NEOPLASIA 4: p53 gene: The Guardian of the genome. functions, regulation and inactivation

[@haripriyar8291]

You're the reason I'm passing exams with a clear concept instead of just writing what's in the book. Thankyou so much :)

[@nathaamruth9751]

😂🙌me too

[@dariofilipovic893]

Harsh truth

[@tharunkumar5587]

so cutee haripriya

[@Arcanescrunchies99]

me too

[@naomiirhontumhan1544]

And 7 year later your videos are still saving lives👏 Thank you 🙏

[@ilovepathologyVijayPatho]

Thank you😊 glad it still helps😊

[@janefrancesladyf]

5 years ago and still very helpful. I can now go into the exam hall in a few hours with more confidence. Thank you.

[@ilovepathologyVijayPatho]

Thank you 😊 best wishes 😊

[@janefrancesladyf]

@@ilovepathologyVijayPatho Thank you

[@ilovepathologyVijayPatho]

Thank you 😊 am glad it helps😊

[@MDISLAM-qw7ic]

P53 is guardian of the genome / old man of the genome/ police man of the genome / care taker / gate keeper of the genome .
The information which did not get from dr.sparsh gupta & dr.najeeb but i have found amazing & very effective information from your channel.
It is why i have subscribed and followed your you tube channel.
Thank you sir and i really love " i love pathology " channel..😊

[@umairhabib4618]

Just 10 minutes lecture give alot of information is a miracle
Thanks sir
Our prayer always with your dedication and hardwork.

[@ilovepathologyVijayPatho]

Thank you 😊

[@zcameron_]

I’m a week out from a huge pathology exam and I really wish I’d just studied from your videos from the beginning. I read all this info in a textbook and never retained it, and now it makes so much more sense to me.
You break concepts up really well and you also keep it focused on the important stuff.
Thank you!

[@marioaraprotopapa1503]

You are a really good teacher , thank you for all the time and energy put in to make these videos extremely clear and concise ♡♡ .

[@ilovepathologyVijayPatho]

Marioara Protopapa thanks so much 😊

[@asmitajain7201]

U are a really wonderful teacher, making the basics so understandable in a simple way, thanks for taking all the efforts in making such wonderful presentations

[@ilovepathologyVijayPatho]

Thank you very much 😊.glad the video was of help 😊
Best wishes.

[@cindysababa0204]

I was reading my book, but it makes no sense to me. You made it clearer! thank you so much!

[@ayokcomfort]

I can relate

[@84-pavithradevi2]

yass!!!

[@andreapella4234]

I love you. This is so well explained i'm in tears.

[@Josef2820]

Man i really have to thank you so much for your Video. Somehow we dont have anything that easy to understand in germany related to p53
Thanks a lot !!!!!

[@irem0090]

Josef Boy Björn same hab nix gefunden

[@pinrani98794]

i already have subscribed to this channel and gave thumbs up to this channel/video. He will be fool who will not do this ... great work and proper guidance provided .... bravo....

[@kniiknoi6197]

Wow ... Great video. Excellent, detailed yet simplified tuition. Thanks a lot

[@shaileshrao8694]

Neoplasia was one of the hardest topics i've ever studied and thanks to your videos my concepts are very clear!!
please keep uploading more videos on pathology it is indeed very very helpful!!❤❤❤

[@ilovepathologyVijayPatho]

Thanks so much..glad these videos are helping 😊 do share with your friends

[@Artsylove4]

I'm super thankful that I found ur channel sir..

[@chinmayeechhotaray7116]

Thanks dude...i was searching for p53 explanation and ended up in your video with perfect explanation.....you helped me a lot.

[@drabdul86]

Thank you Sir , I am from Pakistan , u made this tough topic much easy to understand , love you

[@mahfuzajebun5968]

Best pathology tutorials site I have ever seen.. Really grateful to u .

[@ilovepathologyVijayPatho]

Thank you.

[@vaishnavik7367]

You're a gem sir. Pls upload some more videos. I have my uni exams in 10 days and your videos on neoplasia are a saviour.
Keep it up, good luck :)

[@ChukimeRMarak]

One of the besttttt explanations I've come across. So systematic and made easy to grasp the concept. So grateful to have found this.

[@ilovepathologyVijayPatho]

Thank you 😊

[@songbaolin5479]

Thanks to the author，I will finish my paper easily.

[@080mirdhulak9]

Just an amazing clear cut concept I have ever seen🤩

[@lucelence6312]

Thank you so much for making the concept clear and easy to understand

[@parthjobanputra3742]

I have my exam tomorrow n this video helped me to drill the concept really quick... ty ... great explanation...😎🤘

[@20imke]

Thanks for helping me understand it so easily. Textbooks are just overcomplicating everything.

[@priyachakraborty2260]

It was great.... 2moro is my exam nd this video worked for me a lot....

[@debigdogk9563]

Great teaching and illustrations thank you for teaching and sharing ❤❤❤❤❤

[@OvErShadOweDaZn]

Keep up the good work! I love this video and it was very helpful in understanding. You are a great instructor.

[@cossav2560]

Thank you from London. Great work.

[@yashkumarprajapati9648]

Beautifully explained!!
Thank you sir 😊

[@samina9199]

Thank you so much sir for making Neoplasia too much easy and understandable😊🎉

[@CytochromeC]

I m actually dealing a while with p53 but the Video is Great

[@krishnamanikalita1612]

You are doing great work sir... thank you so much ❤

[@sanaakbar3663]

Well explained sir. Neoplasia is one chapter that scares me but you have made it more interesting. Your videos have made it more easy for me to go through the text and understand it in a clear way. No amount of paid online classes have made me understand neoplasia as well as these videos . Please keep posting regularly sir!! 🙂

[@kishori4621]

You have made us love Pathology ❤️

[@roohullahaminsafi351]

Thanks sir, really appreciate your hard work and hope to keep loving pathology. Lots of love from Afg🇦🇫

[@shubhamkushwaha8513]

Thank you for the amazing video sir! You explain things so simply!

[@zoyawin]

Thank you so much you made this concept so easy to understand. I was really struggling with this concept. Really helped with studying for my exam!

[@pavansharma8966]

Nicely illustrated about p53 gene regulation in tumor suppression

[@ahmedkhan1560]

Excellent presentation. You made this complex topic so simple that I should recommend that it should be used as a template by the Authors of Molecular pathology Books. Thanks a million, Amjad Ali Khan MD USA

[@afraahmad-g2u]

SIR YOUR VIDEOS REALLY VERY HELPFUL

[@Artsylove4]

U make all the concepts really easy to understand ... thank you so much sir!!

[@ilovepathologyVijayPatho]

Thanks 😊 Glad you liked them

[@laxmihalam6068]

U're amazing sir.please keep it up

[@dartanveer2046]

really a good art of teaching...Amazing...

[@Aman-hk4ov]

Such a great video!

[@animeloverXinuyasha]

Very good job at outlining this topic - this is a perfect and easy to understand introduction to p53, so now I can go and delve deeper! I do wish you had explained a bit more as to what causes p53 inactivation and how, but all in all great video!

[@VijayKumar-ee2si]

Me studying in PG . really u r explained very well and it's very helpfull to understand easily without confusing tq so much sir❤️

[@rakshanas3960]

Pls do more videos ,its very helpful 🥺

[@Pluripotent1234]

Thank u so much sir saw this video before going into exam.. got this question today

[@shahidulhchowdhury6411]

wonderful illustration of role of p53 gene

[@health-and-beaut-secrets]

Best teacher

[@MA-zo5jl]

Wow so amazing and very clear ty so much ❤

[@divyamachevar9156]

You are doing a great job. Please continue doing it, your videos are of great help. Thank you ❤️

[@riyaan1089]

Tqs so much for this very easy explanation

[@alienatedaliens]

This was so helpful and clear, thank you!

[@karishmadeegan8297]

Thank you so much Sir for such a beautiful explanation. I wish you all the best, may you continue to educate lots of students like me. I study at Imperial College London and will tell my friends about your channel. Thank you!!!

[@ilovepathologyVijayPatho]

Thank you 😊

[@shahmaf1768]

Thank you so much for the video because I was very tired with p53

[@nandugopan5973]

Thank you so much sir❣️

[@oviya7715]

The concept is clear and easy to understand thanks to the author

[@ThuriaElhassan]

it's really really helpful .thank you

[@tejasgadekar6153]

Great video

[@NoorKhan-pv3ex]

your lecture is just👌

[@rusulkeshwan9297]

Many thanks for you, you make it very easy

[@gargichakraborty1083]

Great explanation !

[@disloyaltyovercovid8350]

Thank you! The video is very clear!

[@haroldkumar4766]

Good stuff and explanation! However I wish p53 videos also mention that it's part of the BAX/BAK pathway and Bcl2 as that can be a point of confusion.

[@svartmetall48]

I realise this is a very brief look at p53, so I'll leave out some of the simplifications, but I would say one thing needs to be corrected regarding the molecular weight. p53 was named because it ran on an SDS-PAGE gel at 53 kDa, not because its molecular weight is 53 kDa. Due to the fact that p53 is quite proline rich it is a more rigid structure with annoying "kinks" in it, and thus it migrates differently on SDS-PAGE. As I am sure you know, proteins don't necessarily migrate at their actual mass (and there are a plethora of reasons for this). p53 is around 44 kDa.

[@svartmetall48]

@johnny torres Probably a good thing if you attend KI. I should know, I taught some of the undergraduate labs that med students took! ;)

[@elizabethmendes5935]

great explanation and intro to the background of p53!

[@ilovepathologyVijayPatho]

Thank you 😊

[@sanmeetkour8777]

Thank you sir ..god bless ..you made it so easy to understand 😊

[@clarksims3776]

Thanks for posting this. It was very informative.

[@munkhbilegenkhbat4492]

very goodjob that explaining p53 also known as guardian of genome. But don't forget some virus can disable cell's p53 protein which means p53 can also protect cell from oncogen viruses like HPV.

[@RuchiKumari-lu7cg]

Thanku sir a lot i really get concept from ur video thn i can make concept

[@cutyteeshu8068]

Loving this series of neoplasia... ❤❤ But I'm too late to reach hence regretting 😢

[@keshavgupta5297]

i love your channel ......all videos are just amazing.......please upload some more videos of pathology
#Medico

[@ilovepathologyVijayPatho]

Thanks:-)

[@euge6994]

Thank you so much! This was really helpfull and clear.

[@maryamaslam1612]

These are so helpful and easy to understand :) THANK YOU!!!!

[@rohit_roars]

Thank you for your explanation sir...

[@sugu239]

Great presentation

[@draasthak]

Very nice
Crisp and precise

[@yaqeenyousef8094]

thank youu sooo much you arethe best in pathology :)

[@ilovepathologyVijayPatho]

Yaqeen Yousef Thank you very much 😊

[@beesmooth6060]

Sir, what book do you recommend for exam point of view for second year mbbs?

[@drbiologyarun]

Amazing explanation.. Thank you 😊

[@alaaeltayeb9213]

this is a great time saving explanation
thanks alot

[@ShohobiddinErgashev-c5y]

Good explanation

[@councellortalang4959]

Wow❤❤❤❤❤❤🙏🙏

[@bayanalkhalifa1853]

the most helpful video! Thank u so much!

[@vrog]

Amazingly done.

[@AliKhan-sr1cm]

Great work bro

[@solangecontreras8325]

Thank you!!!! The information helped me a lot with my classes

[@ilovepathologyVijayPatho]

I'm so glad that it helped

[@varshilpatel2122]

Now I got it completely 🕺

[@mananvaid2304]

Lovely video! Thanks man! Keep uploading more videos. Greetings from Gujarat.

[@j3v167]

Hi. I have read an article where the P53 gene was mentioned. Could you please explain what is meant by mitochondrial translocation of the p53 gene?

[@Rotzfresh89]

Thank you so much for your efforts. Much appreciated!

[@fatimarushwan]

Great explanation, thanks

[@DRP.K]

Excellent 👍

[@shivanagpal1163]

Sir this video helps to learn a lot in short🙏🏆

[@samtaylor1070]

excellent video, thanks

[@aqibsyed8198]

thanks for best explanations.

[@tabasumashraf4035]

Thankyou ✨

[@saimas_craftastic_world]

Thanku so much sir... Really vey helpful