholesterol loving brain. VITAMIN K 2. Keto diet. Magnesium, Omega 3, Vitamin C. You may be partying to God, please spare me, and then don't forget to fire all your intellectually cowardly MDs. To think none of 'em go to jail. It is a travesty worse than the Holocaust.
What if you can't take a statin or zetia and you are already doing diet and exercise, however imperfectly and you already just had cabg and you are diabetic etc. then what I did not hear that addressed.
My doctor was trying to get me into the Repatha study since my LDL was over 300 due to familial high cholesterol. I was not able to get into the study since I had not had a coronary event and tests did not show artery disease or blockage. So from that I concluded that the study is with people that have had disease BEFORE they entered the study. Doesn't that skew the results? I am currently taking repatha which has dramatically reduced my LDL to acceptable numbers. Since four of my siblings died of heart disease and the statins caused joint and muscle pain above 20 mgs. I am getting Repatha free because of my low income ($20K/year). I have had no side effects after four months of use. I am taking the 20 mgs of Crestor as well as the Repatha.
My LDL is also crazy high- 330. Same as you, I have familial hypercholesterolemia. Did you do the calcium test (CAC)? How did they checked your arteries?
How much is your LDL now?
If you don’t feel like answering here, please email me at nenad.canada@gmail.com
Thank you. 🙏
@@microbladingmap1387 Crazy high? Mine hit 770 (659 LDL) in May of 2018. It's hovered between 500-600 since I went on a high fat diet. Prior it was in the mid 100's but the point is that we can control our numbers through diet and some have higher numbers due to their metabolism. Not all of us should have the same cholesterol numbers like we would blood sugar.
Do the research. Search Dave Feldman and Ivor Cummins....
Dan Scott Love Dave Feldman and Ivor Cummins. My Total Cholesterol on lo carb high fat was 315. Four months later 297. Still high but coming down. LDL was 217. LDL down to 186. VLDL only 12 HDL 99. Triglycerides 61. But they ignore that. Will not take statin. Or any med for it. “Let Food be thy medicine. “ Also have had no cardiac events.
Depends on what kind of study there are doing. If they were studying the effect of the drug in people with familial hypercholesterolemia you would have likely made it. Cholesterol is a risk factor for problems, not necessarily a cause. By selecting people who previously have had an event they are getting a pool of people that are more likely to have a problem that could be helped by lowering cholesterol.
Think of it this way. Gasoline is a risk factor for fires, it does not necessarily cause fires (gasoline + oxygen + a spark causes fires). Its easy to logically say that the more gasoline in an area the higher the risk of fire correct? Well there are some places with lots of gasoline that never have fires (a room with no or low probability for a spark).
In our world we can look at a room and determine if its safe to store gasoline or if it would be a fire hazard. With medicine its difficult to do that because there many unknowns and everything is very small. It would be like trying to identify if a place was safe to store gasoline from outer space, much more difficult to do (we could see the building is made of wood for example or on an old power grid).
Now on top of that lets say that we have some new chemical that would reduce the risk or gasoline causing a fire that we have to test from outerspace. That would be very difficult to do, because a lot of these buildings we aren't going to be able to tell if they are even at risk for fire all the way from space. The easiest way to test it would be to use it on an area or building that had previously burned down, because they have proven in the past to have that type of problem. Its possible that the fire could have been caused by something else completely, but we are more likely to find place that this chemical would help. It will be possible to get an answer much more quickly to find out if the chemical works or not. We are going to know that answer much sooner on testing places that previously burned down than just places with lots of gas, because not every place with lots of gasoline will burn down or is even at risk for burning down.
I had terrible side effects. I will never take it again. I rather die of a heart attack. I had problems breathing, palpitations, diahrerra, UTI, headaches, you name it. 😢
How long you used it?
Sounds like an allergy.
I've been on it for 8 months I haven't had any side effects that you mentioned but I did notice around the third month that I was losing interest in everything sports, music, movies I used to go to a lot of sporting events and concerts with my brother and friends I have done nothing just sit and stare at a TV set while it's off don't want to do or go anywhere I talked to my doctor he said it's not a side effect I believe it is I think this drug is very dangerous
Why am I on this drug then??? How does one talk to their doctor about this considering they want me on it?
So I just had a heart attack in Aug 2023, I have always had high Cholesterol and I was never on meds for it. Now I am on a statin and repatha. So here is my question, why would I be on both?
To maximally lower ldl (or more specifically apob). Newer research has found that getting apob below 30 has the lowest risk
@@user-me9pl6it5i thank you for the response. My LDL went down to 12 from 350
This doesn't discuss if there were any studies on those who take Repatha *instead* of statins. But I can confirm that insurance rejection of Repatha is a real thing. You also have to wonder that if it has such a dramatic effect, why the side-effects are so minor? Might there be more significant longer-term effects yet to be discovered?
There are some studies that have been done on Repatha alone. If you search Repatha monotherapy you should be able to find the relevant studies that have been conducted.
you're the best!
My doctor is starting me on this because I’ve tried all the other medications with bad GI issues so I’d rather have no pill and injections to me sound better . It’s not too $ for me about 84$ for 3months. I hope it works . I have familiar hyperlip. Mine is like 300 and LDL is 128 or something I’m really hoping it works . I can’t stand the other pills . But I won’t last long if it has nasty side effects like some said here .
Don't inject this poison into your body. Thought I was dying after the second injection. This drug should be illegal!
Carnivore diet fixes this crap
It doesn't for everyone. Carnivore or sim8lar can cause hyperlipidemia for some people.
It has Polysorbate 80 in it.
Diabetes?
Anyone with increased liver enzymes with this drug?
I tried it for a couple weeks and it was too short to see if I have any issues. It did look like it raised my BP for a few days in the beginning.
It's apparently metabolized in the kidneys, and not the liver, so it is supposed to be good for those who have had liver issues or liver failure.
Great question.
I'm just starting Repatha and my doc wants me to continue taking Atorvastatin along with it.
I am getting off this dam stuff cut the sugars and bad carbs. The copay is $260.00 for a month
WAS THIS MEDICATION MADE WITH RNA OR DNA AN CAN IT CAUSE CANCER
I HAVE HAD CANCER TWICE...
???
Someone, somewhere, has given you really bad information about DNA/RNA derived meds causing cancer.
He said its made in the ovaries of mice