C15 A Longevity Game Changer? | The Studies Reviewed
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- Опубликовано: 9 апр 2024
- C15 or Pentadecanoic acid, also known as Fatty 15 may be an essential fatty acid and we may not be getting enough of it. Here we go through the science of C15, its benefits and natural sources.
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🌐Links in this video
Seraphina Therapeutics
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Serum pentadecanoic acid (15:0), a short-term marker of dairy food intake, is inversely associated with incident type 2 diabetes and its underlying disorders
www.ncbi.nlm.nih.gov/pmc/arti...
Pentadecanoic Acid (C15:0), an Essential Fatty Acid, Shares Clinically Relevant Cell-Based Activities with Leading Longevity-Enhancing Compounds
www.ncbi.nlm.nih.gov/pmc/arti...
Efficacy of dietary odd-chain saturated fatty acid pentadecanoic acid parallels broad associated health benefits in humans: could it be essential?
www.ncbi.nlm.nih.gov/pmc/arti...
The lipidomic correlates of epigenetic aging across the adult lifespan: A population-based study
onlinelibrary.wiley.com/doi/1...
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#C15 #fatty15 #fattyacids 
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To further improve health and mitigate damage to mitochondria, the RDA is insufficient. Increasing dairy consumption would also increase the even-chained, inflammation causing acids/fats and caloric intake. C-15 supplementation would offer swifter resolution for health issues. I suppose if you aren’t worried about aging or health issues, the RDA would be fine..
5:50 That symbol is micromolar, not micromoles.
Excellent analysis, thank you. I just came across another video about it and I wanted to do an in depth look at these other papers. You did that research for me, so thanks again!
A healthy source for C15 is Ghee. It is a high smoke point fat extracted from cows milk which is used in Indian cooking and for many other purposes.
To make ghee, butter is heated to high temperatures (+325 F) for some time. Is ghee still healthy?
@@jaym9846 Ghee's smoke point is 485 F which should be high enough to maintain its healthy attributes. Ghee is used in a lot of high heat Indian cooking but I have never heard of any deterioration concerns.
Far less expensive than the supplement as well.
C15:0 (Pentadecanoic Acid) in Ghee
Pentadecanoic acid is a lesser-known but significant saturated fatty acid found in dairy products, including ghee. It has gained attention due to potential health benefits.
Typical Content in Ghee: The content of pentadecanoic acid (C15:0) in ghee can vary, but it is generally around 1-1.5% of the total fat content. This can vary depending on the source of the milk and the specific processing methods used.
Value of C15:0 in Ghee
Pentadecanoic acid has been studied for its potential health benefits, which include:
Anti-inflammatory Properties: Studies have suggested that C15:0 may help reduce inflammation in the body.
Metabolic Health: There is some evidence to suggest that pentadecanoic acid can support metabolic health and may be associated with a lower risk of metabolic syndrome.
Cardiovascular Health: Some research indicates that C15:0 might have a protective effect on heart health, potentially reducing the risk of cardiovascular diseases. (GPT 4o)
@@jaym9846 As far as I know (and practice), ghee is made at 100 C (212 F). In fact, every recipe I've known of, says not to go beyond 110 C (230 F). I don't know where you did get you number from (325 F -> 163 C). Too high.
Making ghee from butter must be a slow process. Most of the protein and solids should go to the bottom in a slow process. Part will just float. If you burn it at 163 C, it changes its organoleptic properties and will never decant properly.
Is fatty15 the only company that produces this? $40-$45 per month depending if you elect for the subscription. $30-$35 maybe, But $40-$45 a month equals nearly $500 a year. From my understanding they take c14 from plants (abundant source) and add one carbon? (Whatever it is I don’t know!) the point is, it seems a little overpriced for what it is. I want to take it, but sheesh, that’s quite a financial investment on the consumer’s part…
❤❤❤
The presenter made no case for supplementation aside from dietary sources perhaps elevating less desirable FAs. The real issue is if getting the optimum amount comes at a cost of ingesting deleterious amounts of others. My guess is is in the context of a balanced diet, likely not.
I tried to buy C15 . No matter what options I picked it subscribe you for automatic refills even when I picked the 1 month trial. There has to be something else in our body function that is inhibiting the natural production of C15. This cannot be the only method to get C15🤔🤔
They have a lot of staff and advisors who need to be paid hence the high cost
Just eat grass fed butter on some things when you can. Its probably the Dairy industry that funded this study anyway. Who knows.
We needed to know this forty years ago. Better late than never as the saying goes. Thanks
Nice to see you adding biochemical commentary from your expanding knowledge,,, love the evolution of the channel as such....
Thank you for the recommendation of 100 grams of C15 per day, the approximate amount in one tablespoon (12 grams) of butter. Easy enough to add to my day. Thank you so much, Richard!
Hi V, thanks for your comment. Cool! Sounds good.
@@ModernHealthspan hi I recently just emailed you about the chemical cocktail from harvard that I heard about I got a response in the email saying please type your reply above this line what line are you talking about
@@eman1989z I believe it was a mistyping error. I think it was meant that there is about 100mg C15 in 12 grams of butter. That jives with a couple sources I've found that put the C15 content of butter fat at ~1%. Use real cream in your coffee and real butter on your veggies and you're getting more than the postulated 100mg/day.
@@badabing308people are deficient as they move to veganism or plant milks. I use butter , drink full fat milk and use butter in cooking. I don’t go mad but I have 1/2 to 1 pint milk a day and half a tablespoon of butter in cooking as well as goats cheese most days. I read goats milk and cheese is higher that cows milk
One alternative is to use ghee, which is a form of clarified butter containing the pure fat making up butter. So 1 tablespoon of ghee may well met the 100 grams level. I make my own ghee.
A great and timely video. Thank you for this Richard.
Hi Lars, thanks!
If one tablespoon of butter makes the recommendation then there are millions of people around the world that are getting this amount of c15. Dr Venn-Watson in one of her presentations on the internet mentioned that she had started menopause (with all problems) and doubled her dose with good results. This leads me to wonder if this is one of those molecules that gets less and less as we age. Anyway an incredible analysis and review Richard...
There are also many people around the world who have no dairy products or fish in their standard diets. Are they inherently deficient in C15:0?
You look young Richard, thank you for this presentation.
Hi Ben, thanks! I hope that you found the video helpful.
Awesome info, thank you! The lowering of blood sugar for diabetics is interesting.
Thank you for this insightful
Very nice deep dive. Stearic acid (C18:0) is kind of magical, also, and has dropped dramatically in Western diets due to the general fear of fats. Since it didn't fall in consumption simultaneously in the same way across all cultures (France, for instance, continued having stearic acid as part of their diets well after the United States had all but eliminated it), however, there's interesting evidence out there that suggests that the correlation of the fall in stearic acid consumption with the increase in cardiovascular and other problems is not merely coincidental.
Hi Scott, thanks for sharing. Interesting, based on the reading I did I would have thought that an even chained fat would have a negative impact on health - though there did not seem to be a mechanistic explanation for this. I do think eliminating nearly all fats is not a good idea. I did see that Dr Venn-Watson also highlighted the correlation of lower dairy fat and increased CVD as being possibly related to lower C15. There have been many changes in the diet over the last 40 years so difficult to pull it apart after the fact!
Odd number fats like c15 are better than even number fats like c18.
There's one animal study that showed stearic acid as the only fat that greatly reduces visceral fat
Thank you Richard.
Hi Ron, thank you!
Thanks for this video. I just ordered C15 from the company in San Diego.
Amazing Supplement!!!
Why didn't you compare it to steric acid and palmitic acid?
Thank you for this video amd bringing this info in front of us in a concise manner, and before it hit the "mainstream health youtube channels".
Really enjoyable; appreciate the work
One tbsp of butter would be about 120mg C-15. Should be all one needs in a day, even if you eat no other animal products.
OMG thank you so much. I will have more butter..
Grass fed dairy and not fed grains to increase milk production
Around 130 grams of mackerel should give you about the same, perhaps varying with seasonal total fat content.
You all need to read the facts of this pill properly... the C15 you get from fatty 15 is only the good fat(only 1 calorie) whereas the dairy option is full of saturated fat which is not good for you. On top of this, Fatty 15 is easy to absorb where how we get it from food takes so much work, coming with risk of diabetes 2 and heart disease....
I tried taking C15 (aka commercially as "Fatty 15") for a couple of weeks. I had negative neurological symptoms that started, including tingling and numbness in extremities and a psychological sense of unreality and a generalized feeling of being way off. It was frightening. I'm not going to try taking it again,
Hi Thanks for sharing. Can I ask did you reach out to the vendor? Also, do you eat dairy products? If you do, you would probably have similar levels of C15 in the blood.
@@ModernHealthspan I did not contact the company yet. It's the company founded by Venn-Watson, the scientist who did the dolphin studies. I did some subsequent research on C15:0. It is actually one of the fatty acids that is HIGHER in people with MS, a neurological condition. There is actually good research on this. So, the idea that C15:0 is some sort of panacea is not completely accurate--- there are diseases associated with higher levels of C15:0. Omega-3 fatty acids have been shown to help people with MS, which is also interesting. Omega-3 fatty acids make cell walls more flexible, C15:0 makes them more stiff. (BTW, I DO eat butter, a lot of it.)
@@ModernHealthspanThere must be other Areas in ones Body Blocking absorption of this newly discovered c. 15.. or everyone who eats sufficient dairy and Red meat, Would have a Normal Insulin level!
ESPECIALLY IF one has Methylation issues. Which apparently 40% of people do have. OR more!
No wonder. So many people have high Insulin!
Thank you soo interesting! 🎉👏🏻🎉
Eat real butter. Problem solved.
@@LloydsofRochester C15:0 from food is tied up in complex lipids called triacylglycerides, which our bodies cannot absorb.
Oleic acid is labelled omega 9 then EPA 20:5 alpha 5, 8, 11,14, 17. The alpha system is used by chemists but the omega nomenclature is better for biologists. I’d suggest EPA 20:5 omega 3, 6, 9, 12 & 15. It is all correct but not consistent using omega then alpha nomenclature.
I thought dairy products causes inflammation. So adding cheese butter dairy are good fats. Why take a $50 supplement if you get it from your diet?.
Because there's lot more C16 in dairy than C15, and that's inflamatory
C15:0 from food is tied up in complex lipids called triacylglycerides, which our bodies cannot absorb.
The even number chain length saturated fatty acids in dairy are believed to be bad for your health.
Mackerel has some C15 as well, and probably other fatty seafood as well but not measured.
The full fat dairy in our diets have plummeted in the last 40 years which is also the reasoning of the discoverer of the importance of C-15
I put ghee in my coffee. I hope it has the recommended amount of c15!
nope~! there is one hour special done by Thomas DeLauer. not enough. whatever is left is destroyed by the liver if i remember right.
Thank you
If your total daily fat content is high, you will not have high levels of C15 due to type of microbiota in the gut. It’s the gut bacteria that synthesize the C15. A few studies show this. One test compared 5% dietary fat with 35% dietary fat and 70% dietary fat (plus they use different types of fat).
Result: “the concentration of C15:0 decreases as the dietary total-fat content increases (p < 0.05); a ~30% increase in dietary total-fat resulted in a ~35% decrease in circulating C15:0 concentration.”
It didn’t matter what type of fat used. As the total daily fat content rises - the less C15 synthesized. We need the correct gut bacteria to break it down, where it is then usable.
Total fat intake (when high) disrupts the individual fatty acids.
By using cheese to get your C15, you end up with less if you’re eating high fat throughout the rest of the day (from other foods).
That’s why a low fat plant-based diet is the best (with very small amounts of cheese, meat and eggs) and animal based foods can be used as ‘condiments’.
Interesting info: you should include the sources in your comments with a hyperlink.
@@SkyRiver1Usually, hyperlinks get the comment deleted.
”Odd Chain Fatty Acids; New Insights of the Relationship Between the Gut Microbiota, Dietary Intake, Biosynthesis and Glucose Intolerance"
"To summarise, circulating C15:0 and C17:0 are independently derived; C15:0 correlates directly with dietary intake, while C17:0 is substantially biosynthesized, therefore, they are not homologous in the aetiology of metabolic disease. Our findings emphasize the importance of the biosynthesis of C17:0 and recognizing its link with metabolic disease."
"[...] there have been considerable differences in disease risk between C15:0 and C17:0, with C17:0 having the strongest inverse association, indicating different affects/effects."
The usual dose of C15 is 100 mg a day. A 1/8th pad of butter contains 100 mg of C15. C15 is very expensive in capsule form. But buy bars of butter instead. 1/8th pad of butter is dirt cheap.
Is anyone going to point out that diary has both odd and even-numbered fatty acid chains? So drinking milk would both slow down your aging and speed it up??
I
What happens if you take both Rapamycin and C15?
Thanks
Hi Mike, thanks!
Why _salted_ butter? What about unsalted, regular butter?
Unsalted has a little more
Does it mean that eating butter during fasting improves Autophagy?
Ha, all the foods we eat since we embarked on the proper human diet, labeled the Carnivore diet but really it's a way of eating rather than a 'diet'. Loads of info on YT, but Dr Ken Berry is a good starting point.
Hey, I'm a vegan and I'm using High Oleic Sunflower Oil as my C15:0 source. Dr Venn-Watson has completely shifted the dialog to be around dairy products, but there's actually a decent plant source available. I noticed an increase in my NEAT (non-exercise activity thermogensis, in other words fidgeting) after I started on High Oleic Sunflower Oil.
Unless you're a vegan or otherwise don't eat dairy, it would seem relatively easy to get more than the recommended amount through food with small amount Dairy fat.
@@eman1989z 100mg of c15. Supposedly 1 ounce of cheese contains that amount.
@@eman1989z apparently you need 100 mg.
100 grams butter= 830 mg of C15
100 grams of full fat cream= 450 mg
100 grams cheddar cheese = 390 mg
You get all the bad "even chained" saturated fats in dairy.. They cause heart disease..
~18 mg Pentadecanoic acid (C15:0) in 1 kg of Chinese Yam.
C16 comes along with the dairy. C16 is pro-inflammatory.
Does beef tallow contain C-15 in a significant amount of?
That would be great to know
According to the Whole Food Catalogue, beef and beef tallow contain significant amounts of C15:0, up to 450mg and 300mg per 100g respectively
What about ghee ?
Is there a reason to take it as a supplement? I've seen other places say that you can get plenty by eating a little butter or cheese.
Hi thanks for the question. As the slide with the availability in foods shows, it is certainly possible to get the required amount from food sources. You could consider pure C15 as being more healthy as it does not contain the even chained fatty acids that come with butter and cheese.
C15:0 from food is tied up in complex lipids called triacylglycerides, which our bodies cannot absorb.
Looking at the fatty acids in Sphingolipids, it looks like they might be about 15 carbons long. I also don't understand how we're not making any, if it's in beef and butter. Perhaps it's a fermentation byproduct?
Hi Thanks for comment. The papers did address that humans do not make it but did not talk about where it was originally produced and I cannot find an answer.
High amounts in high oleic sunflower oils
I have several reasons to stick with butter and away from seed oils. But thanks for the feedback !
What about just eating the organic sunflower seeds?
This gon have people dying in no time. Good work
It is advertised as OMEGA 3 substitute tho, and as far as i understand it`s not essential as omega3..
Once again proof why we're supposed to consume animals.😋
I tried this product for 3 months. Did nothing. In fact. My HS- CRP increased from 1.5 to 2.4 mg/ L. Scam
This is not good point
@@Kalamak-x3e why not. Their literally say it will lower inflammation and to check your HS CRP after 3 months So I did.
Before you conclude that it is a scam you might want to consider factors. Do you have any MTHFR issues for example? Did you have any other changes, like an injury? I'm not promoting the product, but to conclude that this was the cause after one 3 month period is not definitive. If it were me, I would check my levels again after 3 months away and see if it goes back down. Then try it again for a 2nd round of 3 months to see if it went back up again. One time is never enough to prove cause-effect.
@@ronrothrock7116 I don’t have mthfr genes. But even if I did so what. I would have had it before taking the product and after. And no injuries either. Funny how if my CRP had gone down you would have attributed it to C15. Read some of their testimonies, other report no changes in blood markers after a year. No noticeable improvement in their conditions .
The proof is in the bloodwork. This company hasn’t conducted one human trial. It’s all based on studies with dolphins. Dolphins aren’t humans.
@@ronrothrock7116 no mthfr. No injuries. Now what. The Company rep told me to compare HSCRP after 3 months.
Is C-15 increased or modified by fermenting milk?
If true that we're not making any but ruminants do... that's a legit question.
Hi thanks for your question. I don't have an answer for that, but looking at this table (wholefoodcatalog.info/nutrient/pentadecanoic_acid/foods/high/) it seems that fermenting does not seem to reduce the level by much. It is an interesting question as to how it gets into the milk. Whether the cows make it or get it from their diet.
@@ModernHealthspan Thanks Richard.
If you can get c15 from cheese, then fermenting should be fine. In the Netherlands, a woman was trying to sell us tourists some cheese and attributed her young looks to eating cheese. I took it with a grain of salt but she may be right!
@@marnold2791 The ratio of C:15 to other saturated fats is 1 to 100 in dairy products, so it is not obvious that eating them is worth it. She said in another video that grain fed cows have lower C:15 so it might be better to chose organic dairies.
I'd be curious to know how animals like cows make C:15 and if we could emulate that one way or another in a way that doesn't create other saturated fats at the same time.
Stop eating Country Crock and Can't Believe It's not Butter.
Yes, return to traditional products + cooking...
The trouble with getting C15:0 from food is that it is tied up in complex lipids called triacylglycerides, which our bodies cannot absorb. For this reason C15:0 absorption from only food has not been studied in depth on humans. What we do know is this- natural C15:0 levels started decreasing when the "Low Fat" movement happened in the 80's and 90's.
That said, C15:0 is found in some foods. This means that we all have some baseline level of C15:0. What fatty15 is expected to do is to raise this level to achieve the desired circulating C15:0 concentrations of 10 to 20 uM needed to attain key benefits.
I know when I took this product it did nothing for me so I stopped taking it but glad maybe it was just the amount that I did not get enough of.
U can test your levels of C15.0 at Genova Diagnostics online for around two hundred dollars, then u will know if y need to eat more dairy or supplement 😊
Why do you think our bodies can't absorb triacylglycerides? Of course they can. Triacylglycerides are fat. Regular animal or vegetable fats and oils. They are a normal part of our diet. We absorb them just fine.
All the more reason to be on carnivore diet
Candle fish
Drink coffee with butter?
Good old pumpkin seed oil
If the US Navy (US taxpayer) paid for the add'l C 15 research...then is this natural nutrient patentable and for exclusive manufacture? hmm, sounds a bit hoaky. Maybe a patent from other companies of other nations who didn't pay for the particular research and method of synthesizing but, exclusivity from the people of the gvmnt who paid for it? I could envison a few years of granted exclusivity if the process is so involved/esoteric but other than that...stinks.
This doesn’t seem right. 1 tbsp butter or a bit of cheese? Most people must be full of c15 not deficient. Seems odd. I don’t get it
I think most people avoid high fat dairy products
I developed athersclerosis eating butter, cheese and milk. Eating dairy comes with a lot if bad fats! I'll stick with fatty15. I take 2 per day and feel fantastic and now sleep great. I'm in my 70s.
I'm not sure if taking isolated nutrients is superior to consuming whole foods (ie milk).
You should eat grassfed butter and aged cheese
I guarantee you, it was NOT the saturated fats. Something else, most likely carbohydrates are the cause.
C15 much safer and produces the same benefits as n-3 oils, which are PUFAs that are pro-aging.
Pine nuts has 9.6% of C15. Three grams of pine nuts per day provide the necessary daily dose.
I think you might be off by a few decimal places.
@@michelangelobuonarroti916 300 mg of C15 per day. Do the math, easy.
PlantFAdb is the sourcs
PlantFAdb is the source
you should watch the visser podcast
Way over priced and riding the "latest great thing" wave. Just take a daily dose of Mega-3 three times a day.
You are confused. This literally blows away your Mega-3
I poop out c15 it is
great everyone is now recommending butter.. their cells will look younger when the kick the cardiac bucket at least
So sad, and misinformed.
Why not stearic acid?
Hi thanks for your question, however, I am not clear as to your meaning. The video is not about a supplement but about C15, the fatty acid and the benefits that it has. Stearic acid does not seem to have the negative effects of the other even chained saturated fats and it is available in common food sources. I am not sure if it would be a substitute or not.
@@ModernHealthspan It is cheap even if you ate it as a cosmetic grade powder supplement melted into food, it has mitochondrial fusion effects and it is the slowest to reach fat cells and it directly fights visceral fat and ectopic organ fat (palmitic acid has some of these benefits but not all of them). the main benefit of MCT fats would be driving BCAA catabolism.
What is 'cattle' as a food source. Who eats cattle? The bovine has dozens of different meat cuts with different fat gradients. Which cuts, which fats contain the C:15? Grass fed versus grain fed? Many of us, myself included, are dairy intolerant. We need to know where the C:15 sources are that are non-dairy. You say even chain saturated fatty acids have negative effects versus odd chain fatty acids. What is the profile of the fat sources? Dairy, Cheese, 'Cattle'?
Mackerel has around 80 - 100 mg per 100 grams, which probably varies with their total fat content which may vary with seasons.
I suspect other fatty seafood have some too even though only even number C-chain fatty acids are reported in their nutrition tables.
Just 1 ounce of cheese per day gives you the recommended amount. Unless you're a vegan or otherwise avoid dairy, why consider a supplement?
Where are you getting “recommended amount” from?
@@cactuscanine3531 The video references 100mg as being recommended by the Researcher cited in the video.
This is one of the many problems of a plant-based diet, particulary a plant-exclusive diet. When such diets are studied, they are almost always compared against a standard American diet (SAD). Ironically, SAD is described as animal-based, even though it's 70% plant foods. What never gets included in such studies is a diet that is 70-100% animal foods, especially not one that is whole foods, nose-to-tail, organic, and pasture-raised. Or rather such research is typically only found in Asia where higher meat intake is correlated to better health and longer longevity.
@@MarmaladeINFP Well, there are several people that live past 100 on exclusive plant based diets, so at least certain people can thrive on them Now are these people genetic longevity freaks that would live long on any diet, maybe, maybe not.
Hi Jack, thanks for your comment. I would think that that is correct. The downside is that you get the other saturated fats too, but if you are eating full fat dairy then you have already decided that you are OK with this. As well as vegans, you could see if people are lactose intolerant it would be helpful.
No double bonds, I'm looking at a double bond
Anyone who cites Dr Steven Gundry approvingly should immediately be assumed to be profit-driven bunk prone. PS Does the guy happen to be selling this nonsense?
PS Oh, right. Yup. The guy is flogging stuff. Not a researcher. Not a clinician. Just a marketer.
Thanks
Hi Thanks!