A New LDL-Cholesterol Theory Coming to a Doctor Near You
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- Опубликовано: 23 ноя 2024
- Lets discuss a new LDL cholesterol Hypothesis...
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----------------------------------------Show Notes-------------------------------------
00:45 LDL's link with atherosclerosis is nuanced.
02:30 Initial damage to the arterial wall makes LDL levels problematic.
03:45 Increases risk of arterial wall damage: elevated blood pressure, insulin resistance/diabetes, smoking/vaping, obesity, elevated blood viscosity, consuming oxidizableoils.
08:40 High LDL and high triglycerides suggest insulin resistance and increased cardiovascular risk.
09:50 Start with diet and exercise together.
11:20 Statins have concerning side effects.
13:15 Plaque formation begins early in life.
13:50 High LDL is found in centenarians.
14:44 Centenarians are metabolically healthy.
15:40 Your liver makes LDL cholesterol.
16:10 Every cell in your body requires cholesterol.
18:00 Diets high in seed oils make your LDL more likely to be oxidized.
20:55 30-50% of people who have heart attacks have optimal serum cholesterol.
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15 years ago my older brother had heart attack in the hospital while he went there with his wife-doctor specialist in diabetes. My brother was experiencing pain in his chest and trouble breathing so she decided to visit hospital with him. After they left the ER department where they declared him healthy and sent him for an X ray for pain in his shoulder he collapsed on the stairs and almost died. Defibrillator didn’t resuscitated him at all, one of doctors hit him in the chest with his fist and this brought my poor bro back to life. His cholesterol and LDL was normal. Now after years on statins and filled with stents his cholesterol is extremely low, his life miserable and he and her, the wife believe statins saved his life. Hard to not to agree with them 😂. I’m carnivore for 6 years my cholesterol is high, always was (stoped going to doctors after you know what so don’t know my current 🎉numbers) I never took statins in my life although I was pushed by my doctor since I was 60! And I love my fatty T-bone steaks! My younger brother 70, has 8 stents and he’s plant eating because red meat is the way to graveyard 😂 he’s also on statins. My third brother 72, drinks heavily all his life but since few years he is eating more meat and he’s more or less ok. He took 3 shots though and now he started to age rapidly. He never had heart problem and now is on statins, brainwashig working! All of my other brothers fully vaxxed and supporters of current things. I’m 73 healthy and strong with good muscles
Well done
Only once there is acute injury does the LDL (Apo B) seem to show more causality is what I'm hearing from the video. So, once you have a heart attack you might be stuck on statins until your LDLs come way down. But if you are metabolically healthy, no heart injuries, and high LDL then the LDL is a signal of your high fat diet that you are burning fat as fuel source which is a positive marker.
I'm reading a book called The Clot Thickens, and he describes the cause of Plaque isn't from LDL but from damage to the artery wall. When the wall is damaged, a clot is formed, and then the wall grows over the clot. LDL is not the cause, but particles of LDL can be found in the area but not the cause. Anyone else read it? I'm not done but it's fascinating. Not sure if it's true or not?
Yes Dr Malcolm kendrick wrote this book an expert in this field.
@@eddkennedy6458 Malcolm Kendrick isn't a lipidologist, he's not an expert, he's just a family doctor, and a moron. There is no lab experiment where elevated LDL didn't single handedly replicate the disease.
Highly recommended book. The Clot Thickens ties up all the loose ends.
Im 69, my LDL have always been on the high end and is now skyrocketing because I eat "to much fatty meat". Well, I checked everything and have no plack anywhere. But Im healthy, never smoked, stoped drink 15 years ago, but I had slightly high blood pressure. Now down. Slim and look fit. :-)
I might be a hyper responder.
Malcolm Kendrick is one of the most respected thought leaders in this arena. What he teaches should be made compulsory for all doctors. But then I forget that 93% of doctors are pharma reps ☹️☹️
Mike, you say that we should show our doctors this research about LDL not CAUSING atherosclerosis. That's exactly what I did with my long time cardiologist. What did he do when I handed him several articles on this topic? He belittled me and then he terminated me from his practice. And there lies the PROBLEM!!!
Your doc did you a favor....revealed his true self
He somehow felt threatened by the information!
Yes they are scared witless of confronting the industry.
I have always believed that cholesterol was a balm to soothe inflammation. Inflammation is caused by sugars,omega 6 fats, trans fats, and other highly processed foods,stress, and poor living habits. Your vid is right on. Thanks.
Well your belief is wrong. Elevated LDL is itself inflammatory, it in itself does the damage to the arterial wall. Mutzel here is a complete idiot, and that's being polite.
Like literally when I was at my healthiest working out tones they did testing, and my cholesterol is very high, but that was just because I was using more fats for fuel
Experts not taking bribes already said what cholesterol is. Your body makes it to build and repair cells.Including your brain. LDL is low density so it can pass through cell walls. Cholesterol in the skin makes Vitamin D when exposed to sunlight. It makes testosterone in men.
@@gatesroyale,
You are probably familiar with the ideas about the Lipid Energy Model (LEM) and Lean Mass Hyper Responders (LMHR) that Dave Feldman and Nicholas Norwitz, PhD have been investigating, but if not then you might be interested in their videos here on youtube.
@@ArcoZakus yes actually I first heard of it about a week ago on this doctors carnivore RUclips channel. Can you send me the link that goes further into detail?
Dr Berg started using a very apt analogy. They keep blaming the fire men for fires because they are always present at a fire.
Dr. Berg is a creeper Scientologist.
Interesting term “trapped LDL”. LDL, in the atherosclerotic process, is a repair mechanism. It’s supposed to be there in an attempt to repair the endothelial damage, which occurs in specific, more turbulent, areas of the arteries. As a result of doing what LDL is supposed to be doing, “repair”, it ends up being part of plaque formation; surprisingly, comprising only 1/10 of 1% of the total plaque. The only reason LDL continues to get any attention is because of the continued messaging that it is causal. Atherosclerosis is due to chronically elevated blood pressure, primarily caused by, but not limited to, inflammation due to a poor diet. Thank you for spreading the word on this.
Can you please explain in detail what causes damage to arteries
@@FactsCountdown The video did a great job of explaining that, were you not paying attention? He repeated it numerous times, I mean, many, many, many many many times.
@@FactsCountdown The best explanation I’ve seen on RUclips is by Dr. Abs, Drug Companies Lies: Cholesterol = Heart Disease .
LDL is a transport mechanism of cholesterol and serves a useful purpose. It's the damaged LDL due to factors like diabetes and other oxidative stresses, and especially combined with hypertension, diabetes, and smoking that promotes plaque formation from damaged LDL. It's kind of like trying to mitigate fatalities from car accidents by getting rid of all the cars rather than reduce causes like drunk driving. They're not focusing on the causes.... the vid is spot on.
Correct sir! I was absolved of the bullshit in 2012 on cholesterol. It is low density so it can pass through cell walls and carry nutrition.
I developed arterial plaque sufficient to cause a 90% blockage, leading to a heart attack, 11 years ago. Was not diabetic in any way, not a smoker, not actively hypertensive ... in other words, those things are not prerequisites for developing. plaque. I did, btw, reverse my cvd, by any measure, through eating a diet of whole plant foods. This guy can be kinda clueless.
@@tspicks4360 I had a 99% blockage, however no heart attack, luckily. I required a quintuple bypass. I have used a keto diet and fasting to dramatically improve my health and my high blood pressure. I lost 33Kgs and feel fantastic...
_'Damaged LDL cholesterol'_ - what are you talking about???😅
@@tspicks4360 Check out the oxidated linoleic acid theory of heart disease.
Vessel wall damage is the root cause but they will always focus on the thing they can create a drug for.
And therein lies the rub. Follow the money! Eating correctly never makes big pharma money!
I have had high cholesterol since my first blood test at 30, I am 60 and have never taken statins. My blood pressure was always 130/77 and the doctor always told me I was fine. Now that I am a carnivore and fast for approximately 16 hours on average, my blood pressure is 110/65. I have always done a lot of sports, even at 60 I continue to play soccer competitively. My VO2 MAX is 47.
A step in the right direction. But, when is a study going to be published on how the body repairs the damage caused by smoking,diabetes or high blood pressure?
Water fasting sauna collagen peptides, good sleep, grounding and days with stannous exercise endurance plus days of deep deep rest more then 8 hours all help. Controlling your pH as well. Could it be beneficial like having lemon and water.
70% of people who have a heart attack have normal or low cholesterol. The study shows these people had low cholesterol at least a year before their heart attack, it's not cholesterol but diabetes, blood clotting issues and smoking.
You missed hypertension.
@@thelaststylebender1678hypertension is normally due to insulin resistance " diabetes" or high homocysteine. But you're correct thank you.
Minority of people are also causing damage from overtraining.
But what was their cholesterol for the decades before? It’s about the area under the curve, not a point in time. Many people adopt a healthy diet once they’ve already done substantial harm.
I've come across the oxidated linoleic acid theory of heart disease on RUclips from the channel Low Carb Down Under. Basically, linoleic acid from seed oils build up in the body because the body cannot use this omega-6 fatty acid for energy. So this builds up over years and oxidizes and damages the cholesterol that it is a part of and explains why LDL gets trapped in plaque.
In my humble opinion HDL and LDL are not cholesterol.
It’s better to talk about High and low density lipoprotein.
The HDL and LDL are just transporters from the cholesterol. The HDL deliver the cholesterol in all the places in our body where it’s needed. And the LDL brings it back to the liver.
Thanks for the video from Thailand.
Mike, so well said, thanks for emphasis of the "other factors" ie. what insults the inside of walls of blood vessels,HTN smoking/vaping, high blood sugar damage iron overload....excellent work Mike.thanks
Thanks Mike. With papers like this maybe finally my parents to listen to me, about how cholesterol itself isn't the underlying problem with cardiovascular disease. It's nice to see studies like these catching up to what many of us knew years ago. Maybe in another 10 years the mainstream will recognize how blood sugar is more of an issue with blood pressure than having salty food.
You're a good lad Mike!
You genuinely care.
I can hear it in your voice
"Stop smoking! What are you doing??"
I am a regular viewer of your videos.
I want to share my experience with you.
From 2021 to 2022 I used to do regular intermittent fasting and prolonged fasting. While doing prolonged fasting then I used to get into ketosis and I knew this from the smell of my urine.
After almost a year I did a 3 day water fast and I wore a CGM my sugar was continuously above 130mg/dl. Sometimes it went to 160 also.
I don't think I was in ketosis because there was no change in urine smell.
Also I was absolutely fine unlike the earlier fastings when I had a lot of discomfort.
I feel fresh with much greater mental clarity and energy to do physical activities.
Was my body creating glucose through gluconeohenesis ?
I think you should do research on type 2 diabetes patients to see how fasting works for them.
Pls do reply at your earliest convenience.
Best Wishes
Colonel Madhusudhan Nair . Retired
India
One of the underlying causes that seems to get little mention nowadays is chronic stress. High cortisol levels cause hypertension, and there is some interesting research indicating that cortisol may also damage the endothelium of coronary arteries.
Interesting link and anything else?
Cortisol is corrosive to arteries
@@gatesroyale overtraining is another, obviously most fall on opposite side though. Some individuals get on a treadmill for hours keeping their heartrate way too high. Do that multiple times a week and you have damage that can't repair fast enough.
@@jackoverton8343 thanks for sharing this. I actually witnessed this personally.. you can basically I believe overuse your adrenaline glands and be such a high of Cortizone for so long within a months time you lose all energy. I think the best protocol is you can still keep that high schedule, but two days in between with rest..
Casey Means talks about this. Stress, lack of sleep, and lack of exercise are as big a problem as bad diet.
I think the live videos are really authentic, a nice change from the typical highly edited youtube video
I love every single one of my LDLs! As long as my trigs are low I have no fear. And they are at 43 after 18m on a keto diet with 18:4 IF.
You lost two hours 😂, 18:4…
Watching from the Los Angeles area. I really enjoy your content and information. Thank you for the work you do.
Any “study” you find that says “May cause” you probably need to replace it with “May Not”.
Finally doctors are doctoring… shocking this was not correlated until now
My cardiology professor has put me on an LDL reducing drug called Repatha it does work where nothing else has and is also reported to reduce existing atherosclerotic blockages. Once I believe its done that I will stop taking it.
I’m a doctor working in internal medicine & I’ve made a video discussing dietary fat and cholesterol!!
Don’t know when doctors will start using their brain.
They will NEVER let go of LDL-cholesterol because drug companies just want to create more and more drugs.
Gotta make those payments on their BMW’s.
What do you say about Dr Thomas Dayspring?
@@jeffj318 I’m not convinced. Personally I have seen people reverse atherosclerosis with a ketogenic diet. I have seen people reverse autoimmune conditions, schizophrenia & depression, and even dementia with keto/paleo!!
a whole food plant based diet is definitely MUCH healthier than a SAD, but I’m not convinced that a vegan diet that lacks bioavailable proteins, omega3, vitamins and minerals & is rich in anti-nutrients if not carefully planned is evolutionarily appropriate for humans.
@@jeffj318 A quick look through his page he claims ketogenic diets increase apoB which means they increase risk of heart disease.
Thing is that apoB tells us the sum total of apoB containing particles that include VLDL, IDL & LDL.
In case of insulin resistance, this would be high because the VLDL number would be high, and so would the NUMBER of small LDL (atherogenic type). It makes sense that then, apoB is high in these phenotypes.
Now, in case of ketogenic/low carb diets, LDL-C goes up, but the number of LDL particles may go down, and VLDL definitely goes down. Even if LDL particles are high, they are the large fluffy LDL particles which are not atherogenic, and do not get damaged.
So most studies on apoB that show a higher risk would most likely be showing us an insulin resistant lipid profile rather than a metabolically healthy lipid profile. Since most people who have heart attacks have insulin resistance, they will most certainly have a lipid profile that has high apoB.
I am not sure if we can extrapolate these most common studies to a metabolically healthy phenotype. We definitely need more studies on metabolically healthy people with high HDL-c, low TG, low VLDL, high LDL-c, and maybe even high apo B and do advanced testing such as CCTA/CAC on them to see what their cardiovascular risk may be. But for now, we don't have sufficient evidence. But, my opinion is that just looking at apo B in the context of an otherwise healthy lipid profile JUST because of high number of fluffy LDLs is not prudent.
Hope this makes sense!
… to make more billions
people should read ' The Clot Thickens'. Dr Malcolm Kendrick
Had a heart attack at 57. NEVER had a LDL over 130. What I DID have was high triglycerides, high BP, low HDL, high fasting insulin.
But, the MDs persist that it was my LDL ALONE that caused my cardiac problems. Makes ZERO sense.
The length to which you go to find that one argument that goes your way in a paper literally saying that the magnitude and duration of exposure of LDL has a direct impact on progression of atherosclerosis is pretty amazing.
The paper does suggest that there's a lot of benefit to be had by lowering LDL cholesterol levels e.g. with statins which does kind of conflict with a lot of advice saying LDL isn't 'bad' and you don't need to reduce it. I'm completely confused to be honest, my Dr is adamant I should be on statins but I've been avoiding taking them but I'm beginning to question the wisdom of doing that...
The paper makes the argument for him.
Okay, if blood pressure is what causes atherosclerosis, then we should stop using mouth-wash. The most common cause of blood pressure is inability to produce NO2. And the most common cause of reduced production of NO2 is excessive fluoride consumption. If you already avoid using mouth-wash, and yet have a blood pressure problem, the second most common cause of insufficient NO2 production is arginine deficiency. Either supplement with arginine or citroulline, which we can convert to arginine; or eat a cupfull of watermelon every day.
Another thing: If you are past 40 or 45 and you have arterial damage, your body cannot repair the damage due to minimal production of collagen. Taking collagen supplements will not help, because ingested collagen gets digested down to amino-acids and small peptides; so to re-constitute those nutrients back into collagen you need a ton of vitamin C, plus the amino-acid lysine.
The only way to restore production of collagen after 50 is to follow the Pauli protocol, which is basically 6 grams of vitamin C and 3 grams of lysine per day. That is the MINIMUM; personally I take
10 to 12 grams a day of vitamin C per day. Before you think of the word "mega-dose", consider that humans and orangutans are the only animals that are not capable of producing their own vitamin C. Your dog produces about 17 grams of vitamin C per day. A cow produces more than 100 grams of vitamin C per day. And you might ask why don't we produce it too? We lost the ability. We still have the gene for vitamin C production, but the gene is not getting activated; nobody knows why. Anyways, back in prehistory we did not need to consume vitamin C as citrus fruits or as supplements, simply because we hunted animals for food, and ate them raw. Raw meat has enormous amounts of vitamin C. Cooking, however, destroys it. And no, I am not advocating eating raw meat; that's dangerous nowadays. I'm just saying all that because people have such naive perspectives on nutrition you have to write a whole paragraph to explain each word you write. 99% of people are completely incapable of taking in eve a small piece of info, like the importance of the Pauli protocol to reactivate collagen synthesis. 99% of people just don't click.
Another thing is the gradual clotting of blood as we age, which increases viscosity. There is one simple solution to that: Japanese natto. Consume it, and your blood will quickly go back to the fluidity of a 20 year old's blood. Just eat one square package of natto every other day; the enzyme nattokinase present in it, dissolves blood clots. Natto smells and tastes awful to our western taste, but so, what I do is I fry the natto together with onion, garlic and ginger, and after 15 minutes of frying I throw in a couple of eggs, and make it an omelette or scramble.
Won't the heat from frying natto destroy the active enzymes?
@@jrket8141 No, it doesn't. I never eat natto in any other form than fried, and I notice the difference natto makes in my system whenever I hurt myself and bleed. Same day after eating natto, a wound takes 2 or 3 times as long to stop bleeding. This is precisely because nattokinase in the blood is dissolving the blood clot even as it is trying to form. I once ate natto twice in one day, then hurt my finger, and I was wiping blood with servillettes for the next hour and a half. So be careful. But to answer your question, nattokinase is definitely NOT denatured by the heat of frying. And in fact, cooking doesn't destroy as many things as most people assume. Vitamin C is definitely destroyed by cooking; that is a famous case. And some B vitamins. But most vitamins are detanured by heat, but very slowly; so you might lose a few per-cent potency over a 30 minute boil. You have to check one supplement at a time what cooking or heating will do; there is no blanket rule that can be applied.
@@privateerburrows Thanks
Association is not causation!
Watching replay from Switzerland, thanks for all your videos!
This was a great RUclips. Learned a lot! Thanks!
This research is not differentiating Type A and Type B LDL-C. Type A LDL-C is highly dependent of dietary fat consumption while Type B LDL-C is dependent of high blood glucose level. And the one which causes atherosclerosis is Type B LDL-C which statins cannot lower.
Agreed. It is weird they did not account for that or even talk about it on the paper, if they have such a good handle of the topic.
Yes, it's true! I just fact checked this info on pubmed.
I wish my doctor would do a little research on this. She is trying to push the statins on me!
Yes, it's true! I just fact checked this info on pubmed.
I wish my doctor would do a little research on this. She is trying to push the statins on me!
Also, my oncologist told me about this type a and type b LDL C.
She seems to know more about cholesterol than my GP.
I AM CANCER FREE after 18 months keto/carnivore , NO CHEMO!!
@@andreahatfield1456 If it is type B that is caused by high good glucose levels that is the bad one. Try berberine, chromium/vanadium and TUDCA. I give this to my parents to keep their insulin sensitivity up.
It appears settled science is changing again.
❤great video. Loud and clear, Baton Rouge. Listening to replay. Evangelize the culture.
Wow, You are exactly correct!!! 🎯
I will be more specific. When will a study explain the mechanisms the body employs to repair damaged arteries from smoking, diabetes and high blood pressure?
Do you blame the firemen for the fire? Cholesterol is a fireman at a fire. HELLO What is causing the fire? Processed Veggie/Seed Oils, sugar, processed foods.
Hello from South Africa 😊
Thanks for the informative talk!
...en ek ook.
How about NATTOKINASE?
Blood pressure is a major factor and salt is involved there: The salt contribution seems to be a product of low dietary potassium. That stiffens the arterial wall assisting calcification that attracts LDL as a healing agent. Or so the story goes, so far.
Malcolm Kendrick has been saying this for years.
I have heard enough about blaming the firemen.
Well, the results of this study do suggest that the firemen are actually setting the fire in this case. High blood pressure and diabetes increase risk even at lower LDL levels. People with high risk do not get a higher LDL level as a result of high blood pressure or diabetes (in which case the relation between risk and LDL levels would be similar for people with diabetes and high blood pressure compared to the general population).
@@GerbenWulff Fatty liver causes the small dense LDL.People with high good LDL live longer.
Perhaps a better analogy would be to imagine damage is done to a road. Workmen show up to repair it. As a consequence traffic is congested. But before the damaged road can be fixed, more damage occurs, causing further traffic congestion. And the process continues until traffic is halted altogether.
@@michaelkrull3331 ,
... and the damage to the road never gets repaired.
@@GerbenWulff No The firemen are not setting the fire. sugar, veggie oil/seed oils oxydative stress due to natural aging process, these are setting the fire.
Why does low density cholesterol exist, what is its purpose? I believe the our bodies don’t process high refined oils and fat substitutes that leads to fatty liver and more damage to body cells that need cholesterol to repair nerves and joints.
Dr malcolm kendrick wrote about this in his book the clot thickens long ago
Grade: A-
Reasoning:
The video provides a comprehensive overview of the new LDL cholesterol theory and its implications for heart disease prevention.
The host effectively communicates complex scientific concepts in an accessible manner, making the content engaging and informative.
Interaction with the audience adds value, addressing real-time questions and concerns.
The video could benefit from a more structured format to enhance clarity and flow.
Overall, this video serves as a valuable resource for those interested in the latest research on cholesterol and heart health, offering practical advice for improving metabolic health and preventing cardiovascular disease.
Man. Love the channel, long time follower here. Please don't change your tone, don't get annoyed. Please. When you talk like that in the end it even makes me anxious. Present please in the usual peaceful form.
Love your video lessons. Watching from Wilmington, NC.
Southern Girl here. Great video! Thank You!
Well they need to go deeper because you know damn well there are folks living to a ripe old age with a high LDL, Low LDL is dangerous too! Maybe some folks are affected but certainly not all. Yes type 2 diabetes and obesity are risk factors for so many problems!
It's not so much that they're risk factors, they're just the most obvious symptoms of the same metabolic dysfunction that is causing heart disease and many cancers.
Is it possible the body is depositing cholesterol in area of damage in an attempt to repair or at least aid in repair. The body doesn’t have another mechanism to seal the vascular wound while repairs are carried out? So eventually a rupture of cholesterol plaque kills us but without the initial damage the cholesterol is irrelevant? Or is it a case of cholesterol getting stuck in a vascular wound as it’s flowing by in the blood stream?
Thank you for your work from Vancouver BC
Ignores people with Familial Hypercholesterolemia, according to this they should all have ASCVD, yet they don't. Yeah they give a nod to vessel injury....
Listening/watching from Singapore. Always glad to see/hear your content 👍
We have to look at what causes LDL move into artery wall. And what cause it to stay there. The early atheroscerotic process is reversable without inflammation and excess oxidised lipids which prevent macrophage from releasing the cholesterol from the plaque. Total LDL association is not causal at all. The small very dense subset of LDL may be more causative because this has many characteristic associated with mechanisms that maintain plaque development. These small dense LDL are not measured and the mostly contain oxidised lipids and stay in the blood for extended periods. They occur in a high Triglyceride environment. So it might just all go back to excess TG.
High ApoB particle count is causal to atherosclerosis. Nobody argues that all these other factors are of importance. If you have perfect metabolic health but sky-high ApoB, you are likely going to end up with atherosclerosis.
I forgot how great is starting the day with a Metabolic Mike deep dive!
Greetings from Rome
Just watched this during my treadmill workout. Great information! Working on lowering my BP and Insulin resistance (10.6). My triglycerides are 99 BUT my HDL is 26. Looking for a video that addresses this ratio. Again great stuff.
Continue to increase your exercising on the treadmill and add good fats-Avocados, almonds, nuts and extra virgin olive oil on salads. I put 2 tbsp in my smoothie everyday.
My HDL used to be 40 which is optimal but now it’s 78 because increased my good fats and I walk EVERYDAY.
Good luck in your healthy journey.😊
Can you repair the initial insult over time? My concern is whether this is irreparable damage as someone who’s just started working out.
RUclips used to be more reliable giving me notifications for your streams.
Reducing range for anything which doesn't fully support the establishment narrative is yet another form of censorship. As is likely that my comment may not be visible to anyone but me or get deleted automatically straight away after I post it.
Sometimes you have to unfollow to follow again to get notifications. YT does that to me too.
Watching from Singapore. High LDL (5.1mmol/L) but low Triglycerides (0.63mmol/L), no sugar, kinda normal BP (125/82) and doctor quite insist to put me on statin…
Because suddenly I developed a very low HR, 39, I was taken to the hospital and there I received a stent, diagnosis CAD. Slightly elevated TC and Tr. High HDL moderate LDL. Low CRP. Changed my diet lowering carbs, now TC, Tr slightly above normal, HDL high and LDL went up (because of a low carb diet? as I read?) The initial injury to my arteries is 32 years of heavy smoking; I stopped 27 years ago. Do I need to lower my LDL??? I take statins on and off because of muscle pain.
Hey Mike, have you read Dr. Malcolm Kendrick's book, "The Clot Thickens"? In his book, Dr. Kendrick opines that if a person's coronary glycocalyx and coronary endothelium is healthy and intact, there ain't NO WAY that atherosclerosis can even start, whether your LDL-C is 20mg/dL or 250mg/dL. To your point, it is high glucose, high insulin, smoking, hypertension etc. that actually damages the glycocalyx/endothelium and initiates the atherosclerosis process. As Malcolm Kendrick says, there is ZERO evidence, in ANY medical literature, that proves that LDL, or ANY liporprotein, including small dense LDL's and VLDL's, can damage/disrupt the coronary lining! As lipid researcher, Dr. David Diamond, points out, there are many people with familial hypercholesterolemia, who have LIFELONG high LDL-C, and they do not develop premature atherosclerosis.
What about this APO B lipoprotein that many are now blaming for the damage ?
@@mkkrupp2462 Great question. Since most of our ApoB level is composed of the LDL particles, the ApoB blood level is about as useful for predicting atherosclerosis as LDL-C*****WORTHLESS. As Dr. Malcolm Kendrick says, "LDL-C, LDL-P, ApoB, small dense LDL's are all essentially a distraction which leads us away from the real cause of coronary artery damage----high blood glucose, high blood insulin and INSULIN RESISTANCE.
I just started exercising heavily last month but have been eating natural food with no seed oil, no sugar only a few berries and no carbs. Last week I went in for a blood test. My cholesterol is 290, LDL 211, HDL 60, Triglycerides 80. No diabetes. Will need to keep doing this for another month and get another blood test to confirm if I should go on Statin 😕 i’m quite skinny and at 46. I guess this is familial cholesterolemia?
Watching from Baguio, Philippines. My LDL cholesterol is also high.
Watching from Tasmania Australia
Where can we get the research paper to print to give to our doctor?
Great that you stuck the electrolytes ad in the middle of the video! One of the first things I learned in the keto / low carb space is that glucose holds water the same as salt. But, they want you to lower your salt intake! The obvious point here? Salt is a necessary electrolyte, but, carbs, which add excess glucose to the bloodstream, ARE NOT ESSENTIAL!!! So, excess glucose from carbs ,in addition to the essential salt , that needs to be there, is doubling the volume in the stream! Voila, instant high blood pressure! Cut out the carbs, which cuts out the excess glucose, as well as pre diabetes, lowers the insults to the artery wall.
Yudkin had evidence that cholesterol was linked to sugar, not cholesterol. Recent evidence indicated that sugar raised small LDL (I think it was) not all LDL. And the Framingham study indicated that a high cholesterol diet was protective. I would like to know if they differentiated the LDL.
Professor Bart Kay has been ranting about high blood pressure and turbulence as the root cause of ASCVD for a while now. Additionally, this paper advising reducing LDL "as low as possible" is utterly absurd.
I can't find the citation for this article. I'm curious where the funding came from. That's my top priority regarding how I look at journal articles now.
That is fascinating about things like insulin resistance and high blood pressure can lead to damage to the arterial wall leading to arteriosclerosis. I like how you are explaining research papers that I wouldnt be able to decipher on my own, And I really like how fit your looking brother, I like my Doctors to be displaying signs that they know how to at least keep themselves Fit haha! Andre
My LDL is 244. (Normal blood pressure, non diabetic)
My LDL is over 300. It's always been high. I eat a keto lifestyle. Alll other markers are great, no diabetes, hypertension low A1C high HDL low TRI. My dr said i'm gonna have a heart attack in a month if i dont go on a statin. Well its been months, I should call and let her know that I'm still here...lol
@@rdiemidio65 Another GREAT example of us patients starting to get SMARTER than our doctors!!!📖📈📉🔬🗃📚
This is not a new theory, but it’s good to see increasing
evidence for it.
4:38 Anyone who has read Kendrick’s The Clot Thickens already knew this.
please share the study links with us. Thx
I am an 18/6 IF keto-lacto-ovo-vegetarian. My BP is nominally 100/70. I am also LMHR and if I achieved ketosis through carb restriction alone I'd have nutty apob. Instead, my apob is 118 because I achieve ketosis via IF + *low* carb (about 50g/day). So I attenuate the LMHR triad via carbs but still get into ketosis via intermittent fasting.
*All* of my labs (with the exception of LDL and apob) are *perfect *. My HDL is 57, and my trigs are 115 (ratio is 2.01). My hsCRP is 0.9.
So my approach is to get great metabolic numbers and then to try and mitigate apob as much as possible (via carbs) without losing the great metabolic numbers.
Might we eventually learn that apoB is of doubtful value as a predictor of CVD? 🤔
@@1timbarrett the way I think of it is that apob is the bricks and inflammation is the bricklayer. Remove either one and no plaque wall is built. Given the myriad of problems associated with chronic inflammation though, if you can only remove one, remove inflammation. If you can remove both, then great, but if you can only remove one, make it inflammation.
@@homomorphic Look you're not gaming biology. Keto dieters experience 2x more hospital admissions for heart attacks than general population, and the general population sucks, anything keto is just the worst diet known to man, you are rapidly developing atherosclerosis faster than SAD could produce.
Just love your passion and knowledge Mike. Keep on m'dear. 🎉👍😁
Please list the study or studies you refer to under your videos. Thank you.
Mike, if everything eles is taken care of (good sleep, healthy blood pressure, no insulin resiatnce, active lifestyle, BMI below 25, low stress level etc.) where would you like to see your or someone's HDL level at? Ball park number?
That makes sense if turbulence causes damage due to physical stretching or abrasion. This would indicate that high BP causes the deposition of plaque, not the other way around. Is that right? So how do the other heart disease risk factors cause plaque at high-turbulence arterial locations?
Thank you from Toronto Ontario.
Listening from Peterborough, UK
Red blood cells last longer on low carb or carnivore right ? So hematocrit would be a little higher also ??
Atherosclerotic plaque is essentially a healing mechanism to repair damaged artery walls because of eating sugar and seed oils, both inflammatory agents. As more damage occurs, logically, more plaque will continue to cover the damage.
Great presentation, Mike. Could you tell us where we can go to download a FREE copy of this paper by Ference, et. al.?
I didn't see the Livestream, but I'm watching from Sydney, Australia.
What do you say about a 70 year old that has asymmetric slight hypertension? That is, the systolic can vary between 120 to 160 but the diastolic varies between 65 and 78. This is quite consistent. My A1-c is 4.7 %, my HDL is 70, my LDL is 90 and my total cholesterol is 180. I exercise every day for over 50 years and my pulse varies between 53 to 60 beats per minute. I try to avoid all refined carbohydrates as well and I cook my own food just about all the time. I know what’s in my whole foods & I take fish oil, vitamin D3, C, all the Bs including the reduced form of B9 and 3 forms of the cobalamins for B12 by sublingual introduction. I also take about 400 to 500 mg of magnesium in the form of Lglycinate, L- malate & L-theeonate. I take olive oil and taurine at 5 g and lithium orotate at 2 mg per day. I also take PQQ to enhance mitochondrial genesis & berberine. What about the distribution of large particle to small particle distributions in various LDL conditions? Doesn’t the small particle LDL only gets into the arterial lining yet the large buoyant LDL particles do not and remain physiologically neutral as far as I understand it!
All this is good.
How do you facilitate Vascular insult repair at this point?
Yes fasting, exercise, sleep, eliminating SAD, so on, but what items can help after the above are accomplished?
Thankz!
Do you still offer the bloodwork cheat sheet? If so, how can I download it? I’ve tried several email addresses and never received it. Thanks for your videos.
This all sounds good. What do you say about Dr Thomas Dayspring, liquidologist or Dr Mohammed Alo who believe saturated fat is the problem.
This reads like a paper funded by people who wanna sell Statins
And the new injectable drugs that get your ldl down to 35. That’s safe. No risks at all. Totally safe and effective.
Thank you for this info. For someone with known endothelial dysfunction (CAD and PAD peripheral artery disease) based on this info would you think it important to lower LDL assuming they have addressed all the lifestyle things to reduce endothelial injury? Have been resisting statins for many years, been told statiins don't necessarily reduces one's plaque burden and can itself cause metabolic dysregulation and more.
Do you think psoriatic arthritis can cause plaque/high calcium in the arteries? The reason being inflammation.
Where can I find doctor who doesn’t push statins? 67 years old male Have high LDL and sort of high of triglycerides blood pressure is under control with losartan (120s/80s). A1c is 5.7 Good news is I am very active riding my bike, walk/jog, play ice hockey 1.5 x /week and don’t smoke or drink (1-2x per month). Live near Madison WI. Any suggestions?
What is the result if there is damage to the artery walls and there is no cholesterol to help repair the damage?
I can recommend 7.5mg of Mirtazapine for sleep. Take note that a higher dose will not make you sleep better (use 7.5mg or less).
I've been saying for years, ever since before I started University that cholesterol is more like a patch material and not some evil substance out to destroy your body. and taking away LDL is like removing all the wall patching material in your house without addressing the hyperactive children playing contact sports in the house and punching holes in the walls in the first place. If you have no holes, you don't need patch kits, but if you have to patch the walls regularly, getting rid of the spackle won't solve the damage problem.
Being a young person, I didn't have studies to back me us so I wrote stories with characters representing the different cells and substances and got made fun of because of it. I figured people are too stupid to read a study so maybe a story would help them understand, but they were so indoctrinated to the Lipid Hypothesis, they couldn't suspend that belief long enough to think critically about it. Now decades later, studies are finally showing I had the right idea, but what good does it do when people are still afraid of eggs and downing statins like candy?
Since the carrier is just going out and coming back, that'd be like saying we need More Empty Busses going out to transport people, but we need to LIMIT the busses carrying people to their destination because they get sometimes get stuck in traffic. It's the Same Bus!
Hi Mike! Good video and you are looking good today!! Could any Allulose monk fruit sweetener be causing my triglycerides to go up?? Been on a mostly meat diet. Only things that I occasionally consume are some fruit, alcohol, ninja creami treats made with coconut milk and the Allulose mentioned, and some Lily’s sugar free chocolate. One thing I can think of is that I was not fasting with the blood work and had a “wine party” the previous night!
From Liechtenstein 🇱🇮 thank you
What do you recommend to someone who was obese and had high blood pressure (controlled with med.) for years, finally turned things around with diet and exercise in their early 50's, are off all meds, but still has high LDL cholesterol? All other markers being in the good range. ? The damage was done, but...now what?
I have a question? In the smoking graph, are these assuming that smokers have really good diets? No pre-diabetic issues? How do we separate smoking from crap diets?
70 year from the Netherlands in Helmond high blood pressure and no more diabetes T2