NEOPLASIA 3: TUMOR SUPPRESSOR GENES: Retinoblastoma Gene, Knudson's Two Hit Hypothesis.
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- Опубликовано: 11 дек 2016
- This short tutorial explains the general concepts of tumor suppressor genes and a detailed explaination of Retinoblastoma gene
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Tumor suppression genes- general aspects
Retinoblastoma gene
Knudson’s two Hit Hypothesis
Role of RB in regulation of cell cycle
Mechanism of inactivation of RB
Tumors associated with RB gene mutations
Tumor suppressor proteins( products of TSG)
Regulate cell growth by applying brakes to cell proliferation ( Growth Inhibition)
Failure of growth inhibition is seen in carcinogenesis
Loss of function of these genes is a key event in carcinogenesis
Retinoblastoma Gene ( RB Gene)
First discovered Tumor suppressor gene
Chromosome 13q14
Retinoblastoma: is a childhood tumor with inactivation of this gene.
Knudson’s two-hit hypothesis
Two mutations ( hits) involving both the alleles of TSG ( here RB gene) is a basic requisite for the development of tumor
Retinoblastoma can occur as hereditary or sporadic form
Explanation for the same is given by Knudson’s two-hit hypothesis
RB protein- product of RB gene
Key role in regulation of the cell cycle
“Governor” of the cell cycle
So, How does RB gets inactivated ?OrHow does the Antiproliferative activity of RB is nullified?
1. Germline & somatic
Loss of function Mutations of RB Gene
2. Gene Amplifications of CDK 4 and
Cyclin D genes
3. Functional inactivation of RB
Tumors associated with RB Gene mutations
Retinoblastoma
Osteosarcoma
Glioblastomas
Small cell carcinomas of lung
Breast cancers &
Bladder cancers
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Please watch: "WARBURG EFFECT: Hallmark of CANCER. What, Why & How?"
• NEOPLASIA 6: WARBURG E...
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Absolutely brilliant sir. As a practicing surgical oncologist since more than 25 years, as also a teaching faculty in a medical college, I really appreciate the clarity and lucidity of your excellent presentation. Thank you so much.
Sir Pls do not get inactive. Pls continue ur proliferative potential of spreading knowledge.
This type of mutation in u is welcome sir.
Pls do continue generating such interesting videos
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You explanations of complicated topics makes it so much easy to understand and comprehend the topics that are discussed in dozens of pages. I've been always looking forward for your tutorials. THANK YOU SO MUCH for all the effort.
Albaraa Alfaraidi thanks for those kind words :-)
Is there any notes available and is it helpful in university exam ? Please let me know
Easy to understand... concept clear ....
Respect & love from core of my heart
Its never a boring subject if u have a great teacher
Randomly came here and WOW , u have made difficult topic capable of understanding , Thanks
Your content is so good I don’t even skip the ads.
Thanks a lot, I was struggling a lot with this concept for my cancer biology exam :)
Your explanations r making my preparation very easy.
Thanks a lot sir 😊😊
YOU’RE THE BEST! Thankyou so much
very good explanation, , thank you sir
Clear explanation and easy to grasp the information 🙏🏼
never understood retinoblastoma gene this better
Haha.. That's the problem sir.. We being an oncologist... Just are entangled with the trials... Basics and core fundamentals, I feel are given the least weightage.. 🙏
Your make everything so simple to understand , thank you Sir
Finally understood the topic ❤️ Thank you sir.
I couldn’t be more grateful🙏🏽🙏🏽🙏🏽😩😩
Thank you so much..
It really helpful
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very helpful
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Very happy to the vedio..you made easy for me as preparing for oncosurgery
Thank u so much ...it was very useful 👏🏼
Thanks alot..Very informative and easy to understand video on this topic.It helped me a lot .
Excellent explanation.thankyou sir
Really helpful video. Thank you😊
Thank you Sir🙌🏻
Great explanation thank you
Very useful... thank u so much sir ..
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I love the way you teach sir .. god bless you with still more knowledge 💖...
If possible plz upload more videos tqvm sir
thank you so much for this, you are a lifesaver
felt very grateful thank you so much
Your explanation is mind-blowing. Very useful thanks alooottt
Beautiful explanation..
Excellent explanation sir! 👏
Excellent. Thank you sir.
Great teaching and illustrations thank you for teaching and sharing ❤❤❤❤❤
Sir I m very grateful ..very nice explaination
Beautiful explanation
Well played !! Thank you
Thank you so much for this
very useful video thx from the heart
Awesome content 🔥
Crystal clear topics ...tq...excepting more videos from hematology
Thank u soo much sir!
Thank you so much sir!!!
Great explanation.. Thanks...
Thank you sir..
It helped me a lot..😌😌
10000% solid concept
I love these ❤️
Conceptual approach 👌
Good explanation easy to understand useful for my exams
Very well explained
Excellent!
Excellent video
Awesome. ❤
Very good thanks
Thanks for this
Thankyou so much sir
Super explanation
Great explanation.... Too good.... Robbins can be made so simple?
which is more common inherited or acquired retinoblastoma??
Thank you sir for this beautiful explanation. Please do a video series on wbc malignancies
good presentation
Thank you sooooo much ... robbins is a piece of cake cuz of you
Aaah people are missing out on content 🤩
Very helpful
Too good 🙌
You are amazing thank you sir thank you very much
Finally understanding the topic..tons of pages made soo easy thank you sir..
😊 thank you
Thank you.
The gene for retinoblastoma is transmitted along with a gene for esterase D to which it is closely linked. However, either of the two alleles for esterase D can be transmitted with either allele for retinoblastoma. How do you know that retinoblastoma is not the direct effect of the esterase D genotype?
Please give explanation....
thanks so much
Very useful 👍
May I know your specific references, for example for the pictures, please?
Excellent
Thankew you so much
Thank you!
Why is the retinoblastoma unilateral in 60% of cases? Since there are ×2 hits (in both chromosomes) it should be bilateral. (Affects both retinas).
Thank you
Gracias
thanks a lot
Thank you but please make more videos
Great explanation....Thanks for helping
You are most welcome
Thanks 💚😊
U r ossm sir
thanku sir
Sir, what is loss of function mutations for RB protein ? Can you please make a video on this topic 😢
A plenty of thanks sir.... waiting for systematic pathology videos
Very soon
thank you saar
How normal cell divided? If RB gene is inhibit the cell to go S phase of cell cycle.??
Awesome
Thanks
What happens if you eat food containing cancer cells or tumor?
Damn good ...!
So wonderful . Thank you. You can also checkout my article in pediatriconcall on the same topic
Wishes from madurai medical college😇
Awesome. Thanks a lot
Thanks. Glad you liked it. Any suggestions are welcome.
🔥🔥