" A study found that elevated follistatin levels are associated with an increased risk of mortality and several metabolic disorders, including stroke, coronary events, and chronic kidney disease."
Thanks for the heads-up @algibs9095, here's the link for that study: pubmed.ncbi.nlm.nih.gov/38000997/ Note that this association may be specific for diabetics, as follistatin is increased when the glucagon/insulin ratio is high: www.nature.com/articles/s41467-021-26536-w In non-diabetics, I'd exercise training is the best approach for increasing muscle mass and function, relative to follistatin gene therapy... That said, others may choose a different path!
Thanks. There was an association between LDL and heart disease as well. Ends up that when you have a heart attack, cells rupture and leak out cholesterol. The association went the opposite way then it was presented. People avoided cholesterol thinking it would save them from heart attacks, but really they should have been avoiding heart attacks to save them from cholesterol. Loose associations mean very little. Summer is strongly associated with increases in crime, it's still my favorite season.
Follistatin also may induce insulin resistance in adipose tissue, which can lead to the release of free fatty acids and the development of diabetes. Having read the above as well the study cited below I definitely would not risk it. Best to follow an exercise regimen as the owner of this channel suggested.
There may come a time when age-related anabolic resistance makes it hard to keep muscle mass and function, so within that context it could be important. But do the benefits outweigh the risks? I'm not sure yet.
They don't do it simply because it would be too expensive in the amounts that would make a difference. The product must be injected frequently into all muscle groups. This is expensive and impractical. Especially since most bodybuilders are poor.
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" A study found that elevated follistatin levels are associated with an increased risk of mortality and several metabolic disorders, including stroke, coronary events, and chronic kidney disease."
Thanks for the heads-up @algibs9095, here's the link for that study: pubmed.ncbi.nlm.nih.gov/38000997/
Note that this association may be specific for diabetics, as follistatin is increased when the glucagon/insulin ratio is high: www.nature.com/articles/s41467-021-26536-w
In non-diabetics, I'd exercise training is the best approach for increasing muscle mass and function, relative to follistatin gene therapy...
That said, others may choose a different path!
Thanks. There was an association between LDL and heart disease as well. Ends up that when you have a heart attack, cells rupture and leak out cholesterol. The association went the opposite way then it was presented. People avoided cholesterol thinking it would save them from heart attacks, but really they should have been avoiding heart attacks to save them from cholesterol. Loose associations mean very little. Summer is strongly associated with increases in crime, it's still my favorite season.
Follistatin also may induce insulin resistance in adipose tissue, which can lead to the release of free fatty acids and the development of diabetes. Having read the above as well the study cited below I definitely would not risk it. Best to follow an exercise regimen as the owner of this channel suggested.
Serious body builders do not use this as an injection. But the gene therapy may be useful.
There may come a time when age-related anabolic resistance makes it hard to keep muscle mass and function, so within that context it could be important. But do the benefits outweigh the risks? I'm not sure yet.
@conqueragingordietrying123 he has the correct mindset for sure but it's all too anecdotal for now.
They don't do it simply because it would be too expensive in the amounts that would make a difference. The product must be injected frequently into all muscle groups. This is expensive and impractical. Especially since most bodybuilders are poor.