Reversal of Skin Aging By Reducing Senescent Cells | Dr. Reis Interview Series Ep1
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- Опубликовано: 8 мар 2021
- In this video Dr. Reis, talks about the background to the paper and provides more details on how why skin ages and how the peptide that they investigated helps the reduce the effects of aging. It does this largely by supressing the growth of senescent cells, as these then go on to produce inflammatory secretions which affect the surrounding tissue.
Dr. Carolina Reis is the co-found and CEO of OneSkin Technologies. She holds a biochemistry degree and a Ph.D. focused on stem cell and tissue engineering. After more than 10 years of developing science in academia, she is thrilled to translate basic science into products that will extend our healthspan. As a founder of OneSkin, she and the team have been working to develop the first anti-senescence topical product designed to promote skin health from within. Dr. Reis is an alumnus of IndieBio, the world's largest seed biotech accelerator. She has moved from Latin America to Silicon Valley 4 years ago to found OneSkin and has been actively engaged in the longevity ecosystem in the Bay Area.
Links from this Video
Senotherapeutic peptide reduces skin biological age and improves skin health markers
www.biorxiv.org/content/10.11...
Molclock website
www.molclock.com/
OneSkin Website
www.oneskin.co/
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Good to see a Brazilian Doctor so successful. So, proud of you! Great job!!!
Another fascinating interview series, good job Richard!
Hi JC, thank you for your supportive comment!
Love this channel!
HI Air, thank you for your supportive comment!
Very intresting. The one good thing is that this product probably will drop 50% in price the following 10 years. Will def try in the future. And orally is very intresting, combine it with fisetin and rapamycin hmm
Informative interview about skin aging, thank you!
HI Sparkling, glad you like this video, thank you!
Great video. Thanks.
Hi Ankur, glad you enjoy this video!
Thanks for this. 👍
Hi Ron, thank you for your comment as always!
very informative
very interesting about skin clock
HI Olya, nice to hear from you again, yes, we found it interesting as well. Different organ measure by different clock, it will be more accurate and make sense.
Very intriguing! It's a shame the research is still so early stage. Also, gratz on 8k subs!
Hi EpiGirl1, thank you for your comment and kind words!
If you would like to support our channel, we’d love a coffee…thank you!
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Dr. Carolina Reis’s Interview Series Playlist
ruclips.net/video/Pf0m8fgjItM/видео.html
Our NMN Trial Result Playlist Link
ruclips.net/video/tcmkciJi7yg/видео.html
How about puttning the peptide in a vial and sell it for injection? Or will fda come after u
Great information! How does fisetin compare to OS-1 peptide as a senolytic? Is fisetin organ specific or does it have a systemic senolytic effect ?
OS-1 prevents senescence and is a senescent rescue.
Another option is using for the head skin, whether trigger to grow more hair?
HI Mark, interesting idea!
Interesting to know about C Elegans drink the peptide and increase both healthspan and lifespan. Hopefully can escalate the research to mammal to see the result.
HI Susan, thank you for your comment, yes, we are looking forward to seeing next stage can be progressed as quickly as possible!
convincing
Hi Rui-9-CS, thank you for your comment!
I ordered one OneSkin bottle today.
Hi David, thank you for your comment. Please do update us on your progress after you tried. I'm sure many of our audience would like to know!
This is the product that is connected to then video?
David, please come back and give us your review.
I’m intrigued, but the price tag is high.
where did you order ?
@@Halbared yes
Dr. Reid audio is not clear..
Hi Wayil, thank you for your comment. May be I wore a headphone and mic which made my voice more outstanding and clear so comparably Dr. Reis less clear...
@@ModernHealthspan Appreciate your great channel...
Thank you for an informative interview.
As I know, the cell become senescence to prevent cancer when there is a mutation. If we keep them alive, wouldn't that be bad for us?
The trick is to not let them build up as we age. Which is what happens.
The idea behind senolytics is that they allow the senescent cell to die via apoptosis. If a cell has a damaging mutation, you'd really like it to commit apoptosis and die in an orderly manner.
@@incognitotorpedo42 Thanks for your response
Not very impressed...
a) A third party 'clock' will be more trustworthy. In fact the 'photoage' test is extremely accurate (-/+ 2%), and is offered for free by insiico at young.ai.
b) She claims that senecent cells is major culprit. In the dish azithromycin killed 97% os senecent cells. Fisetin is also very effective. Both very safe, very effective, very cheap, and available. You would only need to do it intermitently.
So I don't see the point. Nonetheless, I will be checking the next interviews.
Sorry: I meant +/- 2 years (which is quite accurate)
great link, thanks. I can follow her argument about epigenetic variations in specialized tissues, I find it quite interresting, I stumbled over an article not long ago that measured quantity of senscent cells in different tissues, and found very big differences. Don’t have the link, sorry, I’m just a layman ipad-surfer :-).
I agree that for commercial credibility purposes there needs to be 3rd party assesments. AI-photoage is not the whole answer here, because AI-black-box issues, ideally there was a 3rd party service to test out epigenetic age in specialized tissues, as well as composition. of senescent cells, however I dont like the idea of sending skin biopsies from my face :-D
oh, i just got the result from young.ai, a result of -15 years. I think that is a bit escessive, I have always looked younger than my age, and I am an active body-hacker, but I do not look my age -15... would love to, of course, maybe I should try those anti-aging skin products :-D
just realized they use in vitro testing... that is not convincing.
Little known fact. Dr. Caroline is actually 67
That's not "age." That's sun exposure. Humans were meant to be a nocturnal species.
she looks young for a 78-year old person.
sounds BS
yitzhill - There's always been a lot of BS coming from the skin care industry. We'll have to wait a decade to see if it's real or not.
I wont be the first to experiment that peptide.