What causes Alzheimer's disease: Amyloid vs Tau

Learning objectives 
Understand the role of microtubules in the brain and their importance in neuronal function.
Describe the function of tau protein in healthy neurons and how it stabilizes microtubules.
Explain why tau is phosphorylated in healthy individuals and how this process helps neuronal plasticity.
Understand the process of hyperphosphorylation in tau and its connection to Alzheimer's disease.
Describe how tau tangles form and spread throughout the brain in Alzheimer's disease.
Discuss other diseases in which tau pathologies are present and how they differ from Alzheimer's disease.
Understand the relationship between tau phosphorylation and inflammation in the brain.
By the end of this video, viewers should be able to explain the critical role of tau protein in the brain, how its abnormal hyperphosphorylation leads to neurodegeneration, and the link between inflammation and Tau phosphorylation. 

[@ElliottJohn1660]

Clear, comprehensive, and entertaining. Great video; deserves more views.

[@The-advicer]

Agreed

[@The-advicer]

Oh I am teh 800 view and also the 5th comment nice

[@inflivia]

excellent synopsis and enjoyed the delivery

[@The-advicer]

thanks hyou are helpin me in my ee

[@SaschaBerresch]

Thank you so much for the explanation. Have you heard of the impact of the enzyme Glutaminylcyclase which produces neuro toxic pyro glu amyloid or N3pE? It it meant to significantly drive the oligomerisation, inflammation and ptau. Also in your last video you did not mention it.