A whopping 28 studies are referenced in this video, and all are linked in the video's description 💊MicroVitamin (multivitamin & mineral that I take): drstanfield.com/products/microvitamin 📜Roadmap - how to look young & feel strong: drstanfield.com/pages/roadmap
do we know what is the mechanism behind these age related changes such as decreased GSH levels, or decreased creatine as we age? i feel like its great we are supplementing creatine etc bc levels are reduced as we age, but i feel like its also a bandaid, if we can target more upstream that be amazing.
Both Creatine and TMG are involved in methylation. Methylation is the correlation. GAA needs to be methylated and TMG remethylates homocysteine back into methionine. Under methylation and over methylation affect whether these supplements will help or harm. Research methylation.
What do you think about the idea that if you consume sulfur-bearing foods (greens like arugula, broccoli) garlic it's adequate to promote methylation? Mushrooms and turmeric are also promoted for this.
In over a decade of trying different suppliments and accumulating an entire shelf full of bottles, there's only a few that gave me noticeable results. And yes, I'm aware that when it comes to nutrition, it can take time to realize change. So there are things like magnesium that are quiet helpers in the background. I'm focusing here on noticeable improvements. Vitamin D got me out of bed, parted the clouds, and reset my circadian rhythm. It may have slightly impacted other hormones like testosterone, but nonetheless, it was a significant catalyst. Methylated B vitamins w/choline & TMG reversed a deficiency that I didn't know I had due to a keto diet by growing back my fingerprints and bringing my skin back into good vibrant health. Thirdly, it is supplimenting with garlic. Yes, garlic supplimentation has stopped all allergies, colds & flu's whatever for going on a year now. I was a sick 4 times a year person, but not anymore. While everyone around me gets sick over and over, I keep on going. Garlic also has the added benefit of lowering blood pressure. Yes, I know that all the focus has been on glycine w/ NAC, and I took them for the entire year prior to this recent year with garlic. The glynac didn't hold any water to the benefits I get from garlic. I still got sick, and it didn't seem to shorten the duration. I'm 49 btw, so glynac should have made a difference. I still use glycine as a sweetner and take magnesium glycinate periodically, but NAC was not the powerhouse that simple humble garlic turned out to be. I do take Taurine and other things, fish oil, creatine, etc. but with these, it's more like going on faith than having noticeable results. I hope this helps.
When I was in my 20’s & 30’s L-Arginine was massive for me I’ve always kept fit and it was an absolute game changer then tapered off in my 40’s because of the Ariginsse enzyme decreasing
The Ca-AKG has some benefits. I found that it darkened my hair and took the colour back about 10 years. There is also some evidence that it helps to reduce fragility as we age. It may not work on mice but it might have benefits for humans.
@xenia_2385 There’s this thing called an “online search.” It’s pretty easy. You can do it using the same equipment you used to type your comment. And in less time than it took you to type your comment. Crazy, right?Good luck!
@@noah5291 yeah plant protein was better longevity in the relevant study. There are lots of cohort studies and some rcts linking red meat with increased heart disease risk
I believe it was announced at ASCO Annual that a study is recruiting 60 colorectal cancer patients ages 18 to 40 with no family history of the disease to see if taurine feeds H2S-metabolizing bacteria, which has been linked to increased incidences of colorectal cancer. Thoughts?
Dr. Brad - thoughts on making your vitamins into just a bulk powder with a little scooper in it that we can eventually purchase instead of the pills? More cost effective for customers and your cost to produce and....some of us also hate pills and prefer the powder route. thanks!
In my experience when I take creatine I get random bald spots. When I stop taking it , the bald spots go away. This is just my experience, I still take creatine every day , for me the the benefits out way the negatives.
Someone should do a study on all popular supplements, where scientific findings and subjective experiences (anecdotal evidence) are summarized and compared. My impression is that there is sometimes a strong contradiction, i.e. that a certain supplement seems to help many people, while pure science tends to speak against it. I don't think we should simply disregard people's experiences and take scientific findings as absolute.
They are ultra low in lucine and do not count as a protein in diet by itself. Without lucine the body won't synthesize protein. And consuming collagen in peptide form will produce collagen repair and growth signaling to the body. Whatever uses the least energy will be the path the body chooses. For example, even if the body is not in ketosis if you consume c8 MCT oil the liver will still make it into ketones because it uses the least energy.
@@StevenBrener I don't count it. But to be fair in high enough doses it may. Collagen is not cheap. Eggs are cheap. Whey protein concentrate is cheap. Ground beef is pretty cheap. Chicken quarters are cheap. Cheaper does not always mean worse. I would get my protein from these sources And use collagen peptides as a supplement. Collagen is in the membrane of eggs that skin around a boiled egg under the shell. It's in connective tissue in meat it's in skin and bone marrow, stuff you can make bone broth out of chicken feet are a good source or soup bones from cows. But consuming 10-15g of collagen by itself will generate collagen signals to the body and your body will assimilate it basically as it is with minimal breaking down to save energy.
We should. Get a balanced dose of nutrients ..too much of anything touted as best or good is harmful ....there are other factors to consider like ones blood profile, genetic. Background , etc ...we still need to know further how on a cellular level how the dynamics of these substances works ...
Would you be able to recommend a brown rice protein powder or pea protein powder. I’m worried about heavy metals in protein powders. Is that something to worry about? Thank you for all your work on these videos!
For the muscle benefits it should be way more than 500mg, also another new effect of TMG is that helps with fat loss in high doses and prevent fat stores when eating in a surplus, but for overall health 500mg of TMG may be enough, thanks for the video.
@@5kribbles there's still more studies to be done, but the current research shows from 4gr to 8gr or so for the muscle building and storing less fat during a surplus, the side effects include diarrhea and vomiting, and some people also become a little lethargic, but there are some studies with even higher doses, as much as 15 grams and it still safe for health, so you could try with 3 gr and then maybe increasing to 5 or 6 grams, it my case I take aprox 6 gr daily without any side effect and I think is true, but I'm still checking with myself the results in the medium to long term if I gained more muscle than normal, but as I said, there's more studies to be done regarding the muscle building and storing less fat. Best
Yerba Prima organic whole psyllium husk for the win! When I started taking 1 tablespoon a day of this it had amazing benefits on my gut and mood health.
Does psyllium husk provide any further benefit when the diet is already very high in fiber, including fiber from fruits, vegetables and grains like oats bran?
I really like the reasonable thinking here. I actually started one list of supplements for healthspan and one for lifespan, each with tier 1 to 5, 1 being the best with very good safety and efficacy profile. So far there is not a single supplement in the tier 1 for longevity.
I know that you need an equal dose of glycine with the NAC in order to help insure your body will synthesize glutathione from the GlyNAC combo (assuming your body won't make enough glycine on its own which is estimated to be a 3 gram limit). So I try to get a GlyNAC supplement or get NAC & glycine separately & do the equal dosing myself. I suppose it would be too much to hope for that the glycine in TMG (TriMethylGlycine) could be used by the body with the NAC to make glutathione. It sounds like you would need TMG & glycine separately to serve the different purposes rather than just take TMG & cross your fingers hoping it will also help make glutathione from the NAC
Creatine makes my skin itch a lot, and mostly over my back. I've tried it several times, avoided it for a few weeks then taken a lower dose. It simply does not agree with me and I'm not sure that this extended itching is not a sign of something deeper. I'm keeping clear.
It is always good at least yearly to get fairly complete blood work, and look at the results. You want to stay on top of liver and kidney health, inflammation, and metabolic health like A1C. Liver problems can cause itches, but so can many other things. I believe we can do things about kidney and liver health because I have.
I read somewhere that tmg increases creatine levels but I can no longer find the source again. I wish someone does research to see if beatine hydrochloride could be this super multipurpose supplement: homocysteine/methyl groups, creatine/muscle and then eventually glycine and of course gut health as per its original function.
Excellent video, as always! I pretty much follow all of your recommendations. The only one I have not taken is TMG, because I was waiting for the research to hit a certain level of proof. Looks like we are there now! I'm a weight-lifter, like you. For acute exercise benefits, I wonder if you could cover the following supplements: - Beta-alanine - Tyrosene
Great podcast Brad! I take 1000mg Glycine and 1200mg NAC daily and it has transformed my asthma. I am finding it difficult to get the required amount of protein daily but I will increase slowly as I change meal plans and add powders etc for their boost. Best Wishes!
Great review, Brad. When I first started taking creatine on an irregular basis more than a decade ago, I had no idea of its multiple benefits. Now it's a regular part of my stack. The thing I'm having trouble getting my head around is the 1.6+ g/kg of protein. At 90 kg, 1.6 means 144 g/day. Given that I don't eat meat, even with two protein smoothies a day, I'm luck to ingest 120 g/day. And yet, I'm pretty muscular, given my 4x/wk resistance training schedule. Re leucine, yes it's the most impt amino acid for muscle protein synthesis, but it also boosts mTOR. I don't want mTOR elevated all the time, so I only ingest whey after workouts, and the rest of the time my protein comes from legumes, yogurt and plant-based protein powders. Keep up the good work, Brad -- you've been very helpful to my quest to "live long and strong". 🙂
Thanks so much. I'll add that I personally use Alpha Ketoglutaric acid for mental health, and alpha ketoglutarate for its nitric oxide-producing effects (I find these not to act the same as each other for me). I don't take them for muscle or longevity, but rather quality of life, and find I must have them on hand, and take them prn, about 4 times per week. PS - I take TMG as an really effective adjunct to ADHD meds, which I heard about trying from Gary Brecka's work, and I was shocked to find it really did work.
Does the TMG have to be taken pre-workout to get the benefit? Also: if I’m already taking glycine at night for sleep, will adding TMG provide any additional benefit?
Just starting to take Creatine. 5 days of upload phase and now 5g per day, but no one told me that diarrhea would be the side effect. Apparently, it affects 1/3 of people taking it, and during the upload phase, it is even worse!
Although I do feel good on Tmg 500mg for the first day or two, it eventually makes me horribly agitated. Same with methyl b complex. Possibly due to overmethylation. I just wish I could find a lower dose of these supplements to find my sweet spot.
Tmg makes me nauseous and insanely lethargic after a few days of taking it, and then I eventually start throwing up. Took me forever to figure out what it was that was doing that to me. Any ideas why that would happen? Too many methyl groups or a back up in my detox pathway?
Thanks for the great video doctor. It does seem that taurine should be on the list. I also take NAC, and magnesium glycinate, so I should have my glutathione precursors covered
@@shubhamvibhuti The glycine content in collagen can vary, but on average, collagen contains about 20-22% glycine by weight. To calculate the amount of glycine in 15 grams of collagen, you can use this average percentage. For 15 grams of collagen, there are approximately 3 grams of glycine in 15 grams of collagen. The recommended daily intake of glycine is not well-established with an official guideline, but some research and expert recommendations suggest that an intake of around 3-5 grams per day could be beneficial for various health purposes. Glycine is considered safe, and the body can handle higher amounts without adverse effects. Personally, I'll raise my intake of collagen to 15 grams. That will cover the minimum intake of glycine.
The glyNAC makes sense. I have taken a product that includes Optiac, which is Japanese manufactured glutathione, because sone people have trouble making glutathione from NAC. They’re likely missing the glycine. I used to take more of these, but I’m kind of pilled out. I added another supplement during the pandemic that body builders use for vascularity. Maybe I’ll drop it though since I’m less afraid of my lungs getting destroyed.
Is there any reason to consume psyllium husk if you eat 125 grams/day of fiber? Anything special about it compared to the fiber in legumes, oats, veggies, fruits? 3 to 5 grams sounds miniscule.
Dr Brad, In your videos you reference that you would start taking certain supplements over 50 years of age. Have you ever considered having an over 50 version of micro vitamin?
I found 2 studies that measured glutathione levels in older adults, one was a group of masters athletes and another was a group that were put on a rigorous exercise program of cardio and resistance training. In both groups glutathione levels were much higher than in sedentary older individuals, nearly at levels of young adults. It’s only 2 studies but my hypothesis is that lower levels of glutathione with aging are an indication of being sedentary and not primarily of aging. In the Glynac studies the subjects were all sedentary and overweight.
Melatonin regulates sleep. Why would you take away your bodies control of your sleep? When I could not sleep and took melatonin it would eventually work but only for 4 hours. I was guaranteed to wake up to early after falling asleep too late. If sleep is the motive then 5htp is a better option. It supplies the body with material that is simple for it to convert to melatonin as needed. No more waking up early. Alternatively tryptophan could be used since it is the building block of both but I have not tried it enough to conclude anything. I fasted for 17 days and could not sleep thinking it was normal. I did the research and found the body needs tryptophan to make melatonin. But I ended the fast to soon to know if it was effective to take while fasting.
Well.. While supplementing with creatine might be harmless, creatine itself can be dangerous. Had a friend who went into the emergency room due to having too high levels of creatine. (But he's a powerlifter, so his body composition is extreme)
I still think it’s sketchy that the study that was being done on creatines relation to hair loss around 2021 was never released. Instead a meta analysis was released, which did claim there wasn’t a connection - but there aren’t any studies that’s chalky specifically looked at that, which to me calls that meta analysis into question. At least unless I missed one.
I've tested creatine 3 times on myself...PSA goes up....stop for 3 mths, retest, PSA drops back to previous. Whatever the "safe study findings" say...I don't think it suits me! (do have bph)
@@Drgluee I have that also though I can't say I noticed a connection between them and creatine usage, but it's possible since they tend to come and go and I might have not connected the dots.
@@dden7670 I'm not sure what I did, but it has been at least over a year and I haven't felt any noticeable PVCs since. But when I was taking creatine, I would have them longer and more intense. I tried cycling off and would have less and then back on and they would increase again.. But I haven't touched creatine for at least a year and a half.
I googled that and this came up: May have a positive impact on BPH Benign Prostatic Hyperplasia (BPH) : Creatine supplementation may have a positive impact on BPH, a non-cancerous enlargement of the prostate gland. It may help improve urinary symptoms associated with BPH.
Hi! Do you offer private/remote consultations? We would be very much interested in having regular consultations with you, but we are in the US. Thank you
I may drop ca-akg, particularly cause it has calcium and I don't think one should be taking calcium in supplements. That said after the intervention program used synthetic megadose of astaxanthin instead of regular dose natural astaxanthin I've grown suspicious of them.
He is not the first to have done gene therapy! A lady from a science company did set the trend,I forgot that blond woman name 😅. It was before the pandemic. She started to look younger even
Caffeine is by far the most effective and safest athletic performance supplement that currently exists. (unless you have some genetic configuration that makes you insensitive to it) The only problem is you can't use it every day or you'll become resistant to it.
You should check out the work of Paul Jaminet (Perfect Health Diet). He's nailed down the necessary human diet and which supplements might be needed based on what you do or don't eat. I'm surprised you don't mention egg yolks.
Of course the collagen peptides will be more effecitve than a random protein powder. The interesting and relevant question is, would a mixture of amino acids in the same proportions as present in collagen peptides have the same effect as collagen.
Collagen peptides are incomplete proteins and collagen peptides signal to the body to repair and make collagen. Protein powder is superior to collagen peptides for muscle growth infinitely.
A whopping 28 studies are referenced in this video, and all are linked in the video's description
💊MicroVitamin (multivitamin & mineral that I take): drstanfield.com/products/microvitamin
📜Roadmap - how to look young & feel strong: drstanfield.com/pages/roadmap
SOY SURELY IS PHYTO ESTROGEN.. ANY VITAMIN , MINERAL PROVEN TO BE EFFECTIVE? I HAVE NOT COME ACROSS ANY CONCLUSIVE STUDY.
How many supplements do you take each day ? And what are they ?
do we know what is the mechanism behind these age related changes such as decreased GSH levels, or decreased creatine as we age? i feel like its great we are supplementing creatine etc bc levels are reduced as we age, but i feel like its also a bandaid, if we can target more upstream that be amazing.
Can study forever Young?
This is health function goes.
Human can imagine things will happen in the future.
1. Creatine
2. Protein
3. TMG (Betaine)
4. Multi vitamin and mineral
5. Omega3 fatty acids (EPA, DHA)
6. Psyllium husk (fiber)
7. Collagen peptides
8. Hyaluronic acid
9. Melatonin
10. Glycine+NAC (for 45yo+)
You are a hero.
❤
What about vit D
I wish a good look to your stomach and liver digesting this on a daily basis. I am sure we will watch in a few years to come about bowel cancers etc.
@@sylvia8112 what?
Both Creatine and TMG are involved in methylation. Methylation is the correlation. GAA needs to be methylated and TMG remethylates homocysteine back into methionine. Under methylation and over methylation affect whether these supplements will help or harm. Research methylation.
What do you think about the idea that if you consume sulfur-bearing foods (greens like arugula, broccoli) garlic it's adequate to promote methylation? Mushrooms and turmeric are also promoted for this.
@@MrTea7I am a Huge MSM fan.
In over a decade of trying different suppliments and accumulating an entire shelf full of bottles, there's only a few that gave me noticeable results. And yes, I'm aware that when it comes to nutrition, it can take time to realize change. So there are things like magnesium that are quiet helpers in the background.
I'm focusing here on noticeable improvements. Vitamin D got me out of bed, parted the clouds, and reset my circadian rhythm. It may have slightly impacted other hormones like testosterone, but nonetheless, it was a significant catalyst. Methylated B vitamins w/choline & TMG reversed a deficiency that I didn't know I had due to a keto diet by growing back my fingerprints and bringing my skin back into good vibrant health.
Thirdly, it is supplimenting with garlic. Yes, garlic supplimentation has stopped all allergies, colds & flu's whatever for going on a year now. I was a sick 4 times a year person, but not anymore. While everyone around me gets sick over and over, I keep on going. Garlic also has the added benefit of lowering blood pressure. Yes, I know that all the focus has been on glycine w/ NAC, and I took them for the entire year prior to this recent year with garlic. The glynac didn't hold any water to the benefits I get from garlic. I still got sick, and it didn't seem to shorten the duration. I'm 49 btw, so glynac should have made a difference. I still use glycine as a sweetner and take magnesium glycinate periodically, but NAC was not the powerhouse that simple humble garlic turned out to be. I do take Taurine and other things, fish oil, creatine, etc. but with these, it's more like going on faith than having noticeable results. I hope this helps.
When I was in my 20’s & 30’s L-Arginine was massive for me I’ve always kept fit and it was an absolute game changer then tapered off in my 40’s because of the Ariginsse enzyme decreasing
The Ca-AKG has some benefits. I found that it darkened my hair and took the colour back about 10 years. There is also some evidence that it helps to reduce fragility as we age. It may not work on mice but it might have benefits for humans.
Me too ! But nac & glicin too😊
@@wtwarrior7GlyNac reduced your grey ? How many mg do you take?
What is Ca-AKG? Thanks
@xenia_2385 There’s this thing called an “online search.” It’s pretty easy. You can do it using the same equipment you used to type your comment. And in less time than it took you to type your comment. Crazy, right?Good luck!
Reasonable overdose of B3 (Niacin/Niacinamide,
im 62 and my kidney function is mild loss of function , is it safe to take Creatine.
That's a question you should ask your nephrologist
1. creatine
2. protein
3. tmg
4. multivitamin
5. omega 3
6. psyllium husk
7. collagen
8. hyaluronic acid
9. melatonin
10. glynac
He does not say one should necessarily eat beef for the protein. He puts quite the emphasis on the right protein powders.
Highlighting for emphasis, he does not say beef.
@@noah5291 yeah plant protein was better longevity in the relevant study. There are lots of cohort studies and some rcts linking red meat with increased heart disease risk
He actually says protein powders either whey or pea protein
Beef?
If you are taking Collagen, do you need to take separate glycine supplements as well?
Based logic - answer is NO.
But for women-a study showed that soy protein helps Japanese women in menopause retain muscle and have very few hot flashes (muscle is metabolism)
was the study sponsored by the soy industry?
You forgot Taurine
I take Magnesium Taurate 😀
@@DrBradStanfield why not both doc ?
@@GULYABANI71 is it necessary if the kind he takes works for him? You only need so much anyway.
I believe it was announced at ASCO Annual that a study is recruiting 60 colorectal cancer patients ages 18 to 40 with no family history of the disease to see if taurine feeds H2S-metabolizing bacteria, which has been linked to increased incidences of colorectal cancer. Thoughts?
@@GULYABANI71 no need he takes Magnesium Taurate
TMG also lowers blood pressure, another benefit.
Dr. Brad - thoughts on making your vitamins into just a bulk powder with a little scooper in it that we can eventually purchase instead of the pills?
More cost effective for customers and your cost to produce and....some of us also hate pills and prefer the powder route.
thanks!
That would be great. Like NOVOS. That would make the consumption very easy. I can’t get my wife to take that many pills. It scares her away.
Working on it 😀
@@DrBradStanfieldwhen will the advanced version become available? Thanks! 😉
What are your views on urolithin A?
In my experience when I take creatine I get random bald spots.
When I stop taking it , the bald spots go away.
This is just my experience, I still take creatine every day , for me the the benefits out way the negatives.
Agreed. Happened to me as well.
EXACTLY THIS! Random bald spots on scalp
Someone should do a study on all popular supplements, where scientific findings and subjective experiences (anecdotal evidence) are summarized and compared. My impression is that there is sometimes a strong contradiction, i.e. that a certain supplement seems to help many people, while pure science tends to speak against it. I don't think we should simply disregard people's experiences and take scientific findings as absolute.
Have you looked at DEHA? Thank you for all your insights.
Do collagen peptides count towards your daily protein intake?
Well how much protein are you eating a day?
They are ultra low in lucine and do not count as a protein in diet by itself. Without lucine the body won't synthesize protein. And consuming collagen in peptide form will produce collagen repair and growth signaling to the body. Whatever uses the least energy will be the path the body chooses. For example, even if the body is not in ketosis if you consume c8 MCT oil the liver will still make it into ketones because it uses the least energy.
@@unou12die thanks. What if you combine it with a more complete protein - such as eggs, chicken, etc? Then does it count?
@@StevenBrener I don't count it. But to be fair in high enough doses it may. Collagen is not cheap. Eggs are cheap. Whey protein concentrate is cheap. Ground beef is pretty cheap. Chicken quarters are cheap. Cheaper does not always mean worse. I would get my protein from these sources And use collagen peptides as a supplement. Collagen is in the membrane of eggs that skin around a boiled egg under the shell. It's in connective tissue in meat it's in skin and bone marrow, stuff you can make bone broth out of chicken feet are a good source or soup bones from cows. But consuming 10-15g of collagen by itself will generate collagen signals to the body and your body will assimilate it basically as it is with minimal breaking down to save energy.
We should. Get a balanced dose of nutrients ..too much of anything touted as best or good is harmful ....there are other factors to consider like ones blood profile, genetic. Background , etc ...we still need to know further how on a cellular level how the dynamics of these substances works
...
what does 1 gramm of fish oil mean? One gramm of EPA+DHA or just one gramm of fish oil that's approximately 300-400mg of EPA+DHA?
Alot of people are posting comments without listening to the video.
@jasonito23 A lot. It's two words.
Would you be able to recommend a brown rice protein powder or pea protein powder. I’m worried about heavy metals in protein powders. Is that something to worry about? Thank you for all your work on these videos!
Check out NOW brand organic unflavored pea protein.
Puori tests and certifies.
Dr.Standfield what about Creatine increase Dht?
How do you feel about collagen peptides vs gelatin?
For the muscle benefits it should be way more than 500mg, also another new effect of TMG is that helps with fat loss in high doses and prevent fat stores when eating in a surplus, but for overall health 500mg of TMG may be enough, thanks for the video.
How much is the higher dose? are there any noted side effects of high dose TMG
@@5kribbles there's still more studies to be done, but the current research shows from 4gr to 8gr or so for the muscle building and storing less fat during a surplus, the side effects include diarrhea and vomiting, and some people also become a little lethargic, but there are some studies with even higher doses, as much as 15 grams and it still safe for health, so you could try with 3 gr and then maybe increasing to 5 or 6 grams, it my case I take aprox 6 gr daily without any side effect and I think is true, but I'm still checking with myself the results in the medium to long term if I gained more muscle than normal, but as I said, there's more studies to be done regarding the muscle building and storing less fat. Best
@@MiguePizar excellent thanks
You missed Vitamin D and Taurine Both have positive benefits worth looking into. What about Red light therapy for skin health and wrinkles?
Yerba Prima organic whole psyllium husk for the win! When I started taking 1 tablespoon a day of this it had amazing benefits on my gut and mood health.
Does psyllium husk provide any further benefit when the diet is already very high in fiber, including fiber from fruits, vegetables and grains like oats bran?
I really like the reasonable thinking here. I actually started one list of supplements for healthspan and one for lifespan, each with tier 1 to 5, 1 being the best with very good safety and efficacy profile. So far there is not a single supplement in the tier 1 for longevity.
Magnesium??
Hi Brad, thanks for your very informative videos.
I know that you need an equal dose of glycine with the NAC in order to help insure your body will synthesize glutathione from the GlyNAC combo (assuming your body won't make enough glycine on its own which is estimated to be a 3 gram limit). So I try to get a GlyNAC supplement or get NAC & glycine separately & do the equal dosing myself. I suppose it would be too much to hope for that the glycine in TMG (TriMethylGlycine) could be used by the body with the NAC to make glutathione. It sounds like you would need TMG & glycine separately to serve the different purposes rather than just take TMG & cross your fingers hoping it will also help make glutathione from the NAC
Any pos or neg effect on the libido from creatine?
Creatine makes my skin itch a lot, and mostly over my back. I've tried it several times, avoided it for a few weeks then taken a lower dose. It simply does not agree with me and I'm not sure that this extended itching is not a sign of something deeper. I'm keeping clear.
It is always good at least yearly to get fairly complete blood work, and look at the results. You want to stay on top of liver and kidney health, inflammation, and metabolic health like A1C. Liver problems can cause itches, but so can many other things. I believe we can do things about kidney and liver health because I have.
Creatine increases DHT which can make your skin oily and or itchy.
I read somewhere that tmg increases creatine levels but I can no longer find the source again. I wish someone does research to see if beatine hydrochloride could be this super multipurpose supplement: homocysteine/methyl groups, creatine/muscle and then eventually glycine and of course gut health as per its original function.
Excellent video, as always! I pretty much follow all of your recommendations. The only one I have not taken is TMG, because I was waiting for the research to hit a certain level of proof. Looks like we are there now!
I'm a weight-lifter, like you. For acute exercise benefits, I wonder if you could cover the following supplements:
- Beta-alanine
- Tyrosene
Great podcast Brad! I take 1000mg Glycine and 1200mg NAC daily and it has transformed my asthma. I am finding it difficult to get the required amount of protein daily but I will increase slowly as I change meal plans and add powders etc for their boost. Best Wishes!
What are the 9 best for older folks? I’m 71. Thanks
Will the Glycine in TMG work with NAC to essentially create GlyNAC?
Did anybody catch how much glycine and nac for dosing? I heard him say 1gr. Is that for each one? Or 500mg for nac and 500 for glycine?
1g each!
Great review, Brad. When I first started taking creatine on an irregular basis more than a decade ago, I had no idea of its multiple benefits. Now it's a regular part of my stack. The thing I'm having trouble getting my head around is the 1.6+ g/kg of protein. At 90 kg, 1.6 means 144 g/day. Given that I don't eat meat, even with two protein smoothies a day, I'm luck to ingest 120 g/day. And yet, I'm pretty muscular, given my 4x/wk resistance training schedule. Re leucine, yes it's the most impt amino acid for muscle protein synthesis, but it also boosts mTOR. I don't want mTOR elevated all the time, so I only ingest whey after workouts, and the rest of the time my protein comes from legumes, yogurt and plant-based protein powders. Keep up the good work, Brad -- you've been very helpful to my quest to "live long and strong". 🙂
Dr. Killa would like to add Taurine and Ubiquinol.
Who
Everybody killa?
Thanks so much. I'll add that I personally use Alpha Ketoglutaric acid for mental health, and alpha ketoglutarate for its nitric oxide-producing effects (I find these not to act the same as each other for me). I don't take them for muscle or longevity, but rather quality of life, and find I must have them on hand, and take them prn, about 4 times per week.
PS - I take TMG as an really effective adjunct to ADHD meds, which I heard about trying from Gary Brecka's work, and I was shocked to find it really did work.
Can you take collagen peptides and collagen supplements without a medical prescription?
Does the TMG have to be taken pre-workout to get the benefit?
Also: if I’m already taking glycine at night for sleep, will adding TMG provide any additional benefit?
What's your take on GABA Dr
Never heard of TMG before, might try it out
Just starting to take Creatine. 5 days of upload phase and now 5g per day, but no one told me that diarrhea would be the side effect. Apparently, it affects 1/3 of people taking it, and during the upload phase, it is even worse!
Please do a video on Trigonelline.
First !!!!!!
Now I’ll watch the video . 😊
Although I do feel good on Tmg 500mg for the first day or two, it eventually makes me horribly agitated. Same with methyl b complex. Possibly due to overmethylation. I just wish I could find a lower dose of these supplements to find my sweet spot.
Tmg makes me nauseous and insanely lethargic after a few days of taking it, and then I eventually start throwing up. Took me forever to figure out what it was that was doing that to me. Any ideas why that would happen? Too many methyl groups or a back up in my detox pathway?
Thanks for the great video doctor. It does seem that taurine should be on the list. I also take NAC, and magnesium glycinate, so I should have my glutathione precursors covered
I've learned from one of your videos that no need to take glycine if I take collagen. Because collagen already consists of glycine.
Siim Land who is also a rejuvenation athlete says otherwise. He says Glycine megdose is needed for collagen turnover. Do watch his videos.
@@shubhamvibhuti The glycine content in collagen can vary, but on average, collagen contains about 20-22% glycine by weight. To calculate the amount of glycine in 15 grams of collagen, you can use this average percentage.
For 15 grams of collagen, there are approximately 3 grams of glycine in 15 grams of collagen.
The recommended daily intake of glycine is not well-established with an official guideline, but some research and expert recommendations suggest that an intake of around 3-5 grams per day could be beneficial for various health purposes. Glycine is considered safe, and the body can handle higher amounts without adverse effects.
Personally, I'll raise my intake of collagen to 15 grams. That will cover the minimum intake of glycine.
Do you ever have chapter markers to make it easier to search throughout your videos?
the melatonin "risk" is tolerance. Thats why doses are so high. Instant results that leave you needing more and more
The glyNAC makes sense. I have taken a product that includes Optiac, which is Japanese manufactured glutathione, because sone people have trouble making glutathione from NAC. They’re likely missing the glycine.
I used to take more of these, but I’m kind of pilled out. I added another supplement during the pandemic that body builders use for vascularity. Maybe I’ll drop it though since I’m less afraid of my lungs getting destroyed.
So glad it doesn’t contribute to hair loss. I heard the rumor that it does and had stopped using it.
Is there any reason to consume psyllium husk if you eat 125 grams/day of fiber? Anything special about it compared to the fiber in legumes, oats, veggies, fruits? 3 to 5 grams sounds miniscule.
Dr Brad, In your videos you reference that you would start taking certain supplements over 50 years of age. Have you ever considered having an over 50 version of micro vitamin?
GlyNAC works fit for me. My sleeping quality functioning as the research promised. And my panda eyes issue improving by ascension.
I found 2 studies that measured glutathione levels in older adults, one was a group of masters athletes and another was a group that were put on a rigorous exercise program of cardio and resistance training. In both groups glutathione levels were much higher than in sedentary older individuals, nearly at levels of young adults. It’s only 2 studies but my hypothesis is that lower levels of glutathione with aging are an indication of being sedentary and not primarily of aging. In the Glynac studies the subjects were all sedentary and overweight.
N=1, "Safety of high dose melatonin". I have been taking high-dose melatonin for over 40 years with nothing but good results in my opinion.
Melatonin regulates sleep. Why would you take away your bodies control of your sleep? When I could not sleep and took melatonin it would eventually work but only for 4 hours. I was guaranteed to wake up to early after falling asleep too late. If sleep is the motive then 5htp is a better option. It supplies the body with material that is simple for it to convert to melatonin as needed. No more waking up early. Alternatively tryptophan could be used since it is the building block of both but I have not tried it enough to conclude anything. I fasted for 17 days and could not sleep thinking it was normal. I did the research and found the body needs tryptophan to make melatonin. But I ended the fast to soon to know if it was effective to take while fasting.
I find L-theanine works better than melatonin.
It will be awesome to part the video in subthemes, thanks.
Dr Brad, could you please review Amla, Triphala and Quercetin benefits?
Is it ok to take creatine with stage 3 kidney disease?
Ask your doctor
Well.. While supplementing with creatine might be harmless, creatine itself can be dangerous. Had a friend who went into the emergency room due to having too high levels of creatine. (But he's a powerlifter, so his body composition is extreme)
creatine and creatinINE ( high with kidney disease ) are not the same thing.
Where can i buy 17-Alpha Estradiol ?
Does creatine makes you have a gout attack?
No, but a goat attack?
Yes!
One of these times do you could touch on Tongkat ali increase in testosterone
isoleucine has actually been linked to ageing, I guess other leucine isomers might be good for you?
I still think it’s sketchy that the study that was being done on creatines relation to hair loss around 2021 was never released. Instead a meta analysis was released, which did claim there wasn’t a connection - but there aren’t any studies that’s chalky specifically looked at that, which to me calls that meta analysis into question.
At least unless I missed one.
TMG is also good for blood pressure.
Skip the creatine if you suffer from BPH. "May" increase prostate size.
I've tested creatine 3 times on myself...PSA goes up....stop for 3 mths, retest, PSA drops back to previous.
Whatever the "safe study findings" say...I don't think it suits me! (do have bph)
It gives me PVCs. Kinda disappointed he left out that it can mess with heart rhythm.
@@Drgluee I have that also though I can't say I noticed a connection between them and creatine usage, but it's possible since they tend to come and go and I might have not connected the dots.
@@dden7670 I'm not sure what I did, but it has been at least over a year and I haven't felt any noticeable PVCs since. But when I was taking creatine, I would have them longer and more intense. I tried cycling off and would have less and then back on and they would increase again.. But I haven't touched creatine for at least a year and a half.
I googled that and this came up: May have a positive impact on BPH
Benign Prostatic Hyperplasia (BPH) : Creatine supplementation may have a positive impact on BPH, a non-cancerous enlargement of the prostate gland. It may help improve urinary symptoms associated with BPH.
Hi! Do you offer private/remote consultations? We would be very much interested in having regular consultations with you, but we are in the US. Thank you
What about vit D?
watch the video he talks about vit D
What about it?
What about ergothioneine?
What about it?
@@senorpepper3405 it seems like our cells have receptors that bind to this specifically. Also our body can't make its own.
@@marcobartz1879 psilocybin ergothioneine?
Creatine can have side effects for some people. Unfortunately it gives me the trots. Does the same thing to my dog.
Tren worked wonders for me.
Make a video reviewing Ray Peat lifestyle and recommendations
why no taurin?
please Dr. tell us about C15 fatty acid
I may drop ca-akg, particularly cause it has calcium and I don't think one should be taking calcium in supplements. That said after the intervention program used synthetic megadose of astaxanthin instead of regular dose natural astaxanthin I've grown suspicious of them.
Can you please make a video on Bryan Johnson, a millionaire undergoing gene therapy?
He is not the first to have done gene therapy! A lady from a science company did set the trend,I forgot that blond woman name 😅. It was before the pandemic. She started to look younger even
Ben button already did this and its not a good idea
he’s gonna tell you he is a quack
His therapies are not proven or disproven yet
I'm surprised that taurine is not on this list.
Dr. Everytime i take creatine, i end up going to the toilet about 20 times a day.
Why?
17-Alpha EstradiolWhere can I buy 17-Alpha Estradiol
Ask santa for it
All I needed in past 5 years on carnivore is meat, eggs, fermented diary, fish.
Caffeine is by far the most effective and safest athletic performance supplement that currently exists. (unless you have some genetic configuration that makes you insensitive to it) The only problem is you can't use it every day or you'll become resistant to it.
Dr Chaffee - carnivore diet - life changing and compelling for many.
I give my 87 year old mom creatine.
I give my 104 year old neighbor trenbolone
You should not give her more than 1000mg
You can give her 1001 mg and she will be fine
How has the creatine improved your mom's health? My mom is 82, and I'd like to know to pass it along to her.
I give my 36-year-old wife toblerone
Can you talk about the newest big study that states multivitamins due not extend longevity at all
Yes they due.
Gly Nac,Taurine,Life Extension Mix,B5,Homocysteine resist
Blew my doctor out of the saddle.
Is the human body only made of muscle tissue?
You should check out the work of Paul Jaminet (Perfect Health Diet). He's nailed down the necessary human diet and which supplements might be needed based on what you do or don't eat. I'm surprised you don't mention egg yolks.
Paleo is a fantasy diet.
4:54 What about in women?
I heard it causes water weight gain
Of course the collagen peptides will be more effecitve than a random protein powder. The interesting and relevant question is, would a mixture of amino acids in the same proportions as present in collagen peptides have the same effect as collagen.
Collagen peptides are incomplete proteins and collagen peptides signal to the body to repair and make collagen. Protein powder is superior to collagen peptides for muscle growth infinitely.
What about leucine and mtor and cancer, etc?
Anyone have any tips if creatine gives you headaches? (and you are already hydrating...)
i like your content but how many times are you going to remake the same video ?