Systemic lupus erythematosus (SLE) - causes, symptoms, diagnosis & pathology
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- Опубликовано: 22 май 2016
- What is systemic lupus erythematosus (SLE)? SLE's an autoimmune disease that can affect any tissue or organ in the body, but most often affects the skin, kidneys, and joints. Find our full video library only on Osmosis: osms.it/more.
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This channel is a gift to medical students
this is a very true statement
Necromancer Nazi wff
totallyyy
Once I start making some money...will surely take the subscription and donate as well
& pre-meds
"Avoid sunlight". Maybe the word "Lupus" is a historical reference to having to stay out of the sun...?
(Werewolves only come out at night)
Michael McCray ha ha..great
No, it's called Lupus because it's like a wolf (Lupus) in sheep's clothing...mimics so many symptoms of other diseases...
So, shouldn't it be named "wolf-rash"? Just saying.@Chaston Ellis
Michael McCray wow
I agree with all these answers. I have lived with lupus for many years but diagnosed in 2016. Stay strong!
May is also Lupus awareness month!
My lecturer took 1 hour for this topic.. and you guys nailed it in 11 mins...
haaaaa
Mate I’m sure your lecturer gets payed hourly or per lecture he teaches, Id bet money that he’s wasting time on purpose 😂
if only you knew how much time it gets to make 1 video
And i didn't uderstand that much from my lecturer
Is there any treatment.....plz help
I have had APS/ autoimmune illness all my life and have finally learned it comes from food!!!! I went 100% organic and have had more progress in 5 months than I've had with any treatment over my 34 years of seeking help. I had to give up all the goodies, you might only need to give up 1, or 3 like red meat, gluten, dairy, nightshade vegetables, caffeine, sugar, and anything highly processed. It's amazing! Actually feeling healthy!!!! Goodbye life long illness!!!!!!
I am a registered nurse with 13 years of experience and diagnosed with SLE approximately 5 years ago. This is the first time that I completely understand the disease process and why each of these tests are ordered during times of disease activity. Thank you!
Me too 😢
😊😊😊
😮
How to cure this I am 1 year in this
@@pratiksharma13u cant u just have to keep it in control
Thanks for this great explanation of Lupus. I’ve been recently diagnosed with Lupus but the doctor didn’t give me any information on this disease. Now I understand what type of this disease this is. Lupus sounds like a complicated disease. It’s quite scary. Everything’s in God’s hands. Hopefully they’ll be a cure soon since so many people suffer from this destructive disease.
It's complicated and scary but can be manageable. I'm sorry you didn't get information from your doctor. Being in the dark is the worst. I've had it for a few years now, but the good thing is, new treatments are in the works.
My mom was just diagnosed as well. Doctor gave her any information either 😢
@@mistysimms2708at what age your mom diagnosed?
I was diagnosed in ‘98 and I’m 2009 I got a kidney transplant but it only lasted 4 years. I am now doing peritoneal dialysis and going through the Transplant Work Up again to try and get on The List once again and hopefully I will get that amazing gift. I have a gorgeous daughter and 3 amazing and gorgeous grandchildren 💖. This video was spot on. I pray for all of us and everyone that is going through some kind of illness. Stay Strong 💪🏼💜💜💜
الشفاء العاجل أن شاء الله
"It's HIP to get lupus" mnemonic for drug inducing lupus: Hydrazaline, Isoniazide, Procainamide.
I'm allergic to sulphur drugs..and Sulphates ... Which means no wine for me..although there are some non sulphate wines out there..expensive..sulphate are used as preservatives in a whole lot of stuff.
I want you to know that there is a cure for lupus and I cured mine with herbal remedy form Dr Ehime who I met on RUclips channel. His name is Dr Ehime.
Hydralazine*,Isoniazid*
I'm being investigated for lupus and this video helps me understand the disease a lot better. Thank you 🙂
Hope our video helped! 🙏🏼
Same here!
I have been suffering from Lupus disease for some year without having a solution to it until i done a research on RUclips i come and cross Dr.Auchi on RUclips channel. That was were i find effective herbal medicine to cure my Lupus disease permanently without having side effect from the herbal product.. i recommend Dr.Auchi herbal medicine for Lupus disease cure...
What symptoms u are having?
@@sm.663 I was having hair lost as my lupus symptoms..
Wowwwww absolutley amazing, you need only 11 minutes in explain this pathology. I understood very well, much better than book. Thank you for this!
Perfect! You're welcome AJ.
Osmosis
please can you Translate to Arabic، I really need this to understand medical words well! Thanks. 😊☺
Nice of you to say that. On my place on this website i will tell people what they can do if the treatment of the doctors don't help. Good luck !
Is their any treatment.....plz help
With this video my headache while learning is gone thanks !
You're welcome! 🤓
Can’t trust anyone, not even your own cells
Shoutout to Osmosis for getting me through 4 years of Nursing School
My mother was diagnosed with SLE and she’s having a flair up… she has it pretty severe and it’s really hard to watch. I’ve had to call my dad to rush her to the hospital bc of serious high fever and bp. She was delirious and in and out of consciousness. I’ll have to leave the country soon to go to the military and try to support my family. My mom is 48 and my dad 49, I’m 17 (18 in a month) and we can barely pay rent… I’m so worried for them but this is the only way they’ll be able to live at least semi comfortably in the last 30 or so years of their lives. I just hope I can get her help and although I care we have a rough relationship and her marriage is not going well either. This just have to get better ❤️🩹
We're rooting for you, Kitt! We admire your resilience! 💖
@@osmosisthank you so much, she’s doing better now and finally out of bed. I can just hope for the best now🙂
I have been suffering from Lupus disease for some year without having a solution to it until i done a research on RUclips i come and cross Dr.Auchi on RUclips channel. That was were i find effective herbal medicine to cure my Lupus disease permanently without having side effect from the herbal product.. i recommend Dr.Auchi herbal medicine for Lupus disease cure...
@@kitt1226 how long did it take for her to get out of bed? Pls tell... I'm 17 and my mother is going through the same, she is in bed... Bad condition.. Idk what to do
كان الله في عونك اخي والشفاء العاجل للوالده
I really like the casual tone of these videos, saying "alright!" and "okay!" often. 😊
Thank you so much for this video, I was diagnosed with severe SLE and Antiphospholipid antibody syndrome around 7 months ago, and although I know the medications and treatments, I want to understand the aetiology and how to interpret my blood results. This is empowering and invaluable. From reading the comments there are so many other sufferers and desperate medical students who feel the same. You've now given me a springboard of terminology research into further
"desperate" lmao
Mehressa Green how old are you?
How is your health now?
@@chandrahasp6697 he's RIP
@@raheemprime6860 r u serious?? So sad for him peace to his soul
Still watching this in 2019. Even though the criteria has changed, the very essence of the disease mechanism is very much briefly explained without missing any important info. Thank you as always, Osmosis!
I have been a doctor for over 5 years now but I don’t think I ever understood SLE before! Thank you!
Glad to help ❤️
I accidentally typed SLE instead of sleep. I was looking for sleep videos. This put me to sleep quicker than any sleep meditations I used before. I now listen to this to fall asleep. Goodnight.
The best SLE video I have seen. Thank you.
Thanks!
Is there any treatment plz help
@@intrestingindia5897 Generally, the treatment plan depends on the severity of the disease ranging from the use of Hydroxychloroquine, NSAIDS, to corticosteroids and immunosuppressants. As with many autoimmune disorders, a specialist is essential for proper treatment. I hope it helps.
I was diagnosed with this recently - with 7 of the criteria met. I’m a freshman in college but I want to be a (cardio thoracic ) surgeon eventually so I found this incredibly interesting, thank you very much.
I can't believe how brilliant these videos are - you are doing everyone a big favor, I'm certain you'll get more traction
+Lencovic Thanks so much!!
Meeting Dr Ewi1 on RUclips has really been one of the best day of my life after years of suffering I have been finally cured from lupus thanks doc God bless you,
Man ur a savior.literally saved my pathology singlehandedly
Best comprehensive yet understandable explanation of lupus I have seen! Thanks.
Nice guys..One suggestion.... Kindly update this SLE video.... The DIAGNOSTIC CRITERIA HAVE BEEN CHANGED since 2012. Thanks in advance.... Keep posting more...
Very well done video. Went through the complex pathophysiology in an easy-to-follow step-by-step process that greatly simplified it, and did it without the boring non-informative and non-beneficial information that plagues other teaching videos. Thank you and keep up the good work.
Thank you for explaining this complicated stuff so well! I suffer from SLE and have struggled to understand for ages.Now both me and my husband are more clarified.
Hi.
How are you now ?
My mother had it before having me. I'm 24 now. She's facing some comlexities now.
Is there any treatment plz help
@@intrestingindia5897 yes I suffer from it too
There are immune modulating drugs to improve it , but SLE chronic and u should continue to these drugs
@@intrestingindia5897 I honestly don't think so, but you can make your life easier with medicine and taking care of food / less salt / taking care of yourself :)
My God, this guy's a genius. Thank God for people who did their homework in school, took their studies seriously, had supportive parents and family and the means to go to medical school. He rattled off his medical jargon and terminology like a total pro. Great explanation of a very, very complex disease.
Came here after my dad had a fall. He’s getting older and he has lupus which has brought along arthritis. I’ve always known he had it but today I couldn’t sleep thinking about him and found this video. Thank you for the knowledge. I always avoided my dads disease but only out of ignorance
We hope this video was able to help, Julian 🙏🏼
Best explanation of lupus I’ve encountered so far. Thanks for it!
I go to Harvard Medical School and my professor posted one of your videos as a resource. Now I've been using Osmosis for months and can honestly say it's one of the best resources on youtube. Thanks so much for the amazing videos! Please keep em coming
Good for you !
thank you so much as a science student I can finally understand my illness at a molecular level
" Alright. Systemic Lupus Erythematosus... 'Kay, we totally got this.." Lol
Hehehe...Immunology is extremely difficult and complex.
ha haa
Julio Sepulveda and poorly understood
kassiani. When your immune system hates your guts...and your heart, kidneys, brain, jionts, skin, pleura and itself :D
Omg my name is julio too
Osmosis can explain a disease more quickly and better than anything. Such an aid in research papers and in nursing school studies! Thanks osmosis!
This channel is a life saver , my pathology teacher she gives us packets and powerpoints but I learn and understand the material better in a video and someone explaining it in full detail with photos. Thank you 😊
This is the best youtube medical lecture channel I have ever seen. Thank you so much.
Thank you!!
I was just diagnosed. Thank you for this video.
One can only explain simply when one has understood clearly...same goes for u Osmosis...thanks for the beautiful channel!
I have my block exam the day after tmrrow and I think this will save me a lot of time. Thank you so much!
I wish I knew people with lupus. I was diagnosed 2 months ago, I’m currently 16 and I feel so alone, I don’t know why there aren’t any teen support groups anywhere, I’ve been searching for awhile
Well, now you do. I have sle lupus.
What are first symptoms?
I feel you, I was diagnosed when I was 13 years old. I'm 19 and I still haven't met any teenager with lupus
@@mihaelatepsic3264 For me I thought I had carpal tunnel syndrome for the longest time, I’d have really bad pains in my joints and I couldn’t even sleep at night. My hands and feet would get swollen and I was really sick. You’ll know when or if somethings wrong, I had to spend a week in the hospital when I was first diagnosed because my lungs were collapsing and I had a few other issues. Hope you’re doing well.
@@quality169 any rash?
So fantastically done - concise but yet mentioning every important detail - great job!
Thank you, Coeway! We're glad you're finding our videos useful. If you haven't yet checked out our educational platform we have a bunch of tools that we think you'd like. These include unreleased videos, tens of thousands of flashcards and multiple-choice practice questions, study workspaces, and daily exam schedule organizers to help you learn medicine. You can sign up for a free trial of Osmosis Prime here: bit.ly/2ut5ZEJ
Meeting Dr Ewi1 on RUclips has really been one of the best day of my life after years of suffering I have been finally cured from lupus thanks doc God bless you,
low dose naltrexone also being used to lower inflammatory reactions in lupus. thank you for this fine video. much appreciated.
I've exam on my head and I was so anxious about that.. But reading comments down here I took a deep breath after coming to know so many people are suffering from this destructive disease and I'm worry to just memorize it. We're not same folks 😢
Absolutely amazing video, this channel will blow up soon!
Thanks!
This channel is AMAZING. 100000 karma points to you for helping a desperate medical student in the middle of the night! :D
🤣🤣🤣
Is there any treatment plz help
Thank you!!! I'm a medical student and the videos are incredible !
Wow I'm in love with this channel. So helpful and saved me having to do loads of research.
My mom has lupus and very bad medical issues, she had surgeries and she has a metal hip and died, brough back to life and was handicapped.
It’s 2022 now my mom has a room for heels and she drives a Mercedes and when she gets out she is wearing 42 inch stilettos 💀💀, this video taught me that my 41 year old mom that drives a Mercedes’ C class and wears 78 inch stilettos has nuclear cells in her-
I'm so glad... Hope she stays for more time
For 2 years my doctors, many rheumatologist and immunologists thought I was fool and tried to convince me I didn t have it. The disease progressed and I needed to go to a clinic in Russia with physicians for them to do deeper analysis and put a diagnosis just more than a month ago. This disease is the worst possible thing with some of other AD and cancers, after my stem cell treatment hope will be better and I have nothing to lose. The worst thing is that after plenty researches I understood that I m the only responsible because the lifestyle I had during the 2016-2017 academic year... So frustrating
How did your treatment go
You (guy or guys) are so great. Thank you so much. The speaker is great too -but I'd recommend him to slow down at the important points and leave his fast speech for the already (ought-to-be) known facts.-
He's great.
Thanks so much ❤️
This channel is the best for understanding disease for everyone! Thank you for your excellent work.
Thank you so much from 2020. What a development though!
Ah, at last - Dr. House's most famous diagnosis, for every single one of his patients, really.
Having Shingles Virus is not the end of life , I got cured after using Doctor Ani John herbal supplement within 14days..
Thanks for the explanation! I just went to the doctor about a persistent malar rash so I am going to get tested against these antibodies as well as anti-Ro and anti-La antibodies for suspicion of SLE.
Thankful for the support system that surrounds lupus!
I was diagnosed with lupus 5 months ago.. For me there were many symptoms.. I went through so many struggles it affected my kidneys. Currently I am taking medications and the disease is in control.. Anyone have gone through lupus blood clots in legs?? If yes please reply me in this..
I will advised you to contact Dr. Odion herbal remedies on you for your permanent cure
Having Shingles Virus is not the end of life , I got cured after using Doctor Ani John herbal supplement within 14days..
First of all, Congrats i'm a big fan of your videos. As far as I know the anti-dsDNA and Anti-Sm are antinuclear antibodies as well, so, it should´t be described as "other autoantibody", am i right ?. Thanks for your videos !
Today was my pathology exam and I just watched this video the previous night as I could not understand the text. It was so helpful. I got question on SLE in the exam. Thank you so much for such crisp summary of one of the major diseases in medicine.
Hi Shantanu! Thanks for sharing! We're glad that our video was able to help in your exam! ❤️
I comprehended deeply this topic by watching you instead of reading Basic Pathology of Robbins, thank you very much
Thumbs up. This is very helpful.Thank you
I got to know from Quora about this channel and it seems as if I have discovered a treasure.Kudos to the team who are so efficient in explaining the topics in such a short span.Very helpful❤
I truly appreciate the admin for uploading this primitive video.. Very useful information was given out.. thanks for the video.
**This is my healing testimony comment about how I was healed from Genital Herpes. I am recommending "Molemen Herbs" on RUclips or Facebook. They have the best holistic natural remedies for better treatment and everlasting cure to all diseases and viruses. You can reach them on phone/ WhatsApp at +13237766767..
Unfortunately, my ANA was negative, and it’s taken years for an answer. I have NPSLE and it took my rheumatologist 1.5 years to put it together. The symptoms I have: RA, Aps, osteoporosis, I’ve had 2 TIA’s, and now shaking in hands, memory loss, uncontrollable movements, peripheral neuropath, and Hashimoto’s…my kidneys and liver are in need of a lot of help. My last labs show my RBC’s too low. Bun too low, Bun/creatinine, too low. Lesions in nose, mouth, skin…W/ all the symptoms, he put it together. Thankfully he found it! Now a treatment plan can begin!
Having Shingles Virus is not the end of life , I got cured after using Doctor Ani John herbal supplement within 14days..
@@jameslight8746 huh? I didn’t say anything about shingles.
@@OnlyJalenPhd then Do you have lupus?
@@DeepakRajput2000 they have tested me for lupus ever since I was in my early 20’s. My husband and I suffered 5 miscarriages, so they thought lupus then. I have every symptom of lupus, but the test is always new.
@@OnlyJalenPhd Does lupus test came back negative?
I love when he said we totally got this. I made me let out a sigh of relief thanks osmosis!! the first semester of advanced patho, and these vids are helping tremendously!!
Always our pleasure to help! 🥰
So happy I found Osmosis! Wonderful teaching tool and enriching for students in class mid-lecture. Thank you +++
Been suffering from SLE and then I have Anisocytosis, anemia, chronic urticaria, and other blood related illnesses. Are they related?
Finally found an interesting way to study pathology... Really very helpful
I studied in robins but i couldn't understand it. after watching this video i got much clarity.
Thank you very much.
Really like your videos.... you explain things so well.would love to see you make a video about nf1 and chiari. Thank you.
Having Shingles Virus is not the end of life , I got cured after using Doctor Ani John herbal supplement within 14days..
awsome ,you dont know how much you help us with your videos 🙆👍👍👍👍
Your channel is a gift, thank you so much!
Hi! I'am colombian doctor and you videos are very specials, of great helps for patients! Congratulations!!! Kepp going
This is incredible, what recommendations could you give me to be a good researcher?
Study. Study your little heinie off! And read about one thing after another, like a trail of breadcrumbs that leads you to your answer. Oh, and Curiosity. Have it ALWAYS in your heart. You'll be great, I know, because you cared enough to ask. Looking forward to the great work you give to the world!
Please tell me,sle specialist doctors lam sle patient
Been sick for 5 months and can’t figure it out. Tested positive for ANA anti body’s and this video was super informative. Thank you
I've been sick for 6 months and they just finally did a full panel and I tested positive for Ana
The best description for SLE ever ❤❤👍thank you
Very informative thank you very much for explanation in detail
Glad you appreciate it, Raza! 🙏
Maybe you could do Still's disease. Is even rarer than lupus, although it is very similar.
We will eventually! You can vote for upcoming videos by becoming a Patreon subscriber. www.patreon.com/osmosis
Best I have seen on this topic! Keep up the good work!
Thanks a lot for the wonderful videos. Wish I had this when I was studying. Congratulations again!
goshhh, this is perfect. Tks sooo much, kisses from brazil
Most welcome, Antonio! 🥰❤️🙏🏼
Having Shingles Virus is not the end of life , I got cured after using Doctor Ani John herbal supplement within 14days..
All I know is Selena Gomez has it so I looked it up. Only one?? Ok
Bruh same here
Me
I know same! I remember hearing her having a kidney transplant back in 2017 before I was a fan of hers. For some reason I got really interested and started looking up about lupus. After that I became a huge fan of hers. She's very opened about talking about lupus. I remember I felt really bad for her when I watched Selena and Chef and when she does her make up her hand keeps shaking because of her Lupus. She's going through so much and people still make fun of her illness. I think she's very inspiring about opening up about her mental health❤
Sorry for her. You should know what to eat, and what not depending on your "immune system". I will cover this subject and other autoimmune diseases in my place on this website. Good luck !
@@miriamkanana423 Hopefully you're feeling good. I will cover this topic one day in my place on this website.
This is such a good overview! Was initially panicking about this topic, but this video made it so simple :D
No even a medical student, didn’t even take basic biology in highschool (which I regret, economics was boring) but I’m here to understand the SLE that has plagued my life. Thank you for the video, it was very easy to understand !
Thanks for the feedback, Sasha! 😊
What if the environmental factor was the Covid vaccine? Has anyone come down with heart inflammation with/or Lupus after vaccination?
I have sle and I didn't die from taking MNRA. I refused it. Thank you God. I am having a flare. Discord rash, and I stay in and take Cell Cept Prednisone plaquinil. Also Short of breath and back pain.
Please do an update in the criteria of diagnosis - SLICC
You've done an amazing job though!! 👍🏼😁
apoptosis does not lead to an inflammatory reaction! in apoptosis the cell is divided into many vesicles with an eat-me signal on the outside of their membrane. the vesicles then get digested by macrophages. this way nothing from the inside of the cell (proteins, dna, etc) gets outside the cells which would trigger an inflammatory reaction.
what's described in the video is necrosis, which is unprogrammed cell death and in which the cell bursts and cell contents are released and trigger an inflammatory reaction.
snowinseptember 7 thats right!
There seem to be important distinctions between the two processes, Necrosis and Apoptosis, that would warrant a possible edit to the video. Are there no methods to induce apoptosis in these damage cells so that inflammation isn't triggered?.
You can have inflammation from apoptosis if the clearance is slow
I think they just forgot to mention that in SLE, you have impaired apoptosis process so apoptosis resembles necrosis.
necrosis is not programmed cell death,
what if the susceptibility genes of less effective clearance is the main, primary reason why B-cells is produce antigens, i mean they produce because macrophages are presenting host-"antigenes" to the Th-cells, and those one are taking a decision to stimulate B-cells and "attack" host cells... is it mean that main problem in Th-cells and bad differentiation at thymus????
and what about less effective clearance? how does it work? the macrophages error?)
Wow yesterday a patient came in with the exact set of symptoms. It all makes sense thanks! It was really helpfull
We're glad to know that this video was able to help! 🙏🏼
Your channel is amazing, I'm actually watching every related video to a specific disease before diving into my books! Thank you very much for your great channel 😎❤
Most welcome 💕
I love your videos
Really it's amazing video
Thank you!
Love love love love your videos! Best ever ! My concepts achieved a clarity finally🙃
You guys are soooo good! I'm an img studying for USMLE and this is like a god gift!
Texting all of my friends about you guys asap! 💖
Thanks a lot
No worries! 🥰
his herbal medication is 100% Cure for Shingles virus and any disease virus and STDs I was cured after 12days of using the herbal medicine I ordered from Dr.Ani John contact him now and get your permanent cure
thank you for this well informative video. I have been trying to explain these things to ppl for a very long time. Diagnosed in 1992....
I posted this on my Facebook page, and I know it will be viewed there.
Thanks!
Hey. My mother was Diagnosed 2 month ago. How do you get through this. How are you feeling. Can u live with this?
I knew this already a long time ago but this video is a great refresher without going to some 200+ pages. I was never interested in Lupus until I got to a department in immunology laboratory that deals with ANA testing. Thank you. Subbed.
A very good thing about this channel is... The recape of whole lecture in few secs
Ooo this is the ANA test for lupus I heard in House md....
Excellent!But 1 question here, shouldn't anti-dsDna and anti-smith be classified as 1 of the ANAs? I just saw wiki wrote that @@
Haha, it was on wiki though :/
This is the best explanation I have heard from a medical
view point. I have heard a lot about how we feel, which I already know how I feel, but this explanation of what actually is going on is fabulous.
We're glad you've enjoyed this explanation! Thank you for sharing your experience!