Somewhat disappointing that Jack does not mention that the alpha secretase pathway is actually promoting neuroplasticity while the beta amyloid pathway which is traditionally thought of as pathogenic is also physiologically recruited for synaptic pruning, and for immune defense.
The accelerating and clumping seem to be indicative of prion disease. Some scientist are beginning to equate Alzheimer disease with prions. From what you are saying in this video I can not see the connection. What do you think?
Not quite. The seeding and templating process by which small aggregates termed oligomers recruit non pathologically folded forms of the protein to become more problematic is termed "prion like" but it's not fully prion because ingestion of these proteins does not cause templating like a true Prion would enable.
Somewhat disappointing that Jack does not mention that the alpha secretase pathway is actually promoting neuroplasticity while the beta amyloid pathway which is traditionally thought of as pathogenic is also physiologically recruited for synaptic pruning, and for immune defense.
The accelerating and clumping seem to be indicative of prion disease. Some scientist are beginning to equate Alzheimer disease with prions. From what you are saying in this video I can not see the connection. What do you think?
Not quite. The seeding and templating process by which small aggregates termed oligomers recruit non pathologically folded forms of the protein to become more problematic is termed "prion like" but it's not fully prion because ingestion of these proteins does not cause templating like a true Prion would enable.