Prevention >>>>> treatment 📜Roadmap - how to look young & feel strong: drstanfield.com/pages/roadmap 💊MicroVitamin (multivitamin & mineral that I take): drstanfield.com/products/microvitamin
1. Cognitive stimulation: Engaging in mentally challenging activities at work or through hobbies can reduce dementia risk by building cognitive reserve. 2. Hearing health: Untreated hearing loss is linked to increased dementia risk. Using hearing aids can help mitigate this risk. 3. Vision care: Vision loss is associated with higher dementia risk. Regular eye check-ups and addressing vision issues are important. 4. Managing depression: Depression, especially in midlife, is linked to increased dementia risk. Treating depression can reduce this risk. 5. Exercise: Regular moderate to vigorous exercise can increase brain volume and improve brain health. 6. Head protection: Traumatic brain injuries, even mild ones, are associated with increased dementia risk. Proper head protection in sports and activities is crucial. 7. Smoking cessation: Quitting smoking can reduce dementia risk to levels similar to those who never smoked. 8. Cholesterol management: High LDL cholesterol is linked to increased dementia risk. Statins may help reduce this risk. 9. Weight management: Obesity, especially central obesity, is associated with higher dementia risk. Even modest weight loss can improve cognition. 10. Diabetes management: Earlier onset of type 2 diabetes is linked to higher dementia risk. Some anti-diabetic medications may help reduce this risk. 11. Blood pressure control: Managing blood pressure, ideally keeping it around 120/80 mmHg, can help reduce dementia risk. 12. Alcohol reduction: Heavy alcohol consumption is linked to increased dementia risk. Cutting out alcohol entirely may be the safest option for brain health. 13. Social engagement. 14. Air pollution reduction.
Half of those (2,3,4,8,9,10,11) are often linked to insulin resistance and the resulting inflammation of poor metabolic health. Some even go so far as saying that a change in diet also got rid of alcohol & cigarette cravings (7 & 12). And, if you feel good about your body and what you look like, you’re a lot more likely to want to engage socially (13). And part of improving metabolic health often includes exercise, especially once someone has lost enough fat that an interest in exercise emerges. Some say they actually couldn’t NOT move their body once they lost the fat and felt good again. Focus on your metabolic health, and most of the rest will follow naturally. Decrease or eliminate sugar, ultra-processed food, and seed/vegetable oils. Eat less often and lower your carb intake. When you reverse insulin resistance, which is linked to every chronic disease, you start to feel better and want to take care of yourself.
Oral health plays a critical role, too. Bacteria associated with periodental disease are systemic and often involved in particularly vascular dementia (chronic inflammation).
Oh this is a good point! In dogs, oral health problems can lead to kidney failure and other issues. We're not dogs, but it's clear oral health is a cross-species thing.
Thanks so much for this overview of the 57-page “Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission.” (Kudos also to The Lancet for making this literature review available for free, with site registration.) One thing the report missed, under the category of cognitive stimulation, was engagement with music. After attending an NIH-sponsored program “Music & the Mind,” I adopted some strategies for DIY music therapy. It has helped me reverse early dementia symptoms like word-finding difficulties.
My dad had macular degeneration and became very depressed about losing his independence. He was depressed, angry and bitter for about 10 years and developed Alzheimer’s Disease. I always thought those two things were linked to his contracting Alzheimer’s Disease. He smoked cigarettes for 30-40 years and quit but then began smoking cigars thinking since he wasn’t inhaling like he did with cigarettes he’d not get lung cancer. He never was one for exercise and spent a lot of time sitting in his car due to his work and sitting once he got back home. I’ve never smoked and have exercised and maintained my weight all my life. I have a lot of interests and I’m 64. I hope that I’m doing enough to prevent this horrible disease. I’m an occasional drinker but do not drink regularly.
Studies have found that the carotenoids linked to reducing risk for macular degeneration, ie lutein and zeaxanthin, are also linked to reducing risk of dementia and Alzheimer's.
Hearing loss, especially greater than 2 threshold shifts, also produces social isolation even if the individual is physically in the presence of others. I managed this in the workplace for most of my career. You could see those with profound hearing loss just have a lost look. Turn the volume down now.
The suggested remedy is using hearing aids. But when I tried that, the sounds often were so loud as to be painful. Even my tinnitus was louder. Now I know why my older relatives refused to wear their hearing aids. So turning up the volume is a better option for me. Surprisingly, getting my ears cleaned at the ENT clinic improved my hearing, even though they were surprised to see that the required audiology test showed significantly improved hearing after the cleaning. My GP couldn’t see anything in my ear canals, but the clinic found there was shed skin along with some wax. Something to try even if your doctor tells you your ear canals look clean.
And vice versa is also true. Social isolation leads to poor receptiveness. So unless i know someone's gonna talk to me, i don't really understand what they're saiyng, but my hearing is good, even after 3 back-to-back "metal" concerts.
I have a certain amount of hearing loss from using earbuds,but I notice that it's OTHERS who have a "lost look" on their faces because of lack of education in certain subjects. Also about social isolation: If one is a female one is constantly encountering people (especially males) who are looking for an idiot to take advantage of to save money on street walkers and I'm not an idiot.Now what? One has to get away from these users and I'm too busy for them.Being too busy for them will give me the intellectual stimulation that I need.What needs to be said in this video about preventing mental decline is the importance of adequate nutrition in preventing mental decline
Thankfully I've began approaching all these areas since the pandemic, I'm in my 30's and I don't want to impair "old me's" future. No more cigarretes, on my final drops of a benzo (withdrwal sure is hellish) and diabetes is in remission. I have to thank Dr. Brad, because his videos have been part of my growth since that time too.
Brilliant summary. This can change so many people's lives!! My grandfather had dementia, it is a terrible thing. I found the book 'Mindfire' to be very eye opening about neuroinflammation and brain health.
My brother in law was 67 when diagnosed with Alzheimer's and LBD over a year ago. He has been doing the Bredesen protocol and has seen some reversal of his symptoms. He is living independently with carer support but soon will require no ongoing care. If you prefer to eat cake, drink alcohol and not exercise it's not for you and you do need resources to pay for all the supplements/treatments.
Thank you very much for this overview, Dr. Stanfield. I am going to share it with a few people in my family. Very helpful in designing a strategy to lower the risk of the disease.
High Intensity Health podcast reviews studies that of thousands of people showing that the people with the highest LDL lived the longest and had the least all cause mortality.
Yeah, that was a Swedish study that followed a large group of people from when they were in their 60s, until the oldest members of the group were above 100 years old. It's a really interesting study. Personally, I'd rather try Berberine or alternative supplements, lifestyle change, or take my chances with high LDL cholesterol rather than resort to taking Statins, which has been associated with all kinds of awful side effects.
Another excellent and actionable summary, Dr. Brad! Not only does this affirm that the choices I've made are right ones, but this discussion provides more evidence and context. People of all ages should watch this video.
Half of those (2,3,4,8,9,10,11) are often linked to insulin resistance and the resulting inflammation of poor metabolic health. Some even go so far as saying that a change in diet also got rid of alcohol & cigarette cravings (7 & 12). And, if you feel good about your body and what you look like, you’re a lot more likely to want to engage socially (13). And part of improving metabolic health often includes exercise, especially once someone has lost enough fat that an interest in exercise emerges. Some say they actually couldn’t NOT move their body once they lost the fat and felt good again. Focus on your metabolic health, and most of the rest will follow naturally. Decrease or eliminate sugar, ultra-processed food, and seed/vegetable oils. Eat less often and lower your carb intake. When you reverse insulin resistance, which is linked to every chronic disease, you start to feel better and want to take care of yourself.
I thought the Amyloid Plaque theory has been junked. And Statins have been shown to worsen insulin sensitivity and increase your risk of developing higher blood glucose levels and T2D, so, there is a major contradiction here. 25% of the cholesterol in the body is in the brain, so lowering levels doesn't appear to be a great strategy.
Thanks for all the great videos. A lot of work goes into this. Appreciate all of your advice. What would be great is chapters to break up the content for scrolling? That way you can skip through items. Sometimes I like theory and sometimes if I know the topics I go to the parts that's about the execution.
I've seen several youtubers say that including chapter markers cuts retention and engagement way down, and thus hurts them badly in the RUclips algorithm.
@@georgewashington3619 I got arythmias from taking 2 omega-3 capsules, 1 seems fine though but we're all different. Still I had a terrible time before I realized what was causing it, and still no idea why.
My father was diagnosed with early onset Alzheimer’s at just 58 years old. He was healthy by every metric on your list except for alcohol - which he consumed in the region of 30 units per week for about a 20 year period. I always had a hunch it was connected.
although there were studies that shows increased nicotine, either by smoking or not, actually works on preserving brain function... what are your thought about the matter
@@dylan.-6527 Smoking has long been correlated with a reduced risk of Parkinson's, but no one understood why. Nicotine was ruled out. Recently, some researchers discovered that low amounts of carbon monoxide (believe it or not), which is of course present in cigarette smoke, causes a particular type of cellular stress that may be helping clear out the fibrils. They're now investigating whether orally administered low-dose carbon monoxide may be a helpful therapy for Parkinson's.
its been shown that the more you let people know its never too late to quit smoking encourages smoking, smokling caseation ads encourage smoking because people convince themselves they will just be able to give up and if its never too late, just give up a day before your going t die, no problems!
Sadly macular degeneration is not something you can treat. There are some interventions for wet but they are not very effective. Same with hearing loss. The best bet for prevention is to keep your cardio health up as the blood flow is vital to eyes and ears. Also avoiding loud noises both acute and ongoing. Get cataracts treated early. Most old people let them get pretty bad before they are treated. I deal with the elderly and some decline is inevitable and you get to pick what goes first depending on genetics and lifestyle. Brain? Eyes? Ears? Frailty? What we need is a true anti aging therapy that prevents them all.
"Units" of alcohol does not provide information; it's noise. People do not drink "Units". They drink bottles of beer, glasses of wine, shots of whiskey, etc. Fluid ounces of "12% wine", or "5% beer", or "80 proof (40%) whiskey", where the percentage is "% alcohol by volume" (ABV) - that would be useful. In the U.S., alcoholic beverages are labeled "% ABV", not "Units".
Dr Brad Standfield mentions in this study the use of anti-depressants as a possible treatment for depression and thus reduce the risk of dementia, but this is strange because multiple studies are now showing anti-depressants such as SSRI/SNRIs are known to increase the risk of Dementia vs those who go to talk therapy/counselling.
@@DrBradStanfield go over the Statin data sometime. Drs have widely dliff interpretations of the data. Some say it's only 1% benefit yet tons of sides, others say 25% benefit etc..
Statins and other cholesterol lowering pharmaceutical interventions (Ezetimibe, etc.) are a literal fountain of youth- for me, a low dose statin with Ezetimibe (10mg) is part of my longevity practice. All my biomarkers moved greatly in the right direction (hsCRP, etc.) in addition to LDL-C (34 mg/dl) and ApoB (46 mg/dl).
Red light therapy is starting to seem promising. They've found that it greatly reduces blood sugar spikes after eating and increases insulin sensitivity. I was already using a panel for injury/gym recovery, so good to know.
Why are other experts saying statins cause dementia? They are stating that the brain needs cholesterol to function and that the increase in prescribed statin drugs over the years has sky rocketed the prevalence of memory issues. It's confusing to get such conflicting information.
i really dont like Statins, seems they are finding any excuse to shoehorn it into you regardless of risk. its a big money earner, has side effects and has limited benefits?
“People” and “Adults” mentioned in studies but I want to know the breakdown on how many women were involved, had they been through menopause, were they taking HRT, were women even involved in the studies?
And he mentioned that older people (65 or older?) can have BP of 130 .... wondering if it's because for some older adults can get too low BP (and faint, fall, etc). Around 12:00.
What if people who are more cognitively active at work just have better brains in general and this is just selection bias? How do we know if the elderly that are hard at hearing or blind are simply misdiagnosed as having dementia because they just can't hear or see you?
Keep learning, Challenge your mind! Wow well , That'd explain how I've kept my mind healthy! I always love learning new things!! Even when I am writing, I always challenge myself to use new words or write something differently!
Interesting comment on resuvastatin, as there were previous meta analyses that said they were associated *with* dementia. I'm sure the standard confounders apply. It wouldn't surprise me if LDL's association with dementia wasn't similar to LDL's association with heart disease - a context based, nuanced view (e.g. some people with "sky high LDL have no significant heart disease or progression, while a significant # of people with "normal" LDL do).
There are people who eat candy all day and don't develop diabetes while others only eat salads or meats and go on to develop diabetes. Does this mean candy is healthier for blood sugar control?
@@volos_olympus No, but it might mean there is context to diet and its effect on diabetes. That's the problem with associations, they can't tell you context. It's also a problem with cherry picking a single biomarker and making a recommendation based on its association with something. Imagine if we did that with "weight" and gave people with 10 pounds of "overweight" muscle the same recommendations we give to people with 10 pounds of "overweight" fat. Would you put your thumbs in your ears and insist that "extra weight" is correlated with diabetes?
That report stated that high LDL cholesterol was defined as being >3 mmol/L, but when I did a quick Google search to see how that converted to mg/dl, It said that was equivalent to 54 mg/dl which is extremely low. What am I missing?
I used to play in a lot of tournaments, then I started playing online in the early 2000s. I have substantial doubts it is as effective as assumed. The elevation in stress hormones like cortisol and adrenaline is not ideal. Solving chess tactical puzzles is probably more beneficial, as there is far less stress involved. At least for most people. I think it is good to have variety in mental tasks as well.
Us commom citizens who our doctor does not want to prescrine Rosuvastatin due to a within range cholesterol, how can we get the benef of this? How can we get hold of Rosuvastatin?
i'm extremely skeptical about the cognitive reserve theory especially when used with a bread term like "dementia" i don't see how engaging in cognitive activities would help against vascular dementia for example
@@lauchlanguddy1004 i don't think so, i think it can only slightly delay before symptômes show up but i t won't stop it from happening not slow it down. a bit like going jobless and living off your saved money. in all cases, you're still jobless and your money is slowly decreasing, you can live decently slightly longer but at the end you will inevitably run out of money
" buy my vitamins!" I use 2 pose as a legitimate doctor who hasn't sold out but really just buy my vitamins so I can get rich and bad mouth al l the competition. That's me... Sorry I fooled you all
How long can someone with hearing loss caused by loud music and age go without hearing aids? I am neurodivergent and have misophonia and hyoeracusis, am insanely easily distracted, and fear that I'd lose my mind if I had to hear much of the noises I hear daily.
Thank you Brad for this video. Isn't it interesting that diet and nutrients only play a minor role in this Lancet study. Apparently there is no clear scientific evidence yet. Still amazing that omega 3, vitamins, other minerals are not mentioned. What is your interpretation?
my uncle developed dementia on stating that reversed when he stopped taking them. I've heard of many others that have had the same experience. Recommending statins to prevent dementia is reckless
Nice, I was surprised that sleep (quality) wasn’t on this list. I engage in 95% of those healthy practices, including for 20yrs keeping ldlc in low 40’s. 7-8 red wines /week, damn, not sure I want to give that up, I’m reasonably sure the increases in cortisol levels would offset the alcohol reduction benefits. (There’s a clear thinking rationalization, it must be working)
Many of said methods have chicken and egg conundrum. Do people with better brains tend to seek more cognitive activities, or are cognitive actions driven by some other stimulus which then results in better brains? Do people who actively seek vision correction/hearing correction have better brains to begin with than those that have brains that just ignore these problems? These effects are very difficult to tease apart.
Was the LDL level adjusted for ApoE4 allele and chol/HDL ratio and trig levels? these are all confounders that need to be looked at as they track together.
The recommendations for Apoe4 and especially Apoe4 + carriers go further and should habe been mentioned. Alcohol consumption for example differs a bit, also it is much more important to do a lot of sports, HIT training in particular.
yes the Apoe4 is a worry, as is my genetic through the roof LDL cholesterol, however very high LDL runs in the family with many long lives and good hearts. Dad and mum had very high LDL with good diet and not a millimetre of fat, not an ounce. Mum went at 0ver 90 with alz, but had a very traumatic early life, and dad in 80's with rapid cancer 9but worked in Nuclear industry.....). Dad worked hard till he died and no hint of dementia. Great grandfather the same, big drinker and not fat, high cholesterol, highly active till his 90's. Died as a result of a fishing trip in the back of beyond. He got drunk and fell in the river. His companions were drunk and dragged him home and put him in bed soaked. he died of double pneumonia before antibiotics were common. Lots of long livers from back then, hard workers in harsh conditions, lived off bread, boiled potatoes and boiled mutton, pretty much. I note in the country many many pass at over 90 and some still running farms over 90, met one a few years back, looked early 80' and as fit and as sharp as. We are missing something simple
Yes, they do, you can find research papers about it. But if you pair quetiapine with metformin most of its metabolic side-effects go away, so I guess the dementia one might too. I do quetiapine by the way, and pair it with berberine, because it's similar to metformin but isn't a prescription drug
Switch to mirtazapine, low dose. Unfortunately, it can be an issue for those of African or Asian descent. Much increased risk of severe allergic reactions. I'm Caucasian/north European and I have no problem taking it, but I've had friends develop SJS (also white), including an Asian friend of mine who took some that wasn't prescribed to her.
@@DoubtingThomas333 I'm nordic. I used mirtazapine before but now I'm afraid psychiatrist will prescribe only antipsychotic drugs since I have a condition. I know one girl who takes them too and has skin problems due to them or unhealthy diet. My problem with them is slight fat on stomach.
13:08 I'd bet the light-to-moderate drinkers get their reduced dementia outcomes from being more social and happen to be having alcohol in social settings. Massive assumption but I'd think in this age cohort teetotalers may be less social than light-to-moderate drinkers. Same with heavy drinkers, using alcohol to mask deeper problems/stressors. Being sh*tfaced rarely means being functionally social lol
Man i wish there was a drug that would just kickstart my weight loss with no side effects, one that i'll take for a week and in an year to maintain 8%bf.
Dr. Brad, if I were to buy micro vitamin, would I receive version six or are you still trying to get rid of version five supply before you release six?
Here is my problem with your video you and all the best influencers is you always come down on alcohol my biggest problem something I do every night I do most of the list I'm 60 and pretty tuff but I can't stop drinking I don't drink crazy but every night I have something I'm so close to the list I really appreciated your research I am playing but I really do drink and struggle with it and I am onboard with most of the list keep up the good work you make a difference
Im wondering how exercise is good... When it only damages the body, gives inflammation,loeers immune system,elevatćtes other vlood markers,makes us tired,ages us faster makes us eat more and more ..and we app know calorie restriction with getting all necessary nutrients is best of health and longevity Bigger heart = more stress the heart its good for running but bad for health... Where im wrong ...
LDL is indeed a lipoprotein, but it carries cholesterol. Hence the term LDL cholesterol. It is well-established in medical research that elevated levels of LDL cholesterol are associated with an increased risk of atherosclerosis, which can lead to heart disease, stroke, and other cardiovascular problems. The claim that LDL cholesterol is “not unhealthy and not risky” is not supported by current scientific consensus. While cholesterol is essential for certain bodily functions, too much LDL cholesterol poses health risks, especially in the context of heart and brain health.
I have 2.3-2.5 mmol of LDL (89-97mg/dL) and would love to take a small statin like you are but no Australian doctor would prescribe me one since I'm not considered high. I'm 39. Is there any way I can try a low dose statin?
You could just take some citrus Bergamot extract. It reduces LDL more than any other natural statin, lowers inflammation, and shifts LDL particle population from small, dangerous particles to larger, less dangerous particles
I lost interest when you mentioned statins. whats going on Dr. JACC analysis found no cognitive differences between people taking different types of statins, other research has found a higher rate of brain-related side effects related to a category of statins called lipophilic statins. data is is not clear.
Prevention >>>>> treatment
📜Roadmap - how to look young & feel strong: drstanfield.com/pages/roadmap
💊MicroVitamin (multivitamin & mineral that I take): drstanfield.com/products/microvitamin
1. Cognitive stimulation: Engaging in mentally challenging activities at work or through hobbies can reduce dementia risk by building cognitive reserve.
2. Hearing health: Untreated hearing loss is linked to increased dementia risk. Using hearing aids can help mitigate this risk.
3. Vision care: Vision loss is associated with higher dementia risk. Regular eye check-ups and addressing vision issues are important.
4. Managing depression: Depression, especially in midlife, is linked to increased dementia risk. Treating depression can reduce this risk.
5. Exercise: Regular moderate to vigorous exercise can increase brain volume and improve brain health.
6. Head protection: Traumatic brain injuries, even mild ones, are associated with increased dementia risk. Proper head protection in sports and activities is crucial.
7. Smoking cessation: Quitting smoking can reduce dementia risk to levels similar to those who never smoked.
8. Cholesterol management: High LDL cholesterol is linked to increased dementia risk. Statins may help reduce this risk.
9. Weight management: Obesity, especially central obesity, is associated with higher dementia risk. Even modest weight loss can improve cognition.
10. Diabetes management: Earlier onset of type 2 diabetes is linked to higher dementia risk. Some anti-diabetic medications may help reduce this risk.
11. Blood pressure control: Managing blood pressure, ideally keeping it around 120/80 mmHg, can help reduce dementia risk.
12. Alcohol reduction: Heavy alcohol consumption is linked to increased dementia risk. Cutting out alcohol entirely may be the safest option for brain health.
13. Social engagement.
14. Air pollution reduction.
Thank you for the summary. 🌹
❤
Social engagement should be number 1
@@jimj2683 I agree.
Half of those (2,3,4,8,9,10,11) are often linked to insulin resistance and the resulting inflammation of poor metabolic health. Some even go so far as saying that a change in diet also got rid of alcohol & cigarette cravings (7 & 12). And, if you feel good about your body and what you look like, you’re a lot more likely to want to engage socially (13). And part of improving metabolic health often includes exercise, especially once someone has lost enough fat that an interest in exercise emerges. Some say they actually couldn’t NOT move their body once they lost the fat and felt good again.
Focus on your metabolic health, and most of the rest will follow naturally. Decrease or eliminate sugar, ultra-processed food, and seed/vegetable oils. Eat less often and lower your carb intake. When you reverse insulin resistance, which is linked to every chronic disease, you start to feel better and want to take care of yourself.
Oral health plays a critical role, too. Bacteria associated with periodental disease are systemic and often involved in particularly vascular dementia (chronic inflammation).
Oh this is a good point! In dogs, oral health problems can lead to kidney failure and other issues. We're not dogs, but it's clear oral health is a cross-species thing.
Thanks so much for this overview of the 57-page “Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission.” (Kudos also to The Lancet for making this literature review available for free, with site registration.)
One thing the report missed, under the category of cognitive stimulation, was engagement with music. After attending an NIH-sponsored program “Music & the Mind,” I adopted some strategies for DIY music therapy. It has helped me reverse early dementia symptoms like word-finding difficulties.
My dad had macular degeneration and became very depressed about losing his independence. He was depressed, angry and bitter for about 10 years and developed Alzheimer’s Disease. I always thought those two things were linked to his contracting Alzheimer’s Disease. He smoked cigarettes for 30-40 years and quit but then began smoking cigars thinking since he wasn’t inhaling like he did with cigarettes he’d not get lung cancer. He never was one for exercise and spent a lot of time sitting in his car due to his work and sitting once he got back home. I’ve never smoked and have exercised and maintained my weight all my life. I have a lot of interests and I’m 64. I hope that I’m doing enough to prevent this horrible disease. I’m an occasional drinker but do not drink regularly.
If that’s you and it’s a recent pic, you look incredible for 64.
Studies have found that the carotenoids linked to reducing risk for macular degeneration, ie lutein and zeaxanthin, are also linked to reducing risk of dementia and Alzheimer's.
@@jonoave Unfortunately, they're also linked to increased risk of lung cancer in smokers. Quit now folks, and if you've never started, don't!
@@jonoave Thank you. I take those off and on. I was thinking recently that I need to get back in them. Thank you for the reminder! 🎉
@@anthropos8081 Thank you!
Hearing loss, especially greater than 2 threshold shifts, also produces social isolation even if the individual is physically in the presence of others. I managed this in the workplace for most of my career. You could see those with profound hearing loss just have a lost look. Turn the volume down now.
The suggested remedy is using hearing aids. But when I tried that, the sounds often were so loud as to be painful. Even my tinnitus was louder. Now I know why my older relatives refused to wear their hearing aids. So turning up the volume is a better option for me.
Surprisingly, getting my ears cleaned at the ENT clinic improved my hearing, even though they were surprised to see that the required audiology test showed significantly improved hearing after the cleaning. My GP couldn’t see anything in my ear canals, but the clinic found there was shed skin along with some wax. Something to try even if your doctor tells you your ear canals look clean.
And vice versa is also true. Social isolation leads to poor receptiveness. So unless i know someone's gonna talk to me, i don't really understand what they're saiyng, but my hearing is good, even after 3 back-to-back "metal" concerts.
I have a certain amount of hearing loss from using earbuds,but I notice that it's OTHERS who have a "lost look" on their faces because of lack of education in certain subjects. Also about social isolation: If one is a female one is constantly encountering people (especially males) who are looking for an idiot to take advantage of to save money on street walkers and I'm not an idiot.Now what? One has to get away from these users and I'm too busy for them.Being too busy for them will give me the intellectual stimulation that I need.What needs to be said in this video about preventing mental decline is the importance of adequate nutrition in preventing mental decline
@@Sharperthanu1 are you okay ?
Thankfully I've began approaching all these areas since the pandemic, I'm in my 30's and I don't want to impair "old me's" future. No more cigarretes, on my final drops of a benzo (withdrwal sure is hellish) and diabetes is in remission. I have to thank Dr. Brad, because his videos have been part of my growth since that time too.
Brilliant summary. This can change so many people's lives!! My grandfather had dementia, it is a terrible thing.
I found the book 'Mindfire' to be very eye opening about neuroinflammation and brain health.
Straight to the point. Very well presented and explained. Appreciate much.👏👏
You need to remember, Brad, that correlation does not mean causality.
My brother in law was 67 when diagnosed with Alzheimer's and LBD over a year ago. He has been doing the Bredesen protocol and has seen some reversal of his symptoms. He is living independently with carer support but soon will require no ongoing care. If you prefer to eat cake, drink alcohol and not exercise it's not for you and you do need resources to pay for all the supplements/treatments.
Hey love the setup improvements. Your sound is super clear and the lighting is nice
This is very good! Keep up this kind of information. We are listening!
Yes!!
Thank you very much for this overview, Dr. Stanfield. I am going to share it with a few people in my family. Very helpful in designing a strategy to lower the risk of the disease.
תודה!
I hope this video gets many views. It can really make a difference in people's lives.
High Intensity Health podcast reviews studies that of thousands of people showing that the people with the highest LDL lived the longest and had the least all cause mortality.
would love to hear High Intensity Health reacting to this video, or that Brad reacts to his videos :)
Yeah, that was a Swedish study that followed a large group of people from when they were in their 60s, until the oldest members of the group were above 100 years old. It's a really interesting study.
Personally, I'd rather try Berberine or alternative supplements, lifestyle change, or take my chances with high LDL cholesterol rather than resort to taking Statins, which has been associated with all kinds of awful side effects.
yes have seen it in my family
Another excellent and actionable summary, Dr. Brad! Not only does this affirm that the choices I've made are right ones, but this discussion provides more evidence and context. People of all ages should watch this video.
Please do a video on the physical and mental effects of emotional trauma and stress, anxiety. (different from Depression)
And if healing from trauma can reverse the damage
Half of those (2,3,4,8,9,10,11) are often linked to insulin resistance and the resulting inflammation of poor metabolic health. Some even go so far as saying that a change in diet also got rid of alcohol & cigarette cravings (7 & 12). And, if you feel good about your body and what you look like, you’re a lot more likely to want to engage socially (13). And part of improving metabolic health often includes exercise, especially once someone has lost enough fat that an interest in exercise emerges. Some say they actually couldn’t NOT move their body once they lost the fat and felt good again.
Focus on your metabolic health, and most of the rest will follow naturally. Decrease or eliminate sugar, ultra-processed food, and seed/vegetable oils. Eat less often and lower your carb intake. When you reverse insulin resistance, which is linked to every chronic disease, you start to feel better and want to take care of yourself.
I would say upper body physical exercise, getting pleasurable social stimulation, anti-inflammatory nutrition and adequate sleep should be the top 4.
You are such a great doctor. Thank you for caring so much about us. Please stay safe and healthy.
Rhythm control in atrial fibrillation (AF) has also been associated with a reduced risk of dementia.
An important risk rarely discussed.
explains why learning new language is so developing
Excellent report. So many head hits as a kid and young man. If I had only known... lol
I thought the Amyloid Plaque theory has been junked. And Statins have been shown to worsen insulin sensitivity and increase your risk of developing higher blood glucose levels and T2D, so, there is a major contradiction here. 25% of the cholesterol in the body is in the brain, so lowering levels doesn't appear to be a great strategy.
A lot of those who dogged Statins for years are coming back to LOW DOSE Statins. It’s confusing. I don’t know who to believe anymore.
Thanks for all the great videos. A lot of work goes into this. Appreciate all of your advice. What would be great is chapters to break up the content for scrolling? That way you can skip through items. Sometimes I like theory and sometimes if I know the topics I go to the parts that's about the execution.
I've seen several youtubers say that including chapter markers cuts retention and engagement way down, and thus hurts them badly in the RUclips algorithm.
I've just learned via Food for the Brain research that taking B vitamins and Omega 3 supplements reduces dementa risk considerably.
@@georgewashington3619 I got arythmias from taking 2 omega-3 capsules, 1 seems fine though but we're all different. Still I had a terrible time before I realized what was causing it, and still no idea why.
@@georgewashington3619 The Physionics channel covered this recently, including the question about oxidation. It's worth watching, if you haven't.
Nutritional yeast
Sardines and tuna in water, eggs, and flaxseed flour ( which I mix yougert ) all contain Ômega 3.
Organic canola oil as well.
Always enjoy your suoer informative videos, Brad
Thank you for this information Dr Stanfield.🙏🏻
My father was diagnosed with early onset Alzheimer’s at just 58 years old. He was healthy by every metric on your list except for alcohol - which he consumed in the region of 30 units per week for about a 20 year period. I always had a hunch it was connected.
although there were studies that shows increased nicotine, either by smoking or not, actually works on preserving brain function... what are your thought about the matter
FWIW I heard Peter Attia state he regularly will orally intake small amounts of Nicotine
@@dylan.-6527 Smoking has long been correlated with a reduced risk of Parkinson's, but no one understood why. Nicotine was ruled out. Recently, some researchers discovered that low amounts of carbon monoxide (believe it or not), which is of course present in cigarette smoke, causes a particular type of cellular stress that may be helping clear out the fibrils. They're now investigating whether orally administered low-dose carbon monoxide may be a helpful therapy for Parkinson's.
Approved video; all points are not superfluous.
its been shown that the more you let people know its never too late to quit smoking encourages smoking, smokling caseation ads encourage smoking because people convince themselves they will just be able to give up and if its never too late, just give up a day before your going t die, no problems!
Wondering if you could use chapters so I can skim - particularly when I short on time
Sadly macular degeneration is not something you can treat. There are some interventions for wet but they are not very effective. Same with hearing loss. The best bet for prevention is to keep your cardio health up as the blood flow is vital to eyes and ears. Also avoiding loud noises both acute and ongoing. Get cataracts treated early. Most old people let them get pretty bad before they are treated.
I deal with the elderly and some decline is inevitable and you get to pick what goes first depending on genetics and lifestyle. Brain? Eyes? Ears? Frailty? What we need is a true anti aging therapy that prevents them all.
Dr Brad, have you looked into the possibility of methylene blue being used to help prevent and even reverse early stage cognitive decline?
"Units" of alcohol does not provide information; it's noise. People do not drink "Units". They drink bottles of beer, glasses of wine, shots of whiskey, etc. Fluid ounces of "12% wine", or "5% beer", or "80 proof (40%) whiskey", where the percentage is "% alcohol by volume" (ABV) - that would be useful. In the U.S., alcoholic beverages are labeled "% ABV", not "Units".
Thank you very much. Very informative.
I would like to know what Dr. Stanfield thinks about the constrained total daily energy expenditure model.
I play social doubles tennis a couple of times per week. Judging by some of our players in their 70s and 80s I'd say it's highly beneficial.
Very important information.
Good one. Thank you. 🌻
Dr Brad Standfield mentions in this study the use of anti-depressants as a possible treatment for depression and thus reduce the risk of dementia, but this is strange because multiple studies are now showing anti-depressants such as SSRI/SNRIs are known to increase the risk of Dementia vs those who go to talk therapy/counselling.
study link or name?
@@venicebeachsurfer He is not pushing anything. He is communicating what research is showing.
This guideline reviewed all of the latest studies. I presented their conclusions
@@DrBradStanfield go over the Statin data sometime. Drs have widely dliff interpretations of the data. Some say it's only 1% benefit yet tons of sides, others say 25% benefit etc..
Yeah weird, depression medication can lead to dementia…
Statins and other cholesterol lowering pharmaceutical interventions (Ezetimibe, etc.) are a literal fountain of youth- for me, a low dose statin with Ezetimibe (10mg) is part of my longevity practice. All my biomarkers moved greatly in the right direction (hsCRP, etc.) in addition to LDL-C (34 mg/dl) and ApoB (46 mg/dl).
what about taking up musiscal instrument later in life?
No mention of vitamin d3, red-light therapy, or ketogenic diet?
Red light therapy is starting to seem promising. They've found that it greatly reduces blood sugar spikes after eating and increases insulin sensitivity. I was already using a panel for injury/gym recovery, so good to know.
@@manmoth4 cool, yea look up red light therapy for dementia
That old man at 0:09 is the richest man born in Brazil btw. Jorge Paulo Lemann. 100% sure of it.
Why are other experts saying statins cause dementia? They are stating that the brain needs cholesterol to function and that the increase in prescribed statin drugs over the years has sky rocketed the prevalence of memory issues. It's confusing to get such conflicting information.
i really dont like Statins, seems they are finding any excuse to shoehorn it into you regardless of risk. its a big money earner, has side effects and has limited benefits?
“People” and “Adults” mentioned in studies but I want to know the breakdown on how many women were involved, had they been through menopause, were they taking HRT, were women even involved in the studies?
Great video! Thanks!
And he mentioned that older people (65 or older?) can have BP of 130 .... wondering if it's because for some older adults can get too low BP (and faint, fall, etc). Around 12:00.
I’m living a healthy lifestyle, do the right things, but I had a concussion in the past. Am I now doomed?
What if people who are more cognitively active at work just have better brains in general and this is just selection bias? How do we know if the elderly that are hard at hearing or blind are simply misdiagnosed as having dementia because they just can't hear or see you?
Keep learning, Challenge your mind!
Wow well , That'd explain how I've kept my mind healthy!
I always love learning new things!!
Even when I am writing, I always challenge myself to use new words or write something differently!
Helpful to know and follow 👍
Hi Brad, great videos - can you do a video on Kava?☺️
Interesting comment on resuvastatin, as there were previous meta analyses that said they were associated *with* dementia. I'm sure the standard confounders apply. It wouldn't surprise me if LDL's association with dementia wasn't similar to LDL's association with heart disease - a context based, nuanced view (e.g. some people with "sky high LDL have no significant heart disease or progression, while a significant # of people with "normal" LDL do).
There are people who eat candy all day and don't develop diabetes while others only eat salads or meats and go on to develop diabetes. Does this mean candy is healthier for blood sugar control?
@@volos_olympus No, but it might mean there is context to diet and its effect on diabetes. That's the problem with associations, they can't tell you context. It's also a problem with cherry picking a single biomarker and making a recommendation based on its association with something. Imagine if we did that with "weight" and gave people with 10 pounds of "overweight" muscle the same recommendations we give to people with 10 pounds of "overweight" fat. Would you put your thumbs in your ears and insist that "extra weight" is correlated with diabetes?
If only hearing aids didn't cost more than $5000
I'm going to try Costco. Seem to be much cheaper for hearing aids. Will see how it works out.
@@johnhollar6001 No Costco anywhere near where I live but I think that was the price I was quoting based on the ones my dad was using.
WHAT??
😂
@@DillaryHuff Terrible joke
@@natesofamerica What can I tell ya, I'm approaching dad age 😂
Learn to play a musical instrument. It stimulates all areas of the brain. ✌🏻🇺🇸🎸
That report stated that high LDL cholesterol was defined as being >3 mmol/L, but when I did a quick Google search to see how that converted to mg/dl, It said that was equivalent to 54 mg/dl which is extremely low. What am I missing?
Take up playing online chess, it works wonders.
What benefits have you noticed?
And videogames. Boomers make fun of video gamers but many of them would benefit from something that mentally challenges them and tests reflexes
Online definitely but in person in tournaments also great. The engagement is multidimensional
In person chess is a good complement because of the social aspect. Onlime chess can be a massive source of procrastination
I used to play in a lot of tournaments, then I started playing online in the early 2000s. I have substantial doubts it is as effective as assumed. The elevation in stress hormones like cortisol and adrenaline is not ideal. Solving chess tactical puzzles is probably more beneficial, as there is far less stress involved. At least for most people.
I think it is good to have variety in mental tasks as well.
Us commom citizens who our doctor does not want to prescrine Rosuvastatin due to a within range cholesterol, how can we get the benef of this? How can we get hold of Rosuvastatin?
Avoid statin ...
I take ADHD drugs prescribed medication. Anyone knows if ADHD drugs can increase cardiovascular risk? Or have a negative impact in lifespan?
Dr, please do a video on Lpa Lipoprotein a and proven ways to lower it. Thanks.
i'm extremely skeptical about the cognitive reserve theory especially when used with a bread term like "dementia"
i don't see how engaging in cognitive activities would help against vascular dementia for example
but seems true for other dementias
@@lauchlanguddy1004 i don't think so, i think it can only slightly delay before symptômes show up but i t won't stop it from happening not slow it down.
a bit like going jobless and living off your saved money.
in all cases, you're still jobless and your money is slowly decreasing, you can live decently slightly longer but at the end you will inevitably run out of money
Consider going back to university after 40 if you can afford it and manage it.
" buy my vitamins!" I use 2 pose as a legitimate doctor who hasn't sold out but really just buy my vitamins so I can get rich and bad mouth al l the competition. That's me... Sorry I fooled you all
What if I play pool in a smoking pool hall but I wear a n95 mask?
And if I do all of them, I will be 2000% smarter too? I already feel it, because I came up with this question. 🎉
How long can someone with hearing loss caused by loud music and age go without hearing aids? I am neurodivergent and have misophonia and hyoeracusis, am insanely easily distracted, and fear that I'd lose my mind if I had to hear much of the noises I hear daily.
So I need to start reading more
Thank you Brad for this video. Isn't it interesting that diet and nutrients only play a minor role in this Lancet study. Apparently there is no clear scientific evidence yet. Still amazing that omega 3, vitamins, other minerals are not mentioned. What is your interpretation?
Statins are a really bad idea. Too many bad brain side effects. High omega 3 diet is a better idea with moderate exercise; not too strenuous.
my uncle developed dementia on stating that reversed when he stopped taking them. I've heard of many others that have had the same experience. Recommending statins to prevent dementia is reckless
Nice, I was surprised that sleep (quality) wasn’t on this list. I engage in 95% of those healthy practices, including for 20yrs keeping ldlc in low 40’s. 7-8 red wines /week, damn, not sure I want to give that up, I’m reasonably sure the increases in cortisol levels would offset the alcohol reduction benefits. (There’s a clear thinking rationalization, it must be working)
Many of said methods have chicken and egg conundrum. Do people with better brains tend to seek more cognitive activities, or are cognitive actions driven by some other stimulus which then results in better brains? Do people who actively seek vision correction/hearing correction have better brains to begin with than those that have brains that just ignore these problems? These effects are very difficult to tease apart.
Was the LDL level adjusted for ApoE4 allele and chol/HDL ratio and trig levels? these are all confounders that need to be looked at as they track together.
Will microvitamin be available in EU? Shipping is expensive
I can see it on Iherb is it legit?
Which statins should I start taking? My cholestrol is good, would it benefit me taking them anyway?
Good video thanks
Everything but your ldl mention….i don’t agree with that one…
LMHR ✌️👍💪
@@hagenyong1 Yup! I’m one of those 😎
statins pass the blood/brain barrier reducing the necessary cholesterol in the brain that the brain makes for itself.how can that be good?
The recommendations for Apoe4 and especially Apoe4 + carriers go further and should habe been mentioned. Alcohol consumption for example differs a bit, also it is much more important to do a lot of sports, HIT training in particular.
yes the Apoe4 is a worry, as is my genetic through the roof LDL cholesterol, however very high LDL runs in the family with many long lives and good hearts. Dad and mum had very high LDL with good diet and not a millimetre of fat, not an ounce. Mum went at 0ver 90 with alz, but had a very traumatic early life, and dad in 80's with rapid cancer 9but worked in Nuclear industry.....). Dad worked hard till he died and no hint of dementia. Great grandfather the same, big drinker and not fat, high cholesterol, highly active till his 90's. Died as a result of a fishing trip in the back of beyond. He got drunk and fell in the river. His companions were drunk and dragged him home and put him in bed soaked. he died of double pneumonia before antibiotics were common. Lots of long livers from back then, hard workers in harsh conditions, lived off bread, boiled potatoes and boiled mutton, pretty much. I note in the country many many pass at over 90 and some still running farms over 90, met one a few years back, looked early 80' and as fit and as sharp as. We are missing something simple
I don’t know if I can believe these studies specifically #8
Do antipsychotic sedative sleep meds such as quetiapine increase risk of dementia?
Yes, they do, you can find research papers about it. But if you pair quetiapine with metformin most of its metabolic side-effects go away, so I guess the dementia one might too. I do quetiapine by the way, and pair it with berberine, because it's similar to metformin but isn't a prescription drug
@@Anna-mv9ew So their negative effects are related to weight gain? If I eat healthy and exercise but take high doses of quetiapine can I stay healthy?
Most drugs do
Switch to mirtazapine, low dose.
Unfortunately, it can be an issue for those of African or Asian descent. Much increased risk of severe allergic reactions.
I'm Caucasian/north European and I have no problem taking it, but I've had friends develop SJS (also white), including an Asian friend of mine who took some that wasn't prescribed to her.
@@DoubtingThomas333 I'm nordic. I used mirtazapine before but now I'm afraid psychiatrist will prescribe only antipsychotic drugs since I have a condition. I know one girl who takes them too and has skin problems due to them or unhealthy diet. My problem with them is slight fat on stomach.
"..to cut out alcohol together" funny verbal slip
Methylene blue and nicotine (NOT tobacco)
13:08 I'd bet the light-to-moderate drinkers get their reduced dementia outcomes from being more social and happen to be having alcohol in social settings.
Massive assumption but I'd think in this age cohort teetotalers may be less social than light-to-moderate drinkers. Same with heavy drinkers, using alcohol to mask deeper problems/stressors. Being sh*tfaced rarely means being functionally social lol
LDL Cholesterol... like the stuff in red meat? Yeah, I'm pretty much done for.
Man i wish there was a drug that would just kickstart my weight loss with no side effects, one that i'll take for a week and in an year to maintain 8%bf.
Dr. Brad, if I were to buy micro vitamin, would I receive version six or are you still trying to get rid of version five supply before you release six?
The MicroVitamin formula is updated roughly every 6-9 months
@@DrBradStanfield thanks Dr. Brad
@@DrBradStanfield sorry when was the last time you updated it?
Here is my problem with your video you and all the best influencers is you always come down on alcohol my biggest problem something I do every night I do most of the list I'm 60 and pretty tuff but I can't stop drinking I don't drink crazy but every night I have something I'm so close to the list I really appreciated your research I am playing but I really do drink and struggle with it and I am onboard with most of the list keep up the good work you make a difference
alcohol is not uncommon amongst the longest livers
I😂 hope you are right cheers @@lauchlanguddy1004
I actually feel that statins make dementia worse because the brain needs fat. LDL cholesterol is actually suppose to be beneficial to the brain.
What low dose statin are youvusing
Im wondering how exercise is good...
When it only damages the body, gives inflammation,loeers immune system,elevatćtes other vlood markers,makes us tired,ages us faster makes us eat more and more ..and we app know calorie restriction with getting all necessary nutrients is best of health and longevity
Bigger heart = more stress the heart its good for running but bad for health...
Where im wrong ...
Everywhere
Exercise especially HIT training can be stressful for the body which kills old cells and creates stem cells to fix the damage. Natural chemo therapy.
Brad, high “ LDL cholesterol” is lipoprotein, not cholesterol, and have been well demonstrated to be not unhealthy and not “risky”.
LDL is indeed a lipoprotein, but it carries cholesterol. Hence the term LDL cholesterol. It is well-established in medical research that elevated levels of LDL cholesterol are associated with an increased risk of atherosclerosis, which can lead to heart disease, stroke, and other cardiovascular problems. The claim that LDL cholesterol is “not unhealthy and not risky” is not supported by current scientific consensus. While cholesterol is essential for certain bodily functions, too much LDL cholesterol poses health risks, especially in the context of heart and brain health.
I have 2.3-2.5 mmol of LDL (89-97mg/dL) and would love to take a small statin like you are but no Australian doctor would prescribe me one since I'm not considered high. I'm 39. Is there any way I can try a low dose statin?
You could just take some citrus Bergamot extract. It reduces LDL more than any other natural statin, lowers inflammation, and shifts LDL particle population from small, dangerous particles to larger, less dangerous particles
I lost interest when you mentioned statins. whats going on Dr. JACC analysis found no cognitive differences between people taking different types of statins, other research has found a higher rate of brain-related side effects related to a category of statins called lipophilic statins. data is is not clear.