David Sinclair On NMN vs NIACIN - Low Cost NAD Booster? | Vitamin B3 | Nicotinic Acid
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- Опубликовано: 23 сен 2022
- NMN is not the only NAD+ booster.
Another is niacin, also known as nicotinic acid.
It's much, much cheaper. But is it truly an NMN alternative?
In this video, Sinclair shares his views on this supplement
as part of a longevity protocol.
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✅ Watch David Sinclair’s 2022 UPDATED Supplement Protocol:
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✅ Brad Stanfield vs David Sinclair on RESVERATROL
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From the secondary research I have done, slow release niacin to prevent flushing is actually NOT healthy for the liver and you are better off taking regular niacin and living with the flush for a short period of time - easier on the liver. Sounds counter intuitive, but that is what the research shows.
I take slo-Niacin (2500 mg. every day for the past 12 years) and I still get a flush but my liver enzyme’s are good. If a person is taking Niacin, just inform your doctor and test your liver enzymes.
@@kentknight7538 Good advice - but why even put yourself in that position if regular niacin will have the same impact with lower risk.
@@trentriver only because I take it for other things other than to raise NAD
I take TMG to prevent liver damage from niacin
Also molecules change when wet and heated, time release supplements might change from staying in the body too long. They might be exposed to the heat from stomach acid for too long or might be wet for too long from the moisture in your body.
I used to take NMN but now I just take niacin. Niacinimide should also be ok because that's how we get it in the diet. You might not get as much absorption but you don't have to worry about the source being fake or underdosed. The flush is also possibly a helpful mechanism for healing as well. It's not pleasant at first for most people but the flush goes down dramatically as you get used to it.
So dear you use b3 with flash..
Yeah, and much, much cheaper than NMN...i take the flush free niacinamide.
@@robynhope219 thanks a million🌹
@@besot513 glad to help. NMN is for rich ppl.
@@robynhope219 hahaha
It would be great to see a video on the differences, benefits? of NMN vs NR for NAD booster. Can you please make one for this since NMN is being restricted on the market?
I wouldn't be surprised if NIACIN will be very effective. Basically not the blood level of of the NAD is important, rather the NAD level in mitochondria. On the basis of the classical mitochondriology we could not exclude that niacin directly increase the mitochondrial NAD level.
Hi sir, does nicotinamide( no flush niacin) is good for improving NAD level?
Please keep in mind that dr david sinclair look young because of the intermitent fasting in the first place
if hes in his 60"s he looks young
Also not IF but 20% caloric restriction it seems which the studies often tad it tandem and failed to isolate.
From what I remember as a layperson, excess niacin is "irreversibly converted" and excreted in urine. I discovered this while looking up how much of the excess is excreted and if it can be recovered by drinking ones urine (taking the cheapness to a whole new level). The answer seems to be no...? I'm not sure, since passing it through the digestive system exposes it to stomach acid and different enzymes than are available in most cells. Does anyone know about this?
urine therapy is interesting but uric acid buildups can cause inflammation of joints?
@@darshankv 🤣🤣🤣🤣 in India they said piss cured cancer and corona
You could try recovery via external urine wraps. The only other way is Drip IV as you sleep at night.
i'm hoping some new info about recent info of risk of heart disease with niacin, now i'm taking low dose niacin 2 or 3 times a day..
I think they lied
Ive heard this “more efficient, I think” so much, but haven’t seen it in a study. Evidence please. The recent Niacin study had similar multipliers. Buy the time released, 6-8 hr Niacin, not sustained.
He’s a scammer lol
Thanks. FYI, there is good work (Riekelt H. Houtkooper, 2021 - Jason Howitt, 2022) which shows that execise upregulates pathways which increase NAD+. Probably by improving the salvage pathway. Adam Antebi PhD shows that low insulin upregulates NMN. Nicola Conlon, PhD gives a good summary of the salvage pathway on her Nuchido site (or RUclips channel), but bascially, she shows how certain substances which are found in foods can improve the salvage pathway to the point that NR and NMN are not needed. Her contention is that focusing on the salvage pathway makes more sense, There is also the issue of CD38 which increases with age or with poor gut barrier function and delpletes NAD+. Apigenin helps with CD38 but so does a good diet which maintains gut barrier function and lowers inflammation. MIchael Lustgarden PhD at Tufts U has some good short talks on CD38 and NAD" on his channel I stopped taking NR a while back (direct supplement budget elsewhere) and rely on exercisse, TRE, good diet with plenty of fiber, and making sure my diet includes the natural substances (Quercetin, EGCG ,Apihenin) which help with NAD+ salvage pathway. Am working on monitoing insulin to assure it is kept low.
I’ve been thinking of cutting the NAD out also. To take a therapeutic and recommended dose is becoming prohibitive. What exercise did the study show as advantageous? You provided lots of useful information, thank you. I eat as much parsley and strawberries as I can along with maintaining gut health and eating low sugar. Thank you for the citations listed in your comment. When you said TRE, do you mean a type of stretching and massage?
@@amperage8032 On exercise, the paper presented ar ARDD2021 by R. Houtkooper mentions walking (segment from 6 to 9 minutes ruclips.net/video/HMqQyoo3JaU/видео.html ) at different levels. NAD" from muscle biopsies showed an increase in the 65 to 80 yo to that of 20 -30 yo when the older reached 14,000 steps a day, with 10,000 steps being kind of intermediate. I questioned the lead author, Georges Janssens, about this and he said the 14,000 steps a day wasn't just walking but was comprised of a mix which included some running and biking, bascially some levele of vigorous exercise, not just 14,000 normal steps a day. So, it will depend on your age. I am late 60s and have been walking at least 10K steps a day for over 10 years but also do it a good pace and do other light exercises which includes light weights, stretching etc. Given this study and others I have concluded that exxercie and diet are foundational. In another study Janet Lord's lab has shown that older cyclists had immune fuction of people 30 years junior suggtesting preservation of the thymus gland. On the other hand, there are other studies which show that simply walking at least 10,000 steps a day has tremendous benefits over the averahe person which does 4 to 5K steps a day, in terms of all types of dideases. Instead of buying NMN or NR better to try to eat and be active and put that money into blood tests to track key markers like hsCRP, insulin, HbA1c, etc and try to optimize.
@@amperage8032 TRE means Time Restricted Eating or Intermittent Fasting. I have been using Niacin 500mg, flush version, with TMG close to an year. My LPa, Triglycerides have reduced considerably while rising the LDL significantly. It took a couple of months to adapt the flushing. Liver parameters and glucose levels are not affected at all
Sorry. It is HDL not LDL
@@ckrao55 so you raised cholesterol level, but hdl, meaning it's good? You still taking those supplements? Is 500mg not too much?
Why isn't apigenin raising NAD via blocking CD38 being discussed more than it is ?
No human trials showing effectiveness
Would nad boosters help with certain or any illnesses or diseases.
In other words, would a person in 60s who is ill, benefit from nad boosters?
No body knows cause this guy is a scam artist if you google bim
NAD decreases with age. So definitely yes a older individual will benefit the most from a NAD Booster as there is more room for improvement. Age related diseases will often improve or go away if NAD is restored to youthful levels.
You will get best results at restoring your health by taking a multi faceted approach. Take NAD boosters along with. Intermittent fasting. High intensity exercise such as lifting weights and or interval training. Eating a plant based Diet. Avoiding sugar and Junk food. Do al this and you will greatly improve your health and well-being.
It's a matter of getting enough NAD I suppose you mean NHN pills is enough - Please tell us exactly what to buy: when you search for it it's very unclear if it's enough NMN. Where is your book for sale?
does nicotinamide( no flush niacin) is good for improving NAD level?
They all do, it’s just cheaper
@@Stanley_Baby thank you 🙏
So the kind without the flush works just as good?
Hi Dave ! What the Huck is NR ?
Medical treatments should be based on CLARITY and PRECISION.
The english/ merican language does NOT allow precision and fosters errors ( name of the product, dosage etc)
Unfortunately the AI transcription is even worse than anglomerican language.
The TRANSCRIPTION should be CORRECTED by the AUTHOR of the videotic
presentation !
Is NR safer to take than NMN because of a mouse study that showed a possible link to pancreatic cancer when taking NMN?
if that's so, why isn't it being talked about
@@havad3938 it is mentioned. That's why I bring it up.
You dont hear about niacin because Sinclair cant corner the market on it like he’s trying to do with NMN. No $$$
Glad more people are seeing the light. He did this once with resveratrol and made millions twenty years ago.
so i can take just flush niacin and i am good? 1000mg a day?
@@angenehmerweiblicherfussge7000 yes, that's my feeling. Niacin boosts NAD levels too. that's absolutely proven. I dont think you need to take 1000mg though, work up to 500mg, start with a fourth of a 500mg pill for a week, then a third, then a half. I dont see myself going above 500mg, it produces a powerful flush. but build up to it. I stupidly took a 500mg tablet without titrating up to it and it was a horrible two hours
@@angenehmerweiblicherfussge7000 I've been taking about that but it's only been a week, however I did notice a difference at the gym.
@@angenehmerweiblicherfussge7000 I've been taking 1000mg of niacin daily for about 4 years, since age 50 and, while I have no idea how it has impacted my NAD levels, I do know it has improved my cardiovascular health immensely. However, it is important to consume liver protecting nutrients when taking niacin, as it can elevate dangerous liver enzymes with higher doses. Frankly, I don't think 1000mg is enough to cause liver damage, but it's pretty easy to incorporate liver protection into your routine.
This is such bs. Niacin raises NAD levels to an even greater extent than NMN, but it raises NMN levels as well. SInclair is obviously biased as he wants to take full advantage of the NMN hype
i will research this; but if you have proof, lmk, thx
Really? Do you have a link to this?
so can i take MSM for methylation plus niacin and i am fine with cheap supplements?
@@angenehmerweiblicherfussge7000 that's overkill. nmn will eventually be broken down into b3, so just buy some form of b3 which is cheap
Niacin isn’t profitable I think that’s the problem
Niacin in high doses can make glucose control worse. Also could cause liver issues especially if you take drugs (alcohol, prescription, etc)
I think if you take the niacin and then don't eat carbs for the next 4 to 6 hours you should be ok. Also my understanding is that it's the sustained release niacin that is harmful to the liver
Wrong.
Taking high doses of niacin can deplete your methyl groups which can raise your AST and ALT enzyme levels. Take TMG at a 1:1 ratio and Glycine at a 1/2 the dose you are taking of niacin to help prevent this.
In some studies (not all) it is true for some older unhealthy people, not all of them
@@kakenetit2 why not just take MSM???? its much cheaper.
When is the best timing to take niacin? Fasted, with a meal, after the meal
I think taking with a meal helped to reduce my flush
niacin pulls you out of ketosis so with a meal is best
On an empty stomach you will get a rapid and intense flush. on a full stomach the absorption is more spread out and the flush will take longer to set in be milder but perhaps somewhat longer.
Niacin is easily absorbed and will get in to your system either way.
I prefer to take with meals to draw out absorption and reduce the intensity of skin flush.
Vegemite
really ? we love Vegemite ! Is it high in niacin? I did not know that !
The debate is bc there’s a patent involved aka 🤮🤮🤮
he's downplaying niacinamide so he pdrofits off his nmn. 50mg of niacinamide is cheap cheap.