Reviewing the The Lancet Antidepressant Network Meta-Analysis with Andrea Cipriani and guests
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- Опубликовано: 13 сен 2024
- Join our live Google Hangout with our panel:
Benoit Mulsant (Toronto, Canada)
Roy Perlis (Harvard, USA)
Erick Turner (Oregon, USA)
Andrea Cipriani (Oxford, UK)
Michael Ostacher (Stanford, USA)
Major depressive disorder is one of the most common, burdensome, and costly psychiatric disorders worldwide in adults. The hangout will discuss a recently published meta-analysis of the comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder. The study includes the largest amount of unpublished data to date and will provide the starting point for wide ranging discussion and debate.
Paper to be discussed:
Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis
Cipriani, Andrea et al. The Lancet
Excellent. Thank you so much for sharing it.
Very useful stuff, helping me with my clinical diploma, as a pharmacist, thank you Mr Cipriani, I do have a few questions if he ever reads this comment !
We're the outcome measures surveys?
Will you guys address page 150 in the online appendix???? And why it was left out of the paper????? The total effect size is well below any clinically meaningful benefit
They literally have an entire discussion on the effect size here and point out that it is significant and actually comparable to medications used in other fields of medicine.
@@pg8982 100%
As a member of the online prescribed dependent and harmed community I listened with interest to the discussion by leading academics, all white and male. I was struck by the contrast between the detached discussion of clinical trial data, complex graphs, the differences between statistical and clinical significance, numbers needed to treat and so on so forth and the raw emotions in the online forums as many thousands of patients, a majority of them women, struggle to free themselves from the shackles of these same drugs which have destroyed so many of our lives. Perhaps this demonstrates the immense problems that are evident now, as damaged patients battle to be heard via every media channel possible. No mention was made during this discussion of the prescribed dependent and harmed community, the focus was entirely on the initial stages of prescribing and the need for better treatments for depression. Is it simply the case that the gulf between our community and those with highly paid professional careers is too massive to be bridged?
Well said!!
Harmed community? What is so awful about antidepressants?
@@sandizz The many adverse effects of antidepressants such as akathisia, sexual dysfunction, severe withdrawals, most harmed patients weren't properly warned of the potential for serious harm .