If you take RESVERATROL, make sure you watch this video next: ruclips.net/video/nk1kUA__p9k/видео.html ✅ Become a channel member on Patreon. Join with $1 & get access to the 10 resveratrol habits & earn an honorary mention in future videos. ✅ Upper levels receive my entire supplement routine & brands (worth $100). www.patreon.com/WellnessMessiah
Could you clarify the significant cholesterol increase with resveratrol? It was one of the main points Dr. Brad mentioned in his "Why I stopped taking them" video (7min.40secs.) and I did not find you mentioned that *No beneficial effects of resveratrol on metabolic syndrome* study in your video. Thanks for your efforts, but for further reviews of others reports, please go through all the referenced studies...
I take resveratrol every day and exercise every day, including intense exercise roughly every other day, and I haven't noticed any issues with being able to exercise or recover. If anything, I am in excellent shape and have only gotten better lately. I think I'll just keep taking it daily.
Same here, I run nearly every morning fasted after having my coffee and taking 250mg nmn and feel great. And most NMN supplements already include resveratrol so separating it is impossible.
@@mhaas281I guess the question is why are you taking this supplement knowing that there is legitimate research debunking it. I say this because throughout the pages of history, too many people, smart people, fell for the fountain of youth scam. This youth potion is nothing new and very powerful in its influence. You must ask yourself why do you continue to believe this despite scientific data debunking it.
I’ve been taking daily but I also run long distances 4-5 days a week. And I’ve been noticing my VO2 max has been declining and I’m not recovering well. Definitely going to take a break for a week now then taking every other day
I’d like to know the truth about Resveratrol: is it good for you or is it potentially dangerous? Why did I have a very obvious, repeatable result from taking resveratrol?… I never expected any visible results from taking it but I began to see that it was indeed responsible for increased endurance in a strenuous “ yoga with weights” class during which we increased heart rate and worked our muscles to their limit. I tested it over and over again. I stopped taking resveratrol because of the negativity around it, but I also had to stop taking the class!
Thank you for your explanation. I will change my routine and take Resveratrol on alternate days. Question: would it increase efficacy if taken at night with fat (dinner) rather than in the morning?
How come Dr. Sinclair gets nervous when confronted about this. He looks down and away and say’s “It’s confusing” …. What do you mean by saying “Dr. Brad isn’t a researcher” when all he’s doing is clearly explaining what went wrong with David Sinclair’s research, the mistakes he made and the inaccurate conclusions he drew, and presents the evidence contradicting Sinclair’s claims! Why won’t David Sinclair accept Dr. Brad’s invitation to defend his work?!
Hi A G, I don't mention brands because 1) I don't cooperate with them so you could trust me 2) I once mentioned a brand and they changed the formula leaving me with an egg on my face. However... I'm working on huge resveratrol project, where I show labels of products I use. I don't say the brands. And you could search and find that for yourself based on that label. The resveratrol dose matters greatly, not just the brand.
I have seen numerous videos about anti aging. I have seen interviews,read articles,just name it. You are the best by far,in my opinion I will keep watching!
Good video. Indeed there are some questions still pending in my opinion. The impact on resistance exercise for instance: the inflammation and post recovery and overcompensation is based on stress (caused by mechanical and metabolic work): protein synthesis occurs in the hours post exercise so I do assume resveratrol should not be taken anyway post exercise in these cases. Following your good work and perhaps we'll have a podcast together in the future;-)
Thanks Ben! Besides the NMN, if there are additional uncertainties about longevity protocols you find yourself wondering? Please let me know. I'll take it into account when making research-based videos.
Thank you so much for this super good informations! I was wondering if the cyciling every other day for resveratrol might be valid also for NMN...what's your opinion on this? Thanks a keep up this wonderful work!! Ale from Italy
How are you? I think cycling is not needed with NMN. It works in a "build up" mode. It more like taking magnesium supplement. NAD+ mechanism isn't susceptible no benefited by cycling as far as current data. For example, Sinclair found it takes 9 days for NMN to reach it peak active mode, and you don't want to go down from there.
Rimon, you have the best channel of RUclips. Thank you so much for your efforts to help us. You are amazing. I love your accent too. Where do you come from.? 😊
You're very kind Otto. First, fisetin is very interesting but it has 1% of data compared to resveratrol. Having said, that In 2 weeks' time, you'll get a mind-blowing video on that exact subject. It's a project I've been working on for the last 2 months, took me covering nearly 200 studies, and will include polyphenols as a group. Including how fisetin, quercetin, and resveratrol could fit in the larger longevity strategy. More info on this project here: ruclips.net/video/YAGREiNMK0g/видео.html
I saw your comment below about whether NMN should also be cycled and was wondering what you would think about taking astaxanthin every day. I take it for my skin but maybe shouldnt everyday? I take it to help protect against UV rays.
Hi Claire, can't give personalized advice. I can tell you those fat-soluble antioxidants - unless taken for a specific time for a targeted goal (e.g. 1-3 weeks) can turn off the natural defense system and reduce longevity - WHEN we're young. I"m very careful with them. Astaxanthin should work better after age 70 when we begin to oxidize our brains, eyes, and ears...all fatty tissues. And from what I've seen, it can cross the blood-brain barrier. Today, applied topically against sunshine should be rather safe - I think. Also maybe taking orally before a very sunny vacation and that's it.
Brad did not make money unlike Sinclair, nor did he discredit resveratrol. He simply cited the numerous studies that discredited resveratrol to include CRISPR. Are you saying CRISPR is so incompetent that they misunderstood the studies? Lol maybe. But it's more than likely it is Sinclair that botched the study and refuses to engage in peer reviewed debate.
So what I understand from the video is the benefits of resveratrol are the most when taking it every other day, and dr. Sinclaire also confirms it. So I wonder why dr. sinclaire says in hes book Lifespan that he takes it ever day.
Nice review, just subscribed to your channel. I currently follow the same protocol for resveratrol, although without the “sip” (not an SI unit) of alcohol. Interesting.
@@WellnessMessiah look forward to your podcast. Btw I have no problem taking a measure of red wine or spirit. The only men I have know who lived past 95-years were regular, if minor, drinkers. Anecdotally a “sip” would seem to be the opposite of dangerous.
Excellent question Starwoman. I'd seem like Sinclair doesn't apply it on himself, but it always made sense to me what he found in his research. To alternate and cycle resveratrol. So why? Speculations such as .... - he tried both ways , tested his individual body and maybe got better results for him with everyday routine? Not sure. Your guess is good as mine.
Stanfield for all his emphasis on methodology and rigorous/accurate interpretation of data, all too often selectively cherrypicks research just for the sake of being contrarian. His assertion that it is not even clear that activating sirtuins is an anti-aging mechanism based on 1 sirt-2 study is downright ridiculous. To make such a statement while omitting literal piles of research estabilishing the crucial role of sirtuins (and specifically sirt-1) in aging of various tissues from bones to ovaries, is either ignorant (again, Stanfield is MD, not a real researcher) or malicious. He has proven himself to be a somewhat sleazy opportunist and considering his considerable lack of expertise or even academic merit, his public persona is all the more inapproperiate.
Hi Samuel, I see your point. We're all part of the same community. Nobody has a monopoly on science. Because of Brad, I needed to create this video. So he does stimulate back and forth debate and everyone wins from looking deeper into research. It's good for us that he's a contrarian (if indeed he's). You have your smart brains and you'll do the best for your longevity, I'm sure.
@@WellnessMessiah Yes, you are certainly right that there is a value in what he does. His rhetoric and framing of the issue is whats rubbing me the wrong way.
@@samuelhajduk5746 Brad takes supplements like resveratrol than fines some research and changes his mind. He has done this on a few different supplements, so you calling him a contrarian is spot on. Also he has a need for attention probably why he doesn’t pronounce data correctly.
Exactly!!!!! Just a cheap way to gain followers and notoriety on social media by discrediting others through an ironic lack of knowledge in data interpretation while claiming that it’s important to be detailed 😂😂. It’s why nobody he attacks really give him the time of day. He contributes nothing himself and they know he has no clue in the actual science. Should stick to writing scripts. 😂
In my opinion, Dr Brad Stanfield is not misinterpreting the studies, instead he is interpreting to suit his agenda which is to go against the hype in order to acquire followers as the opposite, positive and obvious opinions are already saturated with many Doctors and researchers. Conclusion, Dr Stanfield’s interpretation is a marketing strategy.
I am taking Resveratrol and it is creating good affect on me especially I am physically energetic. I felt my stomach full every time. I am taking from 15 days.
1:06 "On its face value there is no reason to go against Sinclairs take on Resveratrol" ... The skeptic in me can think of 720 million reasons for him not to change his take in the face of new evidence.
Hi, I hope this comments finds you well. I’m a scuba diver- few months ago I started to take resveratrol , nmn, metformin and some other molecules mentioned by Mr Sinclair. For the first time during my dives (I’m a nitrox diver) I started to experience scary heart palpitations when I was below 20m - it usually would happen at 30-25m depth. At first I thought it was narcosis but then I decided to stop taking resveratrol (intuition) and my dives were going perfectly again. The same problem occurred when I used a hyperbaric chamber (I have it at my gym) - I experienced the same reaction as during diving and they had to take me out of the chamber. When I used it without resveratrol I was again- absolutely fine. Does it make sense to you? I hope you can shine some light on this as it’s been really on my mind. This days I never take resveratrol when I’m on a diving trip or when I know I may use hypoberic. Tks for your time .
Hi Edyta, how are you? Nice meeting you here. Terrible experience. The whole goal of supplements is to improve our well-being, obviously, it's not worth it. It sounds like something that causes your body to become more irritable under physical stress (Water, oxygen levels). I don't have an explainable mechanism. Possible explanations: Allergy to resveraratrol Allergy to compound in the capsule itself, including remains from the plant from which resveratrol was extracted. Over activation of the stress system by resveratrol via an unknown mechanism. Too much high dose. Have you asked your doctor maybe? In the next video on this channel, I show how resveratrol dose changes the reaction of our bodies.
Hi Rimon, I’m very well thank you. Yes , it wasn’t the best experience to get a major heart palpitations at 27m and trying to ascend as slowly as possible. I’m glad I worked out what it was tbh as diving is my passion. I do think it might have been a combination of high doze (1g) and high oxygen… I do breathe 30-33% O2 being on nitrox. I was even more certain it was resveratrol after it happened in hyperbaric. Anyway I do agree with your comment of taking it every other day- I’ve also decreased a dose to 0.5g. I noticed that 1g makes me anxious somehow but I feel fine with 0.5g. Regarding my doctor- I’ve only recently had my first visit with functional medicine doctor but we didn’t have a chance to talk Abt this particular problem. I’m sure I will get a chance during my second app. Thank you for your time. Keep well.
@@edytarabijewska Maybe you should just stop taking that crap, because apparently your body is allergic to it. Instead, have a nice corned beef sandwich on rye with mustard and cole slaw and a knish, and I'm sure you'll be good to go.
Did you have your B12 checked ? Glad you trusted your gut!❤️🇨🇦 . I know my mom had CT scan and no dementia or Alzheimer’s but has some blood vessel disease. I know blood flow is important. I want to try NMN with mom and myself. She’s 40 pounds overweight but her spine is damaged,so she’s not able to exercise. She can go for small walks but her spine and neck are really painful. I’m hoping the NMN will help, so she can stop taking Advil,because it’s the only thing that works. Yes it’s best to stop,because NO-ONE knows your body like you do. and sure enough you noticed a change. My dad decided to do keto, and he was super fit and drank 3-4 glasses of red wine per week.However he dropped dead of a myocardial infarction, and my grandma died from the widow maker. He ate meat. He discovered he had prostate cancer because he left it to late ,but it wasn’t that that killed him. The heart surgeon I got said to me, “ I know immediately who eats meat and who doesn’t as soon as I look into their chests in the OR. He said I want you to watch “ Forks Over Knives on Netflix “ I said ok. Now it’s been 5 yrs and Dr ( David Merlmutter ) Drop Acid says your uric acid should be lower than 5.5. Mine was a 3.2 . My blood work has 100% changed since I stopped eating red meat, I do eat organic chicken once in a while and wild caught salmon when I can get it though. I can only speak for myself but with a family history of heart and stroke,I think he’s right. I mean I definitely didn’t stop to think about my 60 yr old self at 35 . So getting the DHA and EPA are super important. Everyone’s brain is shrinking, and blood flow is important. But when in doubt, throw it out,or check it out ! ❤️🇨🇦
Just a wild guess Edyta, resveratrol increased total cholesterol significantly, from the *No beneficial effects of resveratrol on methabolic syndrom* study Rimon forgot to mention at 1:25 (from Dr. Brad's video around the 8th min. mark). In higher pressurized environments, serum-cholesterol may clot arteries more easily which could cause palpitations... I bet you'd not be the only one showing those symptoms under those conditions.
There is possibly a link between cycling creatine and Resveratrol. One creates cellular on a small scale promoting recovery demands and the other providing the energy needed to meet those demands. Research would be needed but this is possibly a compass.
Do you have a reference for the paper David Sinclair said showed regular diet fed mice had benefit when resveratrol was given on alternating days? I've looked at some of his papers but could not find that data in the supplemental material.
Hi David! I remember seeing that in 2019 when I delved into this for my own supplementation. Now, I went intuitively to the original study, and you're right - No mention there in the supplemental data. But it says in the paper: "Analyses of the other groups will be presented at a later date." The standard diet + resveratrol on and off had to be "other groups". I think that I've seen it in a subsequent paper, that I've seen that. Not easily dug, but you're right about the original paper here: www.ncbi.nlm.nih.gov/pmc/articles/PMC4990206/ If you find it, let me know. I need time to find what I read in 2019.
@@Rebelsandglam Getting back to you 1. 2008 study. " subjected to every-other-day feeding (EOD)..." Supplementary data: "Beginning at one year of age, SD and EOD (ME -"every other day") groups were fed a standard AIN-93G diet or AIN-93G plus 0.01% or 0.04% resveratrol... The EODLR had the longest survival times..." 2. Sinclair mentions that clearly in this paper from 2014 I think that's what I read in 2019: www.ncbi.nlm.nih.gov/pmc/articles/PMC3970218/ I'm quoting: "However, resveratrol does extend mouse lifespan when provided in a high calorie diet or in standard chow fed to mice every other day"
@@WellnessMessiah Thanks for checking. If I find it I'll let you know. This paper has some EOD feeding results in Figure 4. Although interestingly only the low resveratrol group had a significant benefit: www.ncbi.nlm.nih.gov/pmc/articles/PMC2538685/
Interesting that Sinclair appears to take it every day (skipping days when he forgets for whatever reason). Would be good if somebody could ask him about this in the context of these studies.
I've noticed that supplements seem to reduce my kidney function. So I've cut back to just good diet, daily exercise (alternating RT, Zone 2, HIIT and 10K steps) and occasional fasting. Maybe that's enough. I used to take resveratrol, but can't imagine taking it now.
there is no controversy, just a GP (Stanfield) that knows about as much molecular cell biology as my english school teacher. There is *some* discussion about the exact involvement of sirtuins, but the overwhelming evidence (and not just from the Sinclair lab) shows that they are absolutely involved in CR mediated lifespan increase. Obviously they are not the only pathway, but there is never just one pathway regulating "big" functions like cell senescene, so its not an either/or with respect to sirtuins and rapamycin. If anything, supplementing nutritionally, with resveratrol and NMN is far preferable than taking a drug like rapamycin. Also, if you read the paper showing the low level replicative stress carefully, they do discuss their results in the context of the plethora of evidence on resveratrol and lifespan extension, and they are not actually mutually exclusive because low level relicative stress is actually one of the putative mechanisms unerpining lifespan extension even accroding to Sinclair's layman explanation. OVerall the literature has an astounding amount of data linking caloric restriction, sirtuins and sirtuin activator compounds and the rest is various randos on the internet trying to catch a bit of the spotlight and make a name for themselves (like that stanfield guy) on youtube by throwing around provovative statements like "convtoversy about resveratrol", which is laughable. Thankfully real science doesn't care about them
Thank you very much for your great job. Could you please summarize it in a few words for a stupid, 52 kg, 56 years old woman: how much resveratrol and how frequenty to take it? I really appreciate your research and thank for that
Whatever dude, Brad only discussed data results not mechanisms. If the data he analyzed is wrong, then show us compelling data resveratrol shows benefits. You told us there is a huge number of studies but failed to mention a single one.
Hi Rimon, thank you for your explanation. I'm curious to know more about your background as a researcher, where you studied, and if you have published or co-authored any papers on ageing yourself?
Hi Jessica, my background is unique, which makes my results unique. I did study chemistry, biochemistry, metabolism (certified in Metabolic Typing), and statistics). From here, you can start thinking about data. Besides that, the actual research was done outside of the academy (and more around humans - my clients and my body) , which makes it complementary to the yeast and mice Sinclair mostly researched. I explained more about me and my research in this video (first you'll find results, then the 4 pillars of my research): ruclips.net/video/S0zvpeWvU_k/видео.html
@@WellnessMessiah @Wellness Messiah with Rimon thank you for your response and that sounds like an impressive background. Your video is very informative and well presented. I am finding it so hard to parse information on ageing when the top ageing experts like Professor David Sinclair, Charles Brenner, Matt Kaeberlein and Brian Kennedy all disagree with each other and argue so vehemently about it on Twitter. It's honestly so bad for science communication and for lay people like me wanting to know if they should take a supplement and which molecule is better. I wish the ageing experts would come together for some sort of friendly joint debate or discussion. My impression is that while there are some studies studies, there maybe aren't large-scale, strong human trials on supplements like NR, NMN, metformin, rapamycin, so forth? Or they are still underway? It's so confusing, honestly lol.
@Jessica _S I agree with you, it's very confusing. Remember that each lab researcher has seen different results. I think it's -- part of their identity. Also, the answer many times is intuition. Because each study gives a tiny, tiny cube of evidence (that may be incorrect), as well. Thus, lab researchers, many have different intuitions about where we should go. And it's very difficult to put intuition into a debate. You can only prove the cubes. Only your mind can see the big picture - hard to argue around that. The results I have put were never done in a single study but followed by the intuition of how the human body works. Metformin - many, many human studies. Been in use in humans for 60-70 years now. NR& NMN - Most of the human studies are from NR because it has a patent. So there is money in it. It doesn't take anything from NMN There is a lot of benefit in mice studies, our evolutionary cousins.
Did you not do a video where you suggested too much resveratrol was more beneficial to those who were sick (I.e. cancer patients) and less is more beneficial for healthy people? Why are you taking 1g, isn’t that higher dose? I thought you suggested between 250-500mg for healthy people?
Hi Tom, yes, check the date of this video. It's much older. Intentionally, I'm documenting here my own journey. For you, it means that I will update things, tweak them, and give the reason,. So people will have no choice but to continue to hear my babbling. Besides, most of the research here is still 100% correct. No need to remove this video
Good question Christian. Do you mean, you stay in fat-burning mode the whole exercise session? Can't give personalized advice, if it were me, any cardiovascular activity (and even resistance) I'd delay resveratrol afterward. It may even help with the recovery this way.
Hi There, it's mere speculation. Nevertheless, in the last video in the resveratrol series, I go into speculating why Sinclair does what he does and adding a clip of his response about his dose, too. Did you happen to see any videos from the 4 that were released so far?
@@WellnessMessiah this is the first video that youtube suggested me. Can you share the title of the video you are talking about with your speculations about Sinclair?
Thank you, Arnold. Next week we'll go deeper on this channel on Resveratrol, with 2 videos, the second using David Sinclair's direct research and some more.
Thank you Enrico, you're very kind. Also, there is the dose controversy. Have you had the chance to check it too? ruclips.net/video/Js_l_G1x8V4/видео.html
That study about exercise was short term, people forget your body adapts to things over time. Why don't they run blood test on people who have taken resverstrol for years. Cause a lot of those people seem in great shape. It appears resverstrol didn't harm their exercise.
Hi Aventus, good insight from you. In the next project in this channel I only focus on long-term studies. I explain this resveratrol project here: ruclips.net/video/YAGREiNMK0g/видео.html
External antioxidants = supplements. The same results have not been showed in consuming antioxidant rich whole plant foods. In fact, the opposite results have been showed
@ How aer you? If I got your point right (not sure), also plants have many other molecules and their levels of antioxidants are not as high as in supplements. They have additional benefits beyond the scope of youtube comments. So you have a point.
@@WellnessMessiah I’m good man thanks :) My point being is that these studies which indicate that antioxidants are bad have studied supplements. However, when you study plant foods rich in antioxidants (Blueberries, Cacao, etc) you do not find the same results. So, you cannot say antioxidants are bad, only that supplemental antioxidants are bad. Otherwise, this would a very reductionistic statement. Plants contain thousands of phytochemicals, when ingested as a whole, they provide antioxidant effects but also other effects that have not been shown to be bad on exercise or on youth. I’m not saying supplements are bad, I take more than 20 supplements. But I have noticed people claiming antioxidants are bad and they’re basing these claims on these studies which only studied supplements. That’s like studying an anthocyanin supplement, getting a result, and claiming that antioxidants are bad. But antioxidants from blueberries aren’t bad. In fact, they’re good. Plants contain hundreds of thousands of phytochemicals in a food matrix and this significantly changes how it acts on the body. You see it time and time again. Isolating one compound and studying it and seeing it doesn’t work. However, when you take plant itself, it works better. Resveratrol might be an exception because of its low bioavailability and that it exists only in very small milligrams in plants.
Your initial premise is WRONG!! There is no such thing as reversing aging, unless you go back in time. You can slow down the aging process, but nit reverse it.
Fashion clown meets a serious researcher, that is my take on Stanfield vs Sinclair. I am aware this does sound rude but american medics are nothing better but any marketing driven "professional".
Stanfields a Gp who’s just found a way to gain followers by discrediting others. Won’t be holding my breath for what he actually contributes to the longevity world.
You stated he has been endorsing this drug his entire life though it has not been around his whole life. Did you misspeak or what here? Makes you seem less credible.
![Lil Uzi Vert - Chill Bae [Official Music Video]](http://i.ytimg.com/vi/D7F42F_JM3U/mqdefault.jpg)
If you take RESVERATROL, make sure you watch this video next:
ruclips.net/video/nk1kUA__p9k/видео.html
✅ Become a channel member on Patreon.
Join with $1 & get access to the 10 resveratrol habits & earn an honorary mention in future videos.
✅ Upper levels receive my entire supplement routine & brands (worth $100).
www.patreon.com/WellnessMessiah
One glass of redwine (Pinot Noir) contain only 1 mg. ?? And you take 1.000 mg. every second day ...
Could you clarify the significant cholesterol increase with resveratrol? It was one of the main points Dr. Brad mentioned in his "Why I stopped taking them" video (7min.40secs.) and I did not find you mentioned that *No beneficial effects of resveratrol on metabolic syndrome* study in your video.
Thanks for your efforts, but for further reviews of others reports, please go through all the referenced studies...
I take resveratrol every day and exercise every day, including intense exercise roughly every other day, and I haven't noticed any issues with being able to exercise or recover. If anything, I am in excellent shape and have only gotten better lately. I think I'll just keep taking it daily.
Same here, I run nearly every morning fasted after having my coffee and taking 250mg nmn and feel great. And most NMN supplements already include resveratrol so separating it is impossible.
@@mhaas281I guess the question is why are you taking this supplement knowing that there is legitimate research debunking it. I say this because throughout the pages of history, too many people, smart people, fell for the fountain of youth scam. This youth potion is nothing new and very powerful in its influence. You must ask yourself why do you continue to believe this despite scientific data debunking it.
I’ve been taking daily but I also run long distances 4-5 days a week. And I’ve been noticing my VO2 max has been declining and I’m not recovering well. Definitely going to take a break for a week now then taking every other day
I’d like to know the truth about Resveratrol: is it good for you or is it potentially dangerous? Why did I have a very obvious, repeatable result from taking resveratrol?… I never expected any visible results from taking it but I began to see that it was indeed responsible for increased endurance in a strenuous “ yoga with weights” class during which we increased heart rate and worked our muscles to their limit. I tested it over and over again. I stopped taking resveratrol because of the negativity around it, but I also had to stop taking the class!
Thank you for your explanation. I will change my routine and take Resveratrol on alternate days. Question: would it increase efficacy if taken at night with fat (dinner) rather than in the morning?
How come Dr. Sinclair gets nervous when confronted about this. He looks down and away and say’s “It’s confusing” …. What do you mean by saying “Dr. Brad isn’t a researcher” when all he’s doing is clearly explaining what went wrong with David Sinclair’s research, the mistakes he made and the inaccurate conclusions he drew, and presents the evidence contradicting Sinclair’s claims! Why won’t David Sinclair accept Dr. Brad’s invitation to defend his work?!
Thanks fo the video, I wanted to ask which brand RESVERATROL do you recommend taking?
Hi A G, I don't mention brands because 1) I don't cooperate with them so you could trust me
2) I once mentioned a brand and they changed the formula leaving me with an egg on my face.
However... I'm working on huge resveratrol project, where I show labels of products I use. I don't say the brands. And you could search and find that for yourself based on that label.
The resveratrol dose matters greatly, not just the brand.
I have seen numerous videos about anti aging. I have seen interviews,read articles,just name it.
You are the best by far,in my opinion I will keep watching!
Very impressed with your explanations and research. Thank you. I subscribed.
You're very kind, thank you:)
the most professional video I saw on this subject
Finally got you on board haha
Good video. Indeed there are some questions still pending in my opinion. The impact on resistance exercise for instance: the inflammation and post recovery and overcompensation is based on stress (caused by mechanical and metabolic work): protein synthesis occurs in the hours post exercise so I do assume resveratrol should not be taken anyway post exercise in these cases. Following your good work and perhaps we'll have a podcast together in the future;-)
Thank you soooooo much for this clear analysis. It's the first video I watch from you. For sure I'll go to the others.
Thanks Ben! Besides the NMN, if there are additional uncertainties about longevity protocols you find yourself wondering?
Please let me know. I'll take it into account when making research-based videos.
May i know if i am already taking Grape Seed extract ( that contains polyphenols), do we still need to eat Resveratrol?
Thank you so much for this super good informations! I was wondering if the cyciling every other day for resveratrol might be valid also for NMN...what's your opinion on this? Thanks a keep up this wonderful work!! Ale from Italy
How are you?
I think cycling is not needed with NMN. It works in a "build up" mode. It more like taking magnesium supplement.
NAD+ mechanism isn't susceptible no benefited by cycling as far as current data.
For example, Sinclair found it takes 9 days for NMN to reach it peak active mode, and you don't want to go down from there.
Save your money. Niacin 60mg is equivalent 1000mg NMN in raising NAD levels.
@@Terrybear27 Interesting! Can you provide articles or evidence to dig more into It? Thanks!
Very commendable script, and "bomb shell" subject selection. Thanks for this. Truly "need to know" information.
Rimon, you have the best channel of RUclips. Thank you so much for your efforts to help us. You are amazing. I love your accent too. Where do you come from.? 😊
Great video!
What are your thoughts about quercetin and fisetin?
I think about taking them alternately with resveratrol.
You're very kind Otto.
First, fisetin is very interesting but it has 1% of data compared to resveratrol.
Having said, that
In 2 weeks' time, you'll get a mind-blowing video on that exact subject. It's a project I've been working on for the last 2 months, took me covering nearly 200 studies, and will include polyphenols as a group.
Including how fisetin, quercetin, and resveratrol could fit in the larger longevity strategy.
More info on this project here:
ruclips.net/video/YAGREiNMK0g/видео.html
@@WellnessMessiah
Thanks a lot! I'm looking very forward to the video!
I saw your comment below about whether NMN should also be cycled and was wondering what you would think about taking astaxanthin every day. I take it for my skin but maybe shouldnt everyday? I take it to help protect against UV rays.
Hi Claire, can't give personalized advice. I can tell you those fat-soluble antioxidants - unless taken for a specific time for a targeted goal (e.g. 1-3 weeks) can turn off the natural defense system and reduce longevity - WHEN we're young.
I"m very careful with them.
Astaxanthin should work better after age 70 when we begin to oxidize our brains, eyes, and ears...all fatty tissues.
And from what I've seen, it can cross the blood-brain barrier.
Today, applied topically against sunshine should be rather safe - I think. Also maybe taking orally before a very sunny vacation and that's it.
@@WellnessMessiah that’s very helpful… fat soluble antioxidants … I won’t take everyday. Thank you for the response.
In which university or institution does Rimon Lumen do his research? I couldn't find much information about his background.
Great explanation, thanks a lot, Rimon! Dr. Brad is not a researcher and may misinterpret the result. your explanation is on time!
Exactly. Just making a name for himself by discrediting others. What’s he contributed to the area longevity ? I’ll wait ….. 😂
Brad take money for that!
Brad did not make money unlike Sinclair, nor did he discredit resveratrol. He simply cited the numerous studies that discredited resveratrol to include CRISPR. Are you saying CRISPR is so incompetent that they misunderstood the studies? Lol maybe. But it's more than likely it is Sinclair that botched the study and refuses to engage in peer reviewed debate.
@@WaGwan-n6x Sinclair is a quack
So what I understand from the video is the benefits of resveratrol are the most when taking it every other day, and dr. Sinclaire also confirms it. So I wonder why dr. sinclaire says in hes book Lifespan that he takes it ever day.
Thank you Rimon. Much appreciated your effort and the clarification. I’m adjusting my routine in consequence.
Nice review, just subscribed to your channel. I currently follow the same protocol for resveratrol, although without the “sip” (not an SI unit) of alcohol. Interesting.
You're very kind David. We'll see in two weeks why red wine - but not alcohol - could strengthen our resveratrol supplement. Have a good day :)
@@WellnessMessiah look forward to your podcast. Btw I have no problem taking a measure of red wine or spirit. The only men I have know who lived past 95-years were regular, if minor, drinkers. Anecdotally a “sip” would seem to be the opposite of dangerous.
Appreciate your balanced and non vindictive approach, if only others could do likewise.
Hi, thank you for this video. I am just wondering why Dr Sinclair says that he takes Resveratrol every day.
Excellent question Starwoman.
I'd seem like Sinclair doesn't apply it on himself, but it always made sense to me what he found in his research. To alternate and cycle resveratrol.
So why? Speculations such as ....
- he tried both ways , tested his individual body and maybe got better results for him with everyday routine? Not sure.
Your guess is good as mine.
I’ve listened to interviews where he only does excise once a week
Stanfield for all his emphasis on methodology and rigorous/accurate interpretation of data, all too often selectively cherrypicks research just for the sake of being contrarian.
His assertion that it is not even clear that activating sirtuins is an anti-aging mechanism based on 1 sirt-2 study is downright ridiculous.
To make such a statement while omitting literal piles of research estabilishing the crucial role of sirtuins (and specifically sirt-1) in aging of various tissues from bones to ovaries, is either ignorant (again, Stanfield is MD, not a real researcher) or malicious.
He has proven himself to be a somewhat sleazy opportunist and considering his considerable lack of expertise or even academic merit, his public persona is all the more inapproperiate.
Hi Samuel, I see your point.
We're all part of the same community. Nobody has a monopoly on science. Because of Brad, I needed to create this video. So he does stimulate back and forth debate and everyone wins from looking deeper into research. It's good for us that he's a contrarian (if indeed he's).
You have your smart brains and you'll do the best for your longevity, I'm sure.
@@WellnessMessiah Yes, you are certainly right that there is a value in what he does.
His rhetoric and framing of the issue is whats rubbing me the wrong way.
@@samuelhajduk5746 Brad takes supplements like resveratrol than fines some research and changes his mind. He has done this on a few different supplements, so you calling him a contrarian is spot on. Also he has a need for attention probably why he doesn’t pronounce data correctly.
Exactly!!!!! Just a cheap way to gain followers and notoriety on social media by discrediting others through an ironic lack of knowledge in data interpretation while claiming that it’s important to be detailed 😂😂. It’s why nobody he attacks really give him the time of day. He contributes nothing himself and they know he has no clue in the actual science. Should stick to writing scripts. 😂
@@trevorrogers8289 couldnt have said it better.
In my opinion, Dr Brad Stanfield is not misinterpreting the studies, instead he is interpreting to suit his agenda which is to go against the hype in order to acquire followers as the opposite, positive and obvious opinions are already saturated with many Doctors and researchers. Conclusion, Dr Stanfield’s interpretation is a marketing strategy.
Please clarify why you take 1 g of resveratrol only once every other day and not daily?
I am taking Resveratrol and it is creating good affect on me especially I am physically energetic. I felt my stomach full every time.
I am taking from 15 days.
1:06 "On its face value there is no reason to go against Sinclairs take on Resveratrol" ... The skeptic in me can think of 720 million reasons for him not to change his take in the face of new evidence.
Thank you for the video - great summary of Dr. Sinclair's recommendations!
A big thank for all your useful and sensible explanations. I was taking resveratrol in the wrong way!
Hi, I hope this comments finds you well. I’m a scuba diver- few months ago I started to take resveratrol , nmn, metformin and some other molecules mentioned by Mr Sinclair. For the first time during my dives (I’m a nitrox diver) I started to experience scary heart palpitations when I was below 20m - it usually would happen at 30-25m depth. At first I thought it was narcosis but then I decided to stop taking resveratrol (intuition) and my dives were going perfectly again. The same problem occurred when I used a hyperbaric chamber (I have it at my gym) - I experienced the same reaction as during diving and they had to take me out of the chamber. When I used it without resveratrol I was again- absolutely fine.
Does it make sense to you? I hope you can shine some light on this as it’s been really on my mind. This days I never take resveratrol when I’m on a diving trip or when I know I may use hypoberic. Tks for your time .
Hi Edyta, how are you? Nice meeting you here. Terrible experience.
The whole goal of supplements is to improve our well-being, obviously, it's not worth it.
It sounds like something that causes your body to become more irritable under physical stress (Water, oxygen levels).
I don't have an explainable mechanism.
Possible explanations:
Allergy to resveraratrol
Allergy to compound in the capsule itself, including remains from the plant from which resveratrol was extracted.
Over activation of the stress system by resveratrol via an unknown mechanism.
Too much high dose.
Have you asked your doctor maybe?
In the next video on this channel, I show how resveratrol dose changes the reaction of our bodies.
Hi Rimon, I’m very well thank you. Yes , it wasn’t the best experience to get a major heart palpitations at 27m and trying to ascend as slowly as possible. I’m glad I worked out what it was tbh as diving is my passion. I do think it might have been a combination of high doze (1g) and high oxygen… I do breathe 30-33% O2 being on nitrox. I was even more certain it was resveratrol after it happened in hyperbaric. Anyway I do agree with your comment of taking it every other day- I’ve also decreased a dose to 0.5g. I noticed that 1g makes me anxious somehow but I feel fine with 0.5g.
Regarding my doctor- I’ve only recently had my first visit with functional medicine doctor but we didn’t have a chance to talk Abt this particular problem. I’m sure I will get a chance during my second app. Thank you for your time. Keep well.
@@edytarabijewska Maybe you should just stop taking that crap, because apparently your body is allergic to it. Instead, have a nice corned beef sandwich on rye with mustard and cole slaw and a knish, and I'm sure you'll be good to go.
Did you have your B12 checked ? Glad you trusted your gut!❤️🇨🇦 .
I know my mom had CT scan and no dementia or Alzheimer’s but has some blood vessel disease. I know blood flow is important. I want to try NMN with mom and myself. She’s 40 pounds overweight but her spine is damaged,so she’s not able to exercise. She can go for small walks but her spine and neck are really painful. I’m hoping the NMN will help, so she can stop taking Advil,because it’s the only thing that works. Yes it’s best to stop,because NO-ONE knows your body like you do. and sure enough you noticed a change.
My dad decided to do keto, and he was super fit and drank 3-4 glasses of red wine per week.However he dropped dead of a myocardial infarction, and my grandma died from the widow maker. He ate meat. He discovered he had prostate cancer because he left it to late ,but it wasn’t that that killed him. The heart surgeon I got said to me, “ I know immediately who eats meat and who doesn’t as soon as I look into their chests in the OR. He said I want you to watch “ Forks Over Knives on Netflix “ I said ok. Now it’s been 5 yrs and Dr ( David Merlmutter ) Drop Acid says your uric acid should be lower than 5.5. Mine was a 3.2 . My blood work has 100% changed since I stopped eating red meat, I do eat organic chicken once in a while and wild caught salmon when I can get it though. I can only speak for myself but with a family history of heart and stroke,I think he’s right. I mean I definitely didn’t stop to think about my 60 yr old self at 35 . So getting the DHA and EPA are super important. Everyone’s brain is shrinking, and blood flow is important. But when in doubt, throw it out,or check it out ! ❤️🇨🇦
Just a wild guess Edyta, resveratrol increased total cholesterol significantly, from the *No beneficial effects of resveratrol on methabolic syndrom* study Rimon forgot to mention at 1:25 (from Dr. Brad's video around the 8th min. mark). In higher pressurized environments, serum-cholesterol may clot arteries more easily which could cause palpitations... I bet you'd not be the only one showing those symptoms under those conditions.
There is possibly a link between cycling creatine and Resveratrol. One creates cellular on a small scale promoting recovery demands and the other providing the energy needed to meet those demands. Research would be needed but this is possibly a compass.
why would you not put that supplemental data out front. this does not pass the smell test.
Great summary but it does not explain why Sinclair is taking it every day despite his findings in his own study with mice to take it every other day
Do you have a reference for the paper David Sinclair said showed regular diet fed mice had benefit when resveratrol was given on alternating days? I've looked at some of his papers but could not find that data in the supplemental material.
I’m wondering if he was talking about the mice that were fed EOD, every other day diet?
Hi David! I remember seeing that in 2019 when I delved into this for my own supplementation.
Now, I went intuitively to the original study, and you're right - No mention there in the supplemental data.
But it says in the paper: "Analyses of the other groups will be presented at a later date."
The standard diet + resveratrol on and off had to be "other groups".
I think that I've seen it in a subsequent paper, that I've seen that. Not easily dug, but you're right about the original paper here:
www.ncbi.nlm.nih.gov/pmc/articles/PMC4990206/
If you find it, let me know. I need time to find what I read in 2019.
@@Rebelsandglam Getting back to you
1. 2008 study.
" subjected to every-other-day feeding (EOD)..."
Supplementary data:
"Beginning at one year of age, SD and EOD (ME -"every other day")
groups were fed a standard AIN-93G diet or AIN-93G plus 0.01% or 0.04% resveratrol...
The EODLR had the longest survival times..."
2. Sinclair mentions that clearly in this paper from 2014 I think that's what I read in 2019:
www.ncbi.nlm.nih.gov/pmc/articles/PMC3970218/
I'm quoting: "However, resveratrol does extend mouse lifespan when provided in a high calorie diet or in standard chow fed to mice every other day"
@@WellnessMessiah Thanks for checking. If I find it I'll let you know. This paper has some EOD feeding results in Figure 4. Although interestingly only the low resveratrol group had a significant benefit: www.ncbi.nlm.nih.gov/pmc/articles/PMC2538685/
Interesting that Sinclair appears to take it every day (skipping days when he forgets for whatever reason). Would be good if somebody could ask him about this in the context of these studies.
Is there a linkage between resveratrol and cholesterol or ldl? Some people say that it increases ldl, which is bad
What coconut yogurt are you using please????
I've noticed that supplements seem to reduce my kidney function. So I've cut back to just good diet, daily exercise (alternating RT, Zone 2, HIIT and 10K steps) and occasional fasting. Maybe that's enough. I used to take resveratrol, but can't imagine taking it now.
Thank you so much for your work and explanations.
there is no controversy, just a GP (Stanfield) that knows about as much molecular cell biology as my english school teacher. There is *some* discussion about the exact involvement of sirtuins, but the overwhelming evidence (and not just from the Sinclair lab) shows that they are absolutely involved in CR mediated lifespan increase. Obviously they are not the only pathway, but there is never just one pathway regulating "big" functions like cell senescene, so its not an either/or with respect to sirtuins and rapamycin. If anything, supplementing nutritionally, with resveratrol and NMN is far preferable than taking a drug like rapamycin. Also, if you read the paper showing the low level replicative stress carefully, they do discuss their results in the context of the plethora of evidence on resveratrol and lifespan extension, and they are not actually mutually exclusive because low level relicative stress is actually one of the putative mechanisms unerpining lifespan extension even accroding to Sinclair's layman explanation. OVerall the literature has an astounding amount of data linking caloric restriction, sirtuins and sirtuin activator compounds and the rest is various randos on the internet trying to catch a bit of the spotlight and make a name for themselves (like that stanfield guy) on youtube by throwing around provovative statements like "convtoversy about resveratrol", which is laughable. Thankfully real science doesn't care about them
Thank you very much for your great job. Could you please summarize it in a few words for a stupid, 52 kg, 56 years old woman: how much resveratrol and how frequenty to take it? I really appreciate your research and thank for that
The version of NMN I take includes resveratrol as do most nmn supplements.
Awesome Video!
Thank you!
Hey Anthony, you're welcome.
A mouse days rest is not the same as humans days rest, one day for a mouse is a lot more of its life than one day for a person!
I really appreciate your work man! Thank you!
Can you please a video on the differences of resveratrol capsules and just powder?
Whatever dude, Brad only discussed data results not mechanisms. If the data he analyzed is wrong, then show us compelling data resveratrol shows benefits. You told us there is a huge number of studies but failed to mention a single one.
Hi Rimon, thank you for your explanation. I'm curious to know more about your background as a researcher, where you studied, and if you have published or co-authored any papers on ageing yourself?
Hi Jessica, my background is unique, which makes my results unique.
I did study chemistry, biochemistry, metabolism (certified in Metabolic Typing), and statistics).
From here, you can start thinking about data.
Besides that, the actual research was done outside of the academy (and more around humans - my clients and my body) , which makes it complementary to the yeast and mice Sinclair mostly researched.
I explained more about me and my research in this video (first you'll find results, then the 4 pillars of my research):
ruclips.net/video/S0zvpeWvU_k/видео.html
@@WellnessMessiah
@Wellness Messiah with Rimon thank you for your response and that sounds like an impressive background. Your video is very informative and well presented. I am finding it so hard to parse information on ageing when the top ageing experts like Professor David Sinclair, Charles Brenner, Matt Kaeberlein and Brian Kennedy all disagree with each other and argue so vehemently about it on Twitter. It's honestly so bad for science communication and for lay people like me wanting to know if they should take a supplement and which molecule is better. I wish the ageing experts would come together for some sort of friendly joint debate or discussion.
My impression is that while there are some studies studies, there maybe aren't large-scale, strong human trials on supplements like NR, NMN, metformin, rapamycin, so forth? Or they are still underway? It's so confusing, honestly lol.
@Jessica _S I agree with you, it's very confusing. Remember that each lab researcher has seen different results. I think it's -- part of their identity.
Also, the answer many times is intuition.
Because each study gives a tiny, tiny cube of evidence (that may be incorrect), as well. Thus,
lab researchers, many have different intuitions about where we should go.
And it's very difficult to put intuition into a debate. You can only prove the cubes. Only your mind can see the big picture - hard to argue around that.
The results I have put were never done in a single study but followed by the intuition of how the human body works.
Metformin - many, many human studies. Been in use in humans for 60-70 years now.
NR& NMN - Most of the human studies are from NR because it has a patent. So there is money in it. It doesn't take anything from NMN
There is a lot of benefit in mice studies, our evolutionary cousins.
Worth sharing with others 😉
Did you not do a video where you suggested too much resveratrol was more beneficial to those who were sick (I.e. cancer patients) and less is more beneficial for healthy people? Why are you taking 1g, isn’t that higher dose? I thought you suggested between 250-500mg for healthy people?
Hi Tom, yes, check the date of this video. It's much older. Intentionally, I'm documenting here my own journey. For you, it means that I will update things, tweak them, and give the reason,. So people will have no choice but to continue to hear my babbling. Besides, most of the research here is still 100% correct. No need to remove this video
Thank you .. This was very helpful.
Thankyou very much for the great Video! What about, when I only make Zone 2 training?
Good question Christian. Do you mean, you stay in fat-burning mode the whole exercise session?
Can't give personalized advice, if it were me, any cardiovascular activity (and even resistance) I'd delay resveratrol afterward. It may even help with the recovery this way.
Thank you very much!! 🙂
how comes that Sinclair takes resveratrol every single day and he also does a lot of excercise?
Hi There, it's mere speculation. Nevertheless, in the last video in the resveratrol series, I go into speculating why Sinclair does what he does and adding a clip of his response about his dose, too.
Did you happen to see any videos from the 4 that were released so far?
@@WellnessMessiah this is the first video that youtube suggested me. Can you share the title of the video you are talking about with your speculations about Sinclair?
Great as usual 👍
Best advice... thank you
Thank you, Arnold. Next week we'll go deeper on this channel on Resveratrol, with 2 videos, the second using David Sinclair's direct research and some more.
Great video thank you
Thank you Pedi!
P.S. Another Resveratrol video analysis comes soon.
You can not paste and post selected clips
Dr. David Sinclair is genius
Agree with you Anaia. He's a genius.
awesome! straight to the point👍🏻
This is really a good video about the controversy of resveratrol. Nice work
Thank you Enrico, you're very kind. Also, there is the dose controversy. Have you had the chance to check it too?
ruclips.net/video/Js_l_G1x8V4/видео.html
Whats the biggest difference. One reads reports and the other one actually writes them. I’d go with Sinclair all day
The issue is that it could not be replicated. Ask the company that payed out millions to David.
That study about exercise was short term, people forget your body adapts to things over time. Why don't they run blood test on people who have taken resverstrol for years. Cause a lot of those people seem in great shape. It appears resverstrol didn't harm their exercise.
Hi Aventus, good insight from you. In the next project in this channel I only focus on long-term studies. I explain this resveratrol project here:
ruclips.net/video/YAGREiNMK0g/видео.html
With alcohol? Thats interesting!
I'll go with Stanfield any day. Sinclair has compan making millions off resveratrol and nmn.
External antioxidants = supplements. The same results have not been showed in consuming antioxidant rich whole plant foods. In fact, the opposite results have been showed
@ How aer you? If I got your point right (not sure), also plants have many other molecules and their levels of antioxidants are not as high as in supplements. They have additional benefits beyond the scope of youtube comments. So you have a point.
@@WellnessMessiah I’m good man thanks :)
My point being is that these studies which indicate that antioxidants are bad have studied supplements.
However, when you study plant foods rich in antioxidants (Blueberries, Cacao, etc) you do not find the same results.
So, you cannot say antioxidants are bad, only that supplemental antioxidants are bad. Otherwise, this would a very reductionistic statement.
Plants contain thousands of phytochemicals, when ingested as a whole, they provide antioxidant effects but also other effects that have not been shown to be bad on exercise or on youth.
I’m not saying supplements are bad, I take more than 20 supplements. But I have noticed people claiming antioxidants are bad and they’re basing these claims on these studies which only studied supplements.
That’s like studying an anthocyanin supplement, getting a result, and claiming that antioxidants are bad. But antioxidants from blueberries aren’t bad. In fact, they’re good.
Plants contain hundreds of thousands of phytochemicals in a food matrix and this significantly changes how it acts on the body. You see it time and time again. Isolating one compound and studying it and seeing it doesn’t work. However, when you take plant itself, it works better.
Resveratrol might be an exception because of its low bioavailability and that it exists only in very small milligrams in plants.
Just went to the video you mentioned. Didnt know stanfeild
david likes science, he just likes money more
...in aged men says the study. What is an aged man? 40?
Your initial premise is WRONG!! There is no such thing as reversing aging, unless you go back in time. You can slow down the aging process, but nit reverse it.
it’s making me younger, im oiler and my skin getting acne 😂
Fashion clown meets a serious researcher, that is my take on Stanfield vs Sinclair. I am aware this does sound rude but american medics are nothing better but any marketing driven "professional".
Stanfields a Gp who’s just found a way to gain followers by discrediting others. Won’t be holding my breath for what he actually contributes to the longevity world.
Agree, I just cane to that conclusion too.
The western diet is not a high fat diet, it is a high carbs diet. Fat is healthy if not eaten together with carbs!
Playing basketball DOES make you taller. But you have to dunk 🙃
2:45 I see what you did there
Such a treausure.
Thank you Hannah
good i did not buy that since i execise evryday :)
You stated he has been endorsing this drug his entire life though it has not been around his whole life. Did you misspeak or what here? Makes you seem less credible.