I greatly appreciate how you present some more complex stuff in a concise manner and you are careful about your thoughts and opinions (as in you are clear when it’s your opinion and WHY you hold that opinion but you don’t demonise people in the process of providing it). You are why I adore good pharmacists!!! They have been crucial to my wellbeing and care throughout my life time!! Thanks ☺️
Okay, this is fascinating, considering I've tried Mounjaro and Ozempic. I prefer Ozempic. I have Type II diabetes, so I use the meds primarily for that, secondarily (but certainly wanted) for weight loss. Both were great for keeping my blood sugar lower, but I felt SO sick on Mounjaro....because I'm allergic to grains. All grains. Wheat, rye, oats, rice, corn, ancient grains - if it looks like some kind of grass, I'm allergic. So because I can't eat near as many carbs as most, I am very fats-dependent for my macronutrients. Mounjaro wrecked me at the second- and highest doses. Ozempic is so much more manageable.
Honestly it seems like even if GLP-1 drugs could cause blindness the risk of untreated diabetes doing so is *way* higher so another case of benefits outweighing (perceived) risk.
The active ingredient in Ozempic is semaglutide which is not exclusive to Ozempic. It has actually been on the market in the US for a couple of years and is also in Wegovy and Rybelsus. All of these medications are manufactured by Novo Nordisk which currently owes the patent to semaglutide through 2026 (China), 2031 (Europe and Japan), 2032 (US), and other dates depending on the country. If you are talking about it being available as a generic, there are a couple of things to know: patents on a drug are related to formulation, dosage form, release, device (the injector devices are often trademarked themselves), and indications so sometimes you will see different brand names for medications with the same active ingredient. In this case, Ozempic (injectable) is indicated for T2DM and reduction of cardiovascular events in T2DM patients with CVD. Wegovy (injectable) is indicated for weight loss and reduction of major adverse CV events in patients with a history of CVD and obesity/overweight. It is also given at higher dosages than Ozempic. Rybelsus (daily oral tablet) is indicated for T2DM. So different indications, different dosage forms, different dosing but same active ingredient and they are all manufactured by the same company. In comparison, Eli Lilly produces both Mounjaro and Zepbound which have the same active drug (tirzepatide), dosage form, dosing, and injector device but they have separate indications (Mounjaro is T2DM and Zepbound is weight loss). FYI pharmaceutical companies can extend patent rights or develop new brand name drugs by releasing new dosage forms (capsules, tablets, liquids, suspensions, etc) and new release forms (instant release vs extended release, even new coatings and pill systems to change release). They can also extend patents or develop new brand name drugs by getting the FDA to approve a drug for new indications. As far as the current expansion of the GLP-1 agonist markets with many companies offering compounded semaglutide options, that is because of the FDA does authorize compounding pharmacies to compound medications, even if under patent, in the event of a shortage but it has to be on the FDA drug shortages list. They can also compound if a patient has an allergy or some other sensitivity to ingredients in commercially available medications, is unable to take the dosage forms of commercially available formulations (see this a lot in patients who can’t take anything by mouth), or needs a very specific dose that is not available commercially (see this quite often with hormones). However compounded medications are very expensive and often not covered by insurance, although in some cases you might be able to submit a claim after you purchase it but I honestly haven’t seen a lot of insurance plans cover many compounded medications afterwards, even in cases where there was a very strong necessity for meds to be compounded. I can pretty much guarantee that insurance plans will not cover compounded semaglutide, especially since they already have restrictions and requirements for covering the commercially available medications.
Well if they're going to be vain and take medications they shouldn't just to be *pretty," I see no reason why karma shouldn't take away their sight as payment. 🙄
Weight is medicalized to an insane degree. While I agree that taking meds just for weight loss is insane and dangerous, NOBODY deserves to lose their vision because of it
He is talking about people with diabetes and the correlation between high blood sugars and vision loss. You do know people can get type 2 from various things? HIV medication and some cancer treatments can cause it for example. As if those people want to be sick? As if ANYONE wants to be sick? The easiest thing to do is judge, but you never know what lead to someone's condition. 🤨
I greatly appreciate how you present some more complex stuff in a concise manner and you are careful about your thoughts and opinions (as in you are clear when it’s your opinion and WHY you hold that opinion but you don’t demonise people in the process of providing it). You are why I adore good pharmacists!!! They have been crucial to my wellbeing and care throughout my life time!! Thanks ☺️
Okay, this is fascinating, considering I've tried Mounjaro and Ozempic. I prefer Ozempic. I have Type II diabetes, so I use the meds primarily for that, secondarily (but certainly wanted) for weight loss. Both were great for keeping my blood sugar lower, but I felt SO sick on Mounjaro....because I'm allergic to grains. All grains. Wheat, rye, oats, rice, corn, ancient grains - if it looks like some kind of grass, I'm allergic. So because I can't eat near as many carbs as most, I am very fats-dependent for my macronutrients. Mounjaro wrecked me at the second- and highest doses. Ozempic is so much more manageable.
In a group for essential tremor, incidentally the few people who take these meds say their tremors is gone.
Honestly it seems like even if GLP-1 drugs could cause blindness the risk of untreated diabetes doing so is *way* higher so another case of benefits outweighing (perceived) risk.
I was hoping that ozempic allowed companies access to the main ingredient instead 😅
The active ingredient in Ozempic is semaglutide which is not exclusive to Ozempic. It has actually been on the market in the US for a couple of years and is also in Wegovy and Rybelsus. All of these medications are manufactured by Novo Nordisk which currently owes the patent to semaglutide through 2026 (China), 2031 (Europe and Japan), 2032 (US), and other dates depending on the country. If you are talking about it being available as a generic, there are a couple of things to know: patents on a drug are related to formulation, dosage form, release, device (the injector devices are often trademarked themselves), and indications so sometimes you will see different brand names for medications with the same active ingredient. In this case, Ozempic (injectable) is indicated for T2DM and reduction of cardiovascular events in T2DM patients with CVD. Wegovy (injectable) is indicated for weight loss and reduction of major adverse CV events in patients with a history of CVD and obesity/overweight. It is also given at higher dosages than Ozempic. Rybelsus (daily oral tablet) is indicated for T2DM. So different indications, different dosage forms, different dosing but same active ingredient and they are all manufactured by the same company. In comparison, Eli Lilly produces both Mounjaro and Zepbound which have the same active drug (tirzepatide), dosage form, dosing, and injector device but they have separate indications (Mounjaro is T2DM and Zepbound is weight loss). FYI pharmaceutical companies can extend patent rights or develop new brand name drugs by releasing new dosage forms (capsules, tablets, liquids, suspensions, etc) and new release forms (instant release vs extended release, even new coatings and pill systems to change release). They can also extend patents or develop new brand name drugs by getting the FDA to approve a drug for new indications. As far as the current expansion of the GLP-1 agonist markets with many companies offering compounded semaglutide options, that is because of the FDA does authorize compounding pharmacies to compound medications, even if under patent, in the event of a shortage but it has to be on the FDA drug shortages list. They can also compound if a patient has an allergy or some other sensitivity to ingredients in commercially available medications, is unable to take the dosage forms of commercially available formulations (see this a lot in patients who can’t take anything by mouth), or needs a very specific dose that is not available commercially (see this quite often with hormones). However compounded medications are very expensive and often not covered by insurance, although in some cases you might be able to submit a claim after you purchase it but I honestly haven’t seen a lot of insurance plans cover many compounded medications afterwards, even in cases where there was a very strong necessity for meds to be compounded. I can pretty much guarantee that insurance plans will not cover compounded semaglutide, especially since they already have restrictions and requirements for covering the commercially available medications.
Well if they're going to be vain and take medications they shouldn't just to be *pretty," I see no reason why karma shouldn't take away their sight as payment. 🙄
Damn. What a black hearted thing to say
Weight is medicalized to an insane degree. While I agree that taking meds just for weight loss is insane and dangerous, NOBODY deserves to lose their vision because of it
He is talking about people with diabetes and the correlation between high blood sugars and vision loss. You do know people can get type 2 from various things? HIV medication and some cancer treatments can cause it for example. As if those people want to be sick? As if ANYONE wants to be sick? The easiest thing to do is judge, but you never know what lead to someone's condition. 🤨