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Hi! I'm Italian and live in Italy. I put extra virgin olive oil and red onion practically everywhere, and garlic too. Especially in tomato sauce. We eat it very often.
The video was not too long! It was just the right amount time needed to summarize each study and build a case for your position/s. It was very informative. And none of these other 10 or 20 minute videos that other RUclipsrs have on this topic even come close.
Thanks very much, Rimon. You're obviously very good at reading scientific papers to get useful information, I appreciate your time & effort. Having viewed your earlier videos on resveratrol, I have for some time been taking 1gram on a Monday (cancer protective, I'm 55) then 100mg on Tuesdays, Thursdays & Fridays and none on Wednesdays, Saturday or Sunday. Now I'm considering high dosing for 3 days at the beginning of each month, then keeping to my earlier low dose regime for the rest of the month ?? Will re- watch this videro a couple of times more, there is a lot of information... ;-) I hope your wife's health continues to improve. Dave
Hi Dave thanks for the wishes for my wife. Yeah, your protocol seems good, on the aggressive side. Nobody knows exactly what's the perfect mixup. Not a recommendation/not medical advice - I would probably do 4-5 days every 3 months ages 55-65, and over age 60-65 do it every month. It also depends on our genetic disposition to cancer and family history (more risk = I'd be more aggressive). Again, pure speculation. your guess is as good as mine. The dosage has to be spot on, that's for sure.
Thanks Rimon, no family history of cancer as far as I know, so thanks for the advice, I'll reduce the frequency of high dose resveratrol to 3- 4 months.
Don't know who do you trust reading those papers doesn't mean it comes from right and concern researcher , could be anyone or company they try to sabotage other person search
Initially I was rather concerned by the heavily and almost obsessive criticism of the Dr Sinclairs use cases/dosage for resveratrol as there may have been a personal research case for his high dosage we simply do not know as he was not advocating people do this. However this video/lecture on synergy is really really good, well done it triangulates a pretty diverse roadmap of application that people can choose in multi faceted ways from supplemental to dietary habits. Definitely something to take note from. Thank you
Many are making videos about this stuff like you, but having watched more than just one, only few of you guys make the effort to offer a video with detailed insights, related connections and especially not coming too easy to enthusiastic conclusions just because a published study reports something with an apparent absolute statement. Thanks a lot for the actually interesting videos and content you are creating.
Another excellent video! Very informative. Synergy is something I’ve tried to implement for a long time. One way I do this is by identifying multiple molecules/supplements/foods that activate a given sirtuin, like for example sirtiun 1, and incorporate all of them into my diet and supplement regimen. I know that the studies on this are fairly sparse, but the ones I’ve seen that do look at synergy usually show a positive benefit. So I go with that. Among the ones you mention here I’ve used olive oil for many years, and I definitely take NMN, NR, and NAD+. I don’t drink tea though so I have a green tea extract supplement instead, and I’m very glad there is synergy between the catechins and resveratrol. You mention you’ll be looking at quercetin in the future, might I also suggest curcumin? I know that these two have some degree of synergy, so it might be worth it to look at both. There are some other synergistic pathways that I’ve been interested in lately. One I have mentioned before, nitric oxide. It seems like a critical support function for a lot of things that happen to promote longevity. It even seems to activate some longevity processes directly, hence why I’ve started eating foods high in natural nitrates (leaf vegetables and beets). Another that I’ve started taking an interest in is the gut microbiome, which also seems to be extremely critical for so much related to our health and longevity. Maybe you could look at probiotics in the future too? One other thing that I’m a big fan of is liposomal delivery of molecules to increase bioavailability. Again, the research on this is fairly sparse but it seems to make a big difference in the positive effects of things like resveratrol and also quercetin and curcumin (phytosome delivery). Pretty much any supplement with low bioavailability I try to get a liposomal pill for, so at this point I have a lot of them. Keep up the awesome work! Your videos are so interesting! There is a lot to cover, we’ll never figure out everything, but the journey is fun! Best wishes to you and also in your wife’s recovery - glad she is improving! Keep us posted!
I like your strategy. I think resveratrol will not work without balance with other antioxidants. Nature loves balance! There are hundreds of different herbs, fruits, vegetables. If not fresh, but in dried form. The amount of each (dosage) is less important, then variety. Better to eat 10 mg each of hundreds antioxidants then 1000 mg of resveratrol.
Rimon-I told you that you had the brightest mind in the longevity field-and you just proved it again!! Do you have any opinion on goat cheese and longevity! I can’t wait for the David Sinclair response video Yes, there is a God-his name is Jehovah What is the meaning or purpose of life-to honor and glorify our creator who sooo wonderfully created our marvelous bodies. I pray your wife is getting stronger everyday.
Hi Jo you made me blush again. I will try to integrate your response about God in future videos. Maybe after a response to Sinclair haha. My wife read your comment and your prayer :) P.S. Regarding goat cheese, it has more MCT. And Steven Gundry claims it has a non-inflammatory version of Casein than cows milk. I do not know if it's true. I do appreciate animals that are picky with what they eat, and goats won't eat everything.
what i still dont understand is why ppl never mention olive leaf powder its dirt cheap here what chatgpt thinks about it: Q: how much polyphenols in 5g olive leaf powder. how much polyphenols in the highest polyphenol olive oil 5ml A: The amount of polyphenols in 5g of olive leaf powder can vary depending on several factors such as the type of olive tree, its growing conditions, harvesting time, and the method of processing. However, a study published in the International Journal of Food Sciences and Nutrition reported that the total polyphenol content in olive leaf powder ranged from 90 to 144 mg/g of dry weight. Therefore, 5g of olive leaf powder may contain between 450 to 720 mg of polyphenols. As for the amount of polyphenols in the highest polyphenol olive oil, it is difficult to provide a specific value as it can vary depending on the brand and the method of production. However, some studies have reported that the polyphenol content in extra virgin olive oil can range from 50 to 800 mg/kg. Assuming the highest value, 5ml of the highest polyphenol olive oil may contain up to 4 mg of polyphenols. _______________________________ yea i know olive oil is also oleic acid, but just from a sheer polyphenol perspective its extremely obvious which supplement to take
Hi there - very good comment. Well, I couldn't find synergetic studies with this, hence the exclusion from this video. If the leaves have the exact polyphenol content of olive oil (there are about 3-4 main ones), it should be an excellent source.
Nope, it is not at all clear. Leaves are not fruits. You can not exchange fruits for leaves, just because they are from the same plant...LOOL.... Try with strawberry, apples, almonds, avocados . The leafs always have MORE polyphenols. But guess, they are different and come with strings attached....
Very good presentation thank you kindly for the information. Personally I eat one avocado a day and I usually drink about one shot glass of olive oil with it. I also drink green tea and I also drink this chicken bone broth it also has turmeric and ginger in it every day. Also I try to eat as many blueberries as I can when they’re in season and strawberries. I think now after watching your video it might be important to supplement with resveratrol . I also take a NAC supplement along with a few other supplements as well. Longevity is starting to move forward in a very good direction and I appreciate the information. Please keep up the good work! Thank you kindly!
did not finish to listen this one completely yet (edit: meanwhile I did) but it is GREAT. I highly appreciate your emphasis on non-linearity and synergistic effects and your work for digging out those few papers. Thank you! If all research would re-focus on a more multifactorial design the whole field would be much more advanced.
Still have no idea what a 83 year old woman should be taken dosage of it even though sounds like Sinclair doesn’t take it now. You guys have made one product so confusing.
By the way thanks for summarizing all those papers, and making it accessible to many folks. Love ur channel. When r u going to do the series on pterostilbene / quercetin / fisetin? Some companies already are marketing pterostilbene as a more potent alterna to resveratrol
Also synergy with low dose leucine and ginseng. Low dose leucine 1.1g is low enough to lower sirt activation threshold but not high enough to activate mTor. See Zemel et all human studies
Rimon. Can you please address something that I’ve never seen addressed by anyone else TO THE EXTENT OF PROVING IT ONE WAY OR ANOTHER. I’ve heard doctors claim that when you grind things into a FINE FLOUR (like wheat) you change the molecular structure of it. This seems like it would be pretty straight forward to determine but all I hear are the presumptions that it might be taking place when you grind things into fine powders or flours. Thanks-I love your brain ❤️🙏🏻
@@JenP2776 There is no "ideal" percentage of alcohol, even a small amount of it is toxic, so if you are really caring for your health and want to extend your lifespan you should avoid any alcoholic drink, something which most of us are not willing to do. The idea that red wine prolongs lifespan is a myth created by people who don't want to give up drinking wine. In Sardinia there are quite a lot of centerarians, but they lived longer not because of red wine but in spite of it. There are several more important factors which matter. I like Cannonau but with its 14° of alcohol is one of the strongest wine in all Europe. An average wine is 12°, but most of table wines have 11°. I drink it only on special occasions, celebrations, etc, but not every day. Cheers! 😄
Please respond to another scientist's article on Sirtuins that disagrees Sirtuins are longevity genes. He is a world-noted expert on metabolism. Sirtuins are not conserved longevity genes Charles Brenner Life Metabolism, Volume 1, Issue 2, October 2022, Pages 122-133,
At age 70 I started taking resveratrol 300 mg. 4 days a week (capsules) and 1 GM nmn daily ( capsules). My question - is 300 mg. Considered a low dose considering my age and capsules- thinking less absorption of resveratrol via capsules??
Hi Rimon. Thank you for your great content. Such amazing knowledge. Could you help me. How long after an intense workout session should I wait before taking Resveratrol? Thanks again!
Hi Rimon. I want to ask and perhaps propose an idea. What if we put 100mg resveratrol in 500mg capsule, and add perhaps c8 mct oil, or maybe olive oil. And then capsule it and take it maybe after big meal. What do you think about it?
Hi Bener, mct oil won't have a synergetic effect and I personally consume about 5 grams per day of MCT. Too much for a capsule. Olive oil too, I suspect better to consume it with a table spoon, which is about 3 capsules. Make more sense to create a formula with other polyphenols proven to complement resveratrol and activate other longevity pathways.
Hey Ricco, send an email to wellness messiah at gmail com. However, now due to my wife's stroke, I cannot really do one on one. My wife recovery is about 60% of the job ATM.
@@moniryousefian8782 unoxidized fish oil, NMN, lion's mane (tincture, not powder), high B12, vitamin D (And some others). And a diet high in MCT and no sugar-carbs. Now we're doing hyperbaric oxygen therapy
It is not a question of sth being the best, universally, unequivocally.... Everything has a purpose... Cloves contain campherol, which has different effects.
A lot to "digest" here (lol). I'm taking most of what you talked about here, my latest blood tests would tend to support these benefits. My Md. said "keep doing what you're doing it seems to be working". If you're taking NMN you're likely taking TMG (trimethyl glicine). Is this not a source of glycine? I wondered about cycling low dose and high dose. I may try an occasional high dose.
How should we eat olive oil and in what quantity? Because it is difficult to take many of it (in a salad, for example, probably you will eat only the equivalent to a spoon or two). It is not as easy to it as it is with avocado.
Excelent videos, thanks for sharing your hard work. I have a question about other supplements that I have read a lot about. Magnesium, Curcumin and Creatine. What are your thoughts on those? Also, what do you think about taking NAD+ supplements instead of NMN (very expensive in Brazil)?
Hi Luciano, niacinamide is terrible and will increase aging. Nicotinic acid (niacin) is very good in low doses (50-100mg) divided multiple times per day.
Hi Ken, not medical/personal advice. I knew they did some studies of vitamin K2 on that. I didn't find the publication, but metabolically it makes sense to check it out.
Is it okay for someone younger (30s) to take 1g of mnm? Wouldn't it interfere with the natural formation of nad in the body? Is it better to take nmn every other day?
Rimon, in case you read this: I'm wandering if you read a research paper from Brazil associating olive oil intake with psoriasis flare-ups and if you have an opinion on the findings of this study.
Haven't read it. Questions I would looking for: is it oxidized olive oil?(which increases oxidation), how did the participants take it, which mechanism polyphenols in olive trigger, and do they trigger autoimmune disorder? generally speaking, autoimmune disorders are when the immune system learns something wrong and reacts to it. Meaning, it's wrong to beging with and it should not have reacted in the first place. So it has very little to do with healthy people if it makes sense
All I could imagine is too much oil of any kind, and the impaired bile metabolism often present in PsO/PsA and other similar autoimmune (leaky gut, most often) diseases
Great info - thank you! However, I’m not sure how to proceed. I am 68 years young:) exercise daily, eat a good diet, at a good weight (5’4”/120#) given the new evidence. I’m thinking that I may be taking too many supplements too frequently - daily bio - Fisetin, bio Quercetin, Resveretrol, Pomegranate, among others… would appreciate some thoughtful direction for the optimal daily protocol. Many thanks!
Oh shoot, too much/many antioxidants in a day. Since 2007 ive been working under the concept of antioxidant budget. Take as little as possible. After this episode ill even move some morning ones to lunch, especially resveratrol. Maybe keep water soluble antioxidants in the morning if needed so excess can be peed out (vit c, elderberry, grape)
Because the plants make more RES during the fermentation process.Also, you don't get the sugar that will counteract certain longevity benefits as yeast ferment (convert) the sugar into alcohol.
so if medium does resveratrol is 500-100mg, what is considered high dose? how many days do you take high dose resveratrol for cancer ? and for how long?
I saw in a paper somewhere that high dose Quercetin suppressed Sirt 6. It was in research where they were seeking compounds to activate Sirt 6. It may have been the scientist who discovered that Fucoidan was the most potent Sirt 6 activator. I can’t remember her name, but she is an advisor for donotage I’m in a holding pattern with Quercetin at the moment, but I feel like I am missing out!
Hi There, yes, let me tell you a secret, I wait with Quercetin for different reasons. In fact, I intend to do similar series on Quercetin and Fisetin. Do you prefer to make it in continuation to the Resveratrol series (episode 7-10) or start a new? Sinclair and Brad Stanfield will be on the spot ont that haha.
@@WellnessMessiah I almost want to say a separate series on Sirt6, but it could go either way. So much content! I think at the moment I will limit my Quercetin to high dose 1000mg along with high dose GSE to the 1st, 2nd, and 3rd of each month for senolytic function. Maybe low dose Quercetin every other day in the future? maybe opposite of Resveratrol? I don’t want to cancel out Sirt6 activation. I’ve been loading up on Elderberry extract as it is apparently the 2nd most potent sirt6 activator behind Fucoidan (select strains). I’m about to engage Liposomal AKG with my wife, but we will have to park our Berberine for now. It’s a drag that we have to be so aware of interactions. I greatly appreciate your work. It’s exciting that this science is developing now as we both progress through our 50s, but there is so much to learn. While studies finally exist they remain sparse. Finding the right combo will be so valuable! There are so many pathways, but I feel like we are getting closer and closer, better and better. It sure would be nice if big Pharma and big food would use their resources to help humanity instead of using them to corral.
@@WellnessMessiah Stanfield has been a disappointment. He has been wrong several times. I don’t even watch him anymore to avoid the confusion he has created in the past.
Very good and clear insight. Thank you! Much easier than the last one which was good too but a bit fast for my taste. It is very important to have someone wise like you that can bring light about the new studies and find a way to help applying them.
Did this video cover what is low dose Resveratrol vs high dose? What are the different dose amounts? Perhaps I missed it, but I am not easily finding it. Thanks for any help all
One of your videos (that did a deep dive on low vs high dose resveratrol) provided a formula for calculating the dose relative to someone's weight. Can you provide a time stamp for that info and the title of said video? Or would you mind telling me here? I've been relistinging in an attempt to find it but haven't been able to yet.
Isn't the problem with taking resveratrol supplements as a tablet means that it is activated through the stomach which is not an efficient distributor of resveratrol? A more effective system is to take resveratrol under the tongue or in a form of mouthwash so that it is transported via the tongue/mouth. Not sure if those mouth options for resveratrol are available though. Comments please.
Thank you so much for your valuable studies. Hopefully we will reach 200 years old, i truly think that human will soon discover the way. I'm just wondering do you think it would that be ok to take 50 mg resveratrol 3 days in a raw and then stop for 5 days (because of fasting and sports day so no need to take resveratol) and start again? or is it better to do every other day
yes i think that's fine. I've just read a study low dose quercetin triggers longevity once a week, so those low doses polyphenols seem to have a lingering effect. don't worry.
Hi Bakamon. 100-gram bar of dark chocolate with a cocoa content of 70% or higher contains approximately 0.001 to 0.005 milligrams of resveratrol. This amount is relatively small. However, the polyphenols probably have a synergetic effect with resveratrol. I need to do more research, currently, I'm a fan of 85%+ cocoa content. The main downside is a type of saturated fat, that if your body can't burn, you're in a problem. If you can, it's not a problem. Requires a new video haha
Resveratrol has poor solubility in olive oil. And for green tea why not just have matcha? That way you are injesting everything. What do you think about black elderberry for sirt6 activation?
Hi Brian, isn't matcha just a type of green tea? I guess there is difference in polyphenol content between different strains, but I haven't delved too deep into that. Regarding SIRT-6 I need to do more research. Right now it seems to confer some anti cancer protection, which is why it increases lifespan in mice, 80% of them die from cancer in labs. We only die about 22% BTW
@@WellnessMessiah Matcha is a fine powder of green tea so you consume the whole leaf and you get something like 3 times the EGCG. Because you are eating the whole leaf you can put it directly into smoothies or in a shaker cup and add ice. No need to even heat it.
@@TheBwithers Hi Brain, yes, resveratrol despite what Sinclair says isn't "fat soluble". However, a fatty meal will increase absorption probably by increasing transit time in the gut, allowing more res to get absorbed. So in essence, olive oil can help with this transit time. So solubility isn't absolutely necessary for bioavailability and efficacy. Sometimes we don't know what the heck is happening but the supplement works nevertheless. DMSO is the best solvent for resveratrol I've ever seen, but hard to consume hah
@@WellnessMessiahregarding the absorption, there is one product which I'm trying now, Resverstrol in a hydrogel coating, with 10x better bioavalability... I don't know if is really truth... maybe you can check the product (Google: Optimized Resveratrol Elite) and let us know if is a good alternative for higher absorption or just marketing strategy 😂
I understand the purpose of the video, however, I wonder why there was no mention of forms like trans-resveratrol and also Pterostilbene. As far as I know, resveratrol is hardly absorbed at all.
Yes and no. "Trans-resveratrol" is a specific form of "resveratrol", but they are not completely identical substances: Resveratrol is a broader term referring to a polyphenolic compound, known for its health benefits. This compound exists in two isomeric forms - "trans-resveratrol" and "cis-resveratrol" Moreover, due to extensive metabolism in the intestines and liver, its oral bioavailability is significantly less than 1%. (Walle, 2011) @@WellnessMessiah
What is a better source of Resveratrol? I am currently using micronized 99% transveratrol powder as Dr. Sinclair suggests. But I found new merchants that sell in lower doses via more natural extracts such as japanese knotweed (polygonum cuspidatum) and red grape skin.
Hi Nemanja, best to buy from a company with GMP stamp of the label. japanese knotweed (polygonum cuspidatum) is just the plant that makes resveratrol. not necessarily extra nutrients there. I prefer the brans I showed in the video, around the end(steps)
I have resveratol in powdered form . Can i put it in red wine or olive oil? Or if i have a salad with olive oil, would it be better to pour resveratol over the salad?
It seems like the data is not very solid (statistically ) for asserting low dose resveratrol being better for longevity. The more extreme stress response will slow cell division even more, more similar to caloric restriction it appears, from the data u showed I would'nt be as assertive on the superiority of low dose vs high dose
Hi Anna how are you? Hey Ricco, send an email to wellness messiah at gmail com. However, now due to my wife's stroke, I cannot really do one on one, MAYBE a one-time consultation to invest in my wife's recovery. My wife's recovery is about 60% of the job ATM.
I started looking up Sonclair when i realized the Sinclair-resveratrol connection. So please elaborate, dont just leave a troll comment on such a fine and exhaustive video on the subject.
I'm kinda new to this longevity lifestyle thing. WRT to Reservatrol, I'm taking 1 g of NMN daily. I listened to Dr Sinclair's 2023 supp update on YT and see he's taking 1g of Resveratrol as well. Is this healthy? At what point does the dosage of Resveratrol turn from health to deadly per the study you cited here?
Hi Welcome aboard to our community. The dose impact changes between tissues. I would say 0.5-1.5mg per kilo get the low dose effect. 15-20mg get high dose in most tissues. In between - you will get some high dose and low dose effect depending on the tissue. Make sense?
@@WellnessMessiah it does. seems like the only way to know if it helps is to have routine blood test on important biomarkers to know for sure. I just don’t know what bio markers and how often. I’m definitely not gonna be able to recruit the support of my PCM for testing, so this becomes DIY project to me that is the hard part
@WellnessMessiah I just started to watch your videos and I really appreciate your work. To get the best low dose impact we need to take the 0.5 - 1 5 mg per kg each day or every second day (like in one of dr. Sinclair's experiments you mentioned in one of your videos)? I'm still 40+, with some cancer history in my family, so after 50 I will apply also the 5-7 days 1-2 grams per day every 3 months.
Rimon I take donotage Should you take resveratrol With it like David sinclair I'd rather not because I'm taking so many supplements and i don't want to start drinking red wine lol.
I've taken 10mg astaxanthin and 1000 mg NAC with Glycine and now 250mg on Nmn everyday...I've added R Alpha Lipoic acid and tumeric everyday as well..is that too much..am I back firing and doing more damage than good?...should I go every other day maybe,?...Alternate?...Thx in Advance
i would suggest taking ACV (Vinegar) 1 teaspoon before meals to prevent glucose spikes, cheap and effective, i don't think is too much, but you are forgoting Taurine, you should study your own needs, depends on your age, etc
Hi Pedro it depends on your weight. I have put specific guideline around minute 25
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@@WellnessMessiah Thanks Rimon. I am taking trans Resveratrol, but worry because is light Brown the color, and I listen has to be white powder, or is not true? This is vegan "Nutra Champs" is the name. Very good channel, congrats!
yea well...allegedly green tea is all great n all but man...even VERY low dosage (0.5g matcha powder) taken in the morning mess with my sleep the coming night rather take egcg supplement (which does contain caffeine itself but oh well) really cba with caffeine, such a shitty compound (maybe its got therapeutic effect every once in a while like high dose senolytics but other than that.....no thanks)
Have you checked the amount of arginine in your collagen supplement? In the past, you have warned about taking too much arginine. The collagen supplement that I have has a large amount of arginine.
Hi George, mine doesn't have much (less than plant protein). If you're worried, just take glycine. I take collagen as a protein supplement as well, hence I need a variation of amino acids. IF you don't glycine is excellent.
Thank you! Rimon, how's your sws sleep when you start eating late? Mines trashed and improves when i do breakfast early. I'm going to move resveratrol to lunch but what about olive oil? I like to put it in my morning greens/supplement drink. How about taking grape seed extract with the resy? That's what ive been doing, no ecgc for me (terrified of the liver and prefer to save it for curcumin). Elderberry extract in place of the blueberry/blackberry and drink blackberry, elderflower, blueberry and lignon berry syrups in water all day.
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Resveratrol - the Jekyll and Hyde of longevity supplements.
I'm glad to see some confirmation of your conjectures on resveratrol.
I was told that cranberries powder extract has resveratual in natural form is that true ?! Appreciate your take on it 🙏
Hi
@@georgechristoforou991 Indeed two-faced molecule. Probably in existence for 400 million years, had time to develop different personalities haha
Now I am more confused, but on a higher level.
Hi Esa, what's the most confusing aspect exactly? I will address in future videos
@@WellnessMessiaheverything 😅
Me too😅😅
😅
😜😂
This video is next level.
It clarifies all the muddy water surrounding resveratrol.
Thank you David, Luckily there is a ton of research and we know how res works now :)
I'm an Algérien ( south Mediterranean) and my mom put olive oil on everything even out chest if we are sick or if our hair is messy😂 gid bless her
send your mother my blessings too
Hi! I'm Italian and live in Italy. I put extra virgin olive oil and red onion practically everywhere, and garlic too. Especially in tomato sauce. We eat it very often.
Brava!!!
Many different multi-angle and multi-directional aspects were taken into consideration. Good work!
Thank you DT you're very kind!
The video was not too long! It was just the right amount time needed to summarize each study and build a case for your position/s. It was very informative. And none of these other 10 or 20 minute videos that other RUclipsrs have on this topic even come close.
Thanks very much, Rimon. You're obviously very good at reading scientific papers to get useful information, I appreciate your time & effort.
Having viewed your earlier videos on resveratrol, I have for some time been taking 1gram on a Monday (cancer protective, I'm 55) then 100mg on Tuesdays, Thursdays & Fridays and none on Wednesdays, Saturday or Sunday.
Now I'm considering high dosing for 3 days at the beginning of each month, then keeping to my earlier low dose regime for the rest of the month ??
Will re- watch this videro a couple of times more, there is a lot of information... ;-)
I hope your wife's health continues to improve.
Dave
Hi Dave thanks for the wishes for my wife. Yeah, your protocol seems good, on the aggressive side. Nobody knows exactly what's the perfect mixup.
Not a recommendation/not medical advice - I would probably do 4-5 days every 3 months ages 55-65, and over age 60-65 do it every month. It also depends on our genetic disposition to cancer and family history (more risk = I'd be more aggressive). Again, pure speculation. your guess is as good as mine. The dosage has to be spot on, that's for sure.
Thanks Rimon, no family history of cancer as far as I know, so thanks for the advice, I'll reduce the frequency of high dose resveratrol to 3- 4 months.
Still have no idea whate does for healthy no cancer 82 year old female. Please give amount and how often reply.. Please
Don't know who do you trust reading those papers doesn't mean it comes from right and concern researcher , could be anyone or company they try to sabotage other person search
Restored my interest in taking resveratrol again and new insights. What a great report. Thank you!
Thank you Joe, luckily there is a ton of research and we know how it works now :)
What dosage of NAC and Collagen do you recommend.
Initially I was rather concerned by the heavily and almost obsessive criticism of the Dr Sinclairs use cases/dosage for resveratrol as there may have been a personal research case for his high dosage we simply do not know as he was not advocating people do this. However this video/lecture on synergy is really really good, well done it triangulates a pretty diverse roadmap of application that people can choose in multi faceted ways from supplemental to dietary habits. Definitely something to take note from. Thank you
Many are making videos about this stuff like you, but having watched more than just one, only few of you guys make the effort to offer a video with detailed insights, related connections and especially not coming too easy to enthusiastic conclusions just because a published study reports something with an apparent absolute statement. Thanks a lot for the actually interesting videos and content you are creating.
You're very kind! Yes! no one study tells the whole story, we need to figure this out together:)
Thanks. Very informative as ever. Much appreciated
Thank you Alex you're very kind!
Thanks so much. Will incorporate several of your thoughts into my health span routines. 77 and getting older/stronger.
Cool Elliott, thanks for your comment
Another excellent video! Very informative.
Synergy is something I’ve tried to implement for a long time. One way I do this is by identifying multiple molecules/supplements/foods that activate a given sirtuin, like for example sirtiun 1, and incorporate all of them into my diet and supplement regimen. I know that the studies on this are fairly sparse, but the ones I’ve seen that do look at synergy usually show a positive benefit. So I go with that. Among the ones you mention here I’ve used olive oil for many years, and I definitely take NMN, NR, and NAD+. I don’t drink tea though so I have a green tea extract supplement instead, and I’m very glad there is synergy between the catechins and resveratrol.
You mention you’ll be looking at quercetin in the future, might I also suggest curcumin? I know that these two have some degree of synergy, so it might be worth it to look at both.
There are some other synergistic pathways that I’ve been interested in lately. One I have mentioned before, nitric oxide. It seems like a critical support function for a lot of things that happen to promote longevity. It even seems to activate some longevity processes directly, hence why I’ve started eating foods high in natural nitrates (leaf vegetables and beets). Another that I’ve started taking an interest in is the gut microbiome, which also seems to be extremely critical for so much related to our health and longevity. Maybe you could look at probiotics in the future too?
One other thing that I’m a big fan of is liposomal delivery of molecules to increase bioavailability. Again, the research on this is fairly sparse but it seems to make a big difference in the positive effects of things like resveratrol and also quercetin and curcumin (phytosome delivery). Pretty much any supplement with low bioavailability I try to get a liposomal pill for, so at this point I have a lot of them.
Keep up the awesome work! Your videos are so interesting! There is a lot to cover, we’ll never figure out everything, but the journey is fun!
Best wishes to you and also in your wife’s recovery - glad she is improving! Keep us posted!
Thank you for you wishes for my wife Jason. You always have intelligent comments!
People have had liver damage from the green tea supplements. Its too concentrated from what I remember. Better to drink it naturally in tea form.
I like your strategy. I think resveratrol will not work without balance with other antioxidants.
Nature loves balance!
There are hundreds of different herbs, fruits, vegetables. If not fresh, but in dried form.
The amount of each (dosage) is less important, then variety. Better to eat 10 mg each of hundreds antioxidants then 1000 mg of resveratrol.
Yes, what you said is most likely to be true!
What antioxidants
living balance is the key of health, good habits should be in your lifestyle. thanks for sharing and have a good health!
Thank you Rimon. I will be incorporating some changes into our routine. Wishing you and your wife the best
Thank you Jon for your wishes for my wife. Luckily there is a ton of research and we know how res works now :)
Rimon-I told you that you had the brightest mind in the longevity field-and you just proved it again!! Do you have any opinion on goat cheese and longevity! I can’t wait for the David Sinclair response video Yes, there is a God-his name is Jehovah What is the meaning or purpose of life-to honor and glorify our creator who sooo wonderfully created our marvelous bodies. I pray your wife is getting stronger everyday.
Hi Jo you made me blush again. I will try to integrate your response about God in future videos. Maybe after a response to Sinclair haha. My wife read your comment and your prayer :)
P.S. Regarding goat cheese, it has more MCT. And Steven Gundry claims it has a non-inflammatory version of Casein than cows milk. I do not know if it's true. I do appreciate animals that are picky with what they eat, and goats won't eat everything.
what i still dont understand is why ppl never mention olive leaf powder
its dirt cheap
here what chatgpt thinks about it:
Q: how much polyphenols in 5g olive leaf powder. how much polyphenols in the highest polyphenol olive oil 5ml
A: The amount of polyphenols in 5g of olive leaf powder can vary depending on several factors such as the type of olive tree, its growing conditions, harvesting time, and the method of processing. However, a study published in the International Journal of Food Sciences and Nutrition reported that the total polyphenol content in olive leaf powder ranged from 90 to 144 mg/g of dry weight. Therefore, 5g of olive leaf powder may contain between 450 to 720 mg of polyphenols.
As for the amount of polyphenols in the highest polyphenol olive oil, it is difficult to provide a specific value as it can vary depending on the brand and the method of production. However, some studies have reported that the polyphenol content in extra virgin olive oil can range from 50 to 800 mg/kg. Assuming the highest value, 5ml of the highest polyphenol olive oil may contain up to 4 mg of polyphenols.
_______________________________
yea i know olive oil is also oleic acid, but just from a sheer polyphenol perspective its extremely obvious which supplement to take
Hi there - very good comment. Well, I couldn't find synergetic studies with this, hence the exclusion from this video.
If the leaves have the exact polyphenol content of olive oil (there are about 3-4 main ones), it should be an excellent source.
Nope, it is not at all clear. Leaves are not fruits. You can not exchange fruits for leaves, just because they are from the same plant...LOOL.... Try with strawberry, apples, almonds, avocados . The leafs always have MORE polyphenols. But guess, they are different and come with strings attached....
Very good presentation thank you kindly for the information.
Personally I eat one avocado a day and I usually drink about one shot glass of olive oil with it. I also drink green tea and I also drink this chicken bone broth it also has turmeric and ginger in it every day. Also I try to eat as many blueberries as I can when they’re in season and strawberries. I think now after watching your video it might be important to supplement with resveratrol . I also take a NAC supplement along with a few other supplements as well. Longevity is starting to move forward in a very good direction and I appreciate the information. Please keep up the good work! Thank you kindly!
Would love to hear about balancing women's hormones ...over 40
If you have gathered any info . THANKS 🙏🏼
did not finish to listen this one completely yet (edit: meanwhile I did) but it is GREAT. I highly appreciate your emphasis on non-linearity and synergistic effects and your work for digging out those few papers. Thank you!
If all research would re-focus on a more multifactorial design the whole field would be much more advanced.
Hi monnoo, you're very kind. Yes, about 1:25 or 1:30 is synergetic research. Few and far between.
What a great session Thanks a million Rimon ❤ love how you refer to facts 👌
You're very kind! Yes! no one study tells the whole story, we need to figure this out together:)
hello sir can you make a video about astaxanthin? i want to know more about it. thank you
thanks Rimon A great , more clear session , I love how you sectioned your session Concluding with habits ❤
Is dark red grape juice as good as wine for reservatrol synergy?
Excellent!
Amaaazing session Full of findings Definitely will get your deal once I am back home 👏👏👏
Thank you :) you're very kind
Still have no idea what a 83 year old woman should be taken dosage of it even though sounds like Sinclair doesn’t take it now. You guys have made one product so confusing.
By the way thanks for summarizing all those papers, and making it accessible to many folks. Love ur channel. When r u going to do the series on pterostilbene / quercetin / fisetin? Some companies already are marketing pterostilbene as a more potent alterna to resveratrol
Thank you.
Very good presentation .
Need time stamps
You're right. Hopefully, I will do it today
Also synergy with low dose leucine and ginseng. Low dose leucine 1.1g is low enough to lower sirt activation threshold but not high enough to activate mTor. See Zemel et all human studies
Rimon. Can you please address something that I’ve never seen addressed by anyone else TO THE EXTENT OF PROVING IT ONE WAY OR ANOTHER. I’ve heard doctors claim that when you grind things into a FINE FLOUR (like wheat) you change the molecular structure of it. This seems like it would be pretty straight forward to determine but all I hear are the presumptions that it might be taking place when you grind things into fine powders or flours. Thanks-I love your brain ❤️🙏🏻
Cannonau is a wine that has the highest level of resveratrol.
Thanks for this comment Jen. Didn't know that.
Cannonau? You can find Cannonau in America? I live where Cannonau is produced (Sardinia) and IMO it has too much alcohol to be benficial.
@@lungarotta Yes, Cannonau is exported. The alcohol content is the percentage that is mentioned in this video as being ideal.
@@JenP2776 There is no "ideal" percentage of alcohol, even a small amount of it is toxic, so if you are really caring for your health and want to extend your lifespan you should avoid any alcoholic drink, something which most of us are not willing to do. The idea that red wine prolongs lifespan is a myth created by people who don't want to give up drinking wine. In Sardinia there are quite a lot of centerarians, but they lived longer not because of red wine but in spite of it. There are several more important factors which matter. I like Cannonau but with its 14° of alcohol is one of the strongest wine in all Europe. An average wine is 12°, but most of table wines have 11°. I drink it only on special occasions, celebrations, etc, but not every day. Cheers! 😄
@@lungarotta I appreciate you sharing your perspective!
LOVED IT ......DONE !!!!
THANK YOU . New subscriber🙏🏼
I’m loving how important olive oil to sirt-1
Please respond to another scientist's article on Sirtuins that disagrees Sirtuins are longevity genes. He is a world-noted expert on metabolism.
Sirtuins are not conserved longevity genes
Charles Brenner
Life Metabolism, Volume 1, Issue 2, October 2022, Pages 122-133,
Thanks I will put your paper in my reading list
This guy fkn rules
At age 70 I started taking resveratrol 300 mg. 4 days a week (capsules) and 1 GM nmn daily ( capsules). My question - is 300 mg. Considered a low dose considering my age and capsules- thinking less absorption of resveratrol via capsules??
Hi Sandy, it's a medium dose. Meaning, some tissues will see it as high dose (liver, colon), and some as a low dose.
Hi Rimon. Thank you for your great content. Such amazing knowledge.
Could you help me. How long after an intense workout session should I wait before taking Resveratrol?
Thanks again!
Now I saw this here as well :)
Wow this is a brilliant episode.
What is considered low dose and is that daily. Thank you for you kindness and patience.
Do you know about any study about the effects of higher dosis of resveratrol? Or what is the maximum dosis considered safe?
Hi Rimon. I want to ask and perhaps propose an idea.
What if we put 100mg resveratrol in 500mg capsule, and add perhaps c8 mct oil, or maybe olive oil. And then capsule it and take it maybe after big meal.
What do you think about it?
Hi Bener, mct oil won't have a synergetic effect and I personally consume about 5 grams per day of MCT. Too much for a capsule.
Olive oil too, I suspect better to consume it with a table spoon, which is about 3 capsules. Make more sense to create a formula with other polyphenols proven to complement resveratrol and activate other longevity pathways.
Well done Rimon. Bravo
Thank you and happy new year, full of youth and love
Porfavor les suplico traduscan los videos de David Sincler
Hey Rimon,
How can i become a client of you?
Apreciate you answer 👍
Hey Ricco, send an email to wellness messiah at gmail com. However, now due to my wife's stroke, I cannot really do one on one. My wife recovery is about 60% of the job ATM.
@@WellnessMessiahhi Rimon,
Thank you so much for your kind answer. I fully understand the situation and my thoughts are with you and your wife! 🙏
@@WellnessMessiah
Hi Rimon , I pray for your wife's full recovery 🙏❤👍Amen !!!
Could you please share what is helping her the most ?! Appreciate it
@@moniryousefian8782 unoxidized fish oil, NMN, lion's mane (tincture, not powder), high B12, vitamin D (And some others). And a diet high in MCT and no sugar-carbs. Now we're doing hyperbaric oxygen therapy
Clove is the best
It is not a question of sth being the best, universally, unequivocally.... Everything has a purpose... Cloves contain campherol, which has different effects.
A lot to "digest" here (lol). I'm taking most of what you talked about here, my latest blood tests would tend to support these benefits. My Md. said "keep doing what you're doing it seems to be working". If you're taking NMN you're likely taking TMG (trimethyl glicine). Is this not a source of glycine? I wondered about cycling low dose and high dose. I may try an occasional high dose.
Hi Andy, check the post on TMG I have on the community tab of this channel. It's expansion on TMG.
How should we eat olive oil and in what quantity? Because it is difficult to take many of it (in a salad, for example, probably you will eat only the equivalent to a spoon or two). It is not as easy to it as it is with avocado.
nice work buddie
Excelent videos, thanks for sharing your hard work. I have a question about other supplements that I have read a lot about. Magnesium, Curcumin and Creatine. What are your thoughts on those? Also, what do you think about taking NAD+ supplements instead of NMN (very expensive in Brazil)?
Hi Luciano, niacinamide is terrible and will increase aging. Nicotinic acid (niacin) is very good in low doses (50-100mg) divided multiple times per day.
@@WellnessMessiahIs nicotinamide the same as niacinamide?
@@markaguilera493 im also interested to know if niacinamide is same as nicotinamide? And also why it ages you? Link?
Have you seen any studies that show how to reduce Coronary Artery Calcium?
My CAC scan was just over 1000...NOT good!
Hi Ken, not medical/personal advice. I knew they did some studies of vitamin K2 on that. I didn't find the publication, but metabolically it makes sense to check it out.
Is it okay for someone younger (30s) to take 1g of mnm? Wouldn't it interfere with the natural formation of nad in the body?
Is it better to take nmn every other day?
you don't need to take it until you are 40..45, save your money, or re-invest in high quality food
Rimon, in case you read this: I'm wandering if you read a research paper from Brazil associating olive oil intake with psoriasis flare-ups and if you have an opinion on the findings of this study.
Haven't read it. Questions I would looking for: is it oxidized olive oil?(which increases oxidation), how did the participants take it, which mechanism polyphenols in olive trigger, and do they trigger autoimmune disorder?
generally speaking, autoimmune disorders are when the immune system learns something wrong and reacts to it. Meaning, it's wrong to beging with and it should not have reacted in the first place. So it has very little to do with healthy people if it makes sense
All I could imagine is too much oil of any kind, and the impaired bile metabolism often present in PsO/PsA and other similar autoimmune (leaky gut, most often) diseases
Great info - thank you! However, I’m not sure how to proceed.
I am 68 years young:) exercise daily, eat a good diet, at a good weight (5’4”/120#) given the new evidence. I’m thinking that I may be taking too many supplements too frequently - daily bio - Fisetin, bio Quercetin, Resveretrol, Pomegranate, among others… would appreciate some thoughtful direction for the optimal daily protocol. Many thanks!
Oh shoot, too much/many antioxidants in a day. Since 2007 ive been working under the concept of antioxidant budget. Take as little as possible. After this episode ill even move some morning ones to lunch, especially resveratrol. Maybe keep water soluble antioxidants in the morning if needed so excess can be peed out (vit c, elderberry, grape)
Very informative, Why not just eat red grapes or raisins instead of drinking wine ?
Because the plants make more RES during the fermentation process.Also, you don't get the sugar that will counteract certain longevity benefits as yeast ferment (convert) the sugar into alcohol.
Can advise we can take nmn and GlyNac together?
Not medical/personlzied advice- not a problem at all. they target different longevity mechanisms which can have a synergetic effect.
so if medium does resveratrol is 500-100mg, what is considered high dose? how many days do you take high dose resveratrol for cancer ? and for how long?
I saw in a paper somewhere that high dose Quercetin suppressed Sirt 6. It was in research where they were seeking compounds to activate Sirt 6. It may have been the scientist who discovered that Fucoidan was the most potent Sirt 6 activator. I can’t remember her name, but she is an advisor for donotage
I’m in a holding pattern with Quercetin at the moment, but I feel like I am missing out!
Vera Gorbunova is her name... interestingly, Leucin + quercetin activates Sirt6... by that the paper should be searchable for details
@@monnoo8221 specifically high dose Quercetin was identified as a compound that blocked sirt6. I’ll search for the study.
Hi There, yes, let me tell you a secret, I wait with Quercetin for different reasons. In fact, I intend to do similar series on Quercetin and Fisetin. Do you prefer to make it in continuation to the Resveratrol series (episode 7-10) or start a new? Sinclair and Brad Stanfield will be on the spot ont that haha.
@@WellnessMessiah I almost want to say a separate series on Sirt6, but it could go either way. So much content! I think at the moment I will limit my Quercetin to high dose 1000mg along with high dose GSE to the 1st, 2nd, and 3rd of each month for senolytic function. Maybe low dose Quercetin every other day in the future? maybe opposite of Resveratrol? I don’t want to cancel out Sirt6 activation. I’ve been loading up on Elderberry extract as it is apparently the 2nd most potent sirt6 activator behind Fucoidan (select strains).
I’m about to engage Liposomal AKG with my wife, but we will have to park our Berberine for now. It’s a drag that we have to be so aware of interactions. I greatly appreciate your work. It’s exciting that this science is developing now as we both progress through our 50s, but there is so much to learn. While studies finally exist they remain sparse. Finding the right combo will be so valuable! There are so many pathways, but I feel like we are getting closer and closer, better and better.
It sure would be nice if big Pharma and big food would use their resources to help humanity instead of using them to corral.
@@WellnessMessiah Stanfield has been a disappointment. He has been wrong several times. I don’t even watch him anymore to avoid the confusion he has created in the past.
Very good and clear insight. Thank you!
Much easier than the last one which was good too but a bit fast for my taste.
It is very important to have someone wise like you that can bring light about the new studies and find a way to help applying them.
Hi, what brand of resveratrol you would recommend?
Hi Toni I show examples of brands I'm using (mixing, sometimes this, sometimes that)
in this video:
ruclips.net/video/HC61Gg5lPD4/видео.html
Thx Rimon for ur efforts.
Any specific reason taking collagen and NAC and not NMN or NR?
Theres no reason not too
Did this video cover what is low dose Resveratrol vs high dose? What are the different dose amounts? Perhaps I missed it, but I am not easily finding it. Thanks for any help all
Hi Pedro it depends on your weight. I have put specific guidelines around minute 25
@@WellnessMessiah thank you, I found it at 24:00 actually. And mixing low dose with high dose is addressed at 44:00 for those looking.
One of your videos (that did a deep dive on low vs high dose resveratrol) provided a formula for calculating the dose relative to someone's weight. Can you provide a time stamp for that info and the title of said video? Or would you mind telling me here? I've been relistinging in an attempt to find it but haven't been able to yet.
0.5-1.5mg/kg of body weight is low dose resveratrol. I lean more towards 0.5-1.0 to be on the safe side
@@WellnessMessiahThank you so much. (New follower here, subscribed and appreciative!)
Hi, which matcha grade is better for longevity?
Hi Bryan, I guess there is a difference in polyphenol content between different strains, but I haven't delved too deeply into that.
Isn't the problem with taking resveratrol supplements as a tablet means that it is activated through the stomach which is not an efficient distributor of resveratrol? A more effective system is to take resveratrol under the tongue or in a form of mouthwash so that it is transported via the tongue/mouth. Not sure if those mouth options for resveratrol are available though. Comments please.
how much berries blue and black can be consumed daily to get the best effect with resveratrol
This is genius at its best. I recently found similar content, and it was beyond words. "Your Body Your Temple" by Sophia Wintergreen
What colour should reveratrol powder be?
If you buy alone - white. If you buy with red wine polyphenols - dark brown
@@WellnessMessiah
Thanks
Thank you so much for your valuable studies. Hopefully we will reach 200 years old, i truly think that human will soon discover the way. I'm just wondering do you think it would that be ok to take 50 mg resveratrol 3 days in a raw and then stop for 5 days (because of fasting and sports day so no need to take resveratol) and start again? or is it better to do every other day
yes i think that's fine. I've just read a study low dose quercetin triggers longevity once a week, so those low doses polyphenols seem to have a lingering effect. don't worry.
I wonder how resveratrol would interact with sour sop tea.
Thank you for all the valuable information. What do you think about resveratrol and polyphenols in dark chocolate?
Hi Bakamon. 100-gram bar of dark chocolate with a cocoa content of 70% or higher contains approximately 0.001 to 0.005 milligrams of resveratrol. This amount is relatively small.
However, the polyphenols probably have a synergetic effect with resveratrol. I need to do more research, currently, I'm a fan of 85%+ cocoa content.
The main downside is a type of saturated fat, that if your body can't burn, you're in a problem. If you can, it's not a problem. Requires a new video haha
@@WellnessMessiah Thank you so much for taking the time to write such a thorough answer. You are most appreciated
Does anybody know if Rimon is a Ph or has any university studies? Because if not he is playing with fire!
How much Reservatrol is recommended?
Resveratrol has poor solubility in olive oil. And for green tea why not just have matcha? That way you are injesting everything. What do you think about black elderberry for sirt6 activation?
Hi Brian, isn't matcha just a type of green tea? I guess there is difference in polyphenol content between different strains, but I haven't delved too deep into that.
Regarding SIRT-6 I need to do more research. Right now it seems to confer some anti cancer protection, which is why it increases lifespan in mice, 80% of them die from cancer in labs. We only die about 22% BTW
@@WellnessMessiah Matcha is a fine powder of green tea so you consume the whole leaf and you get something like 3 times the EGCG. Because you are eating the whole leaf you can put it directly into smoothies or in a shaker cup and add ice. No need to even heat it.
@@WellnessMessiah Also what about the resv having poor solubility in olive oil?
@@TheBwithers Hi Brain, yes, resveratrol despite what Sinclair says isn't "fat soluble". However, a fatty meal will increase absorption probably by increasing transit time in the gut, allowing more res to get absorbed. So in essence, olive oil can help with this transit time.
So solubility isn't absolutely necessary for bioavailability and efficacy. Sometimes we don't know what the heck is happening but the supplement works nevertheless.
DMSO is the best solvent for resveratrol I've ever seen, but hard to consume hah
@@WellnessMessiahregarding the absorption, there is one product which I'm trying now, Resverstrol in a hydrogel coating, with 10x better bioavalability... I don't know if is really truth... maybe you can check the product (Google: Optimized Resveratrol Elite) and let us know if is a good alternative for higher absorption or just marketing strategy 😂
Do you take resveratrol every day?
Hi no, I cycle it. Check this episode on why and how:
ruclips.net/video/HC61Gg5lPD4/видео.html
I understand the purpose of the video, however, I wonder why there was no mention of forms like trans-resveratrol and also Pterostilbene. As far as I know, resveratrol is hardly absorbed at all.
trans-resveratrol = resveratrol . The same thing... non-trans is oxidized form and is not studies as it is not active
Yes and no. "Trans-resveratrol" is a specific form of "resveratrol", but they are not completely identical substances:
Resveratrol is a broader term referring to a polyphenolic compound, known for its health benefits. This compound exists in two isomeric forms - "trans-resveratrol" and "cis-resveratrol"
Moreover, due to extensive metabolism in the intestines and liver, its oral bioavailability is significantly less than 1%. (Walle, 2011) @@WellnessMessiah
Can red wine be replaced with balsamic vinegar or grape juice?
What is a better source of Resveratrol?
I am currently using micronized 99% transveratrol powder as Dr. Sinclair suggests. But I found new merchants that sell in lower doses via more natural extracts such as japanese knotweed (polygonum cuspidatum) and red grape skin.
Hi Nemanja, best to buy from a company with GMP stamp of the label. japanese knotweed (polygonum cuspidatum) is just the plant that makes resveratrol. not necessarily extra nutrients there. I prefer the brans I showed in the video, around the end(steps)
I have resveratol in powdered form . Can i put it in red wine or olive oil? Or if i have a salad with olive oil, would it be better to pour resveratol over the salad?
I got a like but still don’t know the proper dose and is it daily of Reveratrol. I’m doing what he said ioomg daily.
It seems like the data is not very solid (statistically ) for asserting low dose resveratrol being better for longevity. The more extreme stress response will slow cell division even more, more similar to caloric restriction it appears, from the data u showed I would'nt be as assertive on the superiority of low dose vs high dose
Hi Rimon.
How is it possible to get in touch with you. I would like to get your professional advice & consultation
Tnx
Ann
Hi Anna how are you?
Hey Ricco, send an email to wellness messiah at gmail com. However, now due to my wife's stroke, I cannot really do one on one, MAYBE a one-time consultation to invest in my wife's recovery. My wife's recovery is about 60% of the job ATM.
hi ! is do not age nmn organic/quality?
I see Sinclaire’s grift keeps on living… amazing!
I started looking up Sonclair when i realized the Sinclair-resveratrol connection. So please elaborate, dont just leave a troll comment on such a fine and exhaustive video on the subject.
would love to see a 5 minute version of this.. without all the small talk....
I'm kinda new to this longevity lifestyle thing. WRT to Reservatrol, I'm taking 1 g of NMN daily. I listened to Dr Sinclair's 2023 supp update on YT and see he's taking 1g of Resveratrol as well. Is this healthy? At what point does the dosage of Resveratrol turn from health to deadly per the study you cited here?
Hi Welcome aboard to our community. The dose impact changes between tissues. I would say 0.5-1.5mg per kilo get the low dose effect. 15-20mg get high dose in most tissues. In between - you will get some high dose and low dose effect depending on the tissue. Make sense?
@@WellnessMessiah it does. seems like the only way to know if it helps is to have routine blood test on important biomarkers to know for sure. I just don’t know what bio markers and how often. I’m definitely not gonna be able to recruit the support of my PCM for testing, so this becomes DIY project to me that is the hard part
@WellnessMessiah I just started to watch your videos and I really appreciate your work. To get the best low dose impact we need to take the 0.5 - 1 5 mg per kg each day or every second day (like in one of dr. Sinclair's experiments you mentioned in one of your videos)? I'm still 40+, with some cancer history in my family, so after 50 I will apply also the 5-7 days 1-2 grams per day every 3 months.
Rimon
I take donotage
Should you take resveratrol
With it like David sinclair
I'd rather not because I'm
taking so many supplements
and i don't want to start drinking
red wine lol.
What about turmeric?
👌
I've taken 10mg astaxanthin and 1000 mg NAC with Glycine and now 250mg on Nmn everyday...I've added R Alpha Lipoic acid and tumeric everyday as well..is that too much..am I back firing and doing more damage than good?...should I go every other day maybe,?...Alternate?...Thx in Advance
i would suggest taking ACV (Vinegar) 1 teaspoon before meals to prevent glucose spikes, cheap and effective, i don't think is too much, but you are forgoting Taurine, you should study your own needs, depends on your age, etc
What amount is small of resveratrol
HI Bard I put a section in the middle on how to customize the est dose for each body. I think around minute 28-30.
Does his fast talking voice with that accent confuse and annoy anyone els3 but me. I can’t take it.
Hi Gloria, started learning English only at age 16. You can use youtube speed to ake it 90% to make it less annoying.
150 mg is low dose?
Hi Pedro it depends on your weight. I have put specific guideline around minute 25
@@WellnessMessiah Thanks Rimon. I am taking trans Resveratrol, but worry because is light Brown the color, and I listen has to be white powder, or is not true? This is vegan "Nutra Champs" is the name.
Very good channel, congrats!
yea well...allegedly green tea is all great n all
but man...even VERY low dosage (0.5g matcha powder) taken in the morning mess with my sleep the coming night
rather take egcg supplement (which does contain caffeine itself but oh well)
really cba with caffeine, such a shitty compound (maybe its got therapeutic effect every once in a while like high dose senolytics but other than that.....no thanks)
Have you checked the amount of arginine in your collagen supplement? In the past, you have warned about taking too much arginine. The collagen supplement that I have has a large amount of arginine.
Hi George, mine doesn't have much (less than plant protein). If you're worried, just take glycine. I take collagen as a protein supplement as well, hence I need a variation of amino acids. IF you don't glycine is excellent.
Why can’t you say what amount your calling low and high dose and how many times a day for how long.
Thank you! Rimon, how's your sws sleep when you start eating late? Mines trashed and improves when i do breakfast early.
I'm going to move resveratrol to lunch but what about olive oil? I like to put it in my morning greens/supplement drink.
How about taking grape seed extract with the resy? That's what ive been doing, no ecgc for me (terrified of the liver and prefer to save it for curcumin). Elderberry extract in place of the blueberry/blackberry and drink blackberry, elderflower, blueberry and lignon berry syrups in water all day.