@@hotenyIn PIHKAL, Shulgin discusses the possibility of an astatine-incorporating phenylethylamine, 2C-A, a recreational dose of which would probably be around 10-20 mg. However, he concedes that acquiring the necessary ~10 mg of astatine might be a bit challenging (since you need a nuclear reactor to produce it, and its half-life is just 8 hours), and that even if you managed to synthesize your dose of 2C-A, the screaming radiation would be enough to send you to the afterlife.
I’m pretty sure 5-methoxy-N,N-dimethyltryptamine is perfectly legal in Mexico. Hamilton Morris did an entire video about it. All Nile has to do is go on a vacation…
Yes, and from today even weed is legal in Germany at least partly. meaning now you can make videos about weed and chemicals in it legally on youtube without trying to hide something.
never ? escaped or intentionally released gain of function modified pathogens ? nerve agent synthesis ? Perhaps you would be correct in the absence of the mentally ill, psychopathic or Islamic Jihadist death cults.
We live in time we are already there in a sense, I'm not sure why ppl say we only live in 3 since we live in 4 but yeah I digress... I wonder how many we could go trough before the brain just get scrambled maybe 3 more or so
There are some full syntheses via P2P on youtube. Well a couple of routes to P2P and one to racemic N-methyl-1-phenylpropan-2-amine from one of the P2P routes. I can't remember the channel name though. It is a horrid drug though. Makes you feel good for a few hours and then shit for days.
@@Sniperboy5551 Not in most places. The US is an oddity there and it is restricted in a bunch of states. It is an S4 prescription only medication where I live.
I started making my own NN like 10 years ago before it was as accessible as it is now. It's hard to explain, but it made the trips feel different. You almost build a bond with the product as you extract and refine it. And can almost trust it more because you helped create it.
phenylhydrazine dissolved in water + hs204 stirred for 30 mins + 4,4-Diethoxybutylamine dissolved in acetonitrile (equal volume as the water). let it run 40c for 8 hours (tryptamine synthesis 90%= yields at large scale) you can add another charge of hs204 and raise temps to 80c for a few hours and cyclize the newly made tryptamine to carboline. fischer indole rxn with no side products. grad school was fun.
i'm glad I stumbled upon this channel. I love all science channels, and glad to see 15 years later people from Nilered/blue, thought emporium, ex&fire ex&ire, ect, all commenting on Periodic Table Videos, univeristy from nottinham, chemist, with Neil and professor. It's finally gone full circle, and glad to see the channels i followed for many many years, finally be recognized.
You're mechanistic pathways are getting solid! 1 little thing I would look out for is the pka of (de)protonated species depicted. For instance, I doubt that the acetophenone is protonated upon nucleophilic attack from the amine, since its pka with the neutral form is less than 0 whereas the amine's pka is around 9 and so is a much stronger base than the carbonyl. That being said, tryptophan is a most likely in neutral form rather than zwitterion in this organic medium so you can think of this step as being assisted by H-bonding from the carboxylic acid with either concerted or stepwise deprotonation by the generated alkoxide. Same goes for the anions on aliphatic nitrogens, the pka of those with the neutral amine is around 35, so I would expect a proton assisted formation and scission of the hemi-aminal
You can increase the yield above 90% by using catalytic amounts of PhAc in refluxing cyclohexanol as a solvent. Gradually add the Trp powder in increments of 10 g / 100 mL until the previous addition is completely consumed (clear liquid). Boiling cHexOH can take almost it’s own mass in TNH2. Work up: Add equal volume of toluene, 1.1 eq. of 5% HCl , separate the aqueous layer and extract the organic phase 4 times with 5% aq. HCl. Wash 3 times with some DCM. Alkalise the combined aq. phases with aq. NaOH, extract product with DCM and evap. RC from MeCN. Although tryptamines are sensitive to strong acids, it’s totally fine for as long as it’s cooled, dilute and you work fast. And use a protective atmosphere throughout the reaction and work up as they oxidize readily, which causes the brown/red discolouration
@@sorenschleifenbaum9013 phAc - acetophenone, TNH2 - tryptamine, MeCN - acetonitrile, RC - re-crystallization My point is that the procedure used by chemiolis is designed to avoid exposing the product to strong acids as this catalyses it’s decomposition, but if you do this nonetheless in a controlled manner, the yield increases actually. An excess of ketone catalyst may actually lead to the formation the corresponding aldehyde instead of the amine of my memory serves me right. I did tryptamine chemistry a couple of years ago and found that if you keep it always cooled and under protective atmosphere (pretty basic organic synthesis stuff), it’s not as difficult to handle as is commonly believed
If I were doing this, I would simply take tryptophan (the amino acid behind all of the magic) and react it with a decarboxylase enzyme as done/performed in most organisms anyways. The biochem approach would best help ensure a 1:1 concentration ratio of your starting material and your end product (thanks to the billions of years of evolution that has lead to these marvels in the first place). OR, what you could do instead is take 2-aminoethyl dihydrogen phosphate and indole as your main primary reactants as you want to add the 2-aminoethyl group to the 3rd position of the indole group. Take a condensing agent such as dilute hydrochloric acid in order to form the imine intermediate and a reducing agent such as iron or zinc (dust/powdered pure form) or borane complexes (BH3-THF or BH3-DMS) with the acidic conditions assisting in the reduction of the imines produced during the intermediate production. Best part about this method is that you can just do it all in batch and then all you've got to do after that is neutralise and purify your samples.
I was wondering if AMT can be made from tryptophan, red P and iodine. I know aminoacids can be decarboxilated with copper carbonate so heat shouldn't break them down. Or even carboxylic acid reduced to an alkane. Just seems like it should work.
@@Raycast_Yes sir! I was super impressed with 4-HO-MET; I tried solving a Rubik’s cube at a healthy +++ and it was like I was solving a Rubiks “hypercube” in 4d; took waaay longer than normal but by God I solved that shit lol very smooth on the way down too, slept great a mere 8 hours later 👍
Nice work on the decarboxylation, didn't know iminium salts could be isolated like that. Depends heavily on the imine I imagine. Letting reactions stand is usually fine (though more of a 1950s and before thing), but the mixture should be homogenous at that point.
"It makes snappy bubbly sounds that are very satisfying"... You had me on that. But the whole of the video just got me curious into your other videos. And got me to sub/bell. JUST in case this gets taken down... One should download/store it somewhere.
Enlightenment is like jumping out of an airplane without a parachute. So the bad news is that you don't have parachute, but the good news is that you discover there is no ground. And then you're just endlessly falling and you never reach the ground. So in a sense, what i'm asking you to do is to jump. And you don't want to jump. You're saying, I'm scared. I'm too scared to jump. And I'm saying, jump. God is telling you, jump, jump into infinite love and it's going to be great. But you're like, what if I kill myself and what if something else happens? I don't know. You just jump into infinite love. Take the leap of faith and you'll discover infinite love. And you're too scared to do it. But then eventually when you do it, then you're just going to discover that there's no ground. You're endlessly falling forever and it's great. But yeah, taking that leap is really difficult. It requires you to face your death. So of course, everybody is too afraid to do it. People are just to scared.
You can look at a wall and you can think of an elephant and you will see an elephant in the wall because as it turns out that's the actual mechanism by which all of reality is created. It's not really that you're hallucinating or something is wrong with you. You're not going crazy if you see an elephant in the wall. What's happening is Law of Attraction is happening. You are materializing the things that you are thinking. From this super fluid state you are able to imagine entirely new worlds and realities and it feels so surreal and unbelievable because it's too good to be true. Reality is pure imagination. TADA!
I'm talking about a robust deeply sophisticated notion of hallucination. Hallucinations that are so real you cannot distinguish them from reality. Hallucinations that are so mesmerizing that... Imagine that you started imagining that you were a kangaroo and you just sat there day after day after day imagining that you were a kangaroo and you imagined it so much that you literally became a kangaroo and you could not remember anymore that you were ever a human. That's the kind of power of imagination that I'm talking about.
Hey man, really nice video. I'm pretty sure that most of your yield disappeared into the oil layer. Why not just hydrolyze the acetone imine with acetic acid for some time with strong stirring in aqueous solution, basify the solution with NaOH, filter it and carry on with the next step?
Useful and really interesting video mate - iv tried a ketone catalysed rxn with cyclohexanone and again with peppermint oil - TOTALLY unsuccessful…it was however my first synthesis so I’m not too surprised. May try again one day using your method tbf….I even tried salting it out the way you did but don’t THINK I ever managed it successfully…ended up buying some lol
that purple colour at the end of the video is pretty nice... i´ve made indigo colours in pink to purple and yellow and green with benzaldehyde and alanine, sodiumhydrogencarbonate and l+ tartaric acid... but i forgot how to make it exactly... last year i knew... damn...
2:25 In "Silence of the Lambs", Hannibal Lecter claims to have eaten a man's liver "with fava beans, and a nice Chianti". This was likely intended as deliberate reference to the list of foods that are considered incompatible with MAO inhibitors; Lecter is gloating that while he may be a cannibal, he doesn't think of himself as "mentally ill", or atleast he's not depressed about his impulses.
@@WuTangChopstick why make it so hard, just look up mimosa hostilis root bark or acacia (anything really) confusa root bark and you're good to extract easy.
How is this not OK you can literally write the federal government and ask them for the information to create LSD bombs etc. it’s called the freedom of information act. It’s what you do with that information that gets you into trouble.
Just a heads up, I've taken MAOIs for a long time and have the degrees to back up my own experience. Tyramine reactions are rarely that severe, they're often similar to a prolonged panic attack with a headache... in fact much of the damage done by them in years gone by was when doctors attempted to tank blood pressure and starved either the heart or brain of sufficient blood flow.
It's also variable, often causing no reaction at all. I got away with eating many tyramine rich foods when I was prescribed them. My shrink warned me that this didn't mean I had immunity or tolerance, and any at any future occasion I might get a severe reaction. It's a crapshoot Also, it's been found that processed commercial pizza cheese (in the US, anyways) has no mozzarella, so doesn't pose the danger once thought. True for a lot of other "aged", but highly processed foods.
I had not considered the idea the chemistry of Tyrosine kinase inhibitors being distantly related to hallucinogenic drugs. Been designing cisplatin-Tki prodrugs with them for my thesis.
You can legally produce 5meo-dmt using melatonin and a few other non restricted off the shelf chemicals (since all the precursor aren't controlled, how will they know u got 5meo?) You can go in a Forest or swamp and find the right tree, flowers, or specific grasses and 40bucks at a Lowe's and you can easily extract your own DMT
There used to be a fantastic "How To" video on an extremely simplistic method of extraction that took 10 minutes. Of course I did not realize that it would be pulled down because I am not a computer guy so I neglected to pay attention. I tried to return to it to write it down & it was gone. POOF! Like that it was deleted. How damn stupid! Something that does absolutely NO HARM & helps multitudes of people with serious issues. Oh No . . . We wouldn't want anything healthy on the web, my goodness, can you imagine how horrific the world would become if people were healthy & happy. What a nightmare -
Am I sitting in a tin can Far above the world Planet Earth is blue And there's nothing I can do Ya i have study these molecule's since i first started chemistry way back when before info was widely available its a good bus ride.
2:25 This effect is pretty overblown. It doesn't apply at all to reversible inhibitors like beta-carbolines because as concentrations of other amines (e.g. tyramine) rise, they displace the inhibitor. (This is also why reversibles are poor antidepressants.) With respect to irreversible inhibitors (e.g. tranylcypromine, phenelzine), which react covalently to destroy the enzyme, the human body still retains (diminished) capacity to metabolize dietary monoamines, both from residual MAO as well as other enzymes (e.g. hepatic cytochrome oxidases). As a result, there is a threshold dose for tyramine-induced hypertension, which varies by person and food source, but in the absolute worst case is still approximately a quarter pound (0.1 kg) of cheese. Probably not the best dietary practice in any case. Like anything else, the effect beyond that point scales with dosage. The symptoms can be uncomfortable but are very rarely medically problematic, as it is very difficult for tyramine alone to raise blood pressure above the levels seen during intense exercise, and the body is capable of clearing systemic tyramine in 1-2 hours. Ironically, fear of this effect has led to inappropriate overtreatment, where powerful antihypertensives are used and cause dangerously low blood pressure since the tyramine is shortly cleared. For context, millions of people were prescribed irreversible MAOIs during the early 60s (when tyramine levels in food were much higher), with no knowledge or warning of this possibility, and there were only a handful of cases of death occurring, which were due to cerebral hemorrhage. Any time your blood pressure rises a lot, even during intense exercise, there is a risk of this happening, but fundamentally it is because of a pre-existing weakness in the cerebral vasculature. This is something that people on MAOIs have to be aware of, but with a little knowledge and common sense, it just isn't a problem. Unfortunately, misperceptions of risk have led to MAOIs being mostly shelved, even though they are highly effective antidepressants and anxiolytics that often work when everything else, even shock therapy, has failed. Candidly, once you've seen the effect a drug like tranylcypromine can have on someone, people who once looked like walking corpses now restored to life, suddenly filled with joy and passion, you will wonder why anyone would accept "I'm not sure if it's placebo" SSRIs.
Couldn't you just start with acetone as the solvent for the decarboxylation if you displace the acetophenone with acetone anyway or ist the bp too low?
I really enjoyed Chemistry in College. I am super good at Math and studied Agricultural Ecology. I almost went into Soil Science. I have this crazy dream of getting Math, Chem and Physics Degrees to discover new things! I've been practicing Silat and Escrima since 1993. I have these really far out ideas all the time. I grew up in Hollywood!
I extracted DMT from elder berry using acetone with a base of benzoic acid and threw in salt with apple cider vinegar to isolate the isotopes. What was left was a sticky substance which gave a high like 5-meo malt Hnicro!! Hnicro is similar to 5-meo DMT without the nitrogen beta Ring!!
The sad thing is Ive been clean for a loooong time, but I will always love pharmacochemistry and even liking videos like this could cause me to lose my job. Youd think intelligent people were some kind of threat...
I remember a teacher was asking us all what we wanted to do when we got older and one kid said he wanted to be a chemist. She was all happy and started to nerd out, then he interrupted her and said he just wanted to make his own drugs. She looked like she got punched in the stomach. Ill never forget it. I think he broke that teacher that day.😅😂
CRUSHER: No. Usually a temporal shift would leave some kind of triptamine residue in the cerebral cortex, but the scan didn't show any. Personally, I think you just enjoy waking everybody up in the middle of the night.
I learned how to make DMT from a kid on RUclips with a Bronx accent said he was in Peru 😂 I thought about making some videos of it but I don't think it's a safe thing for people to be doing on there own it's far to dangerous and luckily I didn't have any serious issues but I hope it becomes legal someday because it's life changing for the better
So the acetone is using its alpha carbon via its enolate form to do nucleophilic attack on the carbon of phenylacetoimine ? Isn’t that carbon a bit statically hindered?
I think he's dutch and here it's legal (I've used it myself a couple of times and it's my go to trip drug lol, hardest I've tripped was with like 15mg of 4-ho-met and a ton of weed, it felt like my head was on my feet and that everything was upsidedown and then back normal again like holy shit it was funny asf)
How do you measure the yield? And also, how do you remove the impurities? Seems like very important safety steps. Would much appreciate some insight into this.
i understand EWG EDG & SN1 VS SN2. but where would i find resources describing condition's where the aliphatic chain is added to as opposed to the phenol ring? is this just anti markovnikov using peroxides as well as SN2 with strong nucleophiles so there is no carbocation intermediate for methyl or hydride shifts? ? EAS & NAS dont seem to cover this.
Assuming you really wanted to make a betacarboline and not an camouflaged intermediate for a different type of drug, why didn't you use anisaldehyde as stochiometric decarboxylation catalyst and use the resulting imine directly for the Pictet-Spengler reaction?
Acetophenone is unreliable for me and is a roll of a dice but cyclohexanone gives consistent 40% to 60% and isophorone is way better. spearmint oil is nice but it must be purified to carvone.
Better use benzyl alcohol how solvent and 2-5mol% isophorone or carvone catalyst and workup vacuum distillation without salt tryptamine, yeld 75-88% in one step
1:18 That's not correct. The 5-HT2A receptor has at least two, I think three, different activation pathways. Serotonin, as a full agonist, will activate all three, while most psychedelics such as DMT, psilocin and LSD will activate just one of those pathways. If you look closely, at the OH of serotonin, which is not part of DMT as that carbon is saturated, is part of the mechanism behind it all. Serotonin will stimulate all 2-3 pathways for the receptor, most psychedelics being partial agonists will just activate one. That imbalanced activation is suspected to be a root mechanism for the psychedelic experience, stimulating without countering with inhibition. If all three pathways are activated, there is stimulation countered by inhibition along with a modulating cascade across neo-cortex and amygdala. LSD is a little bit different, but that's another topic.
6:29 wait i thought imines were base stable, wouldn't it be hydrolyzed in acid? (I know I could totally be wrong here, haven't worked with imines much, may be thinking of something else.)
Also, congrats/good choice on avoiding the use of volatile indoles for this. Having a project that started with skatole for four years, I can tell you that smell don't come out easy.
![Stromae, Pomme - “Ma Meilleure Ennemie” (from Arcane Season 2) [Official Visualizer]](http://i.ytimg.com/vi/1F3OGIFnW1k/mqdefault.jpg)
If it wasn't so illegal, "Making DMT from a Turkey" would be such a NileRed video
Bro should still do it for educational purposes only (and he should add some uranium in it since why not)
@@hotenyIn PIHKAL, Shulgin discusses the possibility of an astatine-incorporating phenylethylamine, 2C-A, a recreational dose of which would probably be around 10-20 mg.
However, he concedes that acquiring the necessary ~10 mg of astatine might be a bit challenging (since you need a nuclear reactor to produce it, and its half-life is just 8 hours), and that even if you managed to synthesize your dose of 2C-A, the screaming radiation would be enough to send you to the afterlife.
I’m pretty sure 5-methoxy-N,N-dimethyltryptamine is perfectly legal in Mexico. Hamilton Morris did an entire video about it. All Nile has to do is go on a vacation…
Broooo😂@@hoteny
@@Sniperboy5551 cartel wouldn’t let go of nilered (their superior chemistry guy)
It truly is a golden age of chemistry youtube.
We're taking back the 50s baby, yeah
ah yes, alchemist, havent heard of that since the renaissance era
Yes, and from today even weed is legal in Germany at least partly. meaning now you can make videos about weed and chemicals in it legally on youtube without trying to hide something.
No way. Do you not remember ChemPlayer?
The god fatger is
Nile red/blue
"No literature was used for Tryptamine synthesis."
Shulgin would be proud :)
May he rest in peace.
I've known and loved
@@robertchampeau6867 phenethylamines and tryptamines both
Ruflux tryptophan in KOH?
Information should never be suppressed
But always is.
i have like 10 yt profiles just for commenting
@@dannacollins2520It is is it?
never ? escaped or intentionally released gain of function modified pathogens ? nerve agent synthesis ? Perhaps you would be correct in the absence of the mentally ill, psychopathic or Islamic Jihadist death cults.
It's only as suppressed as you let it be.
Salute
Its a crime that tryptamines are illegal! Incredible potential in therapy.
hopefully that will start changing soon
@sem9799 not the good ones tho, imo. Maybe some pro-drugs
You could also go insane you shouldn't use them like an afternoon joint
@@S.aTan-._.- Yeah insanely enlightened! I took LSD maybe 100 times
@@Basieeee do a candy flip then
We making it to the 4th dimension 🗣🔥
Higher!
We live in time we are already there in a sense, I'm not sure why ppl say we only live in 3 since we live in 4 but yeah I digress... I wonder how many we could go trough before the brain just get scrambled maybe 3 more or so
pffft.
i'm in the 2nd dimension hurry
Can't wait for the next video: synthesis of (2S)-N-methyl-1-phenylpropan-2-amine!
Uncle Fester did that one with Hamilton's Pharmacopeia, minus the very last step.
There are some full syntheses via P2P on youtube. Well a couple of routes to P2P and one to racemic N-methyl-1-phenylpropan-2-amine from one of the P2P routes. I can't remember the channel name though. It is a horrid drug though. Makes you feel good for a few hours and then shit for days.
@chrisbrent7487 Propylhexedrine is still sold over-the-counter
@@Sniperboy5551 Not in most places. The US is an oddity there and it is restricted in a bunch of states. It is an S4 prescription only medication where I live.
meh that's barely a step above baking soda volcano for a guy like chemiolis
Shoutout all you chemists making chemistry interesting and keeping me learning and changing perspectives of this world
I started making my own NN like 10 years ago before it was as accessible as it is now. It's hard to explain, but it made the trips feel different. You almost build a bond with the product as you extract and refine it. And can almost trust it more because you helped create it.
Yeah, absolutely, even down to brewing beer, you have to share it and since its your own its so spécial
Miss it lol it's been awhile since I launched
For the love of god please help me 😭
phenylhydrazine dissolved in water + hs204 stirred for 30 mins + 4,4-Diethoxybutylamine dissolved in acetonitrile (equal volume as the water). let it run 40c for 8 hours (tryptamine synthesis 90%= yields at large scale) you can add another charge of hs204 and raise temps to 80c for a few hours and cyclize the newly made tryptamine to carboline. fischer indole rxn with no side products. grad school was fun.
I've been thinking about this synthesis for years. Thank you for making a detailed video on it!
Hamilton interviews a “chromium carbene chemist” who talks about it quite a lot
Yeah...me too
This may as well have been in a foreign language for me but i stayed till the end anyway. "That was it. See you." 😂
Yah it sounds identical to me as that Corporate Jargon meme video, but I love falling asleep to complex chemistry RUclips videos!
hell yeah tryptamine time
7:35 why is this filtration so satisfying to watch? Everytime the pump is switched on you can watch the filter get sucked down.
i'm glad I stumbled upon this channel. I love all science channels, and glad to see 15 years later people from Nilered/blue, thought emporium, ex&fire ex&ire, ect, all commenting on Periodic Table Videos, univeristy from nottinham, chemist, with Neil and professor. It's finally gone full circle, and glad to see the channels i followed for many many years, finally be recognized.
This video came out right as I was partaking in some tryptamine-based compounds! Great timing!
😅
Pfp checks out ✅
@@DruggiePlays best part is that’s not at all what I was going for with this pfp lmao
@@TagetesAlkesta It looks like a grapefruit to me.
@@TagetesAlkesta kinda looks like a peyote lol
You're mechanistic pathways are getting solid! 1 little thing I would look out for is the pka of (de)protonated species depicted. For instance, I doubt that the acetophenone is protonated upon nucleophilic attack from the amine, since its pka with the neutral form is less than 0 whereas the amine's pka is around 9 and so is a much stronger base than the carbonyl. That being said, tryptophan is a most likely in neutral form rather than zwitterion in this organic medium so you can think of this step as being assisted by H-bonding from the carboxylic acid with either concerted or stepwise deprotonation by the generated alkoxide.
Same goes for the anions on aliphatic nitrogens, the pka of those with the neutral amine is around 35, so I would expect a proton assisted formation and scission of the hemi-aminal
anime amine anime proton
Tell me more about the zwitterion
Is homie even speaking English???
ON GANG 🗣🗣🗣🔥🔥🔥
You can increase the yield above 90% by using catalytic amounts of PhAc in refluxing cyclohexanol as a solvent. Gradually add the Trp powder in increments of 10 g / 100 mL until the previous addition is completely consumed (clear liquid). Boiling cHexOH can take almost it’s own mass in TNH2. Work up: Add equal volume of toluene, 1.1 eq. of 5% HCl , separate the aqueous layer and extract the organic phase 4 times with 5% aq. HCl. Wash 3 times with some DCM. Alkalise the combined aq. phases with aq. NaOH, extract product with DCM and evap. RC from MeCN. Although tryptamines are sensitive to strong acids, it’s totally fine for as long as it’s cooled, dilute and you work fast. And use a protective atmosphere throughout the reaction and work up as they oxidize readily, which causes the brown/red discolouration
Hey
Few questions,
What is PhAc?
What is TNH2?
What you mean by RC from MeCN?
@@sorenschleifenbaum9013 phAc - acetophenone, TNH2 - tryptamine, MeCN - acetonitrile, RC - re-crystallization
My point is that the procedure used by chemiolis is designed to avoid exposing the product to strong acids as this catalyses it’s decomposition, but if you do this nonetheless in a controlled manner, the yield increases actually. An excess of ketone catalyst may actually lead to the formation the corresponding aldehyde instead of the amine of my memory serves me right. I did tryptamine chemistry a couple of years ago and found that if you keep it always cooled and under protective atmosphere (pretty basic organic synthesis stuff), it’s not as difficult to handle as is commonly believed
@@sorenschleifenbaum9013 PhAc = acetophenone; TNH2 = tryptamine (as the NH2 represents the amino group); RC from MeCN = recrystallise from acetonitrile.
Better benzyl alcohol because good smell and yeld 75-88%
And workup possible without HCl, just fraction vacuum distillation RM after deccarboxylation
If I were doing this, I would simply take tryptophan (the amino acid behind all of the magic) and react it with a decarboxylase enzyme as done/performed in most organisms anyways. The biochem approach would best help ensure a 1:1 concentration ratio of your starting material and your end product (thanks to the billions of years of evolution that has lead to these marvels in the first place).
OR, what you could do instead is take 2-aminoethyl dihydrogen phosphate and indole as your main primary reactants as you want to add the 2-aminoethyl group to the 3rd position of the indole group. Take a condensing agent such as dilute hydrochloric acid in order to form the imine intermediate and a reducing agent such as iron or zinc (dust/powdered pure form) or borane complexes (BH3-THF or BH3-DMS) with the acidic conditions assisting in the reduction of the imines produced during the intermediate production. Best part about this method is that you can just do it all in batch and then all you've got to do after that is neutralise and purify your samples.
better than my organic chem lectures
4-HO-MiPT is one of the magical ones.
Beautiful chemical
I was wondering if AMT can be made from tryptophan, red P and iodine. I know aminoacids can be decarboxilated with copper carbonate so heat shouldn't break them down.
Or even carboxylic acid reduced to an alkane. Just seems like it should work.
4-HO-MET with some weed thoughhh
Like holy shit it gets the inner child out of you
@@Raycast_Yes sir! I was super impressed with 4-HO-MET; I tried solving a Rubik’s cube at a healthy +++ and it was like I was solving a Rubiks “hypercube” in 4d; took waaay longer than normal but by God I solved that shit lol very smooth on the way down too, slept great a mere 8 hours later 👍
The outro cracked me up. "That was it. See you 😒"
I believe there are serious medical applications for tryptamines, in treating ptsd, depression, and anxiety.
I believe it is to do with serotonin
Nice work on the decarboxylation, didn't know iminium salts could be isolated like that. Depends heavily on the imine I imagine. Letting reactions stand is usually fine (though more of a 1950s and before thing), but the mixture should be homogenous at that point.
In 2002 i smoked dmt and it was an orange crystal. Similar to orange in beginning
I smoked red yellow and white dmt in 2023
You hear any loud knocks and or see bright lights shinning through your windows, greet them with a smile xD
We’re gonna be meeting with the gods with this one
"It makes snappy bubbly sounds that are very satisfying"... You had me on that. But the whole of the video just got me curious into your other videos. And got me to sub/bell.
JUST in case this gets taken down... One should download/store it somewhere.
Enlightenment is like jumping out of an airplane without a parachute.
So the bad news is that you don't have parachute, but the good news is that you discover there is no ground. And then you're just endlessly falling and you never reach the ground.
So in a sense, what i'm asking you to do is to jump. And you don't want to jump. You're saying, I'm scared. I'm too scared to jump. And I'm saying, jump. God is telling you, jump, jump into infinite love and it's going to be great. But you're like, what if I kill myself and what if something else happens? I don't know. You just jump into infinite love. Take the leap of faith and you'll discover infinite love. And you're too scared to do it. But then eventually when you do it, then you're just going to discover that there's no ground. You're endlessly falling forever and it's great. But yeah, taking that leap is really difficult. It requires you to face your death. So of course, everybody is too afraid to do it. People are just to scared.
:)
You can look at a wall and you can think of an elephant and you will see an elephant in the wall because as it turns out that's the actual mechanism by which all of reality is created. It's not really that you're hallucinating or something is wrong with you. You're not going crazy if you see an elephant in the wall. What's happening is Law of Attraction is happening. You are materializing the things that you are thinking.
From this super fluid state you are able to imagine entirely new worlds and realities and it feels so surreal and unbelievable because it's too good to be true.
Reality is pure imagination. TADA!
I'm talking about a robust deeply sophisticated notion of hallucination. Hallucinations that are so real you cannot distinguish them from reality. Hallucinations that are so mesmerizing that... Imagine that you started imagining that you were a kangaroo and you just sat there day after day after day imagining that you were a kangaroo and you imagined it so much that you literally became a kangaroo and you could not remember anymore that you were ever a human. That's the kind of power of imagination that I'm talking about.
Jump into infinite love. Sky diving... Talk about feeling! You WILL feel something far, far more than the fear of falling. I L is real
I'll face my death when its my time, life is short as it is. no sense in cutting it short. I'll enjoy the ride while I'm on it 👍
Hey man, really nice video. I'm pretty sure that most of your yield disappeared into the oil layer. Why not just hydrolyze the acetone imine with acetic acid for some time with strong stirring in aqueous solution, basify the solution with NaOH, filter it and carry on with the next step?
It would be such a shame if you methylated the amine
No you're so sexy haha don't methylate the amine
Nah, it would be a waste of time and resources to synthesize such a common naturally occurring compound. It’s done occasionally but…😏
I personally think it wouldn't align with my moral standards.
Useful and really interesting video mate - iv tried a ketone catalysed rxn with cyclohexanone and again with peppermint oil - TOTALLY unsuccessful…it was however my first synthesis so I’m not too surprised. May try again one day using your method tbf….I even tried salting it out the way you did but don’t THINK I ever managed it successfully…ended up buying some lol
Ive always been interested in chemistry. Glad i found your channel. Very cool my friend
If I was taught chemistry and biology this way in school, I would have given a shit.
that purple colour at the end of the video is pretty nice... i´ve made indigo colours in pink to purple and yellow and green with benzaldehyde and alanine, sodiumhydrogencarbonate and l+ tartaric acid... but i forgot how to make it exactly... last year i knew... damn...
2:25 In "Silence of the Lambs", Hannibal Lecter claims to have eaten a man's liver "with fava beans, and a nice Chianti".
This was likely intended as deliberate reference to the list of foods that are considered incompatible with MAO inhibitors; Lecter is gloating that while he may be a cannibal, he doesn't think of himself as "mentally ill", or atleast he's not depressed about his impulses.
DMT is SOOO easy to extract. It's insane.
how to make DMT from tryptophan ?
@@WuTangChopstick why make it so hard, just look up mimosa hostilis root bark or acacia (anything really) confusa root bark and you're good to extract easy.
@@WuTangChopstick no you extract it from mimosa hostilis root bark it's very easy to
Dr. Bones McCoy: In this timeline, Jim, they are going to tell EVERYONE how to synthesize Cordrazine from rubber bands and pineapple.
Push-Pull extraction from Mimosa is a hell lot of easier and less hazardous folks.
My boy is a gift to the enlightened world. Bless you child.
Nice video. I also like how you always explain the reaction mechanisms. Missing o-chem!
- from a p-chemist
I love how not ok this is but RUclips still hasn't seen it yet. 🤣
You're the goat.
Keep up the awesome work dude.
Fist bump. 👊😎
how is it not okay? tryptamine isnt psychoactive or illegal. i didn see any methyl groups on that alkyl chain.
How is this not OK you can literally write the federal government and ask them for the information to create LSD bombs etc. it’s called the freedom of information act. It’s what you do with that information that gets you into trouble.
@@Mp-jw1qg it's still technically manufacturing.
@@williamcunningham1669 manufacturing something legal. whats the problem?
now i want you to replace the hydrogens with methyl groups
👇👇
I recently ran out of 4-HO-MET so this could be useful.
Just a heads up, I've taken MAOIs for a long time and have the degrees to back up my own experience. Tyramine reactions are rarely that severe, they're often similar to a prolonged panic attack with a headache... in fact much of the damage done by them in years gone by was when doctors attempted to tank blood pressure and starved either the heart or brain of sufficient blood flow.
It's also variable, often causing no reaction at all. I got away with eating many tyramine rich foods when I was prescribed them. My shrink warned me that this didn't mean I had immunity or tolerance, and any at any future occasion I might get a severe reaction. It's a crapshoot Also, it's been found that processed commercial pizza cheese (in the US, anyways) has no mozzarella, so doesn't pose the danger once thought. True for a lot of other "aged", but highly processed foods.
I had not considered the idea the chemistry of Tyrosine kinase inhibitors being distantly related to hallucinogenic drugs. Been designing cisplatin-Tki prodrugs with them for my thesis.
You can legally produce 5meo-dmt using melatonin and a few other non restricted off the shelf chemicals (since all the precursor aren't controlled, how will they know u got 5meo?)
You can go in a Forest or swamp and find the right tree, flowers, or specific grasses and 40bucks at a Lowe's and you can easily extract your own DMT
You wouldn’t mind elaborating?🤔
There used to be a fantastic "How To" video on an extremely simplistic method of extraction that took 10 minutes. Of course I did not realize that it would be pulled down because I am not a computer guy so I neglected to pay attention. I tried to return to it to write it down & it was gone. POOF! Like that it was deleted. How damn stupid! Something that does absolutely NO HARM & helps multitudes of people with serious issues. Oh No . . . We wouldn't want anything healthy on the web, my goodness, can you imagine how horrific the world would become if people were healthy & happy. What a nightmare -
@@jamesmaxdavissandsdmt nexus has plenty of teks for extraction
@@andrewaustin6020dmt nexus
Shoutout to squarespace 🙌🏽😅
I love learning new stuff
Fuck yeah 👍
Me too
Did you get inspired by TiKHAL? ;D
Alright you’ve got my attention.
Am I sitting in a tin can
Far above the world
Planet Earth is blue
And there's nothing I can do
Ya i have study these molecule's since i first started chemistry way back when before info was widely available its a good bus ride.
An elf told me that the reaction also works well with spearmint oil as a catalyst 🤓
Nature does it so much cleaner 🎉
eyy a dutch brother, keep up the amazing content
2:25
This effect is pretty overblown. It doesn't apply at all to reversible inhibitors like beta-carbolines because as concentrations of other amines (e.g. tyramine) rise, they displace the inhibitor. (This is also why reversibles are poor antidepressants.)
With respect to irreversible inhibitors (e.g. tranylcypromine, phenelzine), which react covalently to destroy the enzyme, the human body still retains (diminished) capacity to metabolize dietary monoamines, both from residual MAO as well as other enzymes (e.g. hepatic cytochrome oxidases). As a result, there is a threshold dose for tyramine-induced hypertension, which varies by person and food source, but in the absolute worst case is still approximately a quarter pound (0.1 kg) of cheese. Probably not the best dietary practice in any case. Like anything else, the effect beyond that point scales with dosage.
The symptoms can be uncomfortable but are very rarely medically problematic, as it is very difficult for tyramine alone to raise blood pressure above the levels seen during intense exercise, and the body is capable of clearing systemic tyramine in 1-2 hours. Ironically, fear of this effect has led to inappropriate overtreatment, where powerful antihypertensives are used and cause dangerously low blood pressure since the tyramine is shortly cleared.
For context, millions of people were prescribed irreversible MAOIs during the early 60s (when tyramine levels in food were much higher), with no knowledge or warning of this possibility, and there were only a handful of cases of death occurring, which were due to cerebral hemorrhage. Any time your blood pressure rises a lot, even during intense exercise, there is a risk of this happening, but fundamentally it is because of a pre-existing weakness in the cerebral vasculature.
This is something that people on MAOIs have to be aware of, but with a little knowledge and common sense, it just isn't a problem. Unfortunately, misperceptions of risk have led to MAOIs being mostly shelved, even though they are highly effective antidepressants and anxiolytics that often work when everything else, even shock therapy, has failed. Candidly, once you've seen the effect a drug like tranylcypromine can have on someone, people who once looked like walking corpses now restored to life, suddenly filled with joy and passion, you will wonder why anyone would accept "I'm not sure if it's placebo" SSRIs.
Enclomiphine for research purposes would be cool
Couldn't you just start with acetone as the solvent for the decarboxylation if you displace the acetophenone with acetone anyway or ist the bp too low?
I hope he synthesized a get out of jail free card first 🤔
I really enjoyed Chemistry in College. I am super good at Math and studied Agricultural Ecology. I almost went into Soil Science. I have this crazy dream of getting Math, Chem and Physics Degrees to discover new things! I've been practicing Silat and Escrima since 1993. I have these really far out ideas all the time. I grew up in Hollywood!
Science on RUclips = balls of cosmic steel ❤❤
I swear that some of those molecules look like they're straight out of the dune books. The spice must flow!
What does that even mean
@boyznthewoodz770 There is spice that necessarily must flow
@@White_Breederthe tooth
I extracted DMT from elder berry using acetone with a base of benzoic acid and threw in salt with apple cider vinegar to isolate the isotopes. What was left was a sticky substance which gave a high like 5-meo malt Hnicro!! Hnicro is similar to 5-meo DMT without the nitrogen beta Ring!!
Seriously? Does this really work?
@@lextalonis839 no lol, elder berries do not contain DMT. hes just trolling with buzzword nonsense
Hell's yes, I love tryptamines.
very cool video thank you for the time much appreciated.
Apparently converting tryptamines is pretty easy
The interview I’d Hamilton with the “chromium carbene chemist” talks about it a lot.
The sad thing is Ive been clean for a loooong time, but I will always love pharmacochemistry and even liking videos like this could cause me to lose my job. Youd think intelligent people were some kind of threat...
I remember a teacher was asking us all what we wanted to do when we got older and one kid said he wanted to be a chemist. She was all happy and started to nerd out, then he interrupted her and said he just wanted to make his own drugs. She looked like she got punched in the stomach. Ill never forget it. I think he broke that teacher that day.😅😂
Amazing diagrams
CRUSHER: No. Usually a temporal shift would leave some kind of triptamine residue in the cerebral cortex, but the scan didn't show any. Personally, I think you just enjoy waking everybody up in the middle of the night.
I learned how to make DMT from a kid on RUclips with a Bronx accent said he was in Peru 😂 I thought about making some videos of it but I don't think it's a safe thing for people to be doing on there own it's far to dangerous and luckily I didn't have any serious issues but I hope it becomes legal someday because it's life changing for the better
Willymyco? Lol
5-MeO when🗣️🗣️🗣️
actually making it from melatonin would be fun
Good job boys, well done!!
So the acetone is using its alpha carbon via its enolate form to do nucleophilic attack on the carbon of phenylacetoimine ? Isn’t that carbon a bit statically hindered?
4-HO-MET is a tryptamine I found quite enlightening. But I’m not sure if you’re allowed to synthesise it in your state
I think he's dutch and here it's legal (I've used it myself a couple of times and it's my go to trip drug lol, hardest I've tripped was with like 15mg of 4-ho-met and a ton of weed, it felt like my head was on my feet and that everything was upsidedown and then back normal again like holy shit it was funny asf)
If i could get 5 dimensional molecular tag of this i would be happy 9:37
Nice
Ahhh! Magnificent splendor!!!
How do you measure the yield? And also, how do you remove the impurities? Seems like very important safety steps. Would much appreciate some insight into this.
I,d be very willing to be a test subject for any D.M.T. research happening out there. ! ! !
I've been added to so many watch lists tonight because of my recommended videos it's not even funny. 😂 TNT, Dynamite, MDMA and this.
5-meo-MIPT is STILL legal in canada
hey man, I was just wondering if you made that psilocybin model in chimera... and if you did, what computer specs are you using?
Finally ❤
I have experimented with 5Meo amyl triptamine
Sponsored by squarespace, wow 🎉
Omg I love dis! "That was it.. see you!" 😅
Thanks 😊
i understand EWG EDG & SN1 VS SN2. but where would i find resources describing condition's where the aliphatic chain is added to as opposed to the phenol ring? is this just anti markovnikov using peroxides as well as SN2 with strong nucleophiles so there is no carbocation intermediate for methyl or hydride shifts? ? EAS & NAS dont seem to cover this.
Who doesn't love a good tryptamine?
Assuming you really wanted to make a betacarboline and not an camouflaged intermediate for a different type of drug, why didn't you use anisaldehyde as stochiometric decarboxylation catalyst and use the resulting imine directly for the Pictet-Spengler reaction?
How about that! Perhaps you can proceed, and show us how to make the DM* stuffs?
Just look up dmt nexus
Its illegal because if enough tryptamines are consumed the user realizes they don't need laws
True
make amyl nitrite for relaxation next
Acetophenone is unreliable for me and is a roll of a dice but cyclohexanone gives consistent 40% to 60% and isophorone is way better. spearmint oil is nice but it must be purified to carvone.
Better use benzyl alcohol how solvent and 2-5mol% isophorone or carvone catalyst and workup vacuum distillation without salt tryptamine, yeld 75-88% in one step
Let me try i got all those reagents
1:18 That's not correct. The 5-HT2A receptor has at least two, I think three, different activation pathways. Serotonin, as a full agonist, will activate all three, while most psychedelics such as DMT, psilocin and LSD will activate just one of those pathways. If you look closely, at the OH of serotonin, which is not part of DMT as that carbon is saturated, is part of the mechanism behind it all. Serotonin will stimulate all 2-3 pathways for the receptor, most psychedelics being partial agonists will just activate one. That imbalanced activation is suspected to be a root mechanism for the psychedelic experience, stimulating without countering with inhibition. If all three pathways are activated, there is stimulation countered by inhibition along with a modulating cascade across neo-cortex and amygdala. LSD is a little bit different, but that's another topic.
I dont get it, at the end of the first decarboxylation, couldnt you pull the tryptamine with a naphtha like solvent???
6:29 wait i thought imines were base stable, wouldn't it be hydrolyzed in acid? (I know I could totally be wrong here, haven't worked with imines much, may be thinking of something else.)
Also, congrats/good choice on avoiding the use of volatile indoles for this. Having a project that started with skatole for four years, I can tell you that smell don't come out easy.
Tryptipmenes got me off opiods and opiates