I know its fucking confusing, bcoz no one is starting it frm the basic, i have made video too on the same topic, watch it once i hope it will help you..and pls comment if it does..or any doubt..
This is amazing!! I'm have zero intuition for biophysiology but you made it as clear as glass. Thanks for breaking it down into baby steps!! Love your simple but comprehensive diagrams.
This video seemed so simple, I was brand new to this formula a couple of weeks ago. So I kept watching it, but once i slowed the speed right down - then it started kicking in! thank you so much!
my prof has a PhD in neuroscience from harvard and ive listened to him explain this numerous times and never understood it but this video made me understand it finally. ty
Thanks, Neha! Did you know that if you like & review us on Facebook then you’ll get access to our videos a day before they’re published on RUclips? Check it out here: bit.ly/2u35D6J
osmosis! this video is brilliant !! I've read about this topic from endless sources but I've never felt until now that I've truly grasped the concept. Thank you so much for your work. I've watched at least 90% of your pathology videos and honestly After Robbins and Porth you have made my life so much easier! thank you
this is so great, the book i used just glances over most of this to jump to the action potentail. and i was struggeling to understand how the consentration and charges worked.
This helped SO MUCH, especially during COVD-19 where learning things on your own from the university is a bit more difficult to understand on your own, when someone is not lecturing these bulky ideas to you. Great Video!
best video I've seen on ionic basis of resting potentials! thank you, I've been searching and this one is the easiest to follow along and explains the equations/gradients the best
Thanks for another great video! Would have preferred a more conceptual rather than a mathematical explanation though, as well as an explanation of the role of the NaKATP pump and its contribution to the resting membrane potential.
Yes, I agree, it's not so good to just *mention* the Na/K pump, and then say nothing *about* it! I think it simplifies to: the Na/K pump helps maintain the *concentration gradient* , while the *leak channels*, in relation to *both* the concentration gradient *and* the (sort-of opposing) electrostatic gradient, are what balance out to yield the resting membrane potential.
I was always taught that the cell's overall resting membrane potential is closer to -70 mV. Can you explain why this value is different that the -86 mV that you calculated? Thank you so much! This video was SO helpful!
Yeah, they *don't* explain that at all. They do present some interesting information (ie, ion concentration values). They *mention* the Na K pump, but do *not* explain its role in maintaining membrane potential. Not good! And while they *mention* an 'inward rectifier channel', they don't *explain it* at all!
@@dannichols6261 It would be great if they did but I think this video is targeted at people who already have a good understanding of passive and active transport systems. RUclips is great, there are a lot of videos that cover that in depth. I would watch them and go back to this one. Hope this helps :)
When calculating the membrane potential for when the membrane is permeable to multiple ions, why is it that when I do the Goldman equation using the information in your video I get -83mV rather than what you got which was -86mV? I did this: Vm = -61.5 x log( ((150 x 0.9) + (10 x 0.01) + (0.001 x 0.01) + (103 x 0.08)) / ((5 x 0.9) + (142 x 0.01) + (5 x 0.01) + (4 x 0.08)) ) = -83mV
One thing I’d like to add to this is permeability. At rest without any voltage propagating(action potential) the cell is very permeable to potassium so the summation of these will decrease the effect of calcium, sodium, and chloride a lot and only affect the potassium slightly. GHK equation
excellent, excellent video! I was wondering though, why was the calcium +2 intracellular concentration was not 0.0001? in the video it is listed as 0.001
Thank you so much, Arsenic! Did you know that if you like & review us on Facebook then you’ll get access to our videos a day before they’re published on RUclips? Check it out here: bit.ly/2u35D6J
Thank you, Leticia! Did you know that if you like & review us on Facebook then you’ll get access to our videos a day before they’re published on RUclips? Check it out here: bit.ly/2u35D6J
Thanks , when k+ move to outsid by channel , are the particles of Na+ inter in the same time !? and How it do that , by diffusion!? what is name the process in which particles move from low concentration To highe concentration?!
What is the resting membrane potential of excitable cells is close to the equilibrium potential of potassium because. Potassium leak channels makes membrane more permeable to potassium at rest
I do get it but I still cannot get how in guyton did they got the answer -86 millivolts for the exclusive contribution of Sodium and Potassium on RMP in Chapter 5.
![Tee Grizzley - Robbery 8 [Official Video]](http://i.ytimg.com/vi/34_vkNV6wrU/mqdefault.jpg)
i never understood the resting memb. potential but now ... i still don't understand it
mohammed just memorize it 🤷🏽♀️
I know its fucking confusing, bcoz no one is starting it frm the basic, i have made video too on the same topic, watch it once i hope it will help you..and pls comment if it does..or any doubt..
@@Apratim98 Thank you! I just checked out your video and it was really helpful! Thankfully I checked the replies.
Lol, We are on the same boat Mohammed... and I can’t memorize something that I don’t have a basic understanding of...
Me too
This is amazing!! I'm have zero intuition for biophysiology but you made it as clear as glass. Thanks for breaking it down into baby steps!! Love your simple but comprehensive diagrams.
Wow, you make everything SO simple. i was stuck on a couple concepts here, clear 100%!
I find your Osmosis is so clear and easy to remember. I want to be a part of your osmosis. Can't i?
Only video across globe that clearly explains resting membrane potential and equilibrium potential.
Thank you sir 😊
Happy to help 💖
Great, I had been waiting on Physiology from Osmosis for a long time! Thank you!
Very helpful thank you! Its hard teaching yourself this when you are taking online classes because of this quarentine
Hii
This video seemed so simple, I was brand new to this formula a couple of weeks ago. So I kept watching it, but once i slowed the speed right down - then it started kicking in! thank you so much!
Most welcome! 😊
my prof has a PhD in neuroscience from harvard and ive listened to him explain this numerous times and never understood it but this video made me understand it finally. ty
Wow! We're glad that our video was able to help! 🙏🏼 ❤️ 😊
I lkie the way he explains and the presentation is always very nice to watch n clear .
Thanks, Neha! Did you know that if you like & review us on Facebook then you’ll get access to our videos a day before they’re published on RUclips? Check it out here: bit.ly/2u35D6J
osmosis! this video is brilliant !! I've read about this topic from endless sources but I've never felt until now that I've truly grasped the concept. Thank you so much for your work. I've watched at least 90% of your pathology videos and honestly After Robbins and Porth you have made my life so much easier! thank you
Thanks so much! It would be awesome if you and your friends could review us on our Facebook page. facebook.com/pg/OsmoseIt
this is so great, the book i used just glances over most of this to jump to the action potentail. and i was struggeling to understand how the consentration and charges worked.
Thanks! 🙏🏼
This helped SO MUCH, especially during COVD-19 where learning things on your own from the university is a bit more difficult to understand on your own, when someone is not lecturing these bulky ideas to you. Great Video!
Erik Plumeda so true
best video I've seen on ionic basis of resting potentials! thank you, I've been searching and this one is the easiest to follow along and explains the equations/gradients the best
Thanks for another great video! Would have preferred a more conceptual rather than a mathematical explanation though, as well as an explanation of the role of the NaKATP pump and its contribution to the resting membrane potential.
Yes, I agree, it's not so good to just *mention* the Na/K pump, and then say nothing *about* it! I think it simplifies to: the Na/K pump helps maintain the *concentration gradient* , while the *leak channels*, in relation to *both* the concentration gradient *and* the (sort-of opposing) electrostatic gradient, are what balance out to yield the resting membrane potential.
That was a great piece of work!
pro trick : watch series on flixzone. I've been using them for watching all kinds of movies these days.
@Gunner Princeton Yea, have been using flixzone} for since november myself :D
@Gunner Princeton yea, I've been watching on flixzone} for since december myself :)
I was always taught that the cell's overall resting membrane potential is closer to -70 mV. Can you explain why this value is different that the -86 mV that you calculated? Thank you so much! This video was SO helpful!
you're the best, explained it better than my uni professors
Thanks for the feedback! 🙌🏼
for the first time i understood. thank you.
woww you start physio, Thank of billions...
Could you explain what's the role of the Na K pump in calculating the resting membrane potential?
Yeah, they *don't* explain that at all. They do present some interesting information (ie, ion concentration values). They *mention* the Na K pump, but do *not* explain its role in maintaining membrane potential. Not good! And while they *mention* an 'inward rectifier channel', they don't *explain it* at all!
@@dannichols6261 It would be great if they did but I think this video is targeted at people who already have a good understanding of passive and active transport systems. RUclips is great, there are a lot of videos that cover that in depth. I would watch them and go back to this one. Hope this helps :)
Thanks you saved me a lot of time.
You made it quite clear! Thanks!
Brilliant video! Thank you very very much!
You're very welcome! 😊
wow great! Will you guys eventually also do lectures on neuroanatomy/physiology?
we dont fuck with that shit. We are going in on female vag anatomy next!!
We're mostly focusing on pathology still, for now.
very helpful ! thank u
This was really helpful.
That's nice to know! 💕
this is the second time for me watching this, just wanted to say THANK YOU!!!
You really deserve subscription
Thanks for this feedback!
Thank you so much. 2024 and video is one of the most helpful lessons 😍😍😍
Glad it was helpful! ❤️
When calculating the membrane potential for when the membrane is permeable to multiple ions, why is it that when I do the Goldman equation using the information in your video I get -83mV rather than what you got which was -86mV? I did this: Vm = -61.5 x log( ((150 x 0.9) + (10 x 0.01) + (0.001 x 0.01) + (103 x 0.08)) / ((5 x 0.9) + (142 x 0.01) + (5 x 0.01) + (4 x 0.08)) ) = -83mV
you explain good, and understandable mostly, just all of them number towards the end is a lot and a lil confusing
This is the best video on membrane potential 😉glad to have discovered this channel 🙂😌
Welcome aboard! Hope you'll also enjoy our other videos! 😊 🙌🏼 🥰
This helps me to understand the topic better.✌
We're glad our video was able to help, Ayesha! Thanks for letting us know! 🥰
Thank you so much, I wish I found this prior to the test. I would have got these answers right. Damn>
Unexplainable!!!
Unbelievable!!!
Thanks🤗🤗🤗
One thing I’d like to add to this is permeability. At rest without any voltage propagating(action potential) the cell is very permeable to potassium so the summation of these will decrease the effect of calcium, sodium, and chloride a lot and only affect the potassium slightly. GHK equation
Really amazing ........iam really appreciate your great and fruitful work....thanks🙏
that was useful thankyou
please do more physiology videos I'll be grateful for that
hi.. can u explain the resting membrane potential during cardiac surgery.. the usage of cardioplegia to stop the heart..
this is the best vid ever
THANK YOU SO MUCH 💜 SO HELPFUL 💜🥺💜💜💜 THANK U 😭💘💜💜
You're so welcome!
wow!!! super clear, feel so good watching this!!
Thank you this is soo helpful
Very nice video sir , but generally why potassium is more transferred to out side?
I have a way better grasp on this now ty
THANK YOU!
Great physiology
wonderful explained thank you!
You're very welcome, Brenda! 🥰❤️🙏🏼
The first calculation for Potassium is incorrect. It should be -82.8 and not -81.0 as stated in the video.
thank you for this clear explanation!! i have subscribed to your channel and will definitely explore more!!!
Hi Tengku! Glad you enjoy our video! Hope you'll like our other videos too! ❤️
Thank you so much, i finally understood this 🥳
Glad it helped! ❤️
Very good explanation, keep posting videos like this :D
This was really well done!
Thank you, this was VERY helpful! ^_^ Loved it.
very well explained, Great Job ☺☺
Thanks, Mustafa! 😊
excellent, excellent video! I was wondering though, why was the calcium +2 intracellular concentration was not 0.0001? in the video it is listed as 0.001
THANK YOU. Explained it really well mate!
It is the nicest video i've ever watched !! Thank u :*)
Its really great understand! Thanks for making awesome video.
I want to get a really high usmle. Do you have a strategy for that?
Awesome content and i like it so much :DDD
Why CL is more concentrated outside the cell than inside??? Plz
curious: is this true across all of life? Same for bacteria, plants, fungi?
Great video ! thank you again Osmosis
brilliant brilliant video. Thank you A LOT.
Thank you so much, Arsenic! Did you know that if you like & review us on Facebook then you’ll get access to our videos a day before they’re published on RUclips? Check it out here: bit.ly/2u35D6J
Excellent!😍
It would really means a lot and nice if you guys upload dailyy one video consecutively!please.......!!!!
We wish we could! Right now we don't have the funding to do that, but we hope one day we will!
Please upload a video on DIC
disseminated intravascular coagulation
We will eventually! You can vote for upcoming videos by becoming a Patreon subscriber. www.patreon.com/osmosis
I may just pass PT school because of you sir
Including the constant field equation would be useful here!
I UNDERSTAND NOW!
Could anyone explain me from where 61,5 comes in 4:40 ?
are the values of each ions here constant?
Inward rectifier K+ channels pump K+ to inside! Not like leak K+ channels that allow to go to outside
This video is amazing. I am studying bilogical psychology, and the book didnt give me a clear picture of what this process looked like. Amazing stuff!
Wow, thanks for the feedback! 💕
Woow!! Thank you so much for this video!! Awsome explanation
Thank you, Leticia! Did you know that if you like & review us on Facebook then you’ll get access to our videos a day before they’re published on RUclips? Check it out here: bit.ly/2u35D6J
Physiology! Great!
i still don't understand
Thaankkkk uuuu♥️♥️
Great video
want to ask that in guyton the equation has inside/ outside but the equation in video is shows outside/inside. kindly guide me with this thing.
Great work
Thanks! ❤️
isn' t the nerst forlmula with an ln and not a log? because thats what i am learning
great . thank you
Thanks , when k+ move to outsid by channel , are the particles of Na+ inter in the same time !? and How it do that , by diffusion!? what is name the process in which particles move from low concentration To highe concentration?!
If K+ gets in through electrostatic gradient what Is the benefit of pump then its confusing
is there a vedio for donnan membrane equilibrium
Thank u :)
What is the resting membrane potential of excitable cells is close to the equilibrium potential of potassium because.
Potassium leak channels makes membrane more permeable to potassium at rest
Thanks for the video, good work!
I do get it but I still cannot get how in guyton did they got the answer -86 millivolts for the exclusive contribution of Sodium and Potassium on RMP in Chapter 5.
By using the Goldman equations and the given values in the book.
Very nice
Good
awesome
Thank u
I don’t understand ☹️
EXcellent guys. but why such vague jumping from one topic to other all of a sudden?
Very useful :)
Bro you told wrong that Ca +2 is extra cellular fluid instead of intra cellular fluid. 0:37
Thanks for Arabic translation