Longevity community acting like gerangylation, farnesylation, myristoylation, and sumolation of proteins; the donors that achieve this, are some new and revolutionary finds. P.S excessive palmitoylation of proteins leads to obesity due to excessive mitochondrial fission and lack of fusion. Myristoylation of proteins counter balances excessive Palmitoylation pushing you back towards metabolic hormesis. This is why they trial Myristoylglycine for weight loss therapy. Geranylgeroaniol is just a protein modification donor balancing out an imbalance in protein modifications probably driven by the modern western diet.
There may be no need to get GG through supplements; annatto is a very common cooking herb or spice here in Asia, and most likely other places and it’s dirt cheap too. It also is rich in The kind of vitamin E that you mentioned. I make a Vegetable stew every week or so with 3 tablespoons of annatto in it, ground to powder first. It appears that the expensive supplements you recommend Are merely fractional extracts of whole annatto and are probably inferior to it because of the processing and removal of healthy cofactors.
Do you by chance know how much annatto powder you need everyday to match the same 150mg you get in the extracts? What do you think of Bandia Annatto powder brand? Thanks
Apparently, olives (and olive oil) and flaxseed contain GG as do some herbs. Don't know levels though or how this compares to supplements. My TT is high, but can't say that it is due to my significant intake of olives and flaxseed.
Giving credit where it's due, ie. To Dr Barrie Tan, who is the highly regarded Pioneer of Tocotrienol & GG research would give this video a solid endorsement & a boost in your algorithm ranking for sure.
I didn't consider this before, but based on your discussion of vitamin K, it also seems very likely that vitamin K is needed in older people who are trying to fix sarcopenia.
Hi Jeff thanks for your comment. Vitamin K does seem to be required for muscle synthesis and it is used in Japan (as MK-4) as an intervention for sarcopenia.
Not just the tail of any vitamin k2, but the proper form of k2. Which makes things way cooler. Thanks for touching on CoQ10 and steroid hormones too, that all gives a nice overview. I wasn't aware of these simple things. One of the best videos here as far as I'm concerned. 👍
1) I've started taking GG to correct for statin use which, by itself, will decrease COQ10 synthesis. 2) I've also started K2-Mk4 since the most popular, Mk7, has NOT been shown to help scavenge calcium from our arteries like Mk4 has. (Mk7 has a longer half-life, which is the only benefit I've seen stated for it over Mk4.) I put this rationale together from your prior videos and a bit of googling. Thanks for all this analysis and info!
Is there any RCT that shows MK-4 is better than MK-7 at anything? I did not think that such a study exists. Furthermore, it's my understanding that your body converts K1 and MK-7 into MK-4.
@@msplateaugal Perhaps. Absorption. I am not an expert, but I can certainly cite a study: "However, little is known about the bioavailability of nutritional MK-4. To investigate MK-4 and MK-7 bioavailability, nutritional doses were administered to healthy Japanese women." "However, in a previous rat study from our group [18], the intake of a nutritional dose of MK-4 did not increase the MK-4 levels in extrahepatic tissues, whereas MK-7 significantly increased MK-4 in extrahepatic tissues. Thus, MK-7 is a better supplier for MK-4 in vivo than MK-4 itself. "In this study, we demonstrated that a nutritional dose of MK-7 is well absorbed in human, and significantly increases serum MK-7 levels, whereas MK-4 had no effect on serum MK-4 levels. Therefore, the nutritional values of vitamin K2 homologues should be differentiated with regard to bioavailability and efficacy." Sato T, Schurgers LJ, Uenishi K. Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women. Nutr J. 2012 Nov 12
Richard, I think it extraordinary that you can talk on this subject without once mentioning the name of Dr Barrie Tan, without whose work you would never have even heard of GG. Quite shameful actually!
There is a suggested video for Barrie Tan right at the end of this video! Showing up on the left half of the screen right at the end. About Tocotrienols.
Hi Chris, thanks for your comment. We have had Dr Tan on for an interview before and certainly I heard of GG from Dr Tan. I wanted the video to be about the chemical but yes the credit for the raising the awareness should go to Dr Tan. I should have mentioned him.
Thank you so much. I live in México, so it´s relatively easy to get anato directly. It´s name is Achiote. I didn´t know that GG comes from this plant too. God bless you!!!
I will see in a month when I take another blood test. I noticed since I started taking a small dose of a statin my fasting insulin keeps raising. I will see if gg helps to reverse it.
Great presentation on a fascinating, promising new agent. Please update us when new science about and sources of GG come online! Thanks for great work.
Hi thanks for your comment. Assuming that you did mean biased, a couple of comments. Obviously I think that GG is interesting and potentially helpful with aging otherwise I would not have made the video but I did not research potential downsides enough. Which is a good point and I will look at that next time.
@@ModernHealthspanHello, Richard, no worries, "based" is a slang way of saying that something is factual ("based on facts") - so, the opposite of "biased" :P
I have followed Dr. Barrie Tan for several years and been using GG Pure. I've recently switched to Xtend-Quninol which includes CoQ10. Good info thx Richard.
Unfortunately dr Tan is more of a thrifty businessman than a doctor. He found a way to use the leftovers from the production of tocotrienols from annatto, before he just disposed this stuff. Nevertheless, it may still be useful.
@maestroharmony343 That's NOT true! You've twisted his amazing scientific discovery into a mockery of his character - shame on you! Get your facts straight. The accidental "leftovers" (GG) were discovered when distilling for tocotrienols & subsequently found to be of great significance. Dr. Barrie Tan is a highly regarded, forefront Pioneer of Tocotrienols who devoted his whole life to these discoveries so ppl like you can benefit from his extensive work. You owe him a public apology for being a disrespectful ignoramus!
will stop following your RUclips channel due to pharmaceutical company sponsors who pose a conflict of interest with what you publish. A serious program that talks about anti-aging does not accept to sponsor supplements.
Oh really..!! I follow Richard for years and learned tons from his research, although he is not an expert and he is not trying to convince anybody, but rather bring to our attention new cool longevity discoveries. In case I decide, through further investigation, to try one of the products, I highly appreciate getting it in discount, plus, I am glad he is making a little something for all his work and contribution. Thank you Richard!!
![These Molecules Reversed Aging by... YEARS! [TRIIM Study Explained - Study 216]](http://i.ytimg.com/vi/rVoxfABoHh4/mqdefault.jpg)
![These Molecules Reversed Aging by... YEARS! [TRIIM Study Explained - Study 216]](/img/tr.png)
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some foods that may contain geranylgeraniol:
Rice bran oil
Olive oil
Pumpkin seeds
Pistachios
Fish (particularly mackerel)
Beef
Chicken
Pork
Tofu
Wheat germ
Sesame seeds
Sunflower seeds
Hazelnuts
Almonds
Walnuts
Pine nuts
Cashews
Avocado
Spinach
Broccoli
Longevity community acting like gerangylation, farnesylation, myristoylation, and sumolation of proteins; the donors that achieve this, are some new and revolutionary finds.
P.S excessive palmitoylation of proteins leads to obesity due to excessive mitochondrial fission and lack of fusion.
Myristoylation of proteins counter balances excessive Palmitoylation pushing you back towards metabolic hormesis.
This is why they trial Myristoylglycine for weight loss therapy.
Geranylgeroaniol is just a protein modification donor balancing out an imbalance in protein modifications probably driven by the modern western diet.
There may be no need to get GG through supplements; annatto is a very common cooking herb or spice here in Asia, and most likely other places and it’s dirt cheap too. It also is rich in The kind of vitamin E that you mentioned. I make a Vegetable stew every week or so with 3 tablespoons of annatto in it, ground to powder first. It appears that the expensive supplements you recommend Are merely fractional extracts of whole annatto and are probably inferior to it because of the processing and removal of healthy cofactors.
Thanks, great tip - I just ordered some :)
Do you by chance know how much annatto powder you need everyday to match the same 150mg you get in the extracts? What do you think of Bandia Annatto powder brand? Thanks
Apparently, olives (and olive oil) and flaxseed contain GG as do some herbs. Don't know levels though or how this compares to supplements. My TT is high, but can't say that it is due to my significant intake of olives and flaxseed.
Giving credit where it's due, ie. To Dr Barrie Tan, who is the highly regarded Pioneer of Tocotrienol & GG research would give this video a solid endorsement & a boost in your algorithm ranking for sure.
I didn't consider this before, but based on your discussion of vitamin K, it also seems very likely that vitamin K is needed in older people who are trying to fix sarcopenia.
Hi Jeff thanks for your comment. Vitamin K does seem to be required for muscle synthesis and it is used in Japan (as MK-4) as an intervention for sarcopenia.
Very detailed and good presentation, RIchard! GG seems so promising, especially for muscle building!
Thx Richard for the excellent presentation.
Hi AbdelIlah, thank you!
@@ModernHealthspan hi i emailed you but you never responded just that you were reviewing it but you never replied after that
Not just the tail of any vitamin k2, but the proper form of k2. Which makes things way cooler. Thanks for touching on CoQ10 and steroid hormones too, that all gives a nice overview. I wasn't aware of these simple things. One of the best videos here as far as I'm concerned. 👍
Thanks Richard, I'm keen to try G.G after watching your video. However, I'm messaging to find out where can I buy Ishige okamurae supplement from?
1) I've started taking GG to correct for statin use which, by itself, will decrease COQ10 synthesis. 2) I've also started K2-Mk4 since the most popular, Mk7, has NOT been shown to help scavenge calcium from our arteries like Mk4 has. (Mk7 has a longer half-life, which is the only benefit I've seen stated for it over Mk4.) I put this rationale together from your prior videos and a bit of googling. Thanks for all this analysis and info!
p.s., I didn't know GG was also needed for protein synthesis and testosterone! Maybe I should up my dosage... lol. (Currently 150mg/day)
Thanks for sharing
Is there any RCT that shows MK-4 is better than MK-7 at anything? I did not think that such a study exists. Furthermore, it's my understanding that your body converts K1 and MK-7 into MK-4.
@@jackbuaer3828 Is there any reason you know not to take MK-4 instead of MK-7?
@@msplateaugal Perhaps. Absorption. I am not an expert, but I can certainly cite a study:
"However, little is known about the bioavailability of nutritional MK-4. To investigate MK-4 and MK-7 bioavailability, nutritional doses were administered to healthy Japanese women."
"However, in a previous rat study from our group [18], the intake of a nutritional dose of MK-4 did not increase the MK-4 levels in extrahepatic tissues, whereas MK-7 significantly increased MK-4 in extrahepatic tissues. Thus, MK-7 is a better supplier for MK-4 in vivo than MK-4 itself.
"In this study, we demonstrated that a nutritional dose of MK-7 is well absorbed in human, and significantly increases serum MK-7 levels, whereas MK-4 had no effect on serum MK-4 levels. Therefore, the nutritional values of vitamin K2 homologues should be differentiated with regard to bioavailability and efficacy."
Sato T, Schurgers LJ, Uenishi K. Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women. Nutr J. 2012 Nov 12
Richard, I think it extraordinary that you can talk on this subject without once mentioning the name of Dr Barrie Tan, without whose work you would never have even heard of GG.
Quite shameful actually!
There is a suggested video for Barrie Tan right at the end of this video! Showing up on the left half of the screen right at the end. About Tocotrienols.
barrie tan was interviewed on this channel 3 months ago, he isn't being ignored
Hi Chris, thanks for your comment. We have had Dr Tan on for an interview before and certainly I heard of GG from Dr Tan. I wanted the video to be about the chemical but yes the credit for the raising the awareness should go to Dr Tan. I should have mentioned him.
Thank you so much. I live in México, so it´s relatively easy to get anato directly. It´s name is Achiote. I didn´t know that GG comes from this plant too. God bless you!!!
Interesting video and the studies. I was sort of hoping that Richard gave GG a try and indicated what improvements he saw in his exercise performance.
I chose Designs for Health Annatto-GG 300. Use it with Thorne Vitamin K and NutriZing K2.
Hi thanks for sharing. Hope that it works for you.
I will see in a month when I take another blood test. I noticed since I started taking a small dose of a statin my fasting insulin keeps raising. I will see if gg helps to reverse it.
@@maestroharmony343Statin use is what is making you insulin resistant
Great presentation on a fascinating, promising new agent. Please update us when new science about and sources of GG come online! Thanks for great work.
I think this is maybe very important. Can't wait to try it..
Then i will know !
I will believe it when you have proof in at least 3 different animal models, but human data would be best.
...Good food..Good health..better adviser...
based video.
Did you mean "biased?" If so, can you please explain your evidence here?
Hi thanks for your comment. Assuming that you did mean biased, a couple of comments. Obviously I think that GG is interesting and potentially helpful with aging otherwise I would not have made the video but I did not research potential downsides enough. Which is a good point and I will look at that next time.
@@ModernHealthspanHello, Richard, no worries, "based" is a slang way of saying that something is factual ("based on facts") - so, the opposite of "biased" :P
I have followed Dr. Barrie Tan for several years and been using GG Pure. I've recently switched to Xtend-Quninol which includes CoQ10. Good info thx Richard.
Unfortunately dr Tan is more of a thrifty businessman than a doctor. He found a way to use the leftovers from the production of tocotrienols from annatto, before he just disposed this stuff. Nevertheless, it may still be useful.
@@maestroharmony343 what are you saying? He is a doctor who is also a businessman?
@maestroharmony343 That's NOT true! You've twisted his amazing scientific discovery into a mockery of his character - shame on you! Get your facts straight. The accidental "leftovers" (GG) were discovered when distilling for tocotrienols & subsequently found to be of great significance. Dr. Barrie Tan is a highly regarded, forefront Pioneer of Tocotrienols who devoted his whole life to these discoveries so ppl like you can benefit from his extensive work. You owe him a public apology for being a disrespectful ignoramus!
@@maestroharmony343just a disrespectful ignoramus spreading untruths!
I'll have to think about this one.
Hi Scott, thanks for the comment. Not sure if Oreos work the same way as statins!
Joking, my friend. Keep up the good work.@@ModernHealthspan
will stop following your RUclips channel due to pharmaceutical company sponsors who pose a conflict of interest with what you publish. A serious program that talks about anti-aging does not accept to sponsor supplements.
Oh really..!! I follow Richard for years and learned tons from his research, although he is not an expert and he is not trying to convince anybody, but rather bring to our attention new cool longevity discoveries. In case I decide, through further investigation, to try one of the products, I highly appreciate getting it in discount, plus, I am glad he is making a little something for all his work and contribution. Thank you Richard!!
seems like gg is in olive oil and nuts like walnut and almond and pistachio. may account for some of their heart health benefits
What is your favorite top 3 anti aging supplements ? Thank you
Would the use of essenial oils be ok..😉
annatto seed is cheap
ggz all o/
Hi Richard. Thank you.
Hi Ron, thanks!