Eli Lilly's Zepbound, Mounjaro Open Letter: Safety, Supply, and Controversy?
HTML-код
- Опубликовано: 1 авг 2024
- Reacting to Eli Lilly's Open Letter on Tirzepatide: Our Thoughts
In this special report, Laraine and Christopher Durham react to Eli Lilly's recent open letter concerning Mounjaro and Zepbound, medications for diabetes and obesity. They summarize key points of the letter, discuss the implications for compounding pharmacies, and share their personal experiences with these medications. They emphasize the importance of obtaining medications safely and legally, the challenges posed by social media-driven misinformation, and offer suggestions to Eli Lilly for improving product availability and affordability. The Downsized encourages viewers to consult healthcare professionals for medical advice.
The Elily Lilly Open Letter - investor.lilly.com/news-relea...
FDA - www.thefdagroup.com/blog/503a...
DOWNSIZED GLP-1 COMPANION PRODUCT STORE: thedownsized.org/downsized-st...
DOWNSIZED WEBSITE: thedownsized.org/
Start your weight loss journey today! We use Mochi Health: joinmochi.com/. Use Laraine’s code for $40 off: QIYGO8.
00:00 Introduction and Purpose of the Video
00:31 About The Downsized
01:32 Reaction to Eli Lilly's Open Letter
03:54 Discussion on Compounding Pharmacies
06:43 Eli Lilly's Stance on Safety and Regulation
15:02 Final Thoughts and Recommendations
20:04 Closing Remarks and Viewer Engagement
“Lily doesn’t know how they are obtaining these peptides”… That’s such bullcrap. The compounding pharmacies get the peptides from the exact same suppliers as Lily because Lily doesn’t own the peptides and CANNOT trademark them because a peptide is a naturally occurring molecule.
AMEN PRETTY!! FIND A MOUNTAIN TOP!!👍
@@theflamboyantgrandma1890thank you for pointing this out! It’s the big puzzle piece that missing. Lily is trying very hard to hold on to control of these medications. And who can blame them. But do as Christopher suggests…release it in vial form for a reasonable price, and there wouldn’t be this issue. Something tells me the insurance companies have a serious hand in this if you dig a little deeper.
Not true, tirzepatide is a synthetic peptide, but it mimics a naturally produced peptide found in the gut. Tirzepatide is a 39-amino acid linear peptide molecule that activates the body's receptors for two natural incretin hormones, glucagon-like-peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). The synthesis of tirzepatide was first disclosed in patents filed by Eli Lilly and Company. They have spent billions in the research and development related to synthesis and successful use of the peptide. The compounding pharmacies are sourcing from places which copied the chemical formula and made their out tirzepatide and the dosage and instructions of injection follows the Lilly patented protocol.
@@ivalani Yes, and it cannot be trademarked for all those reasons you mentioned. That’s the only point I was making. Thanks for proving my point… But you won!🥇
Who do you currently get your compound from? I can't afford the brand name.
Lilly continues to produce the loading dose of 2.5 mg, getting new patients started on their product, while those who need higher doses are losing sleep, putting in hours on the phone and driving, living in a state of anxiety about trying to get their medicine in the doseage needed. I am losing weight on compounded tirzepatide, which for me has been just as effective as the name brand Zepbound I used starting out. I feel exactly the same on compound - still have hunger suppression, cravings gone, and keeping my supply of colace, miralax and zofran restocked as needed. Due to Eli Lilly's shortage, I use a reputable telehealth provider and Empower pharmacy with my PCP's full support.
Let's stop calling it 'the shortage' because it's Eli Lilly's shortage. They don't own peptides, but they own the shortage that has pushed people toward compounded tirzepatide.
By the way, I like the vial and syringe better. The needle is so small I don't even feel it❤
Thanks we are on the same page - Eli Lilly owns the shortage and seems to be continually surprised by it. The demand should have been easily anticipated and it will only grow
hi what is the name of both; I use a reputable telehealth provider????? and Empower pharmacy which one ????? name please
@@marimerf6685 We use Mochi Health
@marimerf6685 I use Emerge for the past 3 months, and after they confirm with me if I want to stay at same dose or titrate up, they send my prescription to Empower Pharmacy in Houston.
@@marimerf6685
I have a referral code if you want to try Emerge...and assuming I can figure out how to share it🤔
I didn't have a referral code when I signed up, but they offered me one anyway, so you can still get $50 off, my code just gets me $25 off my next two. Lol. I'm not a salesperson, as you can tell
1) Eli Lilly does not have the means to supply the medication to the masses 2) They can't offer the medication at an affordable price. On top of this my insurance refuses to cover weight loss medications. Therefore, I will continue to get compounded tirezepitide medication and will tell all my friends about it too.
You are correct on number one that is why they are investing in plants around the world and the Eli Lilly CEO said they would not be able to keep up until the have an oral option.
On number 2 I assure you they can be wildly profitable and find a significantly lower price. And they will eventually do it - the want own the entire obesity market. Plus the have competition from numerous companies around the world in trials. They will change the marketplace and lower the price
@@thedownsized 2) They CAN offer it at a lower price, however, they are too greedy. I'd glady purchase brand name at less than $400 (what I am currently payin out of pocket) but I just don't see it happening,
Profitability and growth is why they will do it - it will open the market for millions of people. They want the 43% of Americans that are obese as customer. That is much more than the small percentage that can pay the high price today
First of all, Thank you for breaking this down! It was very well presented. Secondly, you guys are a delight to watch! Love all of your videos.
Thank you so much!
Compounding pharmaceutical companies are the best! Get my semiglutide and hrt through them.
I agree!😎
Another awesome episode. 🙌🏻 Thanks for the update. Appreciate you guys.
Thanks for watching!
Eli Lilly’s molecular patent on the tirzepatide (the medicine, not just the pens), expires in 2036. Compounding pharmacies are not meant to provide an alternative source of obtaining medications still under patent. They can only do so when the medications are in shortage (which many Zepbound doses currently are). But once their production can satisfy the demand, I think they will come after compounding pharmacies. Mixing tirzepatide with B12 (for example) is just a way to get around the patent law, not an actual modification to the medication because of a patient’s needs.
This is Christopher. You may be right -Lilly is certainly posturing aggressively. I think more likely that demand will outpace production for years to come and the shortages will continue. Lilly’s CEO said he does not believe shortages will end until they have an oral option.
Great and well-reasoned response, thanks.🌟
And yes, Lilly *does* seem to be ‘feeling the heat’ from competition from compounders.
That said, many of their criticisms of ‘alternatively-sourced’ Tirzepatide are valid, to varying degrees. There are certainly a lot of sketchy/bad actors out there. 😢
Lilly also seems to be blaming ‘vanity users’ for the shortages - aka ppl w/out obesity or T2D using the meds to ‘lose that last 10 lbs’ for bikini season or a wedding or whatever.
This is deflection. There are simply not enough of those ppl to cause the severe degree and persistence of the shortages we’ve been seeing. 😯
Yes, those ppl should NOT be given prescriptions, and they make matters worse… but the ultimate cause of the shortages is Eli Lilly not being able to keep up with demand in general. We’d *still* have shortages even if every vanity user went away tomorrow. 🤨
One small addendum to the vid: Oral Tirzepatide (that’s proven safe and effective in clinical trials and through FDA approval) does not exist yet, but oral Semaglutide does. Novo Nordisk sells it as Rybelsus. Think of it as ‘Oral Ozempic’.
It’s currently approved only for T2D, but new higher doses of it for weight-loss have gone through all the trials, and are awaiting FDA approval. Would expect them to show up before year-end. 👍
ps - For any vid that has graphs or small text, a 720p resolution option is very helpful. 🙏
The red on that is 1080
Perhaps in the YT app. On web, nothing above 360p.
Strange I will check it - it was filmed 1080 in streamyard and uploaded as such
Strange I can watch on my laptop and 65 inch tv at 1080
Excellent content! Thanks for the video and info!!
Glad you enjoyed it!
Great video!
Thanks!
Great content. I’m going to go read the full letter, but I appreciate the CliffsNotes version. Thank you for making this complicated topic easy to understand. 😘
Hi Mindy! Glad you liked it!
Insurance won't cover anything for weightloss even w complications for obesity except diabetes 2. Thank goodness I'm able to buy from my compounding pharmacy for $600 a vile.
That does seem to be very common, but each policy is different. It is great to have options
💯💯💯💯💯💯
thanks
The company has patented the PEN as I understand, so sending vial in the US MAY make their patient null and void. Opening up the market for generic 🤷🏻♀️
Lilly has patents on the GLP-1 GIP compound that is ZepBound / mounjaro
tryslate.greyb.com/engage/US11918623B2?
It only specifies subcutaneous delivery not the injector
They also have a patent on the injector
Eli Lilly does need to recoup their profound investment in development - that’s the expense.
Yes they do but they don’t need the obscene profits per unit. They will more than make up for it in volume even at a $100 dollars a month
The expense they need to recover is the payoffs to FDA and other lobbying companies. Oh, let’s not forget the advertising on news networks so they can control the news content out of fear of losing advertising revenue.
While agree that Eli LIly should be able to recoup on their investment, and they have a right to make a profit. I do not understand why their US customers are being tasked with fronting the costs of their investment. The question has never been answered as to why the American consumer is being charged so much more than their European, Canadian or Austrailian counterparts.
@nyohmd Exactly! Why are prices so outrageous in US compared to UK, Canada, Australia?
@@thedownsized Because of the amount of heavy investment in R&D and our approval process is the gold standard. What gets lost is the amount of taxpayer dollars also goes into R&D, as big Pharma does not shoulder it all. Lots of public univerisities perform the actual the chemical research for these companies.
Although I agree with you that Lilly made some specious statements in their admonitions to buy only their name-branded product instead of compounded alternatives, I must disdain your continual drumbeating about the unequivocal safety of compounding pharmacies. Do you know where your Hallandale pharmacy obtains its ingredients? Regulation of the local dispensary aside, are you confident in the purity and safety of the components they use? The 2012 case of a back pain clinic in Michigan killing eleven patients with a contaminated drug compounded by New England Compounding Center (NECC) illustrates the point that local regulation might not be enough. I know far too well that Florida regulation falls short of protecting consumers in other areas. Can you be assured that the compounds produced out-of-state and sold in Florida are free from contaminants or that they are even genuine terzepatide or semaglutide? If so, how?
Although the owner of NECC, Barry Cadden, received a sentence of 10-15 years for falsifying records and deluding people into believing he was running a clean, safe operation, that doesn't help eleven families with their losses. If we find out too late that state regulation is not enough, then what?
Sure, I understand the desire to save money, and I completely understand that the way big pharma operates in this country, not only are some people priced out of obtaining useful drugs but also those who can afford them are subsidizing cheaper prices for people in other countries. Your desire to economize is well-founded, but when you profess the COMPLETE safety of compounding pharmacies and do not mention their associated risks, however small, I am impelled to comment. People need to be apprised of the whole picture.
This is Christopher - We do not confess the complete safety of compounding pharmacies or honestly any medication - otherwise we would not even mention Lilly’s letter. We clearly state the information and call to our Lilly’s partial story. Unfortunately the branded manufacturers have had their share of issues and recalls as well.
As I have said I would much rather been taking ZepBound then a compound.
It is a big complex story and we all have to make our own choices
@@thedownsized Yep. People forget Novo Nordisk had a contamination problem last year, I believe.