Whole foods >>> supplements 📜Roadmap - how to look young & feel strong: drstanfield.com/pages/roadmap 💊MicroVitamin (multivitamin & mineral that I take, in addition to a great diet): drstanfield.com/products/microvitamin
Dear doctor Stanfield,we need guidance on organic meat,organic fish,their contaminant levels and microplastic levels.Furthermore,congratulations on your newest addition to your family!Wish nothing but hapiness!
Psychedelics are just an exceptional mental health breakthrough. It's quite fascinating how effective they are against depression and anxiety. Saved my life.
Can you help with the reliable source I would really appreciate it. Many people talk about mushrooms and psychedelics but nobody talks about where to get them. Very hard to get a reliable source here in Australia. Really need!
Yes, Liberty_capss I have the same experience with anxiety, depression, PTSD and addiction and Mushrooms definitely made a huge huge difference to why am clean today.
I'm pre-diabetic and have unexplained peripheral neuropathy, the only thing I can associate it with is blood glucose levels. ALA has been a wonder-supplement for me. I take 250mg each day without food and it reduces it by 90% at least, some days it's entirely gone. I eat a whole food diet that I cook myself and meal-plan regularly. My diet is really on-point, I exercise daily, but ALA seems to be the only thing that really makes a difference. If I don't take it, the neuropathy increases to a level where it is difficult to do my workouts due to both finger numbness and foot pain. ALA has been a godsend to me. I sure hope it's not doing more harm than good in the long run, because it has improved my life massively and allowed me to stay more active.
@@lynleflore4332 Indeed, (R) form is the best, i take it together with Nicotinamide Riboside empty stomach first thing in the morning, and i can be 12 hrs neuropathy pain free.
I have just started having neuropathy as well and came to the same conclusion that blood sugar is the cause. I am on the same type of diet. Any little bit of sugar and the pins and needles start.
I have interacted with patients who had acute inflammatory demyelination of the peripheral nerves as shown on nerve conduction studies. In time, their repeated studies were normal. Some nerve damage will be repaired, such as sometimes seen in high toxicity of B6; low B12. Many factors are involved individually.
@DrBradStanfield - also need to check out the study with ALA and multiple sclerosis! It was found that it significantly slowed down brain atrophy over a 1 year period by roughly 70% from what I remember.
One Hit & Two Misses: It took till the end of this video, but he finally said that the R-Lipoic-Acid isomer is superior to ALA…great. But his two misses are doozies. First, he recommends Pregabalin for neuropathic pain, but Pregabalin merely masks pain symptoms without addressing any cause. Second, he is broadly critical of antioxidants (and Vitamin-A in particular) because of Vit-A’s association with cancer. Importantly, Vitamin-A is an Angiogenic; meaning that it supports blood vessel growth. It’s this property (growing fresh blood supply into tumors) rather than its antioxidant properties that are the issue with Vitamin-A.
Also the study which says antioxidant coctail worsened Alzheimer disease had low amount of participants, the method was just a cognitive test and they don't go into details by how much worse it was. Most likely it doesn't affect Alzheimer at all, it was just a slight coincidence that this group performed worse, this is a progressive disease and severity can vary a lot in people. The way he presented it will discourage many people from trying this supplement, which is unfair.
@@ClassicalLiberalWarriorvitamin B1 is what I’ve found most helpful. Benfotiamine is a fat soluble type & has helped over the years. I’m trying a more absorbable type now which I think may be more helpful TTFD.
My father was a triathlete my entire life. He trained religiously 3x per week and ate healthy. Yet died of a heart attack 2 years after retirement. He didn’t take vitamins or supplements. So don’t think exercise alone will extend your life or prevent heart attacks. I’d rather be safe than sorry and do both.
He just wasn't educated in supplements or in a much older generation that didn't take them. Whole foods are great but the soils are so depleted and chemtrails even contaminate organics.
Interesting video with good depth. In addition to the uses mentioned, ALA may also have benefits in older people even who don't have significant chronic disorders, due to its activation of AMPK. I can't post links to papers, since RUclips doesn't allow that, but searching for "alpha lipoic acid AMPK" will turn up information on this. In general, some supplements should be evaluated not only along a disease/no-disease axis, but also along an age axis.
The only problem is most people are walking around with pre diabetes, insulin resistant, obesity etc so ALA in the doses recommended would be a benefit with less side affects than drugs, after all ALA is found naturally in our body and in food so I’ll take my chance with ALA then any prescription drug. But I do get what you’re saying. The only problem is finding perfect healthy people nowadays specially in the western world is hard to find.
exactly.. that's the thing.. notice how he said we have "better ways to treat " diabetes.. aks FDA approved BIG pharma CRAP that will rot out your body from the inside out... and line their pockets better. No.. i'd like to understand exactly how ALA might be responsible for decreased lifespan, because it makes zero sense whatsoever...
The study analyzed data from the Global Dietary Database, the World Bank and dietary surveys to estimate nutrient intake for 15 key vitamins and minerals across 185 countries. From these results, they found that more than 5 billion people globally are not getting enough iodine, vitamin E or calcium from their food, with more than 4 billion not getting enough iron.
For me 600 mg gave me issues. I now take 100 mg with my evening meal. It does wonders for my neuropathy from diabetes. I think I need to raise it to 150 or 200 mg.
A study using the antioxidants 'Vit C' and 'Vit E' in moderate amounts tested the effects it has on muscle gain. It found that it protected muscle from damage as a result of intense exercise and increasing recovery rates. The issue is that it resulted in less than 60% in muscle adaptation. In other words, building muscle was over 60% slower compared to placebo all from just 600mg of Vit C and 200mg of Vit E. However it was found that consuming antioxidants from a natural source instead of supplement form; had no impact on muscle adaptation. This is why I steer clear of antioxidants in supplements, damage is a requirement of building muscle.
Does it depend on when the supplements are taken or not? If they are taken closely (hour or two) after workout maybe they interfere more with muscle building, because you need the initial oxidation, but what if it's hours before a workout or perhaps 4-5 hours after working out?
@@josephjroy6593 Yeah, and Vit C is being sold in jumbo containers ranging from 500mg to 1000mg chewable tablets. While Opti-Men multivitamin contains 300mg of Vit C and 160mg of Vit E.
@@Vladi2102 It's best to wait 5+ hrs after working out. The vitamin C was split into 2 doses of 500mg and the E was all in 1 dose. The other commenter is right, they are much bigger doses than in regular multivitamins (unless you buy the brands that use huge doses.)
Pregabalin may work better on average for neuropathy symptoms, but pregabalin has its own side effects, which some people can’t tolerate-such as marked grogginess and related cognitive impairment and fall risk.
Thanks. I have my Dad, 82, who has Neuropathy working on his feet. I had him on 500mg of R-ALA in the morning and 500mg of R-ALA at night. I am going to drop it to 300mg AM, 300mg PM. I had a feeling 1000mg a day was a little strong. Good to see 600mg a day is all that may be needed. We will save a little and lower the supplement load. This came just in time. He only started 2 weeks ago.
@@theancientsancients1769 What do you suggest for AM and PM? It seemed like the study said 600mg showed best efficacy. I am not sure if it was the R version though. Good point made. I need to watch again for clarification. I have him on 5g Creatine and 4g of taurine a day also. Not for neuropathy, but for longevity and cognition.
@@JacquesTreehorn Most studies are based on Alpha Lipoic Acid and not R Lipoic Acid. R Lipoic Acid is more potent and better absorbed too. For Alpha Lipoic Acid 600mg max a day is fine as suggested in the video . Dr Stanfield mixed up things in terms of difference in dosage of the 2 variants. For R Lipoic Acid don't take more 300 max 150 to 250 max a day . Usually it's one pill . In terms of Creatine if his kidneys are healthy don't ever go more than 5mg. Bryan Johnson Blueprint stack the mix one has all that . In terms of general health anti aging and high quality I can recommend Xtend life which I have used the past 20 years . They have incredible cardiovascular and circulation products and the owner is one of the few that walks the talk in anti aging supplements for 25 years. I gave my late dad the blood flow product which improved his uncontrollable blood pressure. Total balance may be something worthy of looking at too. It's like a one stop for well researched things before all this beginners knew what this things were about. I was researching these things for 20 years started when I was 20 and always people thought I was at least 15 years younger than my age and I can't say it was a family thing as it was not the case for the other 6 siblings . But I always wanted to help people and see them not fall for the marketing hype as I had 2 parent who passed away from neurological conditions which I treated myself from those sources when medicine was ineffective. I may be censored, but you can ask anything .
Thank you, Dr. Stanfield! I often struggle to explain why anti-oxidants are not an unparalleled cure-all. The tight-rope metaphor is helpful to understand that dosing on anti-oxidants can actually be harmful.
Dr. Brad, I am 87 years and suffering from non-diabetic neuropathy and have nerve problem, and I am taking a combo vitamins in which a 600mg R-Alpha Lipoic Acid the best form is included. I am taking it for more than one year now and still taking it once a day. So should I stop taking it now? Your comment please.
NO...if its hping continue. I also have non d SFN from covid. I take 800mg x 2 with alcar. Most of my burning feet is gone. I wlnt stop it though as it has other benefits rsp. Anti aging
Really good for nerve pain is PEA (palmitoylethanolamide). No side effects, lots of reliable research done. PEA is naturally produced within the body cells as a repair mechanism in response to pain and injury. A natural pain management supplement.
@@NateB There are several. E g. "Palmitoylethanolamide in the treatment of chronic pain" (meta analyses), viz PubMed. It also helps when used topically in a cream (in combo with Boswelia or Ketamine). Especially on hands and feet.
Most studies on ALA do not specify the form of acid they use. In particular, studies related to diabetes and MS. In most cases, this means using an acid consisting of an R+S form. Drugs sold in pharmacies for the treatment of diabetic neuropathy also do not indicate the composition of the acid in their instructions and have a dosage of 600 mg. If we assume that it is of the R+S form, then only ~50% of these 600 mg will be absorbed. Therefore, the recommendations of the dosage of the drug become unobvious.
The s form also inhibits the R form’s benefits. There is also a study that shows it lowers the lifespan of mice but it didn’t mention which form they use. I’m using r ala currently because I’m pre diabetic.
Great video. But here is the thing. Just as the analogy of tightrope of maintaining a balance of oxidants and antioxidants applies to certain supplements based on individual differences, same applies when you speak of certain foods or diets. Case in point, some people may have no issues other than argubaly raising their LDL/ApoB and laying down soft plaque from heavy consumption of meat, others could develop gout. The same with high oxylate foods that may be promoted as super healthy for everyone. However, for those prone to forming calcium oxylate kidney stones, these foods including almonds, spinach, chia seeds, black beans, and even cinnamon are best avoided. As an MD, I am sure you know how painful getting and passing these kidney stones can be. More important, recurrent development of kidney stones is known to contribute long term to Chronic kidney Disease, and in extreme cases kidney damage requiring removal of a kidney. Sadly, most people who develop kidney stones have no clue as to their inability to metabolize high oxylate foods until they land in the hospital with painful kidney stones for the first time. This happened to me, and it hapoens to lots of other people.
You mention "brush over" pregabalin/lyrica. You should discuss the harm this drug can do and how diff. It can be to stop it when experiencing side affects. 1st talk from you that i am very dissapointed in. R-ala has been a G_D send for my SFN!!! Burning, aching feet are moztly normal @1600mg.🎉❤
I believe it is important to take anti-oxidants in safe time intervals from workouts, i.e. two hours later and ALA in low dosage like 300 mg. This should give the body sufficient time to develop ITS own anti-oxidative strategy.
I have found I need non flush Niacin (250mg) per day as my blood sugar level was reading around 7 to 8 on the scale. It is now between 4 and 5. I started with 50mg per day and increased over two months until I found the right level for benefit.
High dosage is bad in any supplement; the key is moderation and use only when needed. You can also try planet ayurveda’s green essentials as a health supplement.
I would recommend she stop smoking. Also, drinking more than 1 UNIT of alcohol is generally harmful. I say unit because some people might think 32oz of vodka is 1 drink. Units are more accurate. It's minimally helpful to work on the little bit that ALA would help compared to the much more destructive issues.
@@Santa-ny1yp Of course, I recommend that, but she won't do it, so then what? What can I do to mitigate the damage? I have her taking Magnesium (malate), D3/K2, NAC, collagen (Glycine). Any advice?
@@Schu2505I would also add a good b complex vitamin or a multiple with it added. Especially thiamin and b-12. Alcohol really depletes b vitamins. Also, maybe milk thistle to try and support the detoxification of the liver. Also, vitamin c and e. A good multi vitamin would cover a lot of this. I would go with Thorne or Life Extension as she needs selenium, etc and smoking and drinking really take their toll on the body. The reality is that many people smoked and drink for years and some lived and still live to ripe old ages. My grandfather drank and smoked cigars and lived to 94 but ate very well and remained active. I know several older people who smoked and drank daily and lived until their 90’s but many grew their own produce and all were active. Our diet today and processed foods and stress really take their toll, I think. You’re a supportive partner and I wish you the best of luck.
Your video title confuses the average person because you discuss multiple studies showing ALA's benefits, especially when "Up To Date" recommends considering its use. A better title might have been "Consider Taking This Potent Antioxidant When Appropriate."
Do we know if all vitamin E can increase mortality or is there a difference between synthetic (dl-alpha tocopherol) and naturally occurring (d-alpha tocopherol) vitamin E?
Doc , i think you need to step down the dose a bit , we got an analogy overdose in this video. 2 to 3 analogies per video i would say is sufficient . BTW really appreciate your balanced content.
I’m pre-diabetic and have been diagnosed with fatty liver. I’ve been taking 240mg of the R form in the AM on an empty stomach. Is that enough or should I be taking more?
You said it Brad... "Focus on a nutrient dense diet"... Nothing beats...Diet, Exercise, sleep, stress control, social contacts,...the stuff known for millennia to be very good for us. After more than 4 decades in Pharmacy, with special interest in this, NONE of these 'wonder' supplements have stood the test of time...none. Thanks for the hard work on this as per usual and please ignore the ignoramuses!! They can be 'amusing' though...
yeah so basically eat well and do life style stuff.. age like our grandparents and die from terrible old age symptoms in nursing care.... yeah ... i'll take my supplements as well. i find it interesting that the ALA reduced lifespan. i question this study.... there's no reason that it should.
Food...the problem is..the soil...poor nutrients..not to mention glyphoshate. I remain a IGNORAMOUS. I've stood the test of time outliving most of my friends. Pharma has a very narrow window in my life. Its at times, a necessary evil. N please...theres no need for name calling
ALA 600 mg removes nerve pain in 10-20 minutes for me. Non diabetic occasional neuropathy feet, sometimes hand. Not every day, only when needed. Why buy prescription if this works, too much or empty stomach this can burn a little, but worth it when the neuro goes away.
Many ppl using ALA are doing so as a chelator for chronic heavy metal exposure (amalgams) due to genetic impairment of natural detox mechanisms (apoe4 most well known and also not coincidentally, highly correlated with Alzheimer's disease).
I find R-ALA helps with the after effects from a few different recreational drugs, including the more damaging ones such as Ethanol. I only take it in this context.
Most people eating crap, sugar and subject to environmental toxins are under a huge oxidant stress so it's not a concern to do too much. They need everything they can get their hands on.
@@samvandervelden8243 I'm 65 yrs old, on no prescription medication and ALL my blood markers are great. That's proof enough for me. My doctor who I only use to get my blood tests each year (30 to 50 individual tests) says I'm a unicorn. I tell him I'm educated and informed.
You haven't worked out the difference between an anti oxidant and an electron acceptor. Both are very different. If you understood this you'd know what to combine with it to increase lifespan.
@dollmck8360 An anti oxidant either binds to a substance in such a way as to improve its metabolism or disposal, or it cleaves off an electron to make a substance less reactive. This makes reactive substances less dangerous but also dumps a bunch of electrons into the electron transport chain. If there isn't enough NAD+ or other acceptors to soak these excess electrons, they convert into H2O2, and that depletes catalase in mitochondria and causes damage. Grey hair and fatty liver are usually the result. As well as an imbalance in NAD+ to NADh ratios linked to aging and metabolic disorder. Electron acceptors like NAD+, FAD, Alpha Lipoic Acid, Malate, Fumarate, and others can soak, transport, incorporate, or help the body utilize or dispose of excessive electrons. Especially if age related issues with mitochondrial membrane complexes happen. This is why too many anti oxidants can be dangerous; and why, arguably, all anti oxidant supplements should be cofactored with electron acceptors. Also, why people should be educated about the timing of their use, too. We have a proinflammatory growth phase during the day and an anti-inflammatory repair phase at night. Long comments like this usually get shadow banned for no apparent reason.
@dollmck8360 This is also why there are so many contradictory studies about vitamin E. Some show significant lifespan increases, some show significant decreases in lifespan. Comes down to the fact that vitamin E has powerful reductive abilities and produces a lot of electrons. If a person has mitochondrial membrane complex issues, a deficiency in electron acceptors, a pre-existing imbalance in NAD+ to NADh, or no existing issues, it could be beneficial or detrimental depending on the amount of excess electrons produced and how many acceptors are available to transport them.
@@zekeriasvarg530 - When the mitochondrial electron transport chain becomes overloaded or dysfunctional electrons can leak from the chain and react with molecular oxygen (O2) to form superoxide (O2•-) Superoxide is then rapidly converted to H2O2 by the enzyme superoxide dismutase (SOD) - Excess electrons can also lead to increased NADPH oxidase activity. NADPH oxidases use NADPH as an electron donor to reduce O2 to superoxide This superoxide is then converted to H2O2 by SOD. - Peroxisomes, which are involved in fatty acid metabolism, can also contribute to H2O2 production: During oxidation of very long chain fatty acids, excess electrons are transferred to O2, forming H2O2 as a byproduct
Reworded this to try to avoid random shadowbanning for no apparent reason. - When the mitochondrial electron transport chain becomes overloaded or dysfunctional electrons can leak from the chain and react with molecular oxygen (O2) to form superoxide (O2•-) Superoxide is then rapidly converted to H2O2 by the enzyme superoxide dismutase (SOD) - Excess electrons can also lead to increased NADPH oxidase activity. NADPH oxidases use NADPH as an electron donor to reduce O2 to superoxide This superoxide is then converted to H2O2 by SOD. - Peroxisomes, which are involved in fatty acid metabolism, can also contribute to H2O2 production: During oxidation of very long chain fatty acids, excess electrons are transferred to O2, forming H2O2 as a byproduct. There are a hundred more examples. Especially linked to the reduction of reactive species. Can't be bothered listing them all.
I kindly request recommendations for supplementation to mitigate dementia and Alzheimer’s in otherwise healthy people over 65: it runs in my family. And of course I know very well you can make no recommendations AT ALL to anyone specifically on here, or even generally. That’s not what I’m asking for. I would just appreciate a video on those subjects. Generally. Thank you as always!
@@tagne88 thanks: yep, I have my mom on that. Omega 3s; D3; multi …coq10 ubiquinol…life extension’s two “cognitex” formulas. It’s my impression creatine is increasingly seen as very useful in the aging population: both for maintaining body mass. And for cognitive protection.
I have been taking it due to MTHFR. Not sure if that’s the correct supplement (besides methylated bs) but I know that people with MTHFR don’t have bodies that can detox so well, so doesn’t R Lipoic help with that?
Hi Dr. Brad! How are supplements administered in studies? I assume that in mice, this is done by injection, but in human studies, I assume, people are given these in tablet form. I further assume that when taken in tablet form, the body assimilates from the digestive tract that which is needed - when available. So how exactly can a supplement (other than sugars which become assimilated whether they are necessary or not and acids which attack the intestinal lining) be harmful for/to the inner body outside of the digestive tract? at any event is there any clear evidence to support the notion of assimilation of many of the things we eat. at all,when we don't need them?
Mister Branfield , Bruce Ames made a lot of papers about the ALA and his benefits, notably to rejuvenate the brain in association witl n acetyl carnitine ,as always , you re looking for discussion and you re a real influencer for big pharma
Interestingly, dr.Stanfield even didn’t mention the research and the protocols for the liver treatment by Dr.Burt Berkson M.D.,Ph.D. Hmm… No further comments
But here in America they are killing us with our food. They came to realize that some of us were trying to eat healthy foods, so they started attacking that as well.
You think all antioxidants are generally bad for most people because they inhibit muscle growth from exercise. Yet, you're researching an mTor inhibitor. You know what an mTor inhibitor will do for muscle synthesis, right?
Dr. Stanfield is specifically testing Rapamycin with exercise to confirm or deny whether Rapamycin promotes muscle growth or not. He is doing this because animal models and anecdotal reports say that Rapamycin will facilitate muscle growth in older individuals despite it seeming like the opposite should be true.
@@DrBradStanfield about supplement- reaaally? My experience is that doctors here in Denmark know basically nothing about anything that is not medicine and do not believe in anything alternative.
@mettejensen8653 True. I will not talk to a doctor about supplements. One doctor told me once to get off all my supplements and didn't even tell me why🙃 😅 😂
Just take freshly ground ... at home ... Flex seeds or cold pressed flex seed oil which contains 7 gr ALA in 2 table spoons of oil. No need to take the "plastic fantastic" supplement! ❤😊❤
That is a different ALA altogether. ALA from flaxseed is alpha-linolenic acid, from an omega fat source and completely different than alpha lipoic acid.
I'm 55, post menopause, and I have Hashimoto's thyroiditis. I have Epstein-Barr antibodies. I have PCOS. I have carpal tunnel syndrome, lumbar stenosis and sciatica of the left leg. Long story short, I have most of the complications that accompany Hashimoto's and PCOS (NAFLD, etc). Among several other supplements to try to address symptoms, I take 300mg of R-lipoic acid each day. It will make your urine smell a little weird, FYI. 😅
I cannot agree with this video. My parents and I have been taking ALA for a long time, along with many other antioxidant supplements - without any issues. I have no medical problems and am in perfect health. Haven't ever had Covid, and not even flu or cold for over 10 years. I have perfect blood sugar levels, consistently good blood pressure (around 105 over 65). My resting heart rate is usually in the 50s. Also, look at how many Bryan Johnson takes per day without any issues and great test results, which he shares with the public.
That’s what I’m trying to figure out too, curcumin, astaxanthin, DHA/EPA, high antioxidant diet, specifically for MPS & hypertrophy I’m trying to figure out a balance to maximize muscle growth & minimize cancers etc, like I won’t take curcumin/pepper on a high resistance training day bc I don’t want to blunt gains. Excellent video thanks doc!!
@@FHer-kb7gb Not really, he does talk about lots of potential benefits of Astaxanthin in the video, but he ends by saying that it might not be a good idea to take it precisely because of the effect of strong antioxidants on blunting exercise response. That being said, I personally ended up deciding on taking Astaxanthin given the fact that one potential mechanism by which excessive antioxidants might be bad is because they blunt hormetic responses such as the Nrf2 pathway, but Astaxanthin was curiously found to be an activator of the Nrf2 pathway, which could counteract that, not to mention the potential benefits for eye and skin health that tipped of the scale in favor of taking it for me. That being said, until we get some studies directly evaluating the impact of Astaxanthin supplements on the response to resistance training, all cause mortality, etc. it is still entirely possible that I'm losing that "bet" and Astaxanthin is in fact a net negative for my health. Edit: The modest but statistically significant effect on mouse median and maximal lifespan on the ITP was also a factor on my decision, although that's only in mice and it could very well be the case that it is actually a net negative for humans. As Brad said, unless we have clear data from high quality large scale studies in humans, its always a bet to some degree.
I wonder about polyphenols, they have antioxidant properties, right? Dr Rhonda Patrick seem to believe they are beneficial. How about a video just to clarify that? 😁 I wonder if I should eat dark chocolate and my decaffeinated coffe everyday or not 😅
He has covered Finasteride, for prostate health. In fact, this is the channel where I first learned about it. Studies suggest a strong positive correlation with lifespan too. It doesn't only shrink the prostate, it seems to reduce the occurrence of prostate cancer.
@@serge747bglutathione goes down with age as do the production of two of its precursors- NAC and glycine. It is wise to give the body these precursors and let it produce and distribute glutathione throughout the body. Much better strategy than consuming antioxidants exogenously. I am 71 and take 9 grams of glycine and 2.4 grams of NAC a day. My inflammation as measured by the CRP test has dropped to almost undetectable levels. This doctor has separate videos on the use of Glynac and suggests increasing supplementation as one grows older and glutathione production goes down.
Whole foods >>> supplements
📜Roadmap - how to look young & feel strong: drstanfield.com/pages/roadmap
💊MicroVitamin (multivitamin & mineral that I take, in addition to a great diet): drstanfield.com/products/microvitamin
Dear doctor Stanfield,we need guidance on organic meat,organic fish,their contaminant levels and microplastic levels.Furthermore,congratulations on your newest addition to your family!Wish nothing but hapiness!
Psychedelics are just an exceptional mental health breakthrough. It's quite fascinating how effective they are against depression and anxiety. Saved my life.
Can you help with the reliable source I would really appreciate it. Many people talk about mushrooms and psychedelics but nobody talks about where to get them. Very hard to get a reliable source here in Australia. Really need!
Yes, Liberty_capss I have the same experience with anxiety, depression, PTSD and addiction and Mushrooms definitely made a huge huge difference to why am clean today.
Anxiety happens when you think you have to figure out everything all at once.
Breathe. You're strong. You got this Take it day by day.
Please, how do I reach him?
Is He on insta?
I'm pre-diabetic and have unexplained peripheral neuropathy, the only thing I can associate it with is blood glucose levels. ALA has been a wonder-supplement for me. I take 250mg each day without food and it reduces it by 90% at least, some days it's entirely gone. I eat a whole food diet that I cook myself and meal-plan regularly. My diet is really on-point, I exercise daily, but ALA seems to be the only thing that really makes a difference. If I don't take it, the neuropathy increases to a level where it is difficult to do my workouts due to both finger numbness and foot pain. ALA has been a godsend to me. I sure hope it's not doing more harm than good in the long run, because it has improved my life massively and allowed me to stay more active.
Look into a R-Lipoic Acid supplement. It has resolved my Neuropathy as well.
@@lynleflore4332 Indeed, (R) form is the best, i take it together with Nicotinamide Riboside empty stomach first thing in the morning, and i can be 12 hrs neuropathy pain free.
Yes 250 to 300mgs a day is great am a wellness coach and take it as well ..add biotin will be synergistic even 5 mgs
Have you tried acupuncture?
I have just started having neuropathy as well and came to the same conclusion that blood sugar is the cause. I am on the same type of diet. Any little bit of sugar and the pins and needles start.
I had neuropathy and took ALA for years,and now after a nerve test are showing that i do not have neuropathy any more.
What caused your large fiber nerve damage? Did you have demyelination?
I have interacted with patients who had acute inflammatory demyelination of the peripheral nerves as shown on nerve conduction studies. In time, their repeated studies were normal.
Some nerve damage will be repaired, such as sometimes seen in high toxicity of B6; low B12. Many factors are involved individually.
@ChuckNorris-lf6vo performace Lab energy
@ChuckNorris-lf6vo with R-Lipoic Acid. I follow strict diet also, paleo, and naw keto. No sugar,no glutten since these kills the nerves
@DrBradStanfield - also need to check out the study with ALA and multiple sclerosis! It was found that it significantly slowed down brain atrophy over a 1 year period by roughly 70% from what I remember.
Liver protective effects are fairly profound. I think the key is to avoid megadosing.
The key is to use the active R-ALA
There are people who have lived an active life till their nineties and have been taking ALA for decades. So you may not be entirely correct.
Correct...as opposed to the poison pregabalin/lyrica
He's not smart at all. He's not able to read studies imo.
One Hit & Two Misses: It took till the end of this video, but he finally said that the R-Lipoic-Acid isomer is superior to ALA…great. But his two misses are doozies. First, he recommends Pregabalin for neuropathic pain, but Pregabalin merely masks pain symptoms without addressing any cause. Second, he is broadly critical of antioxidants (and Vitamin-A in particular) because of Vit-A’s association with cancer. Importantly, Vitamin-A is an Angiogenic; meaning that it supports blood vessel growth. It’s this property (growing fresh blood supply into tumors) rather than its antioxidant properties that are the issue with Vitamin-A.
Also the study which says antioxidant coctail worsened Alzheimer disease had low amount of participants, the method was just a cognitive test and they don't go into details by how much worse it was. Most likely it doesn't affect Alzheimer at all, it was just a slight coincidence that this group performed worse, this is a progressive disease and severity can vary a lot in people.
The way he presented it will discourage many people from trying this supplement, which is unfair.
Good points! But WHAT helps regenerate nerves for idiopathic neuropathy patients?
@@ClassicalLiberalWarriorALA… 😊
Sad!!!!@@zekeriasvarg530
@@ClassicalLiberalWarriorvitamin B1 is what I’ve found most helpful. Benfotiamine is a fat soluble type & has helped over the years. I’m trying a more absorbable type now which I think may be more helpful TTFD.
My father was a triathlete my entire life. He trained religiously 3x per week and ate healthy. Yet died of a heart attack 2 years after retirement. He didn’t take vitamins or supplements. So don’t think exercise alone will extend your life or prevent heart attacks. I’d rather be safe than sorry and do both.
He just wasn't educated in supplements or in a much older generation that didn't take them. Whole foods are great but the soils are so depleted and chemtrails even contaminate organics.
I agree about 2 things in this video: More is not always better, and it has to be R-ALA. Always always buy the most active, natural forms.
800mg did nothin 1600mg SFN almost gone.
Interesting video with good depth. In addition to the uses mentioned, ALA may also have benefits in older people even who don't have significant chronic disorders, due to its activation of AMPK. I can't post links to papers, since RUclips doesn't allow that, but searching for "alpha lipoic acid AMPK" will turn up information on this. In general, some supplements should be evaluated not only along a disease/no-disease axis, but also along an age axis.
The only problem is most people are walking around with pre diabetes, insulin resistant, obesity etc so ALA in the doses recommended would be a benefit with less side affects than drugs, after all ALA is found naturally in our body and in food so I’ll take my chance with ALA then any prescription drug. But I do get what you’re saying. The only problem is finding perfect healthy people nowadays specially in the western world is hard to find.
exactly.. that's the thing.. notice how he said we have "better ways to treat " diabetes.. aks FDA approved BIG pharma CRAP that will rot out your body from the inside out... and line their pockets better. No.. i'd like to understand exactly how ALA might be responsible for decreased lifespan, because it makes zero sense whatsoever...
The study analyzed data from the Global Dietary Database, the World Bank and dietary surveys to estimate nutrient intake for 15 key vitamins and minerals across 185 countries. From these results, they found that more than 5 billion people globally are not getting enough iodine, vitamin E or calcium from their food, with more than 4 billion not getting enough iron.
That stuff damn near killed me. Now it makes sense. Thanks
For me 600 mg gave me issues. I now take 100 mg with my evening meal. It does wonders for my neuropathy from diabetes. I think I need to raise it to 150 or 200 mg.
A study using the antioxidants 'Vit C' and 'Vit E' in moderate amounts tested the effects it has on muscle gain. It found that it protected muscle from damage as a result of intense exercise and increasing recovery rates.
The issue is that it resulted in less than 60% in muscle adaptation.
In other words, building muscle was over 60% slower compared to placebo all from just 600mg of Vit C and 200mg of Vit E.
However it was found that consuming antioxidants from a natural source instead of supplement form; had no impact on muscle adaptation.
This is why I steer clear of antioxidants in supplements, damage is a requirement of building muscle.
A study on vitamin A & E and exercise showed that they stopped the improvement in insulin resistance that comes with exercise too.
@@Skelath 600 mg is 10x the daily requirement of Vitamin C while 200 mg of Vitamin E is 15x daily requirement.
They are mega doses.
Does it depend on when the supplements are taken or not? If they are taken closely (hour or two) after workout maybe they interfere more with muscle building, because you need the initial oxidation, but what if it's hours before a workout or perhaps 4-5 hours after working out?
@@josephjroy6593 Yeah, and Vit C is being sold in jumbo containers ranging from 500mg to 1000mg chewable tablets.
While Opti-Men multivitamin contains 300mg of Vit C and 160mg of Vit E.
@@Vladi2102 It's best to wait 5+ hrs after working out. The vitamin C was split into 2 doses of 500mg and the E was all in 1 dose. The other commenter is right, they are much bigger doses than in regular multivitamins (unless you buy the brands that use huge doses.)
Pregabalin may work better on average for neuropathy symptoms, but pregabalin has its own side effects, which some people can’t tolerate-such as marked grogginess and related cognitive impairment and fall risk.
because of how it affect b12 levels in the body
Thanks. I have my Dad, 82, who has Neuropathy working on his feet. I had him on 500mg of R-ALA in the morning and 500mg of R-ALA at night. I am going to drop it to 300mg AM, 300mg PM. I had a feeling 1000mg a day was a little strong. Good to see 600mg a day is all that may be needed. We will save a little and lower the supplement load. This came just in time. He only started 2 weeks ago.
The R version is more potent so even 600mg is too high! Alpha Lipoic Acid is less potent so up to 600mg is ok. L Arginine helps with flow
Have you been listening to too much Dr Standfield? Beware the power of suggestion in reading negativity into things.
@@theancientsancients1769 What do you suggest for AM and PM? It seemed like the study said 600mg showed best efficacy. I am not sure if it was the R version though. Good point made. I need to watch again for clarification. I have him on 5g Creatine and 4g of taurine a day also. Not for neuropathy, but for longevity and cognition.
@@JacquesTreehorn Most studies are based on Alpha Lipoic Acid and not R Lipoic Acid. R Lipoic Acid is more potent and better absorbed too. For Alpha Lipoic Acid 600mg max a day is fine as suggested in the video . Dr Stanfield mixed up things in terms of difference in dosage of the 2 variants. For R Lipoic Acid don't take more 300 max 150 to 250 max a day . Usually it's one pill . In terms of Creatine if his kidneys are healthy don't ever go more than 5mg. Bryan Johnson Blueprint stack the mix one has all that .
In terms of general health anti aging and high quality I can recommend Xtend life which I have used the past 20 years . They have incredible cardiovascular and circulation products and the owner is one of the few that walks the talk in anti aging supplements for 25 years. I gave my late dad the blood flow product which improved his uncontrollable blood pressure. Total balance may be something worthy of looking at too. It's like a one stop for well researched things before all this beginners knew what this things were about.
I was researching these things for 20 years started when I was 20 and always people thought I was at least 15 years younger than my age and I can't say it was a family thing as it was not the case for the other 6 siblings . But I always wanted to help people and see them not fall for the marketing hype as I had 2 parent who passed away from neurological conditions which I treated myself from those sources when medicine was ineffective.
I may be censored, but you can ask anything .
@@JacquesTreehorn you can use more creatine. 5g x2 a day. Do some current research. I upped mine.
Spinach is high in Oxalates.
Thank you, Dr. Stanfield! I often struggle to explain why anti-oxidants are not an unparalleled cure-all. The tight-rope metaphor is helpful to understand that dosing on anti-oxidants can actually be harmful.
Dr. Brad, I am 87 years and suffering from non-diabetic neuropathy and have nerve problem, and I am taking a combo vitamins in which a 600mg R-Alpha Lipoic Acid the best form is included. I am taking it for more than one year now and still taking it once a day. So should I stop taking it now? Your comment please.
Does R-ALA reduce numbness for you?
NO...if its hping continue. I also have non d SFN from covid. I take 800mg x 2 with alcar. Most of my burning feet is gone. I wlnt stop it though as it has other benefits rsp. Anti aging
Really good for nerve pain is PEA (palmitoylethanolamide). No side effects, lots of reliable research done. PEA is naturally produced within the body cells as a repair mechanism in response to pain and injury. A natural pain management supplement.
What is the best paper you know about on this?
@@NateB There are several. E g. "Palmitoylethanolamide in the treatment of chronic pain" (meta analyses), viz PubMed. It also helps when used topically in a cream (in combo with Boswelia or Ketamine). Especially on hands and feet.
@@NateB Sorry, tried to answer you but my answer has been removed. Don't know why. Search PubMed, plse
I use that too. Helps knee pain but R-ala is the wonna for SFN. Its a different pain...loss of mylin sheath.
Interesting. Thank you. I will come back and finish this.
Flax seeds, chia seeds, walnuts and many more are much better for lipid level than broccoli or spinach, also contain much more ala
Acety carnite and B vitamins really helps me study shows impressive glucose control
Most studies on ALA do not specify the form of acid they use. In particular, studies related to diabetes and MS. In most cases, this means using an acid consisting of an R+S form. Drugs sold in pharmacies for the treatment of diabetic neuropathy also do not indicate the composition of the acid in their instructions and have a dosage of 600 mg. If we assume that it is of the R+S form, then only ~50% of these 600 mg will be absorbed. Therefore, the recommendations of the dosage of the drug become unobvious.
You can buy the R form only.
The s form also inhibits the R form’s benefits. There is also a study that shows it lowers the lifespan of mice but it didn’t mention which form they use. I’m using r ala currently because I’m pre diabetic.
Do you prescribe Statins that destroy muscle tissue?
Yes he does. He even takes them himself. He says low dose statins don't cause muscle damage. 🤔🤷
What do you suggest for tinnitus ? Having a hard time with this. Heard this alpha lipoic acid could help.
I know one person who tried hypnosis, but I'm not sure how it went.
I hadn't heard one.
Great video. But here is the thing. Just as the analogy of tightrope of maintaining a balance of oxidants and antioxidants applies to certain supplements based on individual differences, same applies when you speak of certain foods or diets. Case in point, some people may have no issues other than argubaly raising their LDL/ApoB and laying down soft plaque from heavy consumption of meat, others could develop gout. The same with high oxylate foods that may be promoted as super healthy for everyone. However, for those prone to forming calcium oxylate kidney stones, these foods including almonds, spinach, chia seeds, black beans, and even cinnamon are best avoided. As an MD, I am sure you know how painful getting and passing these kidney stones can be. More important, recurrent development of kidney stones is known to contribute long term to Chronic kidney Disease, and in extreme cases kidney damage requiring removal of a kidney. Sadly, most people who develop kidney stones have no clue as to their inability to metabolize high oxylate foods until they land in the hospital with painful kidney stones for the first time. This happened to me, and it hapoens to lots of other people.
You mention "brush over" pregabalin/lyrica. You should discuss the harm this drug can do and how diff. It can be to stop it when experiencing side affects.
1st talk from you that i am very dissapointed in.
R-ala has been a G_D send for my SFN!!! Burning, aching feet are moztly normal @1600mg.🎉❤
I believe it is important to take anti-oxidants in safe time intervals from workouts, i.e. two hours later and ALA in low dosage like 300 mg. This should give the body sufficient time to develop ITS own anti-oxidative strategy.
I take it with ALCAR and it helps alot when I haven't slept well
I have found I need non flush Niacin (250mg) per day as my blood sugar level was reading around 7 to 8 on the scale. It is now between 4 and 5. I started with 50mg per day and increased over two months until I found the right level for benefit.
High dosage is bad in any supplement; the key is moderation and use only when needed. You can also try planet ayurveda’s green essentials as a health supplement.
R lipoic acjd works great for my neuropathy. 600mg daily.
Amazing and good to hear! Is your neuropathy diabetic or idiopathic?
My wife is a smoker, and she drinks 3 drinks per day. I recommended she take ALA (300 mg/day).
I would recommend she stop smoking. Also, drinking more than 1 UNIT of alcohol is generally harmful. I say unit because some people might think 32oz of vodka is 1 drink. Units are more accurate. It's minimally helpful to work on the little bit that ALA would help compared to the much more destructive issues.
@@Santa-ny1yp Of course, I recommend that, but she won't do it, so then what? What can I do to mitigate the damage? I have her taking Magnesium (malate), D3/K2, NAC, collagen (Glycine). Any advice?
@@Schu2505I would also add a good b complex vitamin or a multiple with it added. Especially thiamin and b-12. Alcohol really depletes b vitamins. Also, maybe milk thistle to try and support the detoxification of the liver. Also, vitamin c and e. A good multi vitamin would cover a lot of this. I would go with Thorne or Life Extension as she needs selenium, etc and smoking and drinking really take their toll on the body. The reality is that many people smoked and drink for years and some lived and still live to ripe old ages. My grandfather drank and smoked cigars and lived to 94 but ate very well and remained active. I know several older people who smoked and drank daily and lived until their 90’s but many grew their own produce and all were active. Our diet today and processed foods and stress really take their toll, I think. You’re a supportive partner and I wish you the best of luck.
@@cryptodeath854 thanks!
Nicotine patch?
completely agree with your opinion about balance between oxidant and antioxident.
Everyone always focuses on diabetic neuropathy; what about other forms such as GBS/CIDP?
The word is oxi..da...tive...not oxi...tive...you are skipping a syllable, Doc.
What about those with auto immune diseases and chronic inflammation?
Your video title confuses the average person because you discuss multiple studies showing ALA's benefits, especially when "Up To Date" recommends considering its use. A better title might have been "Consider Taking This Potent Antioxidant When Appropriate."
He got you to watch it n thats all he cares about. Om VERY dissapointed in where he is NOW. Fo me once...he's off my radar. 😢
❤
Do we know if all vitamin E can increase mortality or is there a difference between synthetic (dl-alpha tocopherol) and naturally occurring (d-alpha tocopherol) vitamin E?
Spinach is very high in oxolates. I no longer eat it.
Hey doc when is your microvitsmin set to deliver again. It stopped for a little while right
If you smoke then taking more antioxidants should help reduce a lot of the negative effects
Doc , i think you need to step down the dose a bit , we got an analogy overdose in this video. 2 to 3 analogies per video i would say is sufficient . BTW really appreciate your balanced content.
I’m pre-diabetic and have been diagnosed with fatty liver. I’ve been taking 240mg of the R form in the AM on an empty stomach. Is that enough or should I be taking more?
I have been taken it for 40 years it’s the best never has an issue Parma is fighting it cus it works
You said it Brad...
"Focus on a nutrient dense diet"...
Nothing beats...Diet, Exercise, sleep, stress control, social contacts,...the stuff known for millennia to be very good for us.
After more than 4 decades in Pharmacy, with special interest in this, NONE of these 'wonder' supplements have stood the test of time...none.
Thanks for the hard work on this as per usual and please ignore the ignoramuses!!
They can be 'amusing' though...
yeah so basically eat well and do life style stuff.. age like our grandparents and die from terrible old age symptoms in nursing care.... yeah ... i'll take my supplements as well. i find it interesting that the ALA reduced lifespan. i question this study.... there's no reason that it should.
Food...the problem is..the soil...poor nutrients..not to mention glyphoshate. I remain a IGNORAMOUS. I've stood the test of time outliving most of my friends. Pharma has a very narrow window in my life. Its at times, a necessary evil. N please...theres no need for name calling
ALA 600 mg removes nerve pain in 10-20 minutes for me. Non diabetic occasional neuropathy feet, sometimes hand. Not every day, only when needed. Why buy prescription if this works, too much or empty stomach this can burn a little, but worth it when the neuro goes away.
Many ppl using ALA are doing so as a chelator for chronic heavy metal exposure (amalgams) due to genetic impairment of natural detox mechanisms (apoe4 most well known and also not coincidentally, highly correlated with Alzheimer's disease).
Too much antioxidants?? What are the effects
I take Na-R-ALA when doing MDMA to reduce oxidative stress from it and its neurotoxicity. It works wonders with Mg.
MDMA?! lol
I find R-ALA helps with the after effects from a few different recreational drugs, including the more damaging ones such as Ethanol. I only take it in this context.
Would this be the same with GlyNAC?
That tight rope clip is anxious producing. Thanks for video.
Anti-oxidation rich foods are the way to go.
👍 The tight rope is an apt metaphor.
Most people eating crap, sugar and subject to environmental toxins are under a huge oxidant stress so it's not a concern to do too much. They need everything they can get their hands on.
Where is the evidence that this actually leads to better health outcomes?
@@samvandervelden8243 I'm 65 yrs old, on no prescription medication and ALL my blood markers are great. That's proof enough for me. My doctor who I only use to get my blood tests each year (30 to 50 individual tests) says I'm a unicorn. I tell him I'm educated and informed.
You haven't worked out the difference between an anti oxidant and an electron acceptor.
Both are very different.
If you understood this you'd know what to combine with it to increase lifespan.
Do tell...
@dollmck8360 An anti oxidant either binds to a substance in such a way as to improve its metabolism or disposal, or it cleaves off an electron to make a substance less reactive.
This makes reactive substances less dangerous but also dumps a bunch of electrons into the electron transport chain.
If there isn't enough NAD+ or other acceptors to soak these excess electrons, they convert into H2O2, and that depletes catalase in mitochondria and causes damage. Grey hair and fatty liver are usually the result. As well as an imbalance in NAD+ to NADh ratios linked to aging and metabolic disorder.
Electron acceptors like NAD+, FAD, Alpha Lipoic Acid, Malate, Fumarate, and others can soak, transport, incorporate, or help the body utilize or dispose of excessive electrons. Especially if age related issues with mitochondrial membrane complexes happen.
This is why too many anti oxidants can be dangerous; and why, arguably, all anti oxidant supplements should be cofactored with electron acceptors.
Also, why people should be educated about the timing of their use, too. We have a proinflammatory growth phase during the day and an anti-inflammatory repair phase at night.
Long comments like this usually get shadow banned for no apparent reason.
@dollmck8360 This is also why there are so many contradictory studies about vitamin E.
Some show significant lifespan increases, some show significant decreases in lifespan.
Comes down to the fact that vitamin E has powerful reductive abilities and produces a lot of electrons.
If a person has mitochondrial membrane complex issues, a deficiency in electron acceptors, a pre-existing imbalance in NAD+ to NADh, or no existing issues, it could be beneficial or detrimental depending on the amount of excess electrons produced and how many acceptors are available to transport them.
@@zekeriasvarg530
- When the mitochondrial electron transport chain becomes overloaded or dysfunctional electrons can leak from the chain and react with molecular oxygen (O2) to form superoxide (O2•-)
Superoxide is then rapidly converted to H2O2 by the enzyme superoxide dismutase (SOD)
- Excess electrons can also lead to increased NADPH oxidase activity.
NADPH oxidases use NADPH as an electron donor to reduce O2 to superoxide
This superoxide is then converted to H2O2 by SOD.
- Peroxisomes, which are involved in fatty acid metabolism, can also contribute to H2O2 production:
During oxidation of very long chain fatty acids, excess electrons are transferred to O2, forming H2O2 as a byproduct
Reworded this to try to avoid random shadowbanning for no apparent reason.
- When the mitochondrial electron transport chain becomes overloaded or dysfunctional electrons can leak from the chain and react with molecular oxygen (O2) to form superoxide (O2•-)
Superoxide is then rapidly converted to H2O2 by the enzyme superoxide dismutase (SOD)
- Excess electrons can also lead to increased NADPH oxidase activity.
NADPH oxidases use NADPH as an electron donor to reduce O2 to superoxide
This superoxide is then converted to H2O2 by SOD.
- Peroxisomes, which are involved in fatty acid metabolism, can also contribute to H2O2 production:
During oxidation of very long chain fatty acids, excess electrons are transferred to O2, forming H2O2 as a byproduct.
There are a hundred more examples. Especially linked to the reduction of reactive species. Can't be bothered listing them all.
Isn't ALA recommended for thos people who are G6PD deficient and have slightly compromised immune systems?
I kindly request recommendations for supplementation to mitigate dementia and Alzheimer’s in otherwise healthy people over 65: it runs in my family.
And of course I know very well you can make no recommendations AT ALL to anyone specifically on here, or even generally. That’s not what I’m asking for.
I would just appreciate a video on those subjects. Generally.
Thank you as always!
Magnesium L threonate is excellent for cognition. It had been showed to improve cognition in early dementia patients. It is also neuroprotective
@@tagne88 thanks: yep, I have my mom on that. Omega 3s; D3; multi …coq10 ubiquinol…life extension’s two “cognitex” formulas.
It’s my impression creatine is increasingly seen as very useful in the aging population: both for maintaining body mass. And for cognitive protection.
Tocotrienols show benefit in RCTs
Doesn’t Berberine help diabetics as well? Which is better? Can it be taken with ALA? Thanks!
How do you do the 3D zoom on the scientific paper at @8:18?
I have been taking it due to MTHFR. Not sure if that’s the correct supplement (besides methylated bs) but I know that people with MTHFR don’t have bodies that can detox so well, so doesn’t R Lipoic help with that?
1800mg of ALA protects against the inflammatory stress of smoking and cystic fibrosis
Hi Dr. Brad! How are supplements administered in studies? I assume that in mice, this is done by injection, but in human studies, I assume, people are given these in tablet form. I further assume that when taken in tablet form, the body assimilates from the digestive tract that which is needed - when available. So how exactly can a supplement (other than sugars which become assimilated whether they are necessary or not and acids which attack the intestinal lining) be harmful for/to the inner body outside of the digestive tract? at any event is there any clear evidence to support the notion of assimilation of many of the things we eat. at all,when we don't need them?
i take NA-r-ala its better then any other form
Mister Branfield , Bruce Ames made a lot of papers about the ALA and his benefits, notably to rejuvenate the brain in association witl n acetyl carnitine ,as always , you re looking for discussion and you re a real influencer for big pharma
Interestingly, dr.Stanfield even didn’t mention the research and the protocols for the liver treatment by Dr.Burt Berkson M.D.,Ph.D. Hmm… No further comments
Ah pity I can't get hold of your MicroVitamin in South Africa😭
It always seems like a prescription drug versus OTC. We don't have access to the prescription drug!
But here in America they are killing us with our food. They came to realize that some of us were trying to eat healthy foods, so they started attacking that as well.
Never heard of that ALA, only heard of the other ALA.
You think all antioxidants are generally bad for most people because they inhibit muscle growth from exercise. Yet, you're researching an mTor inhibitor. You know what an mTor inhibitor will do for muscle synthesis, right?
Dr. Stanfield is specifically testing Rapamycin with exercise to confirm or deny whether Rapamycin promotes muscle growth or not. He is doing this because animal models and anecdotal reports say that Rapamycin will facilitate muscle growth in older individuals despite it seeming like the opposite should be true.
Who do i believe? Dr. Brad or Thomas DeLauer? 🙄
Neither 😀
Instead I’d suggest to discuss your health with your primary care physician
@@DrBradStanfield about supplement- reaaally? My experience is that doctors here in Denmark know basically nothing about anything that is not medicine and do not believe in anything alternative.
I go with Thomas DeLauer
@@mettejensen8653 Why?
@mettejensen8653 True. I will not talk to a doctor about supplements. One doctor told me once to get off all my supplements and didn't even tell me why🙃 😅 😂
Just take freshly ground ... at home ... Flex seeds or cold pressed flex seed oil which contains 7 gr ALA in 2 table spoons of oil.
No need to take the "plastic fantastic" supplement!
❤😊❤
That is a different ALA altogether. ALA from flaxseed is alpha-linolenic acid, from an omega fat source and completely different than alpha lipoic acid.
What are your thought on astaxanthine? Very potent antioxydant
Who cares what he thinks?
I'm 55, post menopause, and I have Hashimoto's thyroiditis. I have Epstein-Barr antibodies. I have PCOS. I have carpal tunnel syndrome, lumbar stenosis and sciatica of the left leg. Long story short, I have most of the complications that accompany Hashimoto's and PCOS (NAFLD, etc). Among several other supplements to try to address symptoms, I take 300mg of R-lipoic acid each day. It will make your urine smell a little weird,
FYI. 😅
I use it because I have MS and along with acetyl l-carnitine. It helped with fatigue.
It burns my stomach like battery acid
There are very few antioxidants eg lipoic acid which work in mitochondria
How about read some of the many studies done by Bergson.
I cannot agree with this video. My parents and I have been taking ALA for a long time, along with many other antioxidant supplements - without any issues. I have no medical problems and am in perfect health. Haven't ever had Covid, and not even flu or cold for over 10 years. I have perfect blood sugar levels, consistently good blood pressure (around 105 over 65). My resting heart rate is usually in the 50s. Also, look at how many Bryan Johnson takes per day without any issues and great test results, which he shares with the public.
I have some that I never started taking just because of this question. Thanks!
Doc, no pasa lo mismo con la vitamina C y Astaxantina, los dos mejores y mas potentes antioxidantes que existen.
Astaxanthin?
he did a video on it a few months back
video here: ruclips.net/video/h3xndciLidM/видео.html
That’s what I’m trying to figure out too, curcumin, astaxanthin, DHA/EPA, high antioxidant diet, specifically for MPS & hypertrophy I’m trying to figure out a balance to maximize muscle growth & minimize cancers etc, like I won’t take curcumin/pepper on a high resistance training day bc I don’t want to blunt gains. Excellent video thanks doc!!
Asta is great. I'll take it forever. One of the best out there.
@@FHer-kb7gb Not really, he does talk about lots of potential benefits of Astaxanthin in the video, but he ends by saying that it might not be a good idea to take it precisely because of the effect of strong antioxidants on blunting exercise response. That being said, I personally ended up deciding on taking Astaxanthin given the fact that one potential mechanism by which excessive antioxidants might be bad is because they blunt hormetic responses such as the Nrf2 pathway, but Astaxanthin was curiously found to be an activator of the Nrf2 pathway, which could counteract that, not to mention the potential benefits for eye and skin health that tipped of the scale in favor of taking it for me. That being said, until we get some studies directly evaluating the impact of Astaxanthin supplements on the response to resistance training, all cause mortality, etc. it is still entirely possible that I'm losing that "bet" and Astaxanthin is in fact a net negative for my health.
Edit: The modest but statistically significant effect on mouse median and maximal lifespan on the ITP was also a factor on my decision, although that's only in mice and it could very well be the case that it is actually a net negative for humans. As Brad said, unless we have clear data from high quality large scale studies in humans, its always a bet to some degree.
I wonder about polyphenols, they have antioxidant properties, right?
Dr Rhonda Patrick seem to believe they are beneficial.
How about a video just to clarify that? 😁
I wonder if I should eat dark chocolate and my decaffeinated coffe everyday or not 😅
better not 😀
I’ve been taking ALA as recommended by my plastic surgeon for hair growth. Works great for me
yea dont stop. this guy is just desperate for content he'd rather put out fake garbage than actually something informative
If you're happy to sacrifice some of your life for hair, good on you! Nothing wrong with that.
@@medicallyenhancedThe information presented is supported by medical literature as demonstrated in the presentation.
@@medicallyenhanced I am not allowed to like your words, WOW- who is resposible for that
How many mgs for hair growth? How long before, you could see progress?
Hey Doc, is NAC recommended for 24 year old? Any muscle atrophy or such side effects?
Why does a 24 year old watch this channel? Come back when you are at least in your 30s. lol
NAC is a precursor. It's fine.
Maybe that was why my muscles got so weak . During covid I was popping high doses of vit C !
4:55 Blood sugar levels are not the root cause. They are an effect of metabolic issues still poorly understood.
Wrong. Funded by big pharmaceutical much???
What about NAC and CQ10?
what about graviola?
I thought Metabolic Syndrome and Diabetes t2 were basically the same disease, at different stages of progression. Aren't they?
Doctor - share your view please on Finasteride and Dutasteride for hair loss?
He has covered Finasteride, for prostate health. In fact, this is the channel where I first learned about it. Studies suggest a strong positive correlation with lifespan too. It doesn't only shrink the prostate, it seems to reduce the occurrence of prostate cancer.
JUST STOP EATING SUGAR.
Time to make this guy irrelevant … spreads only scare tactics
What about NAC?
NAC is not an antioxydant but a precursor, your body use it with Glycine to produce the Gluthatione it needs, so not a problem.
@@serge747bglutathione goes down with age as do the production of two of its precursors- NAC and glycine. It is wise to give the body these precursors and let it produce and distribute glutathione throughout the body. Much better strategy than consuming antioxidants exogenously. I am 71 and take 9 grams of glycine and 2.4 grams of NAC a day. My inflammation as measured by the CRP test has dropped to almost undetectable levels. This doctor has separate videos on the use of Glynac and suggests increasing supplementation as one grows older and glutathione production goes down.