I'm a PhD student studying calcium signalling. Tomorrow I will be doing some outreach activities with kids about neuropharmacology, so I came here to remind myself how synaptic transmission works. Wow, I forgot how elegant and wonderful the biology of ion channels can be! Reminds me why I fell in love with pharmacology in the first place. Such a great video, thanks!
I have graduated med school few years back. Recently I have been trying to go through all med school basics while preparing for post grad medical exams. These lectures and illustrations in your page are absolutely brilliant. Did help me recall the basics. I cannot thank your team enough. Please keep up your great work and keep uploading more videos.
thanks this reminded me of it again summary: 1.depolarization so inside is more + than outside as Na+ channels open +40mV 2. Repolarization and K+ channels open, Na+ close 3. Hyperpolarisation as memb is leaky to K+ channels 4. sodium potassium pump works to restore
This is the first time in my whole life I understand the action potential, so easily, like that! Thank you very much 😊☺️ Could you please explain the concept of 'time constant' & 'space constant' in your next physiology video? :))
This is best explanation of this concept I have ever experienced. I finally understand what is happening. I hope my university is paying you for embedding this link in their EdX module!
I was dreading learning this topic for my university degree, but i'm glad to say this video was so incredibly helpful and greatly contributed to my understanding!
Thank you so much for making this video! It really explained action potentials in a really easy to understand manner. It made so much more sense to me than some of my uni lecturers did.
I was looking for a good and simple vedio which can explain the whole action potential process but couldn't and then i saw this one and thanked God i found it. It explains the whole thing in such a good way. Thank you.
Thank you for the kind words, Taylor! Did you know that if you like & review us on Facebook then you’ll get access to our videos a day before they’re published on RUclips? Check it out here: bit.ly/2u35D6J
Thank you sm. I have a 12pg paper on the central nervous system due in 5 days, and I'm staying up all night to complete it. This actually makes sense to me at 4am thank you oml.
This video output is relatively the same as what I've read on physiology books. Summarized and essential. Such a great video. Continue uploading please 👏🏽
Thanks, Alvim, that's the plan! We're glad you're finding our videos useful. If you haven't yet checked out our educational platform we have a bunch of tools that we think you'd like. These include unreleased videos, tens of thousands of flashcards and multiple choice practice questions, study workspaces, and daily exam schedule organizers to help you learn medicine. You can sign up for a free trial of Osmosis Prime here: bit.ly/2ut5ZEJ
Thank you so very much for creating this wonderfully weaved video with a lot of information made simple. It's only because of you that at least now I understood this concept. Thank you. I owe the credits to you if I answer the question correctly in my examination, based on this stuff. Thanks a lot once again!!!!!
Wow osmosis....I had already read most of what you taught... but never had been able to get such a beautiful integration of everything...I had initially skipped on this video since it seemed an easy topic but this was amazing !!!
I finally understand action potentials. I'm honestly shocked, I didn't think I'd get this far in life. Can you guys do a video on the characteristics of action potentials in cardiac muscle? By tomorrow? I have an exam...
We have a video on action potentials in pacemaker cells on our website and will have a video on action potentials of myocytes soon. Check it out! bit.ly/2ut5ZEJ.
Thanks for the feedback, Zoncena! We get a lot of comments suggesting we speed up or slow down the audio, so we've settled on the current pace for now. What a lot of people do is change the speed of the video in RUclips to suit their needs. For example, if you'd like to watch and take notes you can try watching the video at 0.75x speed. Conversely, if you'd like to listen to a video while at the gym you can set the speed to 1.5x the normal speed. Hope this helps!
I think that returning to resting state after hyperpolarisation is not explained well here. It's not the slow closing of the potassium channels that causes it (it would only cause more hyperpolarisation) nor the sodium-potassium pump (as many online sources say) because it would also cause only more negative potential. The potassium leak channels allow extra potassium out of the cell and are the reason for the return to resting state after hyperpolarisation.
Amazing , great job :D ! Honestly makes so much more sense now. I mean my teacher basically taught it without the picture and then with the picture of the synapse and I got so confused. It makes so much more sense explained together.
Absolutely amazing!Your videos have immensely helped me during my FSc and MCAT preparation and now I'm in med college and your channel is still of so much help.Thank you for these!
So beautiful and well explained. You should be really proud of what you have created. Congratulations and thank you very much for sharing this awesome material!
sir i'm in school and wanted to understand synapses in detail , action potential being a big part of it and explained by you made it super easy . just curious do you provide notes for your videos on any website?
well, i read in my textbook that potassium is the only permeable ion and that it likes to stay inside the cell bc of fixed proteins, which causes net resting negative membrane potential. so idk about the potassium channels opening and closing, it doesnt mention that. otherwise i found this very helpful
Thank You for Your video! I thought that myelin sheaths serve to increase the conductivity of an axon, and the thicker they are, the better conductivity. But the video suggests, if I understood correctly, that they prevent signal propagation on the contrary?
Im in college and have learned action potential a million times from professors yet this has been the most helpful.
I agree!
definitely agree
When I start earning my own money, your channel will be the first i donate to. Thanks for keeping the awesome stuff free and regular.
booze and snorting drywall
I wish I had such an awesome help while getting ready for my exams...10y ago hahahah
same here.... legends i swear
Hey..did u donate him money ..after 4 yrs
@@masuma2060 I'm wondering too LOL
FINALLY THE FIRST VIDEO that makes sooooo much sense. I cannot thank you enough.
Thanks for the lovely feedback! 🥰❤️🙏🏼
I'm a PhD student studying calcium signalling. Tomorrow I will be doing some outreach activities with kids about neuropharmacology, so I came here to remind myself how synaptic transmission works. Wow, I forgot how elegant and wonderful the biology of ion channels can be! Reminds me why I fell in love with pharmacology in the first place. Such a great video, thanks!
Oh wow! Glad our video was able to help in such a way! Thanks for letting us know. 🥰❤️🙏🏼
Same here too
I have graduated med school few years back. Recently I have been trying to go through all med school basics while preparing for post grad medical exams. These lectures and illustrations in your page are absolutely brilliant. Did help me recall the basics. I cannot thank your team enough. Please keep up your great work and keep uploading more videos.
Psychology students can feel my pain. I didnt sign up for this!!
Great, informative video. You helped me finally understand this.
Seriously lol none of this helped me become a better counselor. Just drugs, DRUGS..DRUUUUGZZZZ!¡😵💫😬
Without a doubt the most simple and effective demonstration of action potential I have seen! MSc Neuroscience
thanks this reminded me of it again
summary:
1.depolarization so inside is more + than outside as Na+ channels open +40mV
2. Repolarization and K+ channels open, Na+ close
3. Hyperpolarisation as memb is leaky to K+ channels
4. sodium potassium pump works to restore
This is the first time in my whole life I understand the action potential, so easily, like that! Thank you very much 😊☺️
Could you please explain the concept of 'time constant' & 'space constant' in your next physiology video? :))
This is best explanation of this concept I have ever experienced. I finally understand what is happening. I hope my university is paying you for embedding this link in their EdX module!
Undoubtedly one of the most on point videos on the topic.Easy to follow and well explained.Props
I was dreading learning this topic for my university degree, but i'm glad to say this video was so incredibly helpful and greatly contributed to my understanding!
Thank you so much for making this video! It really explained action potentials in a really easy to understand manner. It made so much more sense to me than some of my uni lecturers did.
ruclips.net/channel/UCsQlH1Tn7O1ykPUBfBJU-Kw
I was looking for a good and simple vedio which can explain the whole action potential process but couldn't and then i saw this one and thanked God i found it. It explains the whole thing in such a good way. Thank you.
You're most welcome! Your feedback means a lot to us! 😊
in the last two years, this is the first time i've actually been able to understand impulse transmission. thank you so much.
Oh wow, we're glad to be able to help you understand this topic, Aranya! 😊
i have an ap bio test tomorrow and had been trying to understand this for hours. this is the only thing that helped. THANK YOU!
Glad it helped! 🙏🏼
Very nicely explained the functioning of neurons!
Thank you! 🥰
You got all the important details and STILL managed to make it easy to comprehend. Wow!
the animation really helped! thank you
Glad it helped, Aeusha! 💕
Incredible! Thank you so much. I've been strugglig with this for waaaaay too long
Wow man, the way you explain things is out of this world. Everything makes so much sense. THANK YOU SO SO MUCH!!!
Yaaaasss!!! I am such a visual learner and this was so helpful! Thank you so much for this video!
I wish I had such a great help when I was getting ready to pass my exams...10y ago 😂 Great work! 🖤
Thank you Osmosis ❤️
U explained it in a very simple and easy manner ✨🌠💫
Glad you liked it, Anirudh! 💙
The most useful video on RUclips, Thanks for keeping this free and regular.
Glad you think so, Tona! 🙏🏼
my professor took about 4 lectures to explain what you did in 11 minutes. i am amazed. thank you!
That's great to know, Ashkan! 😊
BEST video I’ve ever watched. Thank you for the many recaps at the end. God bless you!
You guys are the reason I am passing my courses. Never stop making these types of videos!
I don't know why but the ticking on the membrane potential voltage counter is so intuitive that now I understand everything
ooohhhh .......this is amazing🥺🥺🥺!!!!
after watching millions of "action potential videos" finally i understood what that really means. Thanks a lot🤧
Glad it helped you out! 😊
THANK YOU!! This is the best explenation I've seen on youtube. You deserve more views.
Madre mia me acabas de salvar la recuperación de psicobiología. Tus videos son maravillosos acho. Continúa as´´i makina.
This really changes the game in educational videos, amazing work and amazing site!
Thank you for the kind words, Taylor! Did you know that if you like & review us on Facebook then you’ll get access to our videos a day before they’re published on RUclips? Check it out here: bit.ly/2u35D6J
ruclips.net/channel/UCsQlH1Tn7O1ykPUBfBJU-Kw
New videos are about to come. This may solve your purpose for the time being.
This was the first time I understood this concept thanks 😊
We're glad this video helped! 😊
It seems that content is different at each university. Stick with what your lecturers and prescribed textbook say. For example, we are told -70mv.
I noticed that, too. Good point. -70mV will be the right answer for my professor so that's what I'm sticking with.
stupid...just 😅
Thank you! I have a competition this Thursday and this video totally helped me sooo much!!❤❤
Glad we could help and best of luck! 🙏🏼 ❤️ 😊
I swear I own this channel sooo much!
thank you ❤
Always our pleasure! 💕
Thank you sm. I have a 12pg paper on the central nervous system due in 5 days, and I'm staying up all night to complete it. This actually makes sense to me at 4am thank you oml.
Glad to help, Leo! Best of luck with your paper! 🙏🏼 ❤️ 😊
This video output is relatively the same as what I've read on physiology books. Summarized and essential. Such a great video. Continue uploading please 👏🏽
Thanks, Alvim, that's the plan! We're glad you're finding our videos useful. If you haven't yet checked out our educational platform we have a bunch of tools that we think you'd like. These include unreleased videos, tens of thousands of flashcards and multiple choice practice questions, study workspaces, and daily exam schedule organizers to help you learn medicine. You can sign up for a free trial of Osmosis Prime here: bit.ly/2ut5ZEJ
perhaps the best video on nerve impulse conduction!!
Thanks, Himalay! ❤️
Please don't stop uploading such these videos 😍
Thank you so very much for creating this wonderfully weaved video with a lot of information made simple. It's only because of you that at least now I understood this concept. Thank you. I owe the credits to you if I answer the question correctly in my examination, based on this stuff. Thanks a lot once again!!!!!
i just love you guys! No idea how I should pass my exams without this channel ;)
Thank you so much. This is the best action potential video I've seen
Thanks! 😊
CLEAR N STRAIGHT TO THE POINT
This video will definitely help me scoring more in my upcoming medical exams.. Thanks sir..!!
Thank u sir, for explaining the topic in a much much better way than any book can.....
You're welcome and thank you, Meenu! 😊
This video might be the reason I'll pass my exam tomorrow. Thank you.
Our pleasure! 💖
Wow osmosis....I had already read most of what you taught... but never had been able to get such a beautiful integration of everything...I had initially skipped on this video since it seemed an easy topic but this was amazing !!!
Thanks - we will continue to make these physiology videos alongside our pathophysiology ones. Glad you liked it.
U Guys doing great work , and deserves everyone's support and donations .
I cannot even tell you guys how much you've helped me! Means SOOO much. Please don't stop making videos! LOVE FROM INDIA! 💜
Wow. What a clear cut explanation
I finally understand action potentials. I'm honestly shocked, I didn't think I'd get this far in life. Can you guys do a video on the characteristics of action potentials in cardiac muscle? By tomorrow? I have an exam...
We have a video on action potentials in pacemaker cells on our website and will have a video on action potentials of myocytes soon. Check it out! bit.ly/2ut5ZEJ.
Wow! I find this the best explanation I've come across:) Thanks so much..
Was very confused on the function ligand vs voltage gated, thank you.
best explanation, hands down
Now i got to know that what i was thought few years back
Thank you this really helped me a lot 😌
Happy to help! 😊
Thsnks. Im studying veterinary technology so this helps.
Really great video i finally understood the mechanism of action potential , but I hope that in next videos you speak little bit slowly . Thx
Thanks for the feedback, Zoncena! We get a lot of comments suggesting we speed up or slow down the audio, so we've settled on the current pace for now. What a lot of people do is change the speed of the video in RUclips to suit their needs. For example, if you'd like to watch and take notes you can try watching the video at 0.75x speed. Conversely, if you'd like to listen to a video while at the gym you can set the speed to 1.5x the normal speed. Hope this helps!
Wow , I was stuck with some concepts and I found your video just like a miracle. Thank you 💙
For these videos people continue learning and keep going👏🏻👏🏻, thanks alot.
Our pleasure! 😊
You people at osmosis are awesome..
Really really helpful explanation & animation.
Thanks for existing
Thank you so much for the wonderful feedback! 😀
I think that returning to resting state after hyperpolarisation is not explained well here. It's not the slow closing of the potassium channels that causes it (it would only cause more hyperpolarisation) nor the sodium-potassium pump (as many online sources say) because it would also cause only more negative potential. The potassium leak channels allow extra potassium out of the cell and are the reason for the return to resting state after hyperpolarisation.
amazing for the visual learners out there, you rock
Amazing , great job :D ! Honestly makes so much more sense now. I mean my teacher basically taught it without the picture and then with the picture of the synapse and I got so confused. It makes so much more sense explained together.
Glad it helped that well, Blaiklee! 💫 🥰 💖
This is best explanation ever. Amazing job
Wow, thanks! 😊
So beautifully illustrated and easy to understand, thank you!!! 🎉
You're welcome, Mariette! 😊
incredibly clarifying
Absolutely amazing!Your videos have immensely helped me during my FSc and MCAT preparation and now I'm in med college and your channel is still of so much help.Thank you for these!
How u doin👀
please add to your playlists on physiology, you really doing a great job and you have really done a great and assam work......
Right now we're focused just on pathology, but we'd like to do physiology soon!
better than any lecturer
Thank you! 🥰❤️🙏🏼
Best video on the topic by far
Thank you, Milad! 🥰
thanks i was waiting for this topic for my science exhibition
great video! :)
So beautiful and well explained. You should be really proud of what you have created. Congratulations and thank you very much for sharing this awesome material!
sir i'm in school and wanted to understand synapses in detail , action potential being a big part of it and explained by you made it super easy . just curious do you provide notes for your videos on any website?
Hi! We do have high-yield notes on topics that you can access at osmosis.org 😊
Amazing! Best explanation video I found about this topic so far
you cleared my doubt no other could.... thanks a lot.. keep up the good work...
Wonderful short educational video, great visuals and well explained. Thanks!
Thankyou so much🥹❤️This video made the cocepts crystal clear✨
You’re welcome! 😊
Really speechless guys you just made it so easy.Thank you. keep it up.
Thank you for such a clear, accurate explanation
well, i read in my textbook that potassium is the only permeable ion and that it likes to stay inside the cell bc of fixed proteins, which causes net resting negative membrane potential. so idk about the potassium channels opening and closing, it doesnt mention that. otherwise i found this very helpful
영어는 하나도 못알아듣겠는데 그림으로도 찰떡같이 이해되는 마법이다......Thank you!
Amazing.. great work... really helped to understand the concept... better than any book or faculty... Thanks..
such a great video that gives a perfect recap of the action potential's concept. Keep Up The Great Work!
This was very useful for my general biology 2 homework! Thank you!
Well explained and excellent animation! Many thanks for putting this together.
wow, great video very well explained everything is straight from the textbook but able to understand it. loved how you did the recaps thank you
Such a beautiful video, really appreciate the work:)
Thank you! ⭐️ ⭐️ ⭐️
such a great explanation , plz upload the video about Skeletal, Smooth and Cardiac muscle as well
ruclips.net/channel/UCsQlH1Tn7O1ykPUBfBJU-Kw
New videos are about to come. This may solve your purpose for the time being.
teaching matters , as for you , you are the best teacher :)
Awesome video. I FINALLY understood this topic 😊😊
Phenomenal!
this was very helpful! thank you!
You're most welcome! 😊
Very clear, and very understandable! Excellent video, thank you!
Most welcome, Luke! 😊
This video helped me so much, thank you!!
Glad it helped, Josiah! 🙏🏼
Thank You for Your video! I thought that myelin sheaths serve to increase the conductivity of an axon, and the thicker they are, the better conductivity. But the video suggests, if I understood correctly, that they prevent signal propagation on the contrary?
Sir please also upload video on sympathetic and parasympathetic system
Just Nexy Level Explanation 🙏