Research Explained: Is there more than one type of PMDD?
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- Опубликовано: 9 май 2022
- Have you ever wondered if there is more than one 'type' of PMDD? Us too!
There is more and more evidence highlighting the possibility of distinct subtypes of PMDD (and PME!) with unique pathophysiologies (biological causes/pathways) but until recently, there had been no studies using groups of patients to try to distinguish these subtypes.
In this fascinating webinar, Dr. Tory Eisenlohr-Moul and Hafsah Tauseef, BS, from the CLEAR lab at UIC (Chicago), as they explain their recent research: "Are there temporal subtypes of premenstrual dysphoric disorder?: using group-based trajectory modeling to identify individual differences in symptom change".
Learn more about:
- What is PMDD.
- What is PME.
- Why is it important to investigate if there are subtypes of a condition/disorder.
- A simple overview of methods and outcomes of the "Are there temporal subtypes of premenstrual dysphoric disorder?: using group-based trajectory modeling to identify individual differences in symptom change" paper.
- What needs to be done in the future to further understand potential PMDD and PME subtypes-- and what might this mean for patients.
This webinar will suit patients and anyone interested in PMDD/PMD/Cycle Science research.
IAPMD is an international non-profit. Our mission is to inspire hope and end suffering for those affected by premenstrual disorders through peer support, education, research, and advocacy. Founded in 2013, what began as a collective of fellow suffers has grown into a comprehensive lifeline of support, information, and resources for anyone impacted by the core premenstrual disorders: Premenstrual Dysphoric Disorder and Premenstrual Exacerbation of underlying disorders. Since our founding, we’ve helped over half a million people from approximately 100 countries find answers, community, and hope. We are creating a world where people with PMDs can not only survive, but thrive.
Learn More at: IAPMD.org
Thank you so much for sharing this, I used to be a great student who held a 5.0 gpa, top rank, and good grades. With PMDD I ended up having to drop out because it was so unbearable to attend school while dealing with the effects. This information helps me understand a part of myself better.
Thank You for sharing this. I acknowledge the time, energy & academic researchers working on this. I was reminded that people living with PMDD / PME symptoms are lived / living expeerience researchers too. There's clinical research evidence & lived / living expeerience evidence. I have navigated the public health system for many decades & often find myself experiencing the minority spaces. I've observed clinical funding & support typically goes to the 'majority' & people navigating experiences in minority areas and who are allergic & not good with synthetic medications are not properly supported in our current public health system. During the presentation I was reminded that the hormone sensitivities for me as a highly sensitive person (HSP) also connects to energy sensitives which for me are connected to the energy connected to environments, people, places, ingredients....
Thanks so much for sharing your insight - I totally agree that the people who have lived, or are living with premenstrual disorders and researchers too, and absolutely the best advocates! Laura TJ, IAPMD
Many late diagnosed neurodivergent (ND) & autistic people identified as highly sensitive persons prior to diagnosis. While few studies have been done, the most widely cited identified PMDD in 92% of AFAB autistics.
I have a love/hate relationship with the term HSP. The experiences and difficulties experienced by HSPs are absolutely real. My issue is that it can be used to dismiss, obfuscate or prevent someone from seeking mental health treatment. It's also free from the bias, stereotypes, shame, embarrassment, or negative connotations associated with many neurodivergent conditions. Using HSP over other terms may be more palatable to others which could make having your experience understood and needs met more easily.
Regardless, you may find the adult autistic community helpful and informative to make living "turned on" to the world easier.
@@wickjezek5093 thank you, I hear you & agree. Since commenting on this video over a year ago I am still navigating late diagnosis for autism & PME. The adult autistic community is equally diverse and it's not been so easy finding the right autistic/neurodiverse support for what I navigate and experience. I have hope to find the right support eventually 🙏
Thank you so much for all of the work you're doing. This is an incredible resource. I have tried so much for my PME. I was unfortunately not diagnosed until I was 20 so I spent a significant portion of my young life trying to make sense of my psychological distress and battling the stigma for being more symptomatic ("PMS-ing") during my luteal phase. I've tried several psychiatric meds since then as well as 3 different birth control pills. Yaz has been my saving grace! I dont know why drospirenone based BC wasn't my providers first line of defense. But either way, i have found so much relief for my anxiety, depression, lability, and night sweats. I don't think thus was mentioned in this talk but exercise is the second most important thing after contraceptives. Being very active- especially during my PME episodes (as hard as it can be sometimes) has been so pivotal to my emotion regulation.
I'd be curious to know the research behind why exercise is so helpful.
Why PMDD/PME can be missed in young women by providers
And I'd also be curious to know how those with PMDD/PME experience postpartum symptoms.
Thank you again for your research!!
Hi sharing from experience I have PMDD and suffered terrible ppd after having my two kids. Had to go on a ssri 6 months post partum. I was more prepared with my second pregnancy and kept in contact with the psych team throughout my pregnancy. On a positive note I loved being pregnant, the hormones agreed with me and I was very happy.
Super fascinating, thank you for sharing.
Before surgical menopause, I used to calculate how much of my life I was losing to PMDD. 44% of my days were consumed by significant symptoms. I definitely fall into that first group, it literally felt life I was living a half life. Antidepressants and birth control did nothing to help, I didn't get relief until I went into chemical menopause. They found vascular dilation associated with all my reproductive organs, including my ovaries, my surgeon called them "super ovaries". The vascular problems are probably related to my endometriosis, but given how little women's health has been studied, I now wonder if vascular problems could be a factor in PMDD. My PMDD got much worse in the last year I had my ovaries, which coincided with my endo and pelvic pain becoming super severe too.
Thank you for sharing your story - I hope you are getting symptom relief now in surgical menopause! Laura TJ, IAPMD
Thank you for sharing this it is helpful.
Thank you for sharing. Would you mind sharing your age? Is chemical menopause a total hysterectomy? And the most important thing is, how are you feeling now?
Thank you so much for sharing this! I've recently figured out and gotten diagnosed with PMDD. I experience symptoms right before ovulation, settle out after after ovulation, and then symptoms get severe again in the last 5 days of my cycle. I'm glad that you mentioned this presentation in the Q&A.
Thank you so much for sharing this ❤
Hi Cathy. Thank you for your comment. We're so glad to hear this. We hope you found it helpful. - Nichole, IAPMD
Also, treatment/ medicine ought to include wholistic options, pharmaceutical medications cannot be the only option available for PMDD / PME
These scientific research experiments can only be funded by pharmaceutical industries that’s where the $$$ is, so sadly, likely most of the research will be on pharmaceutical drugs.
Thank you for your studies.
Many SSRIs over a 18 months not helpful with negative side effects including insomnia, loss of appetite and eventually a seizure.
Ultimately the Dutch Hormone Complete testing showed high estrogen levels (collected day 19-22). Lowering estrogen with supplements has been helpful.
Hi there. Thank you for your comment. I'm glad to hear that you found something which helped your symptoms. - Nichole, IAPMD
I’ve noticed that certain symptoms have their own independent timelines and may not intensify and subside as a group
Hi there. Thank you for your comment. That's interesting. It will be interesting to see more research on this area of subgroups in the future. - Nichole, IAPMD
I appreciate the information in the video. I wanted to add that instead of SSRI’s for those women who do not like the various negative side effects of anti-depressants should try SAM-e. In fact in Europe many psychiatrists prescribe it as an anti-depressant because it is as effective as SSRI without the cost and side effects! 5 HTP is another seratonin booster!
Hi Alexandra. Thank you for your comment. You're very welcome! - Nichole, IAPMD
St. John's Wort is also a widely used & research backed natural antidepressant.
@@wickjezek5093 just be careful with the combination of st johns wort with other medication. Like birth control pill. And also sunlight
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4th type: “Day 17” or depending on the luteal phase length for individual, but will be a day just after ovulation when a Dysphoria occurs, then series of low symptom days, then 2-3 days of high dysphoria’s days-2 sets of dysphoria series per cycle. This could be a sensitivity not to total amounts of hormones, but to the DOWNWARD SHIFT of the hormones (withdrawal effect regardless of total serum amount; less today than yesterday or less now than 1 hour ago). . Also, a person could be low in estrogen generally and this could even be the reason that the DOWNWARD SHIFT in hormones is experienced as more intense. So, downward shift of progesterone just before menses is more impactful due to generally not producing higher estrogen. This was my and my sister experience for 30 years. Tracked. You should be noticing this and not averaging this out. Maybe this is an even smaller subset of women.
Cont’d… I suspected GABA deficiency due to muscle tension. Ive been helped with that but it also reduced PMDD when I avoided glutamate.
It’s also not the “full luteal phase” type-quite the opposite. Rise in progesterone helps. Its a double bump type that I haven’t seen anyone describe for us laypeople/patients.
I have the downward shift type too!! My symptom timing presents differently to yours but it is similarly 100% related to when my hormones are dipping. Thank you for making this comment--it made me feel more validated in my own experiences since I felt worried they didn't touch on this type in the video.
Could OCD be a background disorder
My husband parental kidnapped my daughter and is forcing me to move out all because of my severe PMDD. I'm borderline suicidal. Has this happened to any other ladies? I'm feel so destroyed.
I had Hasimoto's (my thyroid was removed in 2018) could it be related?, 51 years old and Still with PMDD (worsen)
I wonder how these mechanisms interact with ADHD. I've watched other videos that say that dopamine dysregulation in ADHD is affected by estrogen.
I appreciate the work you've done!
I just have a question: 8:35 Could you clarify the part about endometriosis, please? I had an endometrioid cyst removed a year ago, but I've had most of the symptoms over the last 6 months or so (before the surgery too) . Does it mean my symptoms might be caused by endometriosis, not PMDD?
Any research being done on post surgical menopause PMDD? I am 2 years PO and still can see the exact same pattern.
Hi Helen. Thank you for your comment. Apologies for the delay in replying. I am sorry to hear that you having this issue. Some research is actually being conducted into post-op cycling by Dr Panay in London, UK. We look forward to hearing the outcome of this important research. In the meantime, you are not alone. We run a surgery support group on Facebook. Let me know if you would like the details. - Nichole, IAPMD
The problem with full oophorectomy is that now you have gone into menopause with symptoms very similar to PMDD, except now you also need to supplement with hormones to which a woman with PMDD is sensitive to, so it’s a very difficult decision and one should really weigh out pros and cons. My hunch is that it’s not the best option. Mind you, some women say it saved their lives, so it is a car by case result.
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Thank you. I thought I was crazy. My doctor doesn't believe me that it is related to cycle.
Is the doctor your reference your primary care or obstetrician? Regardless, if you're able you should see a different doctor. I realize that's not an option for everyone everywhere but even a different doctor in the same practice could make a difference in the quality of your care.
Is the a link between PMDD and a history of PCOS
What do those PMDD symptoms in animals look like? And in which animals?
Hi there. Thank you for your question. Unfortunately, we don't believe there has been any research into animals. Apologies. - Nichole, IAPMD
I can tell you 100% has to do with the serotonin and the gabba because I have been through benzodiazepine withdrawal and antidepressant withdrawal and that’s when the PMDD was horrific and still is horrific but no Treatment to help it at all now whenever my period comes and I get the bleedit’s 1 million times worse
They excluded people based on birth control use. But didn’t factor in diet. Are these researchers unaware that the ketogenic diet can treat pmdd. I have heard Dr amen mention this in his book and possibly dr Georgia ede and Dr Palmer.
People hate me I suffer from pmdd
Try 5-HTP and Ashwaganda . Also, vitex agnes-castus, also called Chasteberry...
Hello.
I am trusting Jesus Christ my God with help during the days when my PMDD gets very bad. He alone is God he was crucified for our sins, He died and was resurrected on the 3rd day he ascended into heaven and will come again to Judge the world. He forgives those who ask him for forgiveness for the wrongs they do.
He gives me strength when I am suffering.