Anti-clotting Mechanisms
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- Опубликовано: 7 июл 2024
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►👨🏫💊Antibiotics Lectures: www.medicosisperfectionalis.c... ... Check out my brand new "Electrolytes" course at www.medicosisperfectionalis.c... and use the PROMO code: ELECTROLYTES50 to get a 50% discount. The anti-clotting mechanisms are the reason you are still alive now, and didn't form a clot and die.
These anti-clotting mechanisms include heparan sulfate, heparin, protein C and S, thrombomodulin, prostacyclin (prostaglandin I2) among others.
Primary hemostasis is balanced on the dynamic harmonious antagonism between the smooth endothelium (that prefers laminar blood flow) and thrombocytes (which favor clotting and thrombosis).
Platelets are called thrombocytes "cells of thrombus".
The smooth endothelium is squamous epithelium that lines the blood and lymphatic vessels from the inside.
When platelets roll over the smooth endothelium, nothing happens.
But, once there is an injured endothelium, platelets adhere, activate and aggregate to form a temporary platelet plug (primary hemostasis).
Then, the coagulation factors are stimulated "thanks to subendothelial collagen, tissue thromboplastin and platelet factor 3), coagulation cascade ensues until fibrinogen is converted into fibrin fibers trapping the RBCs and forming a stronger thrombus (secondary hemostasis).
After that, fibrinolysis occur (thanks to tissue plasminogen activator or tPA) to destroy the clot and restore function and flow.
Hemostasis is defined as “cessation of blood bleeding”.
There are 2 types of hemostasis:
1. Primary hemostasis: formation of weak, temporary platelet plug (by platelets).
2. Secondary hemostasis: formation of stronger fibrin meshwork (by coagulation factors).
Get all of my notes and cases (vignettes) here: / medicosis
Check my full playlist on "bleeding and coagulation" here: goo.gl/Dt41Bg
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Disclaimer 1: The information provided here is for educational purposes only, and not to provide medical advice…If you have any symptoms or medical questions, you should talk to your doctor.
Disclaimer 2: I use affiliate links.
To be able to answer exam questions, Try to think of primary hemostasis and secondary hemostasis as two separate entities. 1ry hemostasis involves platelets and 2ry hemostasis involves the coagulation cascade. If you like my videos, please consider leaving a tip at www.paypal.me/perfectionalis/
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Don't miss my 50 hematology 💉 cases (vignettes) on www.patreon.com/medicosis/ ...Try to answer them, and send your answers to my email.
I'm honestly amazed by how underrated your videos are. I honestly think that you are doing a great job and that in the future more and more people will subscribe to your channel.
Thank you so much 😊
I'm studying to be a medical laboratory scientist and your channel has helped me with literally all of my classes lol keep them coming! 💞
I am honored...You made my day! Thanks a million! Please consider sharing my videos with others, it really helps!
I have 20 questions and 50 cases on my patreon page if you wish, www.patreon.com/medicosis/
You do not know how grateful I am to this great channel. thank you sir
You’re very welcome, sir!
Where is the answer of previous video ?😭😭😢😢
الله يوفقك 💙
You are the best.best ever...I am very much grateful to you.thank you sir
My pleasure 😇
U made my life easy thank 😍 u so much
You're welcome!
Excellent explanation!
Thank you so much!
Would you please help me by sharing my videos with others?
THANK GOD for you, coag made easier
Thank you 😊
You are amazing..
Thank you 🙏
you are the best
Thanks 😊
Díky!
Thank you for your support!
I just missed a question on heparin moa 😅
😳🤭🤫
Best videos
Thanks 🙏
I have another question .. does PF 3 the same of membrane phospholipid , we say itis found in granule ?!
Great question!
Please refer to my video: Platelet Structure: ruclips.net/video/95A-j-eL9B8/видео.html
Sorry ,but you are wrong when you write "inactivate V" because they also inactivated , you should write "inactivate Va" because Va activated:) Thank U for lessons❤️
Thank you for correcting me!
I appreciate you!
We understood what was meant.
Answer of previous video ?
What was the question from last video?
I am scrolling through the comments, that’s why I don’t remember the question!
Can you write it here? I will answer it for you.
Th qestion is why when putting the blood in test tube will coagulate by intrinsic pathway althought there is no subendothelium collagen?
Please after you answer fix my comment for people subscibing ,,
The answer is:
Because blood has HMWK, kallikerin, Platelet factor 3, Wet, negatively-charged surface of the glass.
You can find the answers to all the questions for this playlist on my website: www.medicosisperfectionalis.com/
@@MedicosisPerfectionalis th best ever ❤
Thank you 😊
MECHAN-- Moved because of; expedite, AYE! From this, place- AYE! AN= and! AYE!
Vessels, expedite alot-- with each other.