Id just like to thank you for all the videos you put out. It has helped me get a 95/100 on my Ochem Exam and I am so beyond greatful that you are here to teach. Keep doing what you are doing because you're making positive changes in students lives. I was in a negative mindset due to my first exam score being soso low. But these videos gave me hope and it really did change my thoughts and how I felt. I no longer feel like a failure and these videos are the reason for that. Keep fighting through everyone!! I am taking my final exam today :)
Thank you so much for giving Synthesis a very intuitive perspective. I dont have a major in Chemistry, but from this video I have got a very solid orientation of how to think about and solve synthesis problems.
this is a great freaking video to watch/review what you learned after you spend a good chunk of time going over the theory behind in your textbook. good way to synthesize everything you learned.
I swear my professor probably watches your videos. This is precisely what she said what going to be on our test. And you even should the mechanism (Friedel - crafts with carbonation rearrangement) we need to know. I find this too funny. Hopefully I get a 100%
Honestly I wasn’t doing great in organic until I started skipping class. I’m great at pattern recognition (need a ton more data than is provided in class) and learning but horrible in the class setting teachers always talk to slow and don’t challenge me enough to be interested. Here I can just play everything 1.5- 2x speed pause and solve the problem and easily and quickly figure out where I messed up. Normal pace in class kills me and I can not help but zone out. But i can easily absorb everything discussed in class in 20 min by myself. Which is probably the amount of time I actually pay attention in normal class. I can’t remember anything but if I just throw myself into the information and expose myself to as many situations and problems as possible it clicks and all of a sudden and I see everything as images and videos in my head. It makes learning feel like a drug and you get high on the excitement of everything magically fitting together. Learning in class feels like hell the education system has a way of sucking the excitement of even the most interesting of things.
You are a so phantastic teacher!!! God bless you! I‘am looking every video of you and write it down! It’s so helpful!!! I can’t say enough: thank you soooo much!!! 🙏🙏🙏
EAS reactions made easy? More like “Everything made pleasing!” I really like your nice handwriting and clear demonstration on the board. Thank you again so much for making all these videos!
7:39: 🔬 The video explains the reaction of benzene with concentrated sulfuric acid and heat. 14:18: 🧪 The video discusses the reaction between br2 and febr3 with isopropyl and methyl groups, and predicts the major product based on steric effects. 21:34: 💡 The major product in the Friedel-Crafts alkylation reaction is determined by the accessibility of the para position and the bulkiness of the substituent group. 27:59: 🔬 The Friedel-Crafts alkylation reaction has limitations and does not work with strongly deactivating groups like NO2. 34:18: 🔬 The video explains the Gatamine Koch reaction as a method to convert benzene into benzaldehyde. 41:05: 🔬 The video discusses the synthesis of benzoic acid through the addition of an alkyl group and subsequent oxidation. 48:03: 🧪 The video discusses the conversion of an amine to an amide and the subsequent nitration reaction. 55:12: 🔬 The video discusses the use of blocking groups in organic synthesis to control the placement of substituents on aromatic rings.
i have a question why is it a mixture of these two molecules in 2:29 wouldn't the para position be favoured due to steric collision with the ortho position?
@49:40min the protected -NH2 forming amide group, is it still possible to be protonated under acid conditions (HNO3/H2SO4) to deactivate the reactivity of the benzene ring?
56:23 would it even be possible to add a terbutyl group to this ring? Considering that the Friedel Craft's reaction can't occur because the ring is being deactivated by two EWGs, and the other reaction that leads to an alkylation of the benzene ring shown in the video is the one where you add a bromide and then you react this product with (R)2CuLi, but here you already have a bromide on the ring, so you would have many possible side products here(although the product where the Terbutyl group is in the Para position with respect to the nitro group would be the major product of this hypothetical bromation+alkylation reaction route if it is even possible). So i don't think this synthetic route shown in the video is even possible, and if it is, then it's not entirely accurate. But given that this clearly was not the best synthetic route to get to the intended product anyways, it doesn't really matter if it's not 100% correct.
two questions, 1. at 43:26 I realized that he's using potassium permanganate in heat and basic conditions to oxidize to a carboxylic acid, but shouldn't it be acidic so you can go straight to the acid, or use water? I was a little confused on that but I get the rest. 2. can you use other things for iodination because I thought it had to I2/CuCl2, does using nitric acid also work? sorry for the weird question, thanks so much for the help
Thank you so much for all the practice examples and the detailed explanations!!!!! For the reaction at 31:41, can we perform Friedel Craft Acylation reaction to get the product in one step?
Hey, even with some steric effects, wouldnt the ortho position win out rather than the para because there are double the amounts of ortho positions (2) rather than one para position?
i have a question, how can you identify if its a friedel crafts? do we look at both the starting material and reagents and if they are both "meta? as in have a positive charge on the atom that is both attached to the benzene and the reagent?
In prepared para-nitro aniline if l started with (Br) then added (No2) in para position then add (NaNH2) to convert (Br) with (NH2) this situation doesn't happened ,does it ?
u you cant use freidel craft to add a halogen to nitrobenzene. I see u used it in synthesis where u needed to use nitrbenzene to substitute a halogen at the meta carbon b4 reducing nitro group to NH2
Final Exams and Video Playlists: www.video-tutor.net/
Id just like to thank you for all the videos you put out. It has helped me get a 95/100 on my Ochem Exam and I am so beyond greatful that you are here to teach. Keep doing what you are doing because you're making positive changes in students lives. I was in a negative mindset due to my first exam score being soso low. But these videos gave me hope and it really did change my thoughts and how I felt. I no longer feel like a failure and these videos are the reason for that. Keep fighting through everyone!! I am taking my final exam today :)
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I learned more in the first minute than I ever learned doing two weeks worth of this stuff in lecture. Thank you!!!
Thank you so much for giving Synthesis a very intuitive perspective. I dont have a major in Chemistry, but from this video I have got a very solid orientation of how to think about and solve synthesis problems.
I spent a whole day in this video but i understood org chem for the first time😭😭 THANK YOU SO MUCH
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this is a great freaking video to watch/review what you learned after you spend a good chunk of time going over the theory behind in your textbook. good way to synthesize everything you learned.
this literally is one of the best videos I've ever watched
I swear my professor probably watches your videos. This is precisely what she said what going to be on our test. And you even should the mechanism (Friedel - crafts with carbonation rearrangement) we need to know. I find this too funny. Hopefully I get a 100%
Best teacher ever.
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Honestly I wasn’t doing great in organic until I started skipping class. I’m great at pattern recognition (need a ton more data than is provided in class) and learning but horrible in the class setting teachers always talk to slow and don’t challenge me enough to be interested. Here I can just play everything 1.5- 2x speed pause and solve the problem and easily and quickly figure out where I messed up. Normal pace in class kills me and I can not help but zone out. But i can easily absorb everything discussed in class in 20 min by myself. Which is probably the amount of time I actually pay attention in normal class. I can’t remember anything but if I just throw myself into the information and expose myself to as many situations and problems as possible it clicks and all of a sudden and I see everything as images and videos in my head. It makes learning feel like a drug and you get high on the excitement of everything magically fitting together. Learning in class feels like hell the education system has a way of sucking the excitement of even the most interesting of things.
Same here! It sucked at first, and class was such a drag. But he makes it 10x better. Once you understand the stuff its so much fun.
You have been helping me for years. Thank you so much for all of the good times!
You are a so phantastic teacher!!! God bless you! I‘am looking every video of you and write it down! It’s so helpful!!! I can’t say enough: thank you soooo much!!! 🙏🙏🙏
This video saved me. Love your channel
You Sir have just saved my life
EAS reactions made easy? More like “Everything made pleasing!” I really like your nice handwriting and clear demonstration on the board. Thank you again so much for making all these videos!
7:39: 🔬 The video explains the reaction of benzene with concentrated sulfuric acid and heat.
14:18: 🧪 The video discusses the reaction between br2 and febr3 with isopropyl and methyl groups, and predicts the major product based on steric effects.
21:34: 💡 The major product in the Friedel-Crafts alkylation reaction is determined by the accessibility of the para position and the bulkiness of the substituent group.
27:59: 🔬 The Friedel-Crafts alkylation reaction has limitations and does not work with strongly deactivating groups like NO2.
34:18: 🔬 The video explains the Gatamine Koch reaction as a method to convert benzene into benzaldehyde.
41:05: 🔬 The video discusses the synthesis of benzoic acid through the addition of an alkyl group and subsequent oxidation.
48:03: 🧪 The video discusses the conversion of an amine to an amide and the subsequent nitration reaction.
55:12: 🔬 The video discusses the use of blocking groups in organic synthesis to control the placement of substituents on aromatic rings.
it helps me a lott, english is not my motherlanguage but i can understand everything so well!! thankyou sir 🤩
This was exactly what i was searching for! Thanks
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I think at around 5:51 when he said the ethyl wants to direct the chlorine atom in the ortho position he meant meta because he circles position 3.
ily sm. thank youuuu for this video, i appreciate it with all my heart :3
i have a question why is it a mixture of these two molecules in 2:29 wouldn't the para position be favoured due to steric collision with the ortho position?
6:42 ok why did we consider NO2 isn’t it a EWG??
Your videos are really very helpful. Thanks for sharing
At 22:55 why is the benzene with the more substituted carbon the major product? Does benzene prefer more more substituted rearrangements in general?
Great video,perfect explanations,God richly bless you
Hey, how does Br2 not attach to ortho and meta but ortho and para, do you mind explaining please ?
@@drana2626 I can explain, but do you still wanna know lol
@@DarkGourmandsure
@49:40min the protected -NH2 forming amide group, is it still possible to be protonated under acid conditions (HNO3/H2SO4) to deactivate the reactivity of the benzene ring?
56:23 would it even be possible to add a terbutyl group to this ring?
Considering that the Friedel Craft's reaction can't occur because the ring is being deactivated by two EWGs, and the other reaction that leads to an alkylation of the benzene ring shown in the video is the one where you add a bromide and then you react this product with (R)2CuLi, but here you already have a bromide on the ring, so you would have many possible side products here(although the product where the Terbutyl group is in the Para position with respect to the nitro group would be the major product of this hypothetical bromation+alkylation reaction route if it is even possible).
So i don't think this synthetic route shown in the video is even possible, and if it is, then it's not entirely accurate.
But given that this clearly was not the best synthetic route to get to the intended product anyways, it doesn't really matter if it's not 100% correct.
two questions,
1. at 43:26 I realized that he's using potassium permanganate in heat and basic conditions to oxidize to a carboxylic acid, but shouldn't it be acidic so you can go straight to the acid, or use water? I was a little confused on that but I get the rest.
2. can you use other things for iodination because I thought it had to I2/CuCl2, does using nitric acid also work?
sorry for the weird question, thanks so much for the help
You are a legend
At 2:30, the para position is actually the major product because there is less steric hindrance
I was searching for your comment like I just wanted to confirm that I think the same way as someone else
Thank you so much for all the practice examples and the detailed explanations!!!!! For the reaction at 31:41, can we perform Friedel Craft Acylation reaction to get the product in one step?
Thanks so much, you explain things so well!
@45:00 wouldn't NO2 deactive the ring? How would you be able to add a halogen on it?
RevaN only fiedel craft’s reaction is hindered by that. Meaning with a nitrate group you can’t do alkylation or acylation
@@basilkhan1998 Thanks!
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Hey, even with some steric effects, wouldnt the ortho position win out rather than the para because there are double the amounts of ortho positions (2) rather than one para position?
Stability matters more
Thank you sir
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i'm literally gonna go crazy if i draw one more hexagon lol
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quick question: how come in the 1st example there isn't a hydride shift to stabilize 1ary ch3ch2+ into a secondary?
you still get a primary carbocation, so no need to do that.
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44:45 It should been Cl2 with FeCl3 Right?
i have a question, how can you identify if its a friedel crafts? do we look at both the starting material and reagents and if they are both "meta? as in have a positive charge on the atom that is both attached to the benzene and the reagent?
The AlCl3 indicates its a friedel craft alkylation
Why did you choose to do a secondary carbocation instead of a tertiary with the butane carbocation rearrangement?
When you say some substituents "favor" one position (Ortho/ para/ meta), is there a rule for which favors which?
Thank you so much
In prepared para-nitro aniline if l started with (Br) then added (No2) in para position then add (NaNH2) to convert (Br) with (NH2)
this situation doesn't happened ,does it ?
how to know the types of reagents to use, when synthesizing?
why does bromine behave as electrophile because it readily forms br- ion ?
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for the example at 31 mins why cant we do friedel crafts acylation?
nice sir
When we use friedel craft alkylation in the synthesis questions, wont polyalkylations occur?
it depends on the quantities of the benzene ring and the reagent
at minute 45, how does the reaction proceed? i thought nitrobenzene was too deactivating to undergo friedle crafts alkylation
That's halogenation and not a Friedal craft.
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20:05 isn't carboxylate grp meta directing??
carboxyl is meta yeah, idk about the carboxylate though
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You said nitrobenze doesn’t undergo friedel crafts but then did it at 45 min. Can you please explain?
That's halogenation and not a Friedal craft.
Thanks a lot
How many are watching this in 2021.....
how are you suppose to remember all the reagents. Lol it seems hard!!
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u you cant use freidel craft to add a halogen to nitrobenzene. I see u used it in synthesis where u needed to use nitrbenzene to substitute a halogen at the meta carbon b4 reducing nitro group to NH2
This are lot of theories than I thought
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