If you would like to support our channel, we’d love a coffee ☕…thank you! www.buymeacoffee.com/mhealthspan Dr. James Kirkland Interview Series Playlist ruclips.net/video/aZblQ5re2dg/видео.html Mindfulness: Ellen Langer Ph.D. | Harvard University ruclips.net/video/1nf_8fmM_jA/видео.html
Information rich, just like episode 2. I recall that one of the 2020 Conboy Lab experiments with plasma exchange (50% exchange with saline and albumin) there was significant clearance of SCs from the brain. So, plasma exchange may removes SCs in all tissues, which apparently most senolytics do not (they are tissue specific according to Dr. Kirkland). Pays to hear directly from researchers.
Yeah, the weird thing about the Conboy experiment was that they only REMOVED factors from the blood and replaced them with albumin and saline... and got a lot of the same benefits as full parabiosis.
Plasma exchange is hella expensive, though. Here in NZ it's about 2000 usd per treatment. And you'll likely need several treatments. Hopefully the cost comes down in the near future. What's the cost over there?
@@Corteum I think similar costs here in the US, but you can only have it done for certain medcial conditions. I discovered plasma-only donation centers (CSL Plasma for example) which will take about 25% of your plasma in one donation and repeat in 3 days, and allow 2 donations a week. They pay donors. Better for me, and what I started doing is donating plasma (800 mls or about 25% of volume) at my local blood bank. They allow monthly donations. I donate plasma and sometime platelets. Platelet donation can be done weekly or every two weeks and carries with it varying amounts of plasma. Whole blood donation, which I stopped, can only be done once every 8 weeks here and olny removes about 250 mls of plasma. Platelets are in high demand as they go mostly to cancer patients. There is a very small study by Rob Flickenger on using plasma donation, and he has shown that a lot of the same protein expression changes occur as was seen by the Conboys in their 50% tests with the smaller donaton volume. The Conboys also noted that plasma exchange effects seem to lasat at least a month, so I am confident that my monthly donation will have postive some effects over time given that I am older and more likely to benefit.
I really loved this video! You should try to interview Takishima Mika, the 90-year-old Japanese fitness instructor. I know she is not a longevity scientist, but she has consumed mushrooms and two packs of natto everyday for decades. Maybe a real-world case of spermidine working as it should?
This is the best explanation I've seen about senescent cells and senolytics, thank you! Any recommendations on which senolytics to take? Currently I'm taking Quercertin.
Can someone pls tell me how to identify zombie cells..because i strongly suspect i have them in the feet...they feel stiff, sore, with itchy skin blotches. No medical reason found. I have mito dysfunction and severe fatigue the last few yrs but even my functional MD cant answer this question. Can anyone here help me? Thanks!
Hi Wayne, thanks for your question. Hopefully someone more knowledgeable than me can jump in but I did find this paper from Dr. Kirkland www.ncbi.nlm.nih.gov/pmc/articles/PMC7061456/ "Senescent cell clearance by the immune system: Emerging therapeutic opportunities" which talks about how the immune system clears senescent cells. Monocytes/macrophages do seem to be one of the agents.
@@ModernHealthspan Great paper thanks! Confirms that MOs are critical in clearing SCs in a bio-complex arena. I was pondering the question why the elderly were so much more vulnerable to, at least, the Alpha SARS-CoV-2 virus than young people? Could the NAD depletion with aging coupled to chronic inflammation of the elderly be a synergistic factor? One doctor/researcher (Paul Marik) suggested using Vit.D in prevention and early exposure of virus to activate, through polarization of monocytes, the M2 pro-inflammatory state of MOs to fight the virus. If the patient progresses to the immune over-reaction phase of COVID producing pathogenic inflammation, treatment should be shifted away from Vit. D to Vit. C that helps to depolarize MOs to M1 anti-inflammatory state.
@@waynewells2862 Would you think, then, that those with autoimmunity (I have untreated) would not be benefited, and may be harmed, by supplementing with vitamin D? Although it is a pretty broad terminology, my understanding is that vitamin D is an ‘immune modulator’, thus not necessarily ramping a broad immune response, but conforming it to the needs at any time….?? Apologies for the egregiously unscientific explanation above, I am no scientist!
Hi William, thanks for your question. Unfortunately I don't know which one he was referring to. The only one I could find is the following onlinelibrary.wiley.com/doi/full/10.1002/mco2.62, Nicotinamide mononucleotide ameliorates senescence in alveolar epithelial cells.
Great video, I was just discovered to have 1,237,000 thrombocyte platelets per deciliter blood and to have a spleen enlarged to 50% above average for my size in Feb. 2020. My question to the medical community is: Does eating senolytics foods that promote autophagy help to reduce platelet count? My poor spleen needs some help. Fisitin, (in strawberries), Spermidine, (in wheat germ and peas), or taking Quercitin come to mind. Is there a senolytic that works best for thrombocytes?
Look into peptides----chains of amino acids that can activate all kinds of health-optimizing/boosting functions in the body. Look up guys in the space, such as Ryan Smith, Daniel Stickler, and Jean Francois Tremblay. 👍
Gentlemen.. Please let me know when you have research ready that actually works for humans and not rodents. I would love another solution then taking a diabetes drug and other medical treatments which we all know has side effects. Kind regards Martin
![CHILE vs. BRASIL [1-2] | RESUMEN | ELIMINATORIAS SUDAMERICANAS | FECHA 9](http://i.ytimg.com/vi/5ObJt_71AYc/mqdefault.jpg)
If you would like to support our channel, we’d love a coffee ☕…thank you!
www.buymeacoffee.com/mhealthspan
Dr. James Kirkland Interview Series Playlist
ruclips.net/video/aZblQ5re2dg/видео.html
Mindfulness: Ellen Langer Ph.D. | Harvard University
ruclips.net/video/1nf_8fmM_jA/видео.html
Stunningly articulate presentations from a researcher with laboratory and clinical expertise.
Hi Richard, thanks for commenting.
Information rich, just like episode 2. I recall that one of the 2020 Conboy Lab experiments with plasma exchange (50% exchange with saline and albumin) there was significant clearance of SCs from the brain. So, plasma exchange may removes SCs in all tissues, which apparently most senolytics do not (they are tissue specific according to Dr. Kirkland). Pays to hear directly from researchers.
Hi Peter, thanks for sharing. Totally agree. Yes that is what the paper showed.
Yeah, the weird thing about the Conboy experiment was that they only REMOVED factors from the blood and replaced them with albumin and saline... and got a lot of the same benefits as full parabiosis.
Plasma exchange is hella expensive, though. Here in NZ it's about 2000 usd per treatment. And you'll likely need several treatments. Hopefully the cost comes down in the near future. What's the cost over there?
@@Corteum I think similar costs here in the US, but you can only have it done for certain medcial conditions. I discovered plasma-only donation centers (CSL Plasma for example) which will take about 25% of your plasma in one donation and repeat in 3 days, and allow 2 donations a week. They pay donors. Better for me, and what I started doing is donating plasma (800 mls or about 25% of volume) at my local blood bank. They allow monthly donations. I donate plasma and sometime platelets. Platelet donation can be done weekly or every two weeks and carries with it varying amounts of plasma. Whole blood donation, which I stopped, can only be done once every 8 weeks here and olny removes about 250 mls of plasma. Platelets are in high demand as they go mostly to cancer patients. There is a very small study by Rob Flickenger on using plasma donation, and he has shown that a lot of the same protein expression changes occur as was seen by the Conboys in their 50% tests with the smaller donaton volume. The Conboys also noted that plasma exchange effects seem to lasat at least a month, so I am confident that my monthly donation will have postive some effects over time given that I am older and more likely to benefit.
I really loved this video! You should try to interview Takishima Mika, the 90-year-old Japanese fitness instructor. I know she is not a longevity scientist, but she has consumed mushrooms and two packs of natto everyday for decades. Maybe a real-world case of spermidine working as it should?
This is the best explanation I've seen about senescent cells and senolytics, thank you! Any recommendations on which senolytics to take? Currently I'm taking Quercertin.
Fantastic interview
Learned more in 15 minutes here than from most Uni lectures in an hour.
Hi Trojan, thanks for your kind comment.
New knowledge. Can never get enough of new knowledge. Thank you!
Learnt a lots, thank you!
Beneficial interview, thanks.
Can someone pls tell me how to identify zombie cells..because i strongly suspect i have them in the feet...they feel stiff, sore, with itchy skin blotches. No medical reason found. I have mito dysfunction and severe fatigue the last few yrs but even my functional MD cant answer this question. Can anyone here help me?
Thanks!
Great information. Thanks.
Hi Thanks. I do hope that you found it helpful.
Are monocytes/macrophages the agents to clean out senescent cells??
Hi Wayne, thanks for your question. Hopefully someone more knowledgeable than me can jump in but I did find this paper from Dr. Kirkland www.ncbi.nlm.nih.gov/pmc/articles/PMC7061456/ "Senescent cell clearance by the immune system: Emerging therapeutic opportunities" which talks about how the immune system clears senescent cells. Monocytes/macrophages do seem to be one of the agents.
@@ModernHealthspan Great paper thanks! Confirms that MOs are critical in clearing SCs in a bio-complex arena. I was pondering the question why the elderly were so much more vulnerable to, at least, the Alpha SARS-CoV-2 virus than young people? Could the NAD depletion with aging coupled to chronic inflammation of the elderly be a synergistic factor? One doctor/researcher (Paul Marik) suggested using Vit.D in prevention and early exposure of virus to activate, through polarization of monocytes, the M2 pro-inflammatory state of MOs to fight the virus. If the patient progresses to the immune over-reaction phase of COVID producing pathogenic inflammation, treatment should be shifted away from Vit. D to Vit. C that helps to depolarize MOs to M1 anti-inflammatory state.
@@waynewells2862 Would you think, then, that those with autoimmunity (I have untreated) would not be benefited, and may be harmed, by supplementing with vitamin D?
Although it is a pretty broad terminology, my understanding is that vitamin D is an ‘immune modulator’, thus not necessarily ramping a broad immune response, but conforming it to the needs at any time….??
Apologies for the egregiously unscientific explanation above, I am no scientist!
Dr. Kirkland mentions that NAD+ precursors have beneficial effects on senescent cells... anyone know which paper he's referring to? TIA.
Hi William, thanks for your question. Unfortunately I don't know which one he was referring to. The only one I could find is the following onlinelibrary.wiley.com/doi/full/10.1002/mco2.62, Nicotinamide mononucleotide ameliorates senescence in alveolar epithelial cells.
Thanks Richard.
Hi Ron, thanks!
Great video, I was just discovered to have 1,237,000 thrombocyte platelets per deciliter blood and to have a spleen enlarged to 50% above average for my size in Feb. 2020. My question to the medical community is: Does eating senolytics foods that promote autophagy help to reduce platelet count? My poor spleen needs some help. Fisitin, (in strawberries), Spermidine, (in wheat germ and peas), or taking Quercitin come to mind. Is there a senolytic that works best for thrombocytes?
Look into peptides----chains of amino acids that can activate all kinds of health-optimizing/boosting functions in the body. Look up guys in the space, such as Ryan Smith, Daniel Stickler, and Jean Francois Tremblay. 👍
One takeaway is when you are young, your immune system will automatically get rid of senescent cells for you.
Hi Sparkling thanks for sharing.
What is sass?
Interesting!
Still many questions not answered.
Gentlemen.. Please let me know when you have research ready that actually works for humans and not rodents. I would love another solution then taking a diabetes drug and other medical treatments which we all know has side effects. Kind regards Martin
Berberine is an alkaloid found in barberry and other plants. It has potent anti-diabetic effects that promote autophagy and suppress senescent cells
@@gwens5093 thanks for your answer
NMN does nothing for spelling accuracy.
sorry to say but the rocking is annoying to watch....