Resveratrol - The Unfortunate (& Scandalous) Story
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- Опубликовано: 12 сен 2024
- Resveratrol is hyped as an anti-aging wonder, but beneath the headlines lies a dark story. This video explains the resveratrol research history, and the scandal surrounding this supplement
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Here are the links to the research papers referenced in the video:
www.ncbi.nlm.n...
www.ncbi.nlm.n...
www.ncbi.nlm.n...
pubmed.ncbi.nl...
xconomy.com/bo...
www.ncbi.nlm.n...
www.ncbi.nlm.n...
pubmed.ncbi.nl...
• NAD and NAD precursors...
• Resveratrol, Fasting, ...
pubmed.ncbi.nl...
www.ncbi.nlm.n...
www.ncbi.nlm.n...
HTTPS://PUBMED.NCBI.NL...
www.frontiersi...
www.fiercebiot...
pubmed.ncbi.nl...
www.ncbi.nlm.n...
www.ncbi.nlm.n...
www.ncbi.nlm.n...
• #27 - David Sinclair, ...
• #148 - Richard Miller,...
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#Resveratrol #Lifespan #DavidSinclair
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this is why I subscribe to the Dr Stanfield channel. He has no fear reporting current studies bringing the largest of youTube whales or nutritional sacred cows into question... including his own past recommendations! He DOES let the facts "get in the way"; how admirable and edifying.
THanks :-)
Dr. Stan field is one of the best. I love Valter Longo too.
What about NMN, is that effective??
He's great. But I take him with a grain of salt. He is very bias towards "healthspan", so much so, that he compromises lifespan.
He puts too much emphasis on consuming protein & muscle building, which is proven to promote ageing.
@@jeffjohnson5053 great question that is what Dr Sinclair preaches is the combination of nmn to produce nad+
Need to get some of that florescent dye.
So... where do I buy "Fluorescent Dye" pills?
Beat me to it.
Ditching my resveratrol. Thank you for your video.
Very interesting video. I note you focus exclusively on the longevity claims via a single mechanistic pathway. What about the other, non-aging related benefits claimed by NIH and others in the literature? E.g., the “antioxidant, anti-inflammatory, immunomodulatory, glucose and lipid regulatory, neuroprotective, and cardiovascular protective effects” (Meng et. al 2020)?
This study was performed to investigate the effects of resveratrol on metabolic status in patients with type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD). This randomized, double-blind, placebo-controlled trial was performed with 56 patients having T2DM and CHD. The patients were randomly divided into two groups to receive either 500 mg resveratrol per day (n = 28) or placebo (n = 28) for 4 weeks. Resveratrol reduced fasting glucose (β-10.04 mg dL-1; 95% CI, -18.23, -1.86; P = 0.01), insulin (β-1.09 μIU mL-1; 95% CI, -1.93, -0.24; P = 0.01) and insulin resistance (β-0.48; 95% CI, -0.76, -0.21; P = 0.001) and significantly increased insulin sensitivity (β 0.006; 95% CI, 0.001, 0.01; P = 0.02) when compared with the placebo. Resveratrol also significantly increased HDL-cholesterol levels (β 3.38 mg dL-1; 95% CI, 1.72, 5.05; P < 0.001) and significantly decreased the total-/HDL-cholesterol ratio (β-0.36; 95% CI, -0.59, -0.13; P = 0.002) when compared with the placebo. Additionally, resveratrol caused a significant increase in total antioxidant capacity (TAC) (β 58.88 mmol L-1; 95% CI, 17.33, 100.44; P = 0.006) and a significant reduction in malondialdehyde (MDA) levels (β-0.21 μmol L-1; 95% CI, -0.41, -0.005; P = 0.04) when compared with the placebo. Resveratrol upregulated PPAR-γ (P = 0.01) and sirtuin 1 (SIRT1) (P = 0.01) in the peripheral blood mononuclear cells (PBMCs) of T2DM patients with CHD. Resveratrol supplementation did not have any effect on inflammatory markers. Four-week supplementation of resveratrol in patients with T2DM and CHD had beneficial effects on glycemic control, HDL-cholesterol levels, the total-/HDL-cholesterol ratio, TAC and MDA levels. Resveratrol also upregulated PPAR-γ and SIRT1 in the PBMCs of T2DM patients with CHD.
At baseline, peripheral blood mononuclear cell H3K56ac values among the SIRT-1 tertiles did not differ. At trial end, SIRT-1 levels were significantly higher in patients receiving 500 mg resveratrol. At follow-up, patients were divided into tertiles of delta (trial end minus baseline) SIRT-1 value. Significant reductions in H3K56ac and body fat percentage were found in the highest tertile as were increased TAS levels. A multiple logistic regression model showed that the highest delta SIRT-1 tertile was inversely associated with variations in H3K56ac (OR = 0.66; 95% CI 0.44-0.99), TAS (OR = 1.01; 95% CI 1.00-1.02), and body fat percentage (OR = 0.75; 95% CI 0.58-0.96).
Its great you've shed light on extreme claims for resveratrol, but it would have been REALLY helpful to let those of us know that may have supplies of it, of any other valid uses for it.....SURELY it is of "some" measure of benifit for something/anything, perhaps duodendritic recovery spans?...
Thank you for your explanation of the studies. You have covered this topic very well. Your video about Resveratrol before this one, is why I stopped taking Resveratrol. I had been taking it for at least 8 yrs and I'm glad I found your channel. Thank you very much Dr. Standield.
Glad you find the content useful Mark
@@DrBradStanfield Always, I find all your videos useful. What I take instead of Resveratrol is a glutathione supplement. Not sure if you have done a video on glutathione but I would enjoy your take on it. Thanks and keep up the awesome work.
From Subscriber in SE ASIA Simply switch to the Micronized Version with Olive Oil & its proven to be very effective. Follow Dr Sinclair is a rational decision. Many are jealous of his worldwide fame! JIAN & ANDREI PHILIPPINES 🇵🇭 SINGAPORE 🇸🇬 BELOVED MOTHER RUSSIA 🇷🇺
@@jianfrancisco3895 I take a table spoon of Dr GundryMD's Olive Oil every morning.
@@markrobertdevison1227 - it’s far better to take a glutathione precursor than glutathione so the cells can regulate the required quantity.
I think Sinclair said something about resveritral being a sort of vehicle for nmn.
Sinclair says over and over that Riz Verital must be taken with fat and NMN should be taken with it. He quotes resveratrol is the pedal on the car, and nmn Is the gas could you please speak about that
Then how do you square the GSK trials where they tried to improve absorption of resveratrol and failed? Just taking it with fat doesn't improve the absorption of and is a red-herring argument.
@@derrickmickle5491 I don’t Square I was asking I need help I’m not a scientist
Helpful. Thank you
Although the ITP did consult with Sinclair, you didn't address the fact that they just gave the resveratrol to the mice in food without mixing it with fat. As Sinclair said, in their own studies giving it to the mice in regular food without fat didn't extend lifespan.
Surely David Sinclair should have volunteered such critical information to the ITP without being asked. After all he would have an invested interest in this trial showing life extention benefits under such conditions.
Exactly what I was thinking, the most interesting question raised. I'm still waiting on the punchline.
Sinclair is listed as one of the authors on the ITP paper: www.ncbi.nlm.nih.gov/pmc/articles/PMC3598361/
They mixed it in the food (aka: chow) which has more than enough fat.
@@adrianboyddodd8007 yup. But then hundreds of millions of dollars in buy out cash would shut most people’s mouths…
This is one of the best overviews on the whole resveratrol drama
Highly appreciated that u make a video on this controversial topic.
You're awesome!
Thank you as always for a very informative video. Please keep us posted about the latest research on NR, NMN, Niacin, TMG .. Basically your supplement stack. Many thanks.
wine industry made zillion dollars from resveratrol hype and fraud trials. thanks for your honesty and insights.
thanks Dr Brad. you really help the community anti-aging. You have the courage to face the real facts.
Dont listen to Brad, you gonna ,ne stirred away from something good for your health,he's probably a dr that's working for the big pham.
Thank you Doctor Stanfield.
It took courage to call out Dr. Sinclair, a perceived “giant” in the anti-aging field. Thank you
Thanks for watching and leaving a comment
@Dr Brad Stanfield is there any validity for claims that Resveratrol increases Nitric Oxide production, improves genetic health, protects brain from cell damage and makes blood fats healthier?
I purchased Resveratrol from Eternum Labs and these claims are on the container with further claims for Resveratrol on the website.
Thanks for speaking out!
Agree. I am done wasting my money on resveratrol.
@@SeriouslyWeirdDream beet juice lowered my BP, but it’s a shame that it tastes so nasty,.
remember, that even Doc Since. says - hey I am self experimenting on myself...There is a risk.. A lot of this stuff is theoretical! I think the disagreements are very important, to get to the truth! Colelctively - Berg, Ekberg, Stanfield, Sinclair.... all these channels are insanely good! They all could be related....even the names ..in a way...
You missed what Dr.. Sinclair told Dr. Peter Attia and then spun in a different direction. Why?
Perhaps your best video yet ( I hadn’t seen your earlier video on Resveratrol). I have been taking Resveratrol for years and now I feel like a fool that has been duped.
Thank you for the enlightenment. Keep up the good work.
Resveratrol being naturally present in grapes probably needs the other phytochemicals present to provide any benefits. Some things just aren't standalone stars
🙌 👏 🙏 🤝 👍
Your honesty and bravery on challenging such established beliefs have made me a loyal follower of your content. I already appreciated your passion for health, but now I also admire your tenacity as well.
You are wrong @Dr Brad Stanfield. Reveratrol activates Sirt1 indirectly through ampk, no one ever claimed it would activate it directly.
Sinclair himself rarely mentions Reverestrol which indicates he knew all along till being exposed. Now Sinclair only mentions fasting
Excellent commentary
Very well done doc. We need more of this about supplements and disease. Tanks a lot.
awesome content! subscribed :)
It's one thing to say that Resv might not be effective activating sirtuin 1, but It is extremely misleading to say that Resv is harmful to humans because it blunts the benefits of exercise. The benefits of exercise is just one facet of the extremely complex makeup of human wellbeing. Im confident that as a doctor, you are aware of the vast amount of data concluding the benefits of intermittent cellular stress such as from fasting and to hot/cold exposure.
Separately, I believe it has been stated by Dr. Sinclair and others that the mechanism of Resv is still not completely understood, but that it does show evidence of inducing autophagy, albeit maybe not through activating SIRT1. Please correct me if I am wrong, but isn't autophogy a result of stressed cells?
Additionally, autophogy typically occurs after a fasting period where there isn’t as much nutrients being provided to the body. So it makes perfect sense to me that mimicking that state would result in lower physical performance and benefits. Obviously I would have suboptimal performance after not eating for 18 hours, or mimicking the state of fasting.
🙌 👏 🙏 🤝 👍What a real GREAT cmment. I do n o t trust man, I trust mother NATURE (aka GOD)
Merci! Great job!
Thank you for always being on top of research. Love your videos. Very informative.
very interesting thanks so much
It works. Look at your facial skin before and 3 hours later. Skin glows and is more full. No doubt
Why has this information been silenced by the overwhelming ads for Resveratrol?
Why do they keep selling it, if it does no good?
I'm going to drown my tears in some red wine.
I will just spit the grape seeds now! 😆
Great video, so surprising!
Thank u for your useful and brave information
I love your channel and I really appreciate your manner and willingness to explain these things. You are saving lives. At the same time, I have a question that I really want your insight on. What I want to ask is important but it will take me a minute to unpack - please bear with me. I recall David Sinclair stating in an interview that studies involving resveratrol routinely store it at regular temperatures instead of keeping it refrigerated, and he said the researchers aren't respecting the molecule in the way they treat it - and he said resveratrol can actually be harmful if allowed to go bad (if I remember correctly). If he is right about that (for sake of argument) could it be possible that it makes a difference?
I remember reading in a book about oils by Udo Erasmus that the story behind snake oil salesmen might be more complicated than people think. Because, it was derived from a chinese water snake that has higher levels of omega-3 than salmon - but omega-3 goes rancid if not stored properly and can actually be harmful if rancid. So, it's possible that fresh snake oil was actually relieving inflammation but when bottled and carried from town to town in the hot sun, it went rancid - losing its benefit. Interesting, huh? Then, as science progressed, but before the discovery of omega-3 having anti-inflammatory benefits, snake oil developed a reputation for being a con, as scientists said essentially that we were beyond these superstitious ideas and that oil is just oil, there's nothing special about it.
Interesting
Wow...great video!
Well my father has memory problems and we have given him resveratrol and it has made a great difference in his memory and ability to function. According to the research out of Australia resveratrol reverses brain aging by 10 years. Let's wait to hear David Sinclair's response lets not be too hasty.
Wouldn’t this surely had shown up as a positive effect on lifespan in tests?
it is because of the acetylcholinesterase inhibitor effect you have multiple herb and substance with the same effect without the bad.
@@rayquaza6791 explain please
From the testimonies that i have read everywhere is those who have health conditions seems to really benefit from resveratrol. Is your dad still ok taking it?
The density of information, and concentrated way of speaking is something else! Not ONE second is lost!
Can you be a little bit more descriptive lol
very helpful. thank you
Thanks again doc for the timely update on resveratrol. You are a beacon of hope in the medical field.
Ah last time i checked resveratrol along with Sinclair were dismissed over 10 years ago
Thanks Rudy
@@theancientsancients1769 they were for people who read the science. But the problem is the RUclips University students who just watch videos and listen to promos don't know this. Sinclair still pushes it so people still do it. Even WITH all this data, people will still claim it's all wrong and that David Sinclair is right. It's almost like a cult of personality out there.
I agree!
Well done. Thanks
The power of the peer reviewed system is a beautiful thing.
Interesting. Thank you.
Wow, you've made some very good observations. Just shows once again that you cant blindly trust no one.
This gives food for thought. Thanks
Great vid! What are your thoughts on why after so many years, no one has done more studies on resveratrol mixed with fat? Since this is Dr. Sincalir's main calim for dismissing all these studies and justifying his results.
that's what i was wondering, there seems to be sinclair talking about fat and not being consulted on it, then sinclair BEING consulted, but only on DOSAGE and not fat
@@elaineremains So has no one replicated his studies or studied Resveratrol by mixing first in fat?? No One?
@@delaneyondreams not that i know of! but of course i don't know all. however i remember seeing dr sinclair on a video interview a few years ago, and he spoke of the FALL of resveratrol, and how he stayed in bed for a couple of years, but in the end, he was vindicated.. so these studies could be from the FALL and not from the triumphant come back.. tho i have never seen that interview with sinclair again... maybe it was with tom bilyeu... not sure...
We’ve got human data showing harm when supplementing with Resveratrol. If absorption was the only issue (which it isn’t) then how did those trials detect harm? Also, the idea that GSK threw away ~ $1billion dollars simply because they didn’t think to mix resveratrol with fat is outlandish when you think about it
@@DrBradStanfield you have a point about GSK, i was wondering about that myself, but i wondered if this was some sort of conspiracy lol
as far as the trials detecting harm, that COULD be about resveratrol being 'like brick dust without fat'.. brick dust sounds harmful lol
i can't take resveratrol, coz of gastrointestinal problems, but when i did, i took it in high doses and i swear i was looking younger, so i can't say i know what is going on
Where can I get this fluorescent dye though?! 😏
Would love to see you interview Sinclair for his response. He always says “I will always tell the truth.” I have trusted him unwaveringly. What is the truth???
You (generaly) talk about the effect of resveratrol in longevity but you never talk about the antioxidant and the anticancer properties.Can you make a video about it ?
In David Sinclair podcast this week he was still talking about resveratrol as a proven anti ager
Clearly we need more research to address these questions.
I would have liked to heard from David
This was an outstanding review. A lot of people have wasted a lot of money taking resveratrol for over a decade or more.
To start repair mode: 1. Only eat once day with 2 hour feeding window. 2. Fast for 1 day. 3. Fast for 7 days. Fast with water and minerals. 3 is best - after 3 days fasting, triggers full repair mode. Read the manual that came with your body. 1000's of years old idea.
I understand Dr Brad Stanfield's genuine interest in having enough clarity on this Resveratrol issue, but in order to understand one set of data and be able to compare it to another set of data we need to make sure they are in the same context. I believe that the information presented is incomplete. It does not mention the context in which these tests were carried out and whether they are the same ones that Dr. David Sinclair mentions... that everything is due to scientific rigor.
how much more complete doe sit need to be?
Well I totally agree with you. My father has severe memory problems we have been giving him a gram and a half of resveratrol every day with olive oil. We have seen a tremendous improvement in his memory. He is able to function at a much higher level. According to the research out of Australia resveratrol decreases brain aging by 10 years. It has done wonders for my father.
There’s no way that GSK just walks away from a billion dollars and they have an army of scientists. Use your head.
Yes, many thousands of people have reported benefits, especially with NMN and oil. I have followed this for years and read of so many instances of people getting younger. It cannot be a coincidence. You can prove anything with studies and I think Dr Bran Stanfield has a bee in his bonnet.
Right. Those studies are over a decade old and since then Sinclair has started studies on monkeys. Also,i was reading an article that suggest the $720 may have more to do with GSK still pursuing resveratrol as a PRESCRIPTION DRUG. Which could make multiple the amount of over the counter. They stopped the two execs from Healthy Lifespan from selling the over the counter brand at cost as a non-profit
That was great, thanks!
Why does David Sinclair look so young?? He must be doing something right.......
He fasts - OMAD
Wow thank you for this video
So - is David Sinclear now just a supplement salesman hack nowadays? On a similar level as Eric Berg?
I believe Dr.Sinclair does not have his own supplement brand like Eric Berg does????
@@eatmyfeelings6585 he is working on it
I've been researching Resveratrol..
🧬 DNA & genetics, are fascinating fields of study to me.
Subscribed.
Thank You 🙏🏼 Doctor.
Thanks Dr Brad
Thank you for the video. Was there an attempt by David Sinclair to differentiate between taking resveratrol with a “normal diet” vs taking it with olive oil or yogurt?
The olive oil or yogurt just provides some fat for it to dissolve into.Fat soluble supplements are MUCH better absorbed when consumed w fats.
@@scotte9384 Thanks. My question is whether DS is saying Resveratrol works with fatty options vs a normal diet. He seemed to attempt for that distinction in his clip but from what I could tell, this video ignored that detail.
He was directly consulted on the dosing. Can’t imagine he wouldn’t have mentioned, let alone stressed the fat absorption enhancement. He’s always yammering on about it whenever he’s promulgating the compound on podcasts, while not lying about his involvement with the study.
Eye opening…been taking for a time…now am reconsidering…thanks…What do you know about PQQ?
clicks for attention to grow your channel by name dropping & discrediting David Sinclair who is busy furthering longevity for the masses....he's 53 this year & doesn't look a day over 40. Enough said...
Thank you !
This is incredibly helpful. When you first debunked the life extending effects of Resveratrol, I tossed my pills. I stopped taking Basis, which is a product with NAD that includes Resveratrol in the formulation (replaced it with Lipo NMN from AlivebyScience). The last thing I need is to blunt the effects of exercise at my age. I greatly appreciate your in depth reviews of these papers. It saves so much time!
Ha- I am halfway through my first bottle of resveratrol, so this seems like a good time to stop, thanks so much! At my advanced age I assume any further level of replicative stress is something to do without. Looking up recipes for spinach Greek yogurt dip now.
I like the darker longer hair. It looks good on you It gives you a good contrast.
My Vo2 Max actually goes up when taking Nmn+Resveratrol from 55 to ~60 even sometimes over 60. But when i stop taking its constant around 55.
Maybe they must always go together.
Strangely, 2 years later, the Web is full of new articles on resveratrol which seem unaware of this result.
The thing that really bothers me is Sinclair flat out lying about not being consulted on these studies that show RSV does nothing to extend life. He just lies about it and hopes no one will actually look into it. That is not the first time he has lied about such things. This person cannot be trusted, he is simply not a quality source of information.
EXCELLENT Report Dr. Brad............. excellent!
I read that 2013 paper that listed Miller and Sinclair. I’m curious why they only used obese mice eating a high fat diet to prove Resveratrol worked to delay metabolic aging and then seemed to conclude indirectly that their death from hepatic failure (???) was somehow tied to this? Am I reading this right?? Why weren’t there normal weight mice fed Resveratrol mixed with oleic acids in their chow? The protocols are clear enough with dosages but not very clear with the fat. If it’s the MCT, that’s a medium chain fatty acid. Dr Sinclair specifically saw oleic acids like olive oil, which is a long chain fatty acid, mixed with Resveratrol to see this longevity effect. Dr Sinclair may have been consulted but perhaps his protocols not followed.
These are good points!
Excellent
It is sad that scientists and business people have to re-learn the same lessons they’ve learned before. For example, sunk costs should not, under almost any circumstance, influence future investments. Also, separate your personal identity from what you are studying or investing in. Its tale is as old as science itself and as old as business itself. Just the latest iteration.
Thank you dr brad
Dr. Brad:
Maybe I missed it, but did those later studies on mice attempt to deliver the Resveritrol with fats, as Sinclair advised? I was unclear on that. That would at least show that the catalyst was a factor.
Using toxic chemicals like Resveratrol to regulate sirtuins was a bit of an idiotic long shot, anyway.
Considering, we know all the exogenous signalling molecules that regulate the sirtuins, already. The signalling molecules and their carriers.
Sirtuins don't work by themselves, they have to be precisely regulated together, like tuning an equalizer on a stereo.
Thanks so much for your unbiased and open-minded investigating into studies of resveratrol, Dr. Brad. This is a very brave thing to do when so many will have vested interests to deceive the public when large sums of money or status is involved. You have our support in finding out the truth.
Thanks for the support Jane
I started taking it DonotAge NMN and Resveratrol and didn't feel well and stopped. Glad I did.
Glad I found your channel as I’ve just been introduced to this stuff. Interesting about the Resveratrol absorption issue and normal food because I heard Sinclair say recently, and I think this may be his “work around” to validate it, that it is best to pair it with intermittent fasting and taken every second day not every day. Standing on its own you think great, ok, that’s the protocol . But hearing it now in light of what you’ve found makes me see it in a very different light.
what about pterostilbene?
i'm sick and tired of how devious and Machiavellian the whole internet is, I'm done with getting advice online. i will carry on taking this. one person says something is good, one person says its bad. too much conflicting and poor information. just trust yourself. i am not singling out any person or thing, just that nothing concrete i have learned in life ever came from the internet.
I looked into resveratrol studies and accepted that life extension and nootropic claims were unsubstantiated, but decided to take it because of a noted reduction of TMAO, but that's completely negated by raising cholesterol, and blunting the benefit of exercise is unacceptable. Buh bye resveratrol.
Thanks for watching eyebrid
Pycnogenol
@@BryanHocking I continue to take pycnogenol I've been taking it since I was a teenager.
@@rosevanderreijden3216 I took pycnogenol on and off a few times and it makes my muscles twitch. I try to search online to see if that’s one of the side effects but I found nothing. Just wondering if that has happened to anyone else.
@@rosevanderreijden3216 rad
Just observe French people who drink a glass of red wine a day. They are aging healthy.. I think it worked for me also well..
All of that and still the ITP didn't give it to the mice mixed into fat. Unbelievable!
word.. totally what i was thinking
Exactly.
awesome reasearch
Great video Brad. Thanks for this excellent review of why resveratrol is actually... less then useless. I had been putting off taking it because of some concerns I had, and this is the first time I have seen those concerns deeply addressed.
Thank you.
I have been taking Resveratrol since November 2021. My anxiety disappeared and I slept much better - that was he first thing I noticed. Then my energy levels increased - my body seemed to start craving exercise. I don’t think I am imagining any of this. I have noticed no side effects so far.
How much of Resveratrol have you been taking? 500mg?
I experience profound benefits with Japanese Knotweed, but I understand that my case might be very specific. I don’t think this video necessarily implies that resveratrol as a compound has no therapeutic usage at all. For instance it appears that Japanese knotweed has some antimicrobial and immuno-modulating effects (whether that’s purely from resveratrol or from the combination of compounds I don’t know). Same as chemotherapy might be useful for some people.
I've been taking it for over a year now and I too thought that I have been improving.
I think somebody needs to look into GSK's real reason for paying millions for that research. If resveratrol is like the fountain of youth, the pharmaceutical companies will not want it to be popular with the public. No one would put it past a pharmaceutical company to pay to get rid of a legitimate fountain of youth when they make so much money from pharmaceutical drugs that keep people sick. They pay the researchers, Dr Sinclair looks unethical but he gets paid, and people stop taking resveratrol. It's a win for the pharmaceutical companies.
Just a thought.
As interesting as that is, it's anecdotal and nobody can verify the variables our data for said results. Thanks for sharing, though.
I am taking Resveratrol and have noticed better sleep, more energy, and clearer thinking and less arthritis pain. I’m hoping my blood work next month will show improvement as well. I’m not taking it for “the fountain of youth effect,” I’m taking it to see if I will feel better….and I do. I’m happy with it. I am on the Mediterranean Diet.
Update: I had my blood work done and my physician was surprised at the good results. My A1C dropped significantly so I am no longer pre-diabetic. My cholesterol and LDL, which have been elevated for 12 years, came down about 15 points each which has never happened before and I’d only been taking Resveratrol for about 2 months. Overall, I’m very happy with the results. I will continue with it.
I still have a whole bag of trans resveratrol in the fridge ,...... not gonna use that anymore ,..... thanks for this information brother !
Thank you Dr. Brad. It’s amazing how all the data is there but can still be hidden. Your research is so helpful.
Thanks, glad to hear you found the video useful
@@DrBradStanfield why don’t you reply to any of the people questioning you Brad??? You were soo quick to judge David for ‘ignoring you’, yet you ignore every single comment even with direct evidence against your piss poor half truths because you’re full of bs trying to get famous for making up controversy. It’s pathetic.
You are the new braveheart
Sirtuins are supposed to be NAD+ dependent, so modulating NAD+ should keep surtuins expressed to desired levels without need of supplements (speculation). Afterall, they perform various functions and having suboptimal exprsssion of surtuins, as with many other genes, should work against our health and possibly longevity. I am more interested in SIRT6 which, if I remember correctly, Vera Gornunova discussed as being very useful in reparing double strand DNA breaks, which is impiicated in aging.
Thank you
That opens up a can of worms then. So is his celluar reprogramming stuff that he claims works true as well ??
wow great studies- I have been misled
Excellent review presenting all the relevant studies on resveratrol. Thank you 🙏. Certainly GLK wouldn’t have walked away from a billion dollar investment if they had hopes of it showing any positive effects on longevity.
This video sure hasn’t helped your chances of getting Dr Sinclair on your show but your viewers appreciate your insights and integrity.
I don't think Sinclair has a chance if he debates Dr. Stanfield. The jig is up.
Thanks Steven
resveratrol cannot be patented and it was superior to all the resveralogues synthesized. It threatens not just one drug but all drugs. That is why it is under attack by big pharma with plenty of trials designed to see it fail. It has extended the lifespan of multiple short lived species, including healthy shorter lived mouse strains. It has even rejuvenated human cells in vitro, researchers surprised and exclaiming it was practically magical the effect it was having. It has failed to extend lifespan likely due to NAD+ decline in longer lived animals, to overcome that it likely needs coadministration with an NAD+ booster. This is because sirtuins need NAD+ and resveratrol works via activation of multiple sirtuins such as sirt6 and sirt4.
@@diamond_s Dr. Stanfield - would you like to address this?
I’m not really one to buy into conspiracy theories. I prefer to focus on what the data from well conducted trials show, and to start to produce high quality data as well (through my rapamycin trial)