Love this video? Check out our course "Cardiovascular Physiology" made entirely with videos like this (no watermark, no ads): Students, click here: www.alilaacademy.com/courses/cardiovascular-physiology-for-students Teachers, click here: www.alilaacademy.com/courses/cardiovascular-physiology-for-teachers NEW: Now you can also get access to our courses with our RUclips channel membership (Academy Access levels)
I do not understand why I owe a balance at school ,youtube teaches me everything. I'm so grateful for all the people who are taking their time to make these videos in a way everyone understand and receives the information. This is a great video. Thank You subscribing NOW!!!
The heart is essentially a muscle that contracts and pumps blood. It consists of specialized muscle cells called cardiac myocytes. The contraction of these cells is initiated by electrical impulses, known as action potential (AP) Unlike skeletal muscles, which have to be stimulated by the nervous system,the heart generates its own electrical stimulation. In fant, a heart can keep on beating even when taken out of the body. The nervous system can make the heartbeats go faster or slower, but cannot generate them. The impulses start from a small group of myocytes called the pacemaker cells, which constitute the CARDIAC CONDUCTION SYSTEM. These are modified myocytes that lose the ability to contract and become specialized for initiating and conducting action potentials. The SA node is the primary pacemaker of the heart. It initiates all heartbeats and controls heart rate If the SA node is damaged, other parts of the conduction system may take over this role.(AV node , Bundle of His ) The cells of the SA node fire spontaneously generating action potentials that spread through the contractile myocytes of the atria. The myocytes are connected by gap junctions, which form channels that allow ions to flow from one cell to another. This enables the electrical coupling of neighboring cells. An action potential in one cell triggers another action potential in its neighbor and the signals propagate rapidly. The impulses reach the AV node, slow down a little to allow the atria to contract, then follow the conduction pathway and spread through the ventricular myocytes. Action potential generation and conduction are essential for all myocytes to act in synchrony. Pacemaker cells and contractile myocytes exhibit different forms of action potentials. Cells are polarized, meaning there is an electrical voltage across the cell membrane. In a resting cell, the membrane voltage, known as the resting membrane potential, is usually negative. This means the cell is more negative on the inside. At this resting state, there are concentration gradients of several ions across the cell membrane: more sodium and calcium outside the cell, and more potassium inside the cell. These gradients are maintained by several pumps that bring sodium and calcium OUT, and potassium IN. An action potential is essentially a brief REVERSAL of electric polarity of the cell membrane and is produced by Voltage-gated ion channels. These channels are passageways for ions in and out of the cell,and as their names suggest are regulated by membrane voltage. They open at some values of membrane potential and close at others. When membrane voltage INCREASES and become LESS negative,the cell is LESS polarized, and us said to be depolarized. Reversely, when membrane potential becomes MORE negative, the cell is repolarization. For an action potential to be generated, the membrane voltage must depolarize to a critical value called THRESHOLD. The pacemaker cells of SA node SPONTANEOUSLY fire about 80 potentials per minute, each of which sets off a heartbeat, resulting in an average heart rate of 80 beats per minute. Pacemaker cells do NOT have a TRUE RESTING potential. The voltage starts at about -60mV and SPONTANEOUSLY moves upward until it reaches the threshold of -40mV. This is due to action of so-called "FUNNY" currents present ONLY in pacemaker cells. Funny channels open when membrane voltage becomes lower than -40mV and allow slow influx of sodium. The resulting depolarization is known as "pacemaker potential". At threshold, calcium channels open, calcium ions flow into the cell further depolarizing the membrane. This results in rising phase of action potential. At the peak of depolarization, potassium channels open, calcium channels inactivate, potassium ions leave the cell and the voltage returns to -60mV. This corresponds to the falling phase of the action potential. The original ionic gradients are restored thanks to severy ionic pumps,and the cycle starts over. Electrical impulses from the SA node spread through the conduction system and to the contractile myocytes. These myocytes have a different set of ion channels In addition, their sarcoplasmic reticulum, the SR, stores a large amount of calcium. They also contain myofibrils. The contractile cells have a stable resting potential of -90mV and depolarize ONLY when stimulated, usually by a neighboring myocyte. When a cell is depolarized, it has more sodium and calcium inside the cell. These positive ions leak through the gap junctions to the adjacent cell and bring the membrane voltage of this cell up to the threshold of -70mV At threshold,fast sodium channels open creating a rapid sodium influx and sharp rise in voltage. THIS IS THE DEPOLARIZING PHASE. L- type or slow, calcium channels also open at -40mV, causing a slow but steady influx. As the action potential nears its peak, sodium channels close quickly, voltage gated potassium channels open and these result in a small decrease in membrane potential, known as EARLY REPOLARIZATION PHASE. The calcium channels, however, remain open and the potassium efflux is eventually balanced by the calcium influx. This keeps the membrane potential relatively stable for about 200msec resulting in the PLATEAU phase, characteristic of cardiac action potentials. Calcium is crucial in coupling electrical excitation to physical muscle contraction. The influx of calcium from the extracellular fluid, however, is NOT enough to induce contraction. Instead, it triggers a MUCH greater calcium release from the SR, in a process known as "calcium-induced calcium release". Calcium THEN sets off muscle contraction by the same " sliding filament mechanism" described for skeletal muscle. The contraction starts about half way through the plateau phase and lasts till the end of this phase. As calcium channel slowly close, potassium efflux predominates and membrane voltage returns to its resting value. Calcium is actively transported out of the cell and back to the SR. The sodium/potassium pump then restores the ionic balance across the membrane. Because of the plateau phase, cardiac muscle stays contracted longer than skeletal muscle. This is necessary for expulsion of blood from the heart Chambers. The absolute refractory period is also much longer - 250 msec compared to 1msec in skeletal muscle. This long refractory period is to make sure the muscle has relaxed before it can respond to a new stimulus and is essential in preventing summation and tetanus,which would stop the heart from beating.
As senior clinician i have been really encouraged by your lectures. I feel know i have to contirbute my fair share to the world of Medical Science. Thus, I have uploaded my first PPT based video.
These videos are INCREDIBLE!!! Since I am a visual learner, I have been BLESSED to have received "sight" unto how the heart conducts its impulses! Even though I can read about the physiologic movements about the heart (or any other part of the body) I generally CATCH ON TO VIDEO VISUALS! God Bless You, and THANK YOU!!!!
so I thought lets be kind today and this is basically a summary of the video. you're welcome. Action potential cardiac: The contraction of cardiac myocytes (muscles in the heart) are initiated by electrical impulses, known as action potential. It generates its own electrical stimulation and the beats go faster or slower caused by nervous system, but the nerves don’t generate the contraction. The impulses start from a small group of myocytes (pacemakers cells). These are modified myocytes that lose the ability to contract and become specialized in initiating and conducting action potentials. SA node is the primary pacemaker of the heart it initiates all heart beats and controls heart rate. The cells of the SA node start spontaneously generating action potential that spread through the contractile myocytes of the atria. The myocytes are connected by gap junctions, which form channels that allow ions to flow from one cell to another. This enables electrical coupling of neighboring cells, an action potential in one cell triggers another action potential in its neighbor and the signals propagate rapidly. - Cardiac myocytes; muscles that make up the heart - Pacemaker cells; The cells that create these rhythmic impulses; heart rate 1. The impulses reach AV node 2. Slow down little to allow the atria to contract 3. Follow the conduction pathway and spread through the ventricular myocytes - Action potential generation and conduction are essential for all myocytes to act in synchrony. Polarized: there is an electrical voltage across the cell membrane Resting membrane potential, resting voltage, meaning that the cell is more negative on the inside. - More sodium and calcium outside the cell and more potassium inside the cell - Maintained through pumps - When membrane voltage increases and becomes less negative cell is less polarized depolarized. When cell gets more negative cell gets repolarized 80 action potentials/beats per minute Pacemaker cells do not have true resting potential. Action potential in pacemaker cells • The voltage starts at -60 mv and spontaneously goes up to -40mv (threshold) Pacemaker potential - Due to funny currents, only present in pacemaker cells, open when membrane voltage gets lower than -40mv, allows slow influx of sodium (inside the cell) • At threshold calcium channels open calcium ions flow in to the cell, further depolarizing rising (depolarizing) • At the peak of depolarization potassium channels open calcium channels inactivate, potassium ions leave the cell ant the voltage returns to -60mv. falling (repolarization) Electrical impulses from the SA nodes go to the contractile cells. Contractile cells store a large amount of calcium. Action potential in contractile myocytes - A stable resting state of -90mv and depolarize only when stimulated, usually by a neighboring myocyte. - When is cell is depolarized it has more sodium and calcium ions inside to cell, these positive ions leak through the gap junctions to the adjacent cell and bring the membrane voltage up to -70 mv (threshold) - At threshold: fast sodium channels open creating a rapid Sodium influx inside the cell and get a sharp rise in voltage. depolarizing phase - Slow calcium channels opene at -40 causing a slow but steady influx, as the action potential nears its peak sodium channels close quickly, voltage-gated potassium channels open and these resolve in small decrease in membrane potential early repolarization phase - the calcium channels remain open and potassium efflux is eventually balanced by the calcium influx this keeps the membrane potential relatively stable for about 200 milliseconds plateau phase - the calcium inside the cell is not enough to trigger a muscle contraction, instead it releases calcium induced calcium release which sets off muscle contraction contraction starts at half of the plateau phase and lasts until the end. - Calcium channels close, potassium efflux predominates and membrane voltage goes back to it resting value. The sodium potassium pump then restores the ionic balance across the membrane. repolarization Because of the plateau phase cardiac muscle stays contracted longer than skeleton muscle, which is important for pumping blood. Absolute refractory (state after and before resting) state is 250 millisecond compared to 1millisecond in a skeleton muscle. the cardiac muscle has a longer absolute time so it can rest before it starts contracting again, which is important.
I am a medical student from Sri Lanka. Thank you so much for this vedio. In few minutes I covered a full lecturer . Please give us more vedios as these are very creative and easy to understand . Thank you so much once again
I am annoyed at the high cost to hear those complicated lectures, use my gas to get there and wear a specified (and expensive) uniform...when I can come on here in my PJs and learn way faster! Lol! Ugh
I wish when I was at my med school this video already exist. But still grateful now I can remind all my study with the help of this animation and explanation
How on earth this could be explained so logically? I understood everything...Literally six year and ten year old videos are making me pass my exams nowadays... Thank you soooooooooooooo much!!!!!!
Waw! I've never heard so clever explanation! Never ever! If sth is not known or understood, the easiest and usual reaction is to blame the student of not being clever enough. But how many "teachers" are actually clever like you to explain the subject so clearly!?
The confusing topic makes easier through animation. I am glad to watch it. Heavier lecture, nice explanation,and just wow rock; love you guys. Could please explain ABO & RH factor with comparison in a one video; Thankyou.
This is just absolutely wonderful, just beautiful, a job well done, pls keep up the good work, y'all are saving alot of students in medical school in just 7mins🤲
AMAZING VIDEO!! saved myself from the adversity of a one hour lecture that I did not understand at all when this video explained everything I needed to know so clearly
thank you! in medical assisting class but im premed and highly interested in biochemistry, but the scope of a medical assistant is so limited and not as in depth. this animation really made it great for me and satisfied my curiosity :)
I really like this video. Helps a lot, especially for I just start to research on related field and need to learn the fundamentals of cardiac myocytes firing. Thanks!
Alila videos are honestly the most understandable, best explained and well animated medical videos on youtube. Always my go to source for clarification. Im still a student so I dont make a lot of $$ but I will support u guys on patreon because this content is why i consider youtube to have some pretty great content (among all the useless timewasting shit that I indulge in as well from time to time :D)
Love this video? Check out our course "Cardiovascular Physiology" made entirely with videos like this (no watermark, no ads):
Students, click here: www.alilaacademy.com/courses/cardiovascular-physiology-for-students
Teachers, click here: www.alilaacademy.com/courses/cardiovascular-physiology-for-teachers
NEW: Now you can also get access to our courses with our RUclips channel membership (Academy Access levels)
I do not understand why I owe a balance at school ,youtube teaches me everything. I'm so grateful for all the people who are taking their time to make these videos in a way everyone understand and receives the information. This is a great video. Thank You subscribing NOW!!!
because you are a woman
@@halasaleh8509 And YOU are stupid
Yes! I am confused about tuition too, when RUclips is free and so helpful!
it true
Cries in >100k owed
"thank you for watching"
No problem robot lady, thanks for helping me learn!
8 min video replaced a 2 hour lecture, man I really hate my school for complicating life... Thank you for the video!!
"thank you for watching"
Thank YOU for helping me.
ikkrrr
The heart is essentially a muscle that contracts and pumps blood.
It consists of specialized muscle cells called cardiac myocytes.
The contraction of these cells is initiated by electrical impulses, known as action potential (AP)
Unlike skeletal muscles, which have to be stimulated by the nervous system,the heart generates its own electrical stimulation.
In fant, a heart can keep on beating even when taken out of the body.
The nervous system can make the heartbeats go faster or slower, but cannot generate them.
The impulses start from a small group of myocytes called the pacemaker cells, which constitute the CARDIAC CONDUCTION SYSTEM.
These are modified myocytes that lose the ability to contract and become specialized for initiating and conducting action potentials.
The SA node is the primary pacemaker of the heart.
It initiates all heartbeats and controls heart rate
If the SA node is damaged, other parts of the conduction system may take over this role.(AV node , Bundle of His )
The cells of the SA node fire spontaneously generating action potentials that spread through the contractile myocytes of the atria.
The myocytes are connected by gap junctions, which form channels that allow ions to flow from one cell to another.
This enables the electrical coupling of neighboring cells.
An action potential in one cell triggers another action potential in its neighbor and the signals propagate rapidly.
The impulses reach the AV node, slow down a little to allow the atria to contract, then follow the conduction pathway and spread through the ventricular myocytes.
Action potential generation and conduction are essential for all myocytes to act in synchrony.
Pacemaker cells and contractile myocytes exhibit different forms of action potentials.
Cells are polarized, meaning there is an electrical voltage across the cell membrane.
In a resting cell, the membrane voltage, known as the resting membrane potential, is usually negative.
This means the cell is more negative on the inside.
At this resting state, there are concentration gradients of several ions across the cell membrane: more sodium and calcium outside the cell, and more potassium inside the cell.
These gradients are maintained by several pumps that bring sodium and calcium OUT, and potassium IN.
An action potential is essentially a brief REVERSAL of electric polarity of the cell membrane and is produced by Voltage-gated ion channels.
These channels are passageways for ions in and out of the cell,and as their names suggest are regulated by membrane voltage.
They open at some values of membrane potential and close at others.
When membrane voltage INCREASES and become LESS negative,the cell is LESS polarized, and us said to be depolarized.
Reversely, when membrane potential becomes MORE negative, the cell is repolarization.
For an action potential to be generated, the membrane voltage must depolarize to a critical value called THRESHOLD.
The pacemaker cells of SA node SPONTANEOUSLY fire about 80 potentials per minute, each of which sets off a heartbeat, resulting in an average heart rate of 80 beats per minute.
Pacemaker cells do NOT have a TRUE RESTING potential.
The voltage starts at about -60mV and SPONTANEOUSLY moves upward until it reaches the threshold of -40mV.
This is due to action of so-called "FUNNY" currents present ONLY in pacemaker cells.
Funny channels open when membrane voltage becomes lower than -40mV and allow slow influx of sodium.
The resulting depolarization is known as "pacemaker potential".
At threshold, calcium channels open, calcium ions flow into the cell further depolarizing the membrane.
This results in rising phase of action potential.
At the peak of depolarization, potassium channels open, calcium channels inactivate, potassium ions leave the cell and the voltage returns to -60mV.
This corresponds to the falling phase of the action potential.
The original ionic gradients are restored thanks to severy ionic pumps,and the cycle starts over.
Electrical impulses from the SA node spread through the conduction system and to the contractile myocytes.
These myocytes have a different set of ion channels
In addition, their sarcoplasmic reticulum, the SR, stores a large amount of calcium.
They also contain myofibrils.
The contractile cells have a stable resting potential of -90mV and depolarize ONLY when stimulated, usually by a neighboring myocyte.
When a cell is depolarized, it has more sodium and calcium inside the cell.
These positive ions leak through the gap junctions to the adjacent cell and bring the membrane voltage of this cell up to the threshold of -70mV
At threshold,fast sodium channels open creating a rapid sodium influx and sharp rise in voltage.
THIS IS THE DEPOLARIZING PHASE.
L- type or slow, calcium channels also open at -40mV, causing a slow but steady influx.
As the action potential nears its peak, sodium channels close quickly, voltage gated potassium channels open and these result in a small decrease in membrane potential, known as EARLY REPOLARIZATION PHASE.
The calcium channels, however, remain open and the potassium efflux is eventually balanced by the calcium influx.
This keeps the membrane potential relatively stable for about 200msec resulting in the PLATEAU phase, characteristic of cardiac action potentials.
Calcium is crucial in coupling electrical excitation to physical muscle contraction.
The influx of calcium from the extracellular fluid, however, is NOT enough to induce contraction.
Instead, it triggers a MUCH greater calcium release from the SR, in a process known as "calcium-induced calcium release".
Calcium THEN sets off muscle contraction by the same " sliding filament mechanism" described for skeletal muscle.
The contraction starts about half way through the plateau phase and lasts till the end of this phase.
As calcium channel slowly close, potassium efflux predominates and membrane voltage returns to its resting value.
Calcium is actively transported out of the cell and back to the SR.
The sodium/potassium pump then restores the ionic balance across the membrane.
Because of the plateau phase, cardiac muscle stays contracted longer than skeletal muscle.
This is necessary for expulsion of blood from the heart Chambers.
The absolute refractory period is also much longer - 250 msec compared to 1msec in skeletal muscle.
This long refractory period is to make sure the muscle has relaxed before it can respond
to a new stimulus and is essential in preventing summation and tetanus,which would stop the heart from beating.
Thanku😊
todo o meu coração para você
❤❤❤
Thanks
🐐
This was one of the best descriptions of cardiac action potential. The animation is fantastic! Thank you!
The best video so far that I have seen on this subject.
Thank you!
just dropping by to say i agree! thank you @@Alilamedicalmedia !
literally
In 2020 also still the same.
You havent seen the ninja nerd yet
I'm tired of forgetting it and having to watch these videos 293939 times
Me toooo😂😢
Yesss🙃🥲
You saved me the effort of reading , visualizing and comprehending ... 💘
This is amazing, the best explanations about heart physiology I have seen so far!
This has to be the best video that has explained cardiac electrophysiology. Insane stuff. 🔥
As senior clinician i have been really encouraged by your lectures.
I feel know i have to contirbute my fair share to the world of Medical Science. Thus, I have uploaded my first PPT based video.
These videos are INCREDIBLE!!! Since I am a visual learner, I have been BLESSED to have received "sight" unto how the heart conducts its impulses! Even though I can read about the physiologic movements about the heart (or any other part of the body) I generally CATCH ON TO VIDEO VISUALS! God Bless You, and THANK YOU!!!!
not many words to say… just THANK YOU!!!!💝
so I thought lets be kind today and this is basically a summary of the video. you're welcome.
Action potential cardiac:
The contraction of cardiac myocytes (muscles in the heart) are initiated by electrical impulses, known as action potential. It generates its own electrical stimulation and the beats go faster or slower caused by nervous system, but the nerves don’t generate the contraction. The impulses start from a small group of myocytes (pacemakers cells). These are modified myocytes that lose the ability to contract and become specialized in initiating and conducting action potentials. SA node is the primary pacemaker of the heart it initiates all heart beats and controls heart rate. The cells of the SA node start spontaneously generating action potential that spread through the contractile myocytes of the atria. The myocytes are connected by gap junctions, which form channels that allow ions to flow from one cell to another. This enables electrical coupling of neighboring cells, an action potential in one cell triggers another action potential in its neighbor and the signals propagate rapidly.
- Cardiac myocytes; muscles that make up the heart
- Pacemaker cells; The cells that create these rhythmic impulses; heart rate
1. The impulses reach AV node
2. Slow down little to allow the atria to contract
3. Follow the conduction pathway and spread through the ventricular myocytes
- Action potential generation and conduction are essential for all myocytes to act in synchrony.
Polarized: there is an electrical voltage across the cell membrane
Resting membrane potential, resting voltage, meaning that the cell is more negative on the inside.
- More sodium and calcium outside the cell and more potassium inside the cell
- Maintained through pumps
- When membrane voltage increases and becomes less negative cell is less polarized depolarized. When cell gets more negative cell gets repolarized
80 action potentials/beats per minute
Pacemaker cells do not have true resting potential.
Action potential in pacemaker cells
• The voltage starts at -60 mv and spontaneously goes up to -40mv (threshold) Pacemaker potential
- Due to funny currents, only present in pacemaker cells, open when membrane voltage gets lower than -40mv, allows slow influx of sodium (inside the cell)
• At threshold calcium channels open calcium ions flow in to the cell, further depolarizing rising (depolarizing)
• At the peak of depolarization potassium channels open calcium channels inactivate, potassium ions leave the cell ant the voltage returns to -60mv. falling (repolarization)
Electrical impulses from the SA nodes go to the contractile cells. Contractile cells store a large amount of calcium.
Action potential in contractile myocytes
- A stable resting state of -90mv and depolarize only when stimulated, usually by a neighboring myocyte.
- When is cell is depolarized it has more sodium and calcium ions inside to cell, these positive ions leak through the gap junctions to the adjacent cell and bring the membrane voltage up to -70 mv (threshold)
- At threshold: fast sodium channels open creating a rapid Sodium influx inside the cell and get a sharp rise in voltage. depolarizing phase
- Slow calcium channels opene at -40 causing a slow but steady influx, as the action potential nears its peak sodium channels close quickly, voltage-gated potassium channels open and these resolve in small decrease in membrane potential early repolarization phase
- the calcium channels remain open and potassium efflux is eventually balanced by the calcium influx this keeps the membrane potential relatively stable for about 200 milliseconds plateau phase
- the calcium inside the cell is not enough to trigger a muscle contraction, instead it releases calcium induced calcium release which sets off muscle contraction
contraction starts at half of the plateau phase and lasts until the end.
- Calcium channels close, potassium efflux predominates and membrane voltage goes back to it resting value. The sodium potassium pump then restores the ionic balance across the membrane. repolarization
Because of the plateau phase cardiac muscle stays contracted longer than skeleton muscle, which is important for pumping blood. Absolute refractory (state after and before resting) state is 250 millisecond compared to 1millisecond in a skeleton muscle. the cardiac muscle has a longer absolute time so it can rest before it starts contracting again, which is important.
❤
Thanks a lot bro...I fully copied ur comment in my copy by simultaneously watching the video ...thanks a lot 🙏
Thank u so much
OMG thank you so muuuchhh❤❤❤
thankkkk u 🥺
it's an amaaaaaaazing animation ..keep on ...we need animation on physiology of the kidney and autonomic nervous system
I am a medical student from Sri Lanka. Thank you so much for this vedio. In few minutes I covered a full lecturer . Please give us more vedios as these are very creative and easy to understand . Thank you so much once again
Thank you!
Why can't all lectures be this straight to the point and time saving!? 🙄 lol
Excellently explained and shown!! Appreciate this video very much concerning a woman struggling with her heart; thank you.
Why can't my professors just have me watch your videos to learn instead of complicating everything with their lectures? THANK YOU
I am annoyed at the high cost to hear those complicated lectures, use my gas to get there and wear a specified (and expensive) uniform...when I can come on here in my PJs and learn way faster! Lol! Ugh
Where you studying physiology at
😂😂😂
you are so smart to leave this comment
Now I know why they could keep captain Davy Jones' heart inside that chest. amazing video!
HAHAHAHA
Brilliant 7:50 mins of my study!!
I wish when I was at my med school this video already exist. But still grateful now I can remind all my study with the help of this animation and explanation
Nice animation make the subject so easy to understand
اكيد ي زعيم !
This video in Gold. Super-accurate informations with simple animation. Great video!
I have no words to adequately thank Alila Medical Media Thank you🙏🏻🙏🏻🙏🏻🙏🏻🙏🏻🙏🏻
The best explaination I could have got 5 hours before my exam. Thank youuuuuuu very much ❤️❤️
Phenomenal animations that make the material very clear, thank you so much.
soo much space need to see it all
Excellently summarised
one of the best channels, helped a lot with my med school
That is by far the best demonstration on cardiac AP
My physiology lecturer makes us watch these videos at the end of all his lectures
How on earth this could be explained so logically? I understood everything...Literally six year and ten year old videos are making me pass my exams nowadays... Thank you soooooooooooooo much!!!!!!
Thanks and welcome!
Love your channel.
Simplest way to explain the most difficult concepts.Kudos
I just would like to say thank you for such amazing animations and for free available content
really helps a helpless medical student like me, thanks so so so much!!!
you just explained to me like 50 slides from my class that I didn't even understand all within 8 minutes
Best channel on earth. Pkease never stop producing
Waw! I've never heard so clever explanation! Never ever! If sth is not known or understood, the easiest and usual reaction is to blame the student of not being clever enough. But how many "teachers" are actually clever like you to explain the subject so clearly!?
This channel is a blessing ! I have have a college degree in Biology without you tube I’m not sure I would be able to make through.
The confusing topic makes easier through animation. I am glad to watch it. Heavier lecture, nice explanation,and just wow rock; love you guys. Could please explain ABO & RH factor with comparison in a one video; Thankyou.
Your videos really saved me from my anaphy class!!! Thank you
One of the best medical animaton which i was watched. Congrats!
This is just absolutely wonderful, just beautiful, a job well done, pls keep up the good work, y'all are saving alot of students in medical school in just 7mins🤲
Alila, you saved my sanity. Thank you, thank you very much.
The best video about PA i’ve ever seen
best explanation ever, looking forward to smooth muscle contraction and relaxation.
Extremely informative and undiluted. Did clear all my queries.
It just took mins to explain
Each word was worth it!
Thank u
For real alila animations make learning very simple even if for u don't get things
Thank you for this nice & comprehensive video you saved me from the effort of studying so many pages and still not really understand the subject!
With jut 7:50 minutes, you explained what even my text books failed to let me understand, I'm very grateful, I can pass my exams now 😭😭❤❤❤
That was great
THANK YOU VERY MUCH
my final is in a few days. This made more sense than every lecture he's talked about it, youre awesome.
Thanks, and good luck!
Award winning video , thank you so much, may God remember this amazing work, whoo :)))
Very good job......... Best teacher...... Animations make me feel easy to understand.... I'm very grateful to you
Wow, truly "The Best" in how you and your organization present!!! 1st semester BSN-Nursing Student at NOVA Southeastern University!!!
Thank you!
U made this so easy to understand and remember... Thank YOU so much
Thanks for making life much simpler with this video
Excellent overview of cardiac action potential! Organized, well presented, with great, colorful, visual diagrams that helped to reinforce concepts.
Best video on this topic I've watched on you-tube!
I missed the concept in my class,,but through this video I really enjoyed it
You have explained it clearly big up 🙏
Grateful beyond words. Will do my best to support you!
Absolutely brilliantly explained. THANK YOU!
AMAZING VIDEO!! saved myself from the adversity of a one hour lecture that I did not understand at all when this video explained everything I needed to know so clearly
Thank you so much ❤️❤️
This video is simple yet amazingly descriptive .....I loved the animations and explanation. ....keep making more physiology videos
A good elaborative teachings about action potential in the cardiac muscle cells. Am inspired.
wow you summed up a 2 hour lecture into 7 minutes, bless
Excellent Job. Comprehensive and affective.
Covered almost all the cardiac physiology so nicely within 2 mints..thank you for the amazing lctr🙏🙏
what a wonderful piece of work. I should be thanking you.
No doubt the best video described everything in more detail and so easy to understand
Thank you v much
A perfect illustration which really helped me with understanding the cardia action potential system. Thank you!
This is the best website EVER( for basic), it could be more helpful if you could talk about more details.(for medical students)
Thank Youuu
thank you! in medical assisting class but im premed and highly interested in biochemistry, but the scope of a medical assistant is so limited and not as in depth. this animation really made it great for me and satisfied my curiosity :)
intelligent, smart and full of information presentation. easy to understand each points. thanks
After so many years of not understanding this, you have finally helped me grasp this. Thank you so much!
We are happy we could help :) Thanks for watching!
O.... What an effort. Mind blowing .superb vedio.thank you a lot.
Really helpful video, easy to understand with best explanation so far. Thank you for the amazing video !!!
I was so disappointed in my class which is 2h ,
but now I got it! wow thankssss
I really like this video. Helps a lot, especially for I just start to research on related field and need to learn the fundamentals of cardiac myocytes firing. Thanks!
Now I get it!!! This was so helpful. The best explanation I have seen.
Alila videos are honestly the most understandable, best explained and well animated medical videos on youtube. Always my go to source for clarification. Im still a student so I dont make a lot of $$ but I will support u guys on patreon because this content is why i consider youtube to have some pretty great content (among all the useless timewasting shit that I indulge in as well from time to time :D)
Thank you very much, but please support only if you are comfortable enough, we would feel bad otherwise!
Thanks for the very clear summarized explanation!!
May Allah bless you for your efforts💙this is so helpful
this is GREAT. very visual and quick. thank you.
Thank you mam,
For making the concept easily understandable 🙏🏻😊
unbelievably well explained. thank you!!
very good animation very much useful to the medical students.
How important are cardiomyocytes and how do they regulate energy metabolism..plz make a video on this. You are doing a great job...
Wow. How dedicated u r to make us understand such complex idea in simple animation. God bless u and keep it upup!!!
Thank you have make everything so clear with all the amination better then a dead lecture -life saving. XD
Super presentation👍👍👍
I love your teaching. Made the topic easy to understand. thanks
This short video covers everything my lecturer taught in a lesson and its much more informative and understandable....
Thank you so much for your help. May the Lord Jesus bless you!
After this video, I have a much better understanding of the cardiac action potencial cycle.
this vedio is very helpful to understand these potentials of cardiac muscles. thank u so much