Meisenheimer? More like my, so much higher...in educational value than almost every other video on RUclips. Thanks again so much for making and sharing these!
Will NAS occur if there is an activating group and a good leaving group? Or is this process restricted to a deactivated ring and a nucleophilic reagent?
In Chlorobenzene there should slight negative charges in Ortho and para position due to resonance. Then why does a Neucleophile attack the H in the ortho position? Wouldn't it make more sense if it attacked the H in meta position where the electron density is relatively lesser?
In the last reaction. How's the ratio of meta to ortho and para? 1:2:1 (orto:meta:para) Or is para more likely to happen than ortho because of steric hindrance of the CH3 group?
I think that the methyl-group isn´t so bulky, so their is no hindrance. Because of that I suggest, that the ratio ist 1:2:1 as you said. I hope this didn´t come too late :D
You're my favorite chem guy. Thanks for all you do!!! You're consistently amazing.
Meisenheimer? More like my, so much higher...in educational value than almost every other video on RUclips. Thanks again so much for making and sharing these!
Never quit. I love this!!!!
Thank you very much for this clear explanation
9:40 3️⃣50 C
Will NAS occur if there is an activating group and a good leaving group? Or is this process restricted to a deactivated ring and a nucleophilic reagent?
Same doubt...
Doesn't the reaction starting at 14:56 have an activating group (methyl) and a good leaving group (bromo)?
In Chlorobenzene there should slight negative charges in Ortho and para position due to resonance. Then why does a Neucleophile attack the H in the ortho position? Wouldn't it make more sense if it attacked the H in meta position where the electron density is relatively lesser?
17:30 which one is major and minor
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F;U;C;K||||||Y;O;U
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In the last reaction. How's the ratio of meta to ortho and para? 1:2:1 (orto:meta:para)
Or is para more likely to happen than ortho because of steric hindrance of the CH3 group?
I think that the methyl-group isn´t so bulky, so their is no hindrance. Because of that I suggest, that the ratio ist 1:2:1 as you said. I hope this didn´t come too late :D
ok, but what are the other reagents that can go through the benzyne intermediate 😠😠?
Nice
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From your asking that question, I take it you two have chemistry together?
tw