Thank you so much! I wish I had met you on my 2nd year of medical school!! Its just amazing how you make fisiology so clear in my mind!! Your vídeos are gonna make me review everything! I knew i liked those things, I just couldn't figure out how to study efficiently! Thank you again
great videos very helpful with breaking down the information to simple terms and relating the information clinically. Thank You!! I actually understand the process without memorizing it
Hi, around 8:25-8:35 in the video, the main job description of protein C & protein S is the degradation of factors Va and VIIIa, the indirect consequence of which is indeed downregulation of activation of prothrombin into thrombin, but it’s useful to know the regulation points
..great video it was very helpful.. .. i just like to know does thrombin act directly on plasminogen or is that via activated protein c formed by thromin-thromomodulin complex? or by both mechanism.. i use ganong physiology book
i`m an assistant product manager in a pharmaceutical comp.your videos helps me in my work, i wonder if you can make a video about the anti coagulant medications , it`s mode of action , and its side effect.
Mr Wolf, could you please try to answer a question for me. I am an aspiring med student currently with little science background tackling these giants of medical frustration. The extrinsic pathway has been said in other videos to be the primary initator pathway of haemostasis. That is through a breach of the integrity of the vessel by a cut or blunt trauma. The intrinsic pathway, as you have stated, is initiated in the event of endothelial injury. How? I mean what is the endothelial trigger for a clot to start to form? That is, what is the cause of this endothelial injury? Is it to say that the endothelial injury is possible without any external factor, like a cut or blunt force trauma? It's always as a given, but as of now I have been completely unable to find an intravascular event that does not initiate from an activation of the extrinsic pathway. Is there one? That is a lot more than just one question but I am very interested in any intravascular causes of haemostasis. Just to note, the other video I watched said collagen was involved, but the collagen fibres were in the tissue surrounding the vasculature, not part of any of the tunica including the interna which would be classed as subendothelium if I'm not mistaken. Also, how come there was no mention of calcium and factor VIII? Thank you for your consideration, time, and the video. Much appreciated.
You explained something that took me three days, in ten minutes. Salute
Glad you found it helpful!
I am a FNP student, and this has helped me so much in understanding he clotting factors related to hemostasis!!! Thanks!
Thank you so much! I wish I had met you on my 2nd year of medical school!! Its just amazing how you make fisiology so clear in my mind!! Your vídeos are gonna make me review everything! I knew i liked those things, I just couldn't figure out how to study efficiently!
Thank you again
I am emergency consultant....now i can tell you something...i am being fond of your fantastic video...thank you very much
Hi there! Dr. Wolf and the rest of the team here at Health Ed Solutions will be releasing new content weekly starting very soon :)
You have made my life and that of my paramedic students much easier!! Thanks :)
Keep watching, we appreciate the support!
Thanks docter I really enjoyed by this lecture it is combination between texts and full information
great videos very helpful with breaking down the information to simple terms and relating the information clinically. Thank You!!
I actually understand the process without memorizing it
You're welcome and thanks for watching!
great video !! liked the clinical links most.
Hi, around 8:25-8:35 in the video, the main job description of protein C & protein S is the degradation of factors Va and VIIIa, the indirect consequence of which is indeed downregulation of activation of prothrombin into thrombin, but it’s useful to know the regulation points
excellent concise explanation, THANK YOU!
You're welcome and thanks for watching!
So great and helpful! Thanks so much :) It really cleared up a lot for me.
I like this Vedio .. Thank you
Keep up the good work !
Thanks for this video. It's a great help! :)
great video
Great video!!! I really enjoyed this! :)
Thank you. !! you are great
Thank you Chris! We will let Dr. Wolf know the kind words.
This is a excellent video! Does anyone know what software/program he used to create this? I would like to use it to give a presentation.
..great video it was very helpful.. .. i just like to know does thrombin act directly on plasminogen or is that via activated protein c formed by thromin-thromomodulin complex? or by both mechanism.. i use ganong physiology book
Very nice done ! Thank you!
You're welcome and thanks for watching!
thank you very very much ^__________^
Thanks !!
You're welcome and thanks for watching!
wt about inhibitors of tissue plasminogen activators...worth if mentioned...thank u n great vedio...
Thanks for the feedback and thank you for watching our lessons!
u the real mvp
Thank you for watching!
i`m an assistant product manager in a pharmaceutical comp.your videos helps me in my work, i wonder if you can make a video about the anti coagulant medications , it`s mode of action , and its side effect.
Hi there! Dr. Wolf and the rest of the team here at Health Ed Solutions will be releasing new content weekly starting very soon :)
The undergrad boat thanks you as well sir
Glad you found it helpful!
Mr Wolf, could you please try to answer a question for me. I am an aspiring med student currently with little science background tackling these giants of medical frustration.
The extrinsic pathway has been said in other videos to be the primary initator pathway of haemostasis. That is through a breach of the integrity of the vessel by a cut or blunt trauma.
The intrinsic pathway, as you have stated, is initiated in the event of endothelial injury. How?
I mean what is the endothelial trigger for a clot to start to form? That is, what is the cause of this endothelial injury? Is it to say that the endothelial injury is possible without any external factor, like a cut or blunt force trauma?
It's always as a given, but as of now I have been completely unable to find an intravascular event that does not initiate from an activation of the extrinsic pathway. Is there one?
That is a lot more than just one question but I am very interested in any intravascular causes of haemostasis.
Just to note, the other video I watched said collagen was involved, but the collagen fibres were in the tissue surrounding the vasculature, not part of any of the tunica including the interna which would be classed as subendothelium if I'm not mistaken.
Also, how come there was no mention of calcium and factor VIII?
Thank you for your consideration, time, and the video. Much appreciated.
Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!
As a med student: thank you very much.
You're welcome and thanks for watching!
Thank you for the video but I have a question: You've said that Protein C stops Factor 10 to be activated... ok what about factor 5 and factor 7??
BTW I am a medical student
Thanks so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!
✌️✌️medical student in 2020