Timestamps: 01:10 Microbial Burden of Aging 03:45 How Microbes Affect Aging 07:40 Intestinal Permeability During Aging 15:00 What Causes Leaky Gut 17:00 Do You Have Leaky Gut 26:50 Foods That Cause Leaky Gut 28:43 Oral Microbiome and Alzheimer's 32:00 Skin Microbiome 35:40 How to Keep Skin Barrier Intact 40:00 Which Toothpaste and Mouthwash 48:00 How to Test for Oral Microbiome 49:20 Are Fermented Foods Good For You 57:40 Is Glutamine Good 01:00:00 Is Apple Cider Vinegar Good
In response to some of the latter thoughts on gut health without fiber, there are these minor pathways that lead to butyrate (not sure at all if it would fulfill the requirements for gut, hardly..) - "In addition to carbohydrates, in minor fraction, butyrate can also be synthesized from proteins via glutamate, lysine, glutarate, and 4-aminobutyrate pathways (Louis and Flint, 2017; Vital et al., 2017; Mallott and Amato, 2022)." I recently clipped that citation from the paper called "Butyrate producers, “The Sentinel of Gut”: Their intestinal significance with and beyond butyrate, and prospective use as microbial therapeutics"
Thanks @0626love, I'm familiar with the Vital paper, now studying it some more, especially within the context of age-related changes for circulating amino acids that may be used to make butyrate.
What knowledge, I so appreciate All of it. Fantastic job! My question was, what can replace antiseptic mouthwash in the morning after waking up? I appreciate your knowledge and input on this! Thanks
Thanks @anthonyd5643, here's a base formulation: ruclips.net/video/EnkJqACCEE4/видео.html But, I should mention that formulation hasn't wiped out Serratia marcescens, which currently dominates my oral microbiome.
Had to check my shampoo bar's PH, 5.7. I use it as shampoo once a week and to wash my face twice a day. Ask the Dentist is a great site for the mouth. They do talk about the oral microbiome.
There are some functional medicine dentist that discussed this matter about mouthwash and toothpaste. Apparently the assimilation of nitric oxide begins in the mouth.
On oral microB I wonder if mouth breathing while asleep hurts our oral microbiome. There could be dry mouth and loss of saliva during sleep if this happens. For different reasons I've done mouth taping which helps me nasal breathe while asleep and when I do this I tend to have less dry throat and dry mouth.
In my case, mouth breathing isn't generally an issue, unless it's allergy season. I looked for papers on mouth taping and the oral microbiome, no luck so far...
50:30 yea i did actually do that (>500g fermented foods/day), was ok for like 40 days, and then my butthole somehow hurt A LOT (like 8/10 xD) and took me a few days to realize that it mustve been the overly acidic ferments i had been consuming, so then i stopped (now i know why chatgpt suggested not eating too much foods
This was quite interesting, one thing I want to add is that prebiotics are widely used in common skincare, for example Lancome’s GÉNIFIQUE face serum is 10% Bifidus prebiotic.
Thanks @AT-xl9db. While that's great about prebiotic inclusion, note that skin pH and the skin microbiome microbiome is not homogeneous for the whole body. In other words, it's different in different places, so a skin prebiotic would ideally be tailored to the skin location, genotype, and the local microbiome...
Definitely, I only saw bifidobacterium in skincare so far, several products, probably because there are actual studies that show preventative effect of it on skin photoaging, so I am guessing that one is good for everybody…I must attest it works for me very well :)
Would a periodic "cleaning" with general antibiotics work to clear the latent bacteria from the body, and so extend life? Not one that you swallow (so it wouldn't cause gut dysbiosis), perhaps one that's injected.
The concern with that is it would allow for gorwth of antibiotic-resistant Serratia, which would be even harder to kill off, plus abolishing most of my oral (and potentially gut) microbiome, with the hope of it coming back. If this was immediately life-threatening, I'd definitely use the antibiotics, though.
Maybe this single meal principle can help explain why there is a high proportion of centenarians that just lead simple rural lives with healthy diets where their low income prevents travel and their lives and diets dont change. It all cuts down the chance of any adverse systemic effects happening and they arent exposed to the complexities of processed foods.
I posted this comment on Siim's channel a few at the time of the release of the video, but it disappered every time. I think long comments are being deleted by RUclips, so let's se if it stick when I split it up.
You got the best man about longevity on the planet. Where some focuses on glucose levels regarding longevity and others on NAD+, fasting, HRV or something else this man is optimizing ALL the possible variables. Can’t believe he is not in more other longevity podcasts, but fortunately you catched him.
@@vedransimic86 Thanks Vedran. It's either YT or Siim-I almost never delete comments, unless it's blatantly disrespectful or hateful, which is fortunately rare on the channel.
Timestamps:
01:10 Microbial Burden of Aging
03:45 How Microbes Affect Aging
07:40 Intestinal Permeability During Aging
15:00 What Causes Leaky Gut
17:00 Do You Have Leaky Gut
26:50 Foods That Cause Leaky Gut
28:43 Oral Microbiome and Alzheimer's
32:00 Skin Microbiome
35:40 How to Keep Skin Barrier Intact
40:00 Which Toothpaste and Mouthwash
48:00 How to Test for Oral Microbiome
49:20 Are Fermented Foods Good For You
57:40 Is Glutamine Good
01:00:00 Is Apple Cider Vinegar Good
Nice to see you and Siim collaborate.
Absolutely adore these conversations! Please keep doing them. You guys are my fave content creators
Excellent video Michael! You covered a lot in this video. Thank you for your dedicated, excellent efforts.
Thanks @thomastoadally!
In response to some of the latter thoughts on gut health without fiber, there are these minor pathways that lead to butyrate (not sure at all if it would fulfill the requirements for gut, hardly..) -
"In addition to carbohydrates, in minor fraction, butyrate can also be synthesized from proteins via glutamate, lysine, glutarate, and 4-aminobutyrate pathways (Louis and Flint, 2017; Vital et al., 2017; Mallott and Amato, 2022)."
I recently clipped that citation from the paper called "Butyrate producers, “The Sentinel of Gut”: Their intestinal significance with and beyond butyrate, and prospective use as microbial therapeutics"
Thanks @0626love, I'm familiar with the Vital paper, now studying it some more, especially within the context of age-related changes for circulating amino acids that may be used to make butyrate.
Lustgarten Fan 👍
What knowledge, I so appreciate All of it. Fantastic job! My question was, what can replace antiseptic mouthwash in the morning after waking up? I appreciate your knowledge and input on this! Thanks
Thanks @anthonyd5643, here's a base formulation: ruclips.net/video/EnkJqACCEE4/видео.html
But, I should mention that formulation hasn't wiped out Serratia marcescens, which currently dominates my oral microbiome.
@@conqueragingordietrying123 thank you for this
Had to check my shampoo bar's PH, 5.7. I use it as shampoo once a week and to wash my face twice a day.
Ask the Dentist is a great site for the mouth. They do talk about the oral microbiome.
There are some functional medicine dentist that discussed this matter about mouthwash and toothpaste. Apparently the assimilation of nitric oxide begins in the mouth.
Would love to see a conversation between you guys and Bryan Johnson
Definitely @Rupe1992. Maybe tag him on Twitter, under this post to potentially get his attention?
On oral microB I wonder if mouth breathing while asleep hurts our oral microbiome. There could be dry mouth and loss of saliva during sleep if this happens. For different reasons I've done mouth taping which helps me nasal breathe while asleep and when I do this I tend to have less dry throat and dry mouth.
In my case, mouth breathing isn't generally an issue, unless it's allergy season. I looked for papers on mouth taping and the oral microbiome, no luck so far...
I use both natural and every so often I use fluoride. My dentist recommended no fluoride.
50:30
yea i did actually do that (>500g fermented foods/day), was ok for like 40 days, and then my butthole somehow hurt A LOT (like 8/10 xD) and took me a few days to realize that it mustve been the overly acidic ferments i had been consuming, so then i stopped (now i know why chatgpt suggested not eating too much foods
Just mix the vegetables in a vitamix.... I have never a problem with any of my holes...and with enough chewing you can get same Results.
This was quite interesting, one thing I want to add is that prebiotics are widely used in common skincare, for example Lancome’s GÉNIFIQUE face serum is 10% Bifidus prebiotic.
Thanks @AT-xl9db. While that's great about prebiotic inclusion, note that skin pH and the skin microbiome microbiome is not homogeneous for the whole body. In other words, it's different in different places, so a skin prebiotic would ideally be tailored to the skin location, genotype, and the local microbiome...
Definitely, I only saw bifidobacterium in skincare so far, several products, probably because there are actual studies that show preventative effect of it on skin photoaging, so I am guessing that one is good for everybody…I must attest it works for me very well :)
sir-AY-sha mar-SESS-ins
Thanks for that, I've never heard it pronounced before
Would a periodic "cleaning" with general antibiotics work to clear the latent bacteria from the body, and so extend life? Not one that you swallow (so it wouldn't cause gut dysbiosis), perhaps one that's injected.
The concern with that is it would allow for gorwth of antibiotic-resistant Serratia, which would be even harder to kill off, plus abolishing most of my oral (and potentially gut) microbiome, with the hope of it coming back.
If this was immediately life-threatening, I'd definitely use the antibiotics, though.
Maybe this single meal principle can help explain why there is a high proportion of centenarians that just lead simple rural lives with healthy diets where their low income prevents travel and their lives and diets dont change. It all cuts down the chance of any adverse systemic effects happening and they arent exposed to the complexities of processed foods.
I posted this comment on Siim's channel a few at the time of the release of the video, but it disappered every time. I think long comments are being deleted by RUclips, so let's se if it stick when I split it up.
You got the best man about longevity on the planet.
Where some focuses on glucose levels regarding longevity and others on NAD+, fasting, HRV or something else this man is optimizing ALL the possible variables. Can’t believe he is not in more other longevity podcasts, but fortunately you catched him.
With yours excellent Dunedin Pace scores you two, together with Bryan, are confirming examples that leanness is an important longevity variable.
@@vedransimic86 Thanks Vedran. It's either YT or Siim-I almost never delete comments, unless it's blatantly disrespectful or hateful, which is fortunately rare on the channel.
24:28 😳
gee, if body is keeping body safe with immune issues...maybe being a lil more fat is okay if it keeps you healthier!