Maximizing Methylation: The Key to Healthy Aging
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- Опубликовано: 5 окт 2009
- Can you optimize the function of all the systems in your body and protect yourself from nearly all the diseases of aging simply by taking a few vitamins? You can, but you need to know which vitamins to take and how they work. In this weeks UltraWellness blog Dr. Mark Hyman explains the importance of methylation, and how maximizing it can protect your health long term.
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The guy is talking about methylation 10 years ago, talk about ahead of it's time
Way ahead of everyone!
True this is shocking
Methylation destroys dna morons
@@captainpike2468 ROFL source?
I love this guy and Dr. berg!
Just a friendly reminder this video came out 13 YEARS AGO back when RUclips was 90% lyric music videos over generic fanart made in Windows Movie Maker and I've only JUST heard of methylation.
Guys he was talking about this 10 years ago.... Way ahead of time
If you think that’s impressive, check out Dr William Walsh . He was talking about methylation in the 90s
Methylation information starts at 4:30
Thank you!
Awesome!
I've found that taking TMG, along with PS (phosphatidyl serine), CoQ10, folate, B12, and Magnesium Threonate, makes a huge difference in my feelings and functioning. I found my way to these independently, then later learned that many of them are involved in supporting methylation.... that's likely the reason I feel so much better when I take them.
@@willbrink Yes, creatine too! I added it recently
Can i replace tmg with bethaine hcl?
@@fatima546 They're not identical but I would think it would be fine?
What is TMG please? Thank you
@dita4911
TMG is trimethylglycine.
A glycine molecule with three methyl groups.
It's commonly used by those taking mega high doses of a B3 vitamin. Because the body looses methyl groups getting rid of any excess. Long-term low level of methyl groups can have a severe effect.
Glycine is a good buffer for methyl groups. It can hold them or loose them as needed.
By the way. We usually need more glycine.
This guy is coming from future! He talked about this far way from anyone else !!
Today he looks 30 years his senior
Hello, please don't "get to the point faster" as commented. I enjoy your thoroughness and explanations. It's very valuable!
Agreed
Great presentation Dr. Hyman, I really enjoy watching your video's because you bring up important health issues and lay them out in an easy to understand video. Keep up the great work!
I was told I have MTHFR gene mutations c677t and a1298c on April 1, 2022. In June, 2022, I asked my heart doctor what he thought of that, and he seemed to have no clue about the mutations or the methylation process. I was going to have blood work done on September 1, 2022, for my PCP appointment on September 8, and messaged her in advance to ask if she could include a test for homocysteine levels. She said only a specialist could request that test and then during my appointment with her, she also seemed clueless and confused about methylation.
Seek out a "Functional Medicine" Doctor in your area. This is all familiar to them... as compared to a conventional doctor.
Also check out
Dr Troy Spurrill.. And
Dr Jill Carnahan
God Bless 🙌
Thank you for sharing your vast knowledge, Dr Hyman. God bless you.
Thx Dr Hyman for being such a ProActivist about Educating others on their path of Wellness!!! =)
Great video. Very well explained. Very clear, Thank you.
Thanks so much for this important information! Much appreciated…
Wow, doc, you look younger now than you did 11 years ago !!
This is so interesting and helpful. Thank you!
So good, thanks so much.
Melasma is caused by severe adrenal fatigue. Build back your adrenal glands and the melasma will fade.
You are an amazing dr 👌🏻 very educated
This is great very informative and to them point. Thank you.
great video thanks
The knowledge in the last 12 years is better.
Thank you doctor for the detailed descriptions of the deficiency symptoms and how they come about. I thought I'd also mention that those of us who have the MTHFR genetic defect need some alternate forms of certain vitamins like methylfolate instead of folic acid, methylcobalamin rather than cyanocobalamin, and P5P instead of B6.
Yes, cyano -- is cheapest form, and the arsenic atom gets tossed ... so cobalamin can get methylated ... where was the FDA here ...
70 Going On 100
primalslack if you look at the Walsh Research Institute, William Walsh, PhD you will note most severe resistant forms of depression and schizophrenia are Under-methylated, while others may be Over-methylated. Folic acid is not tolerated well by the under-methylated.
There is no such thing as a MTHFR gene mutation or defect, there is no defective gene😳 it is toxicity in the liver which causes methylation problems, if you test positive to the MTHFR gene test all it is showing is high level of inflammation in the body if you detox the liver the test will show negative
@@victoriaarcturus203 false. MTHFR mutation exist. And if you had it and took methyl b12 + methyl folate... you would understand
TRIBOY16 you don’t understand what I am saying, !!
I’m not saying there isn’t a problem, yes there is a problem with methylation, because the liver is overloaded & not able to methylate, what I am saying is a mutated gene is NOT the cause, genes DO NOT mutate, if you test positive to a MTHFT test it is because your liver is under functioning if you detox your liver & take the test again it will show negative, it’s a toxic would problem, not a mutated gene !!!
wrong.,, because it is not genetic, it is epigenetic. Which is related to the mechanism that translate DNA when you need it. This is affected by methylation among other things. It can either suppress or activate certain protein synthesis. Good nutrition and removal of toxins are 2 of the best ways to address any health problem, mental or physical.
Well done keep it up
I suspect that there are certain genes that you will want to repress (e;g; growth hormones involved in cancer) and others that you will want to activate (say for new neural pathways in brain development to better cope with stress). All you need is to target the area of the histones involved in a specific gene regulation. So sometimes you will need methylation and at other times, de-methylation, which tighten or loosen the DNA stand required for transcription.
Doc, you are doing a great job!!!! I wish my family doctor was like that, he gets irritated when I ask questions or any specifics but he seems perfectly fine if I ask somthing simple or dum. I wish my doctor was more like you. Thank you Doc you are cool.
katalina125 Find another doctor!
It's almost impossible these days to find a doctor or veterinarian willing to look at these kinds of things. I understand the problem of finding a different doctor. Those who don't stumble over their own egos are far in between.
It's amazing how much better I feel taking dark greens
Is he eating the green leavy vegetables raw without cooking or is he suggesting the folate survives the cooking process?
I have a question... Is it about having balanced methylation? I read that increase methylation on the glucocorticoid receptor gene is associated with anxiously insecure attached individuals.
So something like a Kefir smoothie with Yellow pepper and eggplant would be ok?
Wow 14 years ago this was talked about, way before modern day biohackers.
No green veggies in winter > Folic acid deficiency, and Vit-B12.
Cant methylate
Homocysteine levels rose
Dark leafy green, wheat germ, oily fish (VB-12), beans
love you
I drink a lot of coffee (black) because I've always been told it doesn't have a negative or positive effect ;\ I drink like 4-6 cups a day this is gonna be hard to get off of.
Low it… I’ ve read about it and they recommend not more of 2 cup per day.. if I remember well
so it sounds like if we have high homo cysteine....then our MTHF is broken....but fixing it always harder than diagnosing it....
Nice video, but it's worth mentioning that Folic Acid and B12 are notorious for not being used efficiently due to gene mutation of MTHFR and MTRR/MAT respectively. For B12 to work it requires a nearly perfect diet and 3 enzymes. TMG/Betaine to the rescue which only requires one enzyme BHMT and is not dependent on diet. Ola Loa is the only single product available to provide complete support for Methylation.
Gregory Kunin is ola loa organic whole food supplement
Greg, thank you! I am 39 and having trouble with B12 and methylation; weakness nervous system is a mess, High homo levels, low low b12, have many gene mutations… I cant find the loa supplement… what are the 3 supplements needed? Betaine, which one, Betaine hcl or Betaine annyhydrous? And bhmt? Thanks a ton!
Greg, what are the 3 enzymes needed? Thanks so much!! ❤
Great presentation- however, folinic acid is much more beneficial to those with genetic defects than folic acid. Also the active form B vits act as methyl donors
You recommended eating cheese... did you not do an entire video on why we should avoid dairy at all costs?
ErikOnly
It probably really depends on where you live and what kind of cheese you have because in America the cheeses are really bad a lot of them have aluminum much more aluminum weigh more aluminum than vaccines.
If one is lucky enough to live in an area that has raw milk real true roll milk from real true grass-fed cows that actually go out in the sunlight and roam around and graze on grass then you are lucky if you can get real honest-to-goodness raw cheese inexpensively .
Nobody recommended eating cheese. The vid said those foods have VK2 in it...that's all. Thats why there are supliments...so we can use em.
This was before the knowledge gained by identifying the MTHFR mutation. Folic acid is a big no no! The supplement to take is the bioavailable methylfolate or folinic acid.
B5 too
What about the high levels of phytic acid in beans, grains & nuts? Doesn’t phytic acid inhibit nutrient absorption?
They are destroyed in cooking .
Destroyed I cooking ?!? What a nonsense
I'd like to know how to obtain vitamin B-1, n 12 without succumbing to synthetic vitamins, or by ingesting nutritional yeast???
Donna Schnaath what’s wrong with nutritional yeast
Can't be done.
"Avod caffeine because it depletes folic acid." I have a MTHFR mutation and was told to avoid folic acid, as it can build up in the body. I take methyl folate. It's folate we want, not the synthetic folic acid.
Doctor or anyone on here; who can I see in NJ or Pa, that can help me with all my mutations. I’m having methylation issues amount high inflammation in the body with B12 in body not working right. Peripheral neuropathy difficulty walking weakness headaches…. Homocysteine high also… hospitalized 3 times now in last few months… 39years old.. I need help. I’m a nurse also… is it a geneticist I see? I had testing through 23 and me and have many mutations… mthhr and cvs gene defects amongst liver pathway being mutated.. where do I start? Thanks!
Look for a local functional medicine doctor. Perhaps, check our Dr Mark Hymanns site... or Dr Jill Carnahan to see if thier practice has a recommendation for your area of residence
Go to a genetic councilor after downloading your raw data from 23nMe.
Good video, except that some persons due to genetics have abnormally high levels of folate in their bodies, and these persons should not take a folate supplement.
profd65 You take methyl folate not folic acid, which will cause build up in your blood.
Great video , but if you are undermethylated , folates are a curse .
Harbin is NOT in the gobi desert.
What about nmn? Does tmg negate the benefits?
keep to niacin
Meat is high in active b12 and b vitamins
Not every methylation of the DNA is productive.
Methylations of important genes can be really devastating.
Methylations are a General process in "genetical physiology". Without Methylations in genetics many things wouldn't work in our Body and in nature as well.
@katalina125 i know right....
800mcg of folic acid and b12 also and still he had that problem?
If he wasn't methylating normally then he wasn't processing these vitamins into their bioactive forms.
THis very mainstream advice, "Limit" this or that, he says, but that is a pandering postponement of the inevitable elimination of taxing foods and alcohol.
yeah, because it is true.. americans think everything is magical.
@@itube0047 As an American I have to agree. It's sad but true 😞
This is an old video. Folic acid is the worst thing you can do it's synthetic! Folinic acid or methylfolate are the ONLY supplements you should take. Of course leafy greens. & dairy, I think not. On point but wrong supplements.
What do you mean by only
It’s now 50 % deficiency
Does that right hand ever leave that section of the screen?
Great recommendations! But
YOU ARE CONFUSING PEOPLE... do not recommend eggs meat cheese and then recommend reducing animal protein! What are you saying?
There is a difference.
Please help .......
For 12 yrs ive had fasciculations n neuropathy n fatigue ..the past 4 years after a remmision of much symptoms aside of fasciculations I've became disabled ..ive seen multiple neurologist
Infectious disease. Doctor n one functional medicine practitioner ..nothing has stabilized my symptoms ...neuro cognitive issues , heavy pressure in head , stiff neck , sore burning muscles, burning spine, nerve conduction issues n nerve pain .muscle stiffness n numb areas. Breathing problens , changes w voice , digestive problrms , rightvside spasticity head to toe, myoclonic surges ..nowhaving trouble lifting arms esoecialy right side n right shoulder, n using my hand to text , trouble walking( very stiff painful n numb) even emg irregularities docs say no als ..latest neuro found lyme in csf , high inflamation , muscle enzymes , slight brain barrier permeability, shrinkage in frontal lobe , functional doc found high aspergilis , low msh , marcons, ....ive supplimented and diet controled so much (on doug kaufman diet but added legumes ) ...showed one mthfr expression ...swiched to myhtelated b n folic ..glutithione , d3 w k , magnesium , coq10, activated charcoal, gi detox , probiotoc , low mold diet, coloidial silver, phosphadytital choline , high dose c , .mimosa , oregano oil , turmeric, krill oil , coconut oil , glutithione, buhner herbs for lyme ( pill form from samsara ) cbd oil , l glutimate , selenium , zink , zeolite, macha , nad+
Manuka a propolis,
I realy feel im not detoxing n have dreams like this .
Trying to save mylinatiin with the choline but have git to deal w this brain inflamation ... I want to be a part of my new sons life amd my grand boys ...
What can i do ?
@@sonicaudio777 research ray peat
@@sonicaudio777 you really need to watch Dr Garrett Smith videos on vitamin D3 as a rat poison and vitamin A toxicity and bile acids in blood causing most health issues. He sells a product called Lactoferrin which works great. He also recommends using as few supplements as possible and testing not guessing. I've stopped using half of my supplements that I was told "is good for me" and I feel better already even though it's only been a couple of weeks. I going to schedule a consultation with him because in my mind what he says make since.
wow 13 yrs ago
Wouldn't you want to minimize methylation? From my understanding, methylation is the biological mechanism in which causes the silencing of gene expression, and is one of the reasons we age, and is thought to be one of the major causes of cancer.
Brett Carter as far I as know it depends on the person, some people need to maximize methylation and some need to minimize it. You can read this interesting article to get a better understanding: jdmoyer.com/2011/09/03/b-vitamins-mood-and-methylation-its-complicated/
***** very interesting topic of methylation. i think at this point we are not sure if we need more/less methylation. seems that methylation of some genes will suppress some cancers, but methylation of others will contribute to other cancers. Tricky business....
Brett Carter Hypomethylation of satellites and retroelements together should account
for the greater part of the decrease in methyl-cytosine content in
cancer cells. Decreased methylation of single-copy genes does not contribute significantly to
the decrease in quantity, but whether hypomethylation may lead to the
reactivation of genes silenced in normal cells is an important issue. here:
www.ncbi.nlm.nih.gov/pmc/articles/PMC2720671/
stay healthy!
Acid Reflux and GERD Great answer, thank you. Yes I've become very interested in DNA methylation as it pertains to oncogenesis and the epigenetics of cancer. I'll definitely check out that paper and thanks again for that great, cited answer. Cheers!
Im homozygous for 2 of the c677t 😢
good info...but maybe just a small suggestion: find a way to get to the point faster...
when I hear take b vitamins....does that mean to take synthetic b vits or just to get t hem from foods like rice bran....molasses......nuts..seeds...etc.....? some of these b vits are made from coal tar base like drugs...and I dont see how that can be good for us.....most DR's never differentiate between the two......
It is almost always better to get it from food, but if you have digestive trouble, it can be difficult. Also, it can be hard to get vitamin B12 from food but a great form to take is sublingual methylcobalamin (methylated B12.) My father has always had a problem with anemia but after taking sublingual methylcobalamin for some time, his blood test showed numbers that were better than ever.
Be aware that Dr. Hyman sells supplements. I like the guy but at the same time I know that if your finances are tied to your way of thinking, your thinking will be influenced. Dr. Gregor (Nutritonfacts.org) who, along with his group, reads every English language study on nutrition, says that most supplements just make for expensive pee. Dr. Campbell (The China Study) takes no supplements and does not recommend them.
We have access to foods that have plenty of B vitamins. Plus those foods have a wide range of other healthy benefits. It would be a bad mistake to take some supplements and think you have your bases covered. After reading about 35 books on nutrition, I believe the way to go is Whole Foods Plant Based Organic (supplement with B12 and D (if you don't get sun)).
Because the supplement, drug, meat, dairy etc. industries have lots of money to influence, most of the information we are exposed to is false. These organizations influence the FDA, USDA, CDC, the organiztion that certifies Dieticians and more.
If you choose to take supplements be sure to do your research. Supplements are not regulated to any meaningful level. It is a buyer beware purchase.
The Annals of Internal Medicine just documented three recent thorough studies on supplements. They also cited past studies all indicating that supplements are at best a waste of money. One of their comments toward the end of their critique stated "stop wasting your money on supplements".
Patrick k
Be careful who you listen to. Supplements have changed my life. I was spending over $1000 a year just in copays for prescription medications. I'm off them all and my chronic fatigue is 900% better along with many other ailments (e.g. asthma gone.) Go natural with a functional medicine doctor and stop paying attention to people who are trained to poison you in the name of health.
midwestMad how did you maintain a job with chronic fatigue? I hear you need at least 10 hours of sleep just to not feel tired the rest of the day.
Very old suggestion. This video should be taken out, because folic acid is toxic to most part of popullation.
Handerson Montalvão U are a dummy. Didn’t u watch the video?
He's WAY lenient compared to Furhman or Barnard.
I’m not eating animal though!!!
Should Overmethylate people really maximize methylation? 😋 🙄 🤔
No they should take some folic acid instead of folate so that pulls out the extra
Homocysteine test
You had me until you said "whole grains"
Doctor Mark "Hymen"? 😳
No coffee???? c'mon man......
Omg 13 years old?
Huh ... Ya !! Huh ? 😊
like a prophet, but a few of the solutions didnt survive test of time haha
"dum" ... lol
He is on the target except when it comes to Saturated Fat and animal protein. Definitely needs to rethink his approach.
Why? His approach is supported by a lot of recent research into harmful effects of animal products.
🤮
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